2024
A computational account of the development and evolution of psychotic symptoms.
Powers A, Angelos P, Bond A, Farina E, Fredericks C, Gandhi J, Greenwald M, Hernandez-Busot G, Hosein G, Kelley M, Mourgues C, Palmer W, Rodriguez-Sanchez J, Seabury R, Toribio S, Vin R, Weleff J, Woods S, Benrimoh D. A computational account of the development and evolution of psychotic symptoms. Biological Psychiatry 2024 PMID: 39260466, DOI: 10.1016/j.biopsych.2024.08.026.Peer-Reviewed Original ResearchPsychotic symptomsSymptom formationEmergence of psychotic symptomsConversion to psychosisPrediction error signalsIncoming sensory informationHallucination severityDiminished signal-to-noise ratioComputational accountPsychiatric interventionNeural systemsHallucinationsIncreasing convictionOver-reliancePsychosisSensory informationLongitudinal developmentSymptomsBelief formationA computational account of the development and evolution of psychotic symptoms
Powers A, Angelos P, Bond A, Farina E, Fredericks C, Gandhi J, Greenwald M, Hernandez-Busot G, Hosein G, Kelley M, Mourgues C, Palmer W, Rodriguez-Sanchez J, Seabury R, Toribio S, Vin R, Weleff J, Woods S, Benrimoh D. A computational account of the development and evolution of psychotic symptoms. Biological Psychiatry 2024, 5 PMID: 38699166, PMCID: PMC11065053, DOI: 10.1016/j.biopsych.2024.08.026.Peer-Reviewed Original ResearchPsychotic symptomsSymptom formationEmergence of psychotic symptomsConversion to psychosisPrediction error signalsIncoming sensory informationHallucination severityComputational accountPsychiatric interventionDiminished signal-to-noise ratioNeural systemsHallucinationsIncreasing convictionOver-reliancePsychosisSensory informationLongitudinal developmentSymptomsBelief formationThe mechanisms underlying conditioning of phantom percepts differ between those with hallucinations and synesthesia
del Rio M, Kafadar E, Fisher V, D’Costa R, Powers A, Ward J. The mechanisms underlying conditioning of phantom percepts differ between those with hallucinations and synesthesia. Scientific Reports 2024, 14: 5607. PMID: 38453946, PMCID: PMC10920618, DOI: 10.1038/s41598-024-53663-3.Peer-Reviewed Original Research
2022
Conditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination Susceptibility
Kafadar E, Fisher VL, Quagan B, Hammer A, Jaeger H, Mourgues C, Thomas R, Chen L, Imtiaz A, Sibarium E, Negreira AM, Sarisik E, Polisetty V, Benrimoh D, Sheldon AD, Lim C, Mathys C, Powers AR. Conditioned Hallucinations and Prior Overweighting Are State-Sensitive Markers of Hallucination Susceptibility. Biological Psychiatry 2022, 92: 772-780. PMID: 35843743, PMCID: PMC10575690, DOI: 10.1016/j.biopsych.2022.05.007.Peer-Reviewed Original ResearchConceptsCH rateIncoming sensory evidenceSensory evidencePerceptual statesTask performanceComputational psychiatrySubset of participantsPrior expectationsHallucination severityBehavioral dataSymptom severityPast experienceStable measureHallucinationsPsychotic symptomsHallucination frequencyTaskSymptom expressionBayesian modelState markerHallucinatorsNonhallucinatorsOverweightingPerceptionSymptom riskRelating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy
Leptourgos P, Bansal S, Dutterer J, Culbreth A, Powers A, Suthaharan P, Kenney J, Erickson M, Waltz J, Wijtenburg SA, Gaston F, Rowland LM, Gold J, Corlett P. Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy. Schizophrenia Bulletin 2022, 48: 912-920. PMID: 35199836, PMCID: PMC9212089, DOI: 10.1093/schbul/sbac006.Peer-Reviewed Original ResearchConceptsGlutamate levelsAnterior insulaPrior beliefsCognitive modelPathophysiological theoriesAuditory cortexClinical hallucinationsAnterior cingulateComputational psychiatryNew treatmentsDorsolateral prefrontalVisual cuesPrior expectationsSame participantsHallucinationsInsulaNegative relationshipCurrent experienceMagnetic resonance spectroscopyBeliefsComputational modelingToneMeasuring Voluntary Control Over Hallucinations: The Yale Control Over Perceptual Experiences (COPE) Scales
Mourgues C, Hammer A, Fisher V, Kafadar E, Quagan B, Bien C, Jaeger H, Thomas R, Sibarium E, Negreira AM, Sarisik E, Polisetty V, Eken H, Imtiaz A, Niles H, Sheldon AD, Powers AR. Measuring Voluntary Control Over Hallucinations: The Yale Control Over Perceptual Experiences (COPE) Scales. Schizophrenia Bulletin 2022, 48: 673-683. PMID: 35089361, PMCID: PMC9077437, DOI: 10.1093/schbul/sbab144.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsPositive clinical outcomesClinical outcomesPilot studyQuality of lifeConvergent validityFrequent auditory verbal hallucinationsExperiences ScaleClinical measuresConventional treatmentNovel interventionsSymptom severitySignificant distressClinical scalesComprehensive batteryPsychosis-spectrum diagnosisVerbal hallucinationsSound psychometric propertiesAVH contentVoluntary controlPsychometric propertiesHallucinationsControl ScaleValidation studyIntervention
2020
Voluntary control of auditory hallucinations: phenomenology to therapeutic implications
Swyer A, Powers AR. Voluntary control of auditory hallucinations: phenomenology to therapeutic implications. Schizophrenia 2020, 6: 19. PMID: 32753641, PMCID: PMC7403299, DOI: 10.1038/s41537-020-0106-8.Peer-Reviewed Original ResearchAuditory verbal hallucinationsNeural underpinningsVoice hearersField's current understandingCognitive constructsLittle systematic examinationVerbal hallucinationsConscious controlVoice hearingPsychosocial factorsAuditory hallucinationsVoluntary controlDevelopment of controlHallucinationsUnderpinningsHearerDegree of controlHealth statusSystematic examinationDistressFunctioningPerceptionRecent workRelationshipConstructsParacingulate Sulcus Length Is Shorter in Voice-Hearers Regardless of Need for Care
Powers AR, van Dyck LI, Garrison JR, Corlett PR. Paracingulate Sulcus Length Is Shorter in Voice-Hearers Regardless of Need for Care. Schizophrenia Bulletin 2020, 46: 1520-1523. PMID: 32432706, PMCID: PMC7707078, DOI: 10.1093/schbul/sbaa067.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsPsychotic disordersParacingulate sulcusT1-weighted structural MRI scansMedial prefrontal cortexStructural MRI scansClinical stateClinical careMRI scansAVH phenomenologyMental illnessClinical counterpartPrefrontal cortexClinical populationsDisordersVerbal hallucinationsHallucinationsIllnessPsychosisSulcus lengthCareGroups of participantsCurrent studyParticipantsNonclinical populations
2019
Beyond Trauma: A Multiple Pathways Approach to Auditory Hallucinations in Clinical and Nonclinical Populations
Luhrmann TM, Alderson-Day B, Bell V, Bless JJ, Corlett P, Hugdahl K, Jones N, Larøi F, Moseley P, Padmavati R, Peters E, Powers AR, Waters F. Beyond Trauma: A Multiple Pathways Approach to Auditory Hallucinations in Clinical and Nonclinical Populations. Schizophrenia Bulletin 2019, 45: s24-s31. PMID: 30715545, PMCID: PMC6357973, DOI: 10.1093/schbul/sby110.Peer-Reviewed Original Research
2018
Hallucinations and Strong Priors
Corlett PR, Horga G, Fletcher PC, Alderson-Day B, Schmack K, Powers AR. Hallucinations and Strong Priors. Trends In Cognitive Sciences 2018, 23: 114-127. PMID: 30583945, PMCID: PMC6368358, DOI: 10.1016/j.tics.2018.12.001.Peer-Reviewed Original ResearchConceptsAberrant perceptionsClinical hallucinationsRecent empirical workConstructive natureHuman behaviorIdentifiable stimuliEmpathic approachPrior beliefsLight of workPerceptionHallucinationsEmpirical workStrong priorsReal worldLaboratory phenomenonNeural networkStimuliApparent disconnectBeliefsPsychosisIndividualsHealthy subjectsSupportInference
2017
Pavlovian conditioning–induced hallucinations result from overweighting of perceptual priors
Powers AR, Mathys C, Corlett PR. Pavlovian conditioning–induced hallucinations result from overweighting of perceptual priors. Science 2017, 357: 596-600. PMID: 28798131, PMCID: PMC5802347, DOI: 10.1126/science.aan3458.Peer-Reviewed Original Research
2016
Hallucinations as Top-Down Effects on Perception
Powers AR, Kelley M, Corlett PR. Hallucinations as Top-Down Effects on Perception. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2016, 1: 393-400. PMID: 28626813, PMCID: PMC5469545, DOI: 10.1016/j.bpsc.2016.04.003.Peer-Reviewed Original ResearchContemporary cognitive neuroscienceCognitive science communityHigh-level cognitionPredictive coding modelHierarchical brain networksCognitive penetrationPerceptual priorsCognitive neurosciencePerceptual processesCognitive neuropsychiatryComputational neuroimagingModular viewMental organizationCoding modelBrain networksPerceptionMental illnessHierarchical modelCognitionNeuroscienceStimuliNeuroimagingHallucinationsNeuropsychiatryFindings
2015
Ketamine-Induced Hallucinations
Powers A, Gancsos MG, Finn ES, Morgan PT, Corlett PR. Ketamine-Induced Hallucinations. Psychopathology 2015, 48: 376-385. PMID: 26361209, PMCID: PMC4684980, DOI: 10.1159/000438675.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsPerceptual inputVerbal hallucinationsPredictive coding modelDelusion-like ideasPerceptual disruptionsPerceptual expectationsPerceptual environmentCoding modelPhenomenological experienceSensory stimuliStimulation environmentAuditory hallucinationsHealthy participantsHallmark symptomFirst-episode psychosisMusical hallucinationsMRI scannerHallucinationsParticipantsMagnetic resonance imaging (MRI) scannerPsychosisAmotivationPerceptVivid hallucinations