2024
The mechanisms underlying conditioning of phantom percepts differ between those with hallucinations and synesthesia
del Rio M, Kafadar E, Fisher V, D’Costa R, Powers A, Ward J. The mechanisms underlying conditioning of phantom percepts differ between those with hallucinations and synesthesia. Scientific Reports 2024, 14: 5607. PMID: 38453946, PMCID: PMC10920618, DOI: 10.1038/s41598-024-53663-3.Peer-Reviewed Original Research
2023
A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing
Drusko A, Baumeister D, McPhee Christensen M, Kold S, Fisher V, Treede R, Powers A, Graven-Nielsen T, Tesarz J. A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing. Scientific Reports 2023, 13: 3196. PMID: 36823292, PMCID: PMC9950064, DOI: 10.1038/s41598-023-29758-8.Peer-Reviewed Original ResearchConceptsHierarchical Gaussian FilterPrior expectationsRelevant individual differencesPain perceptionLearning-based interventionsTesting paradigmCognitive processesSensory evidenceIndividual differencesPsychophysical paradigmInferential processesVisual cuesElectrical cutaneous stimulusPrior weightingPerceptionPain stimuliPrior beliefsIndividual levelNociceptive inputBeliefsGreater relianceStimuliStrong weightingAcute pain stimuliParadigm
2022
Conditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination Susceptibility
Kafadar E, Fisher VL, Quagan B, Hammer A, Jaeger H, Mourgues C, Thomas R, Chen L, Imtiaz A, Sibarium E, Negreira AM, Sarisik E, Polisetty V, Benrimoh D, Sheldon AD, Lim C, Mathys C, Powers AR. Conditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination Susceptibility. Biological Psychiatry 2022, 92: 772-780. PMID: 35843743, PMCID: PMC10575690, DOI: 10.1016/j.biopsych.2022.05.007.Peer-Reviewed Original ResearchConceptsCH rateIncoming sensory evidenceSensory evidencePerceptual statesTask performanceComputational psychiatrySubset of participantsPrior expectationsHallucination severityBehavioral dataSymptom severityPast experienceStable measureHallucinationsPsychotic symptomsHallucination frequencyTaskSymptom expressionBayesian modelState markerHallucinatorsNonhallucinatorsOverweightingPerceptionSymptom risk
2021
Increased face detection responses on the mooney faces test in people at clinical high risk for psychosis
Silverstein SM, Thompson JL, Gold JM, Schiffman J, Waltz JA, Williams TF, Zinbarg RE, Mittal VA, Ellman LM, Strauss GP, Walker EF, Woods SW, Levin JA, Kafadar E, Kenney J, Smith D, Powers AR, Corlett PR. Increased face detection responses on the mooney faces test in people at clinical high risk for psychosis. Schizophrenia 2021, 7: 26. PMID: 34001909, PMCID: PMC8129098, DOI: 10.1038/s41537-021-00156-1.Peer-Reviewed Original ResearchClinical high riskFace perceptionCHR groupDegraded face imagesCognitive processesPerceptual sensitivityRisk mental stateMotivational mechanismsVisual perceptionFace testPerceptual abnormalitiesMental statesCHR participantsCHR subjectsMore facePerceptionDetection responseFace imagesYoung peoplePsychosisClinical measuresParticipantsPrior workFacePrior studies
2020
Voluntary control of auditory hallucinations: phenomenology to therapeutic implications
Swyer A, Powers AR. Voluntary control of auditory hallucinations: phenomenology to therapeutic implications. Schizophrenia 2020, 6: 19. PMID: 32753641, PMCID: PMC7403299, DOI: 10.1038/s41537-020-0106-8.Peer-Reviewed Original ResearchAuditory verbal hallucinationsNeural underpinningsVoice hearersField's current understandingCognitive constructsLittle systematic examinationVerbal hallucinationsConscious controlVoice hearingPsychosocial factorsAuditory hallucinationsVoluntary controlDevelopment of controlHallucinationsUnderpinningsHearerDegree of controlHealth statusSystematic examinationDistressFunctioningPerceptionRecent workRelationshipConstructs
2018
Hallucinations and Strong Priors
Corlett PR, Horga G, Fletcher PC, Alderson-Day B, Schmack K, Powers AR. Hallucinations and Strong Priors. Trends In Cognitive Sciences 2018, 23: 114-127. PMID: 30583945, PMCID: PMC6368358, DOI: 10.1016/j.tics.2018.12.001.Peer-Reviewed Original ResearchConceptsAberrant perceptionsClinical hallucinationsRecent empirical workConstructive natureHuman behaviorIdentifiable stimuliEmpathic approachPrior beliefsLight of workPerceptionHallucinationsEmpirical workStrong priorsReal worldLaboratory phenomenonNeural networkStimuliApparent disconnectBeliefsPsychosisIndividualsHealthy subjectsSupportInference
2017
Pavlovian conditioning–induced hallucinations result from overweighting of perceptual priors
Powers AR, Mathys C, Corlett PR. Pavlovian conditioning–induced hallucinations result from overweighting of perceptual priors. Science 2017, 357: 596-600. PMID: 28798131, PMCID: PMC5802347, DOI: 10.1126/science.aan3458.Peer-Reviewed Original Research
2016
Hallucinations as Top-Down Effects on Perception
Powers AR, Kelley M, Corlett PR. Hallucinations as Top-Down Effects on Perception. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2016, 1: 393-400. PMID: 28626813, PMCID: PMC5469545, DOI: 10.1016/j.bpsc.2016.04.003.Peer-Reviewed Original ResearchContemporary cognitive neuroscienceCognitive science communityHigh-level cognitionPredictive coding modelHierarchical brain networksCognitive penetrationPerceptual priorsCognitive neurosciencePerceptual processesCognitive neuropsychiatryComputational neuroimagingModular viewMental organizationCoding modelBrain networksPerceptionMental illnessHierarchical modelCognitionNeuroscienceStimuliNeuroimagingHallucinationsNeuropsychiatryFindingsGeneralization of multisensory perceptual learning
Powers III AR, Hillock-Dunn A, Wallace MT. Generalization of multisensory perceptual learning. Scientific Reports 2016, 6: 23374. PMID: 27000988, PMCID: PMC4802214, DOI: 10.1038/srep23374.Peer-Reviewed Original ResearchConceptsSound-induced flash illusionMultisensory perceptual learningPerceptual learningSimultaneity judgment taskVisual temporal acuityMeasures of perceptionsAbility of trainingPerceptual trainingFlash illusionMultisensory tasksAudiovisual stimuliMultisensory trainingMultisensory worldJudgment taskGeneralization effectsTemporal acuityInfluence perceptionsDifferent sensesControl conditionStimuliTraining resultsTrainingPerceptionTaskLearning