2024
A computational account of the development and evolution of psychotic symptoms.
Powers A, Angelos P, Bond A, Farina E, Fredericks C, Gandhi J, Greenwald M, Hernandez-Busot G, Hosein G, Kelley M, Mourgues C, Palmer W, Rodriguez-Sanchez J, Seabury R, Toribio S, Vin R, Weleff J, Woods S, Benrimoh D. A computational account of the development and evolution of psychotic symptoms. Biological Psychiatry 2024 PMID: 39260466, DOI: 10.1016/j.biopsych.2024.08.026.Peer-Reviewed Original ResearchPsychotic symptomsSymptom formationEmergence of psychotic symptomsConversion to psychosisPrediction error signalsIncoming sensory informationHallucination severityDiminished signal-to-noise ratioComputational accountPsychiatric interventionNeural systemsHallucinationsIncreasing convictionOver-reliancePsychosisSensory informationLongitudinal developmentSymptomsBelief formationA computational account of the development and evolution of psychotic symptoms
Powers A, Angelos P, Bond A, Farina E, Fredericks C, Gandhi J, Greenwald M, Hernandez-Busot G, Hosein G, Kelley M, Mourgues C, Palmer W, Rodriguez-Sanchez J, Seabury R, Toribio S, Vin R, Weleff J, Woods S, Benrimoh D. A computational account of the development and evolution of psychotic symptoms. Biological Psychiatry 2024, 5 PMID: 38699166, PMCID: PMC11065053, DOI: 10.1016/j.biopsych.2024.08.026.Peer-Reviewed Original ResearchPsychotic symptomsSymptom formationEmergence of psychotic symptomsConversion to psychosisPrediction error signalsIncoming sensory informationHallucination severityComputational accountPsychiatric interventionDiminished signal-to-noise ratioNeural systemsHallucinationsIncreasing convictionOver-reliancePsychosisSensory informationLongitudinal developmentSymptomsBelief formation
2021
Computational Mechanism for the Effect of Psychosis Community Treatment: A Conceptual Review From Neurobiology to Social Interaction
Benrimoh D, Sheldon A, Sibarium E, Powers AR. Computational Mechanism for the Effect of Psychosis Community Treatment: A Conceptual Review From Neurobiology to Social Interaction. Frontiers In Psychiatry 2021, 12: 685390. PMID: 34385938, PMCID: PMC8353084, DOI: 10.3389/fpsyt.2021.685390.Peer-Reviewed Original ResearchComputational modelAssertive community treatmentProcessing-based accountExperience of psychosisEvidence-based clinical interventionsCommunity treatmentPrevious computational modelsCognitive resourcesPositive psychotic symptomsComputational underpinningsComputational mechanismsSocial interactionStrong social elementSensory informationPositive symptomsConceptual reviewClinical interventionsEarly psychosisSocial elementsCandidate mechanismPsychotic symptomsNeurobiologyPsychosisConceptual paperMultiple levels