2020
Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency
Bai H, Sadaghianloo N, Gorecka J, Liu S, Ono S, Ramachandra AB, Bonnet S, Mazure NM, Declemy S, Humphrey JD, Dardik A. Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency. Science Translational Medicine 2020, 12 PMID: 32817365, PMCID: PMC7705473, DOI: 10.1126/scitranslmed.aax7613.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaHemodialysis accessNeointimal hyperplasiaEndothelial nitric oxide synthaseDurable surgical optionUremic male ratsRadial-cephalic arteriovenous fistulaKruppel-like factor 2Nitric oxide synthasePeak systolic velocityLong-term patencyReintervention rateSecondary patencyImproved hemodynamicsFemale patientsReimplantation techniqueSurgical optionsSystolic velocityMale ratsOxide synthaseFistula modelPatencyHemodynamicsDifferent hemodynamicsFemale animals
2009
Stent placement in the superficial femoral artery for patients on chronic hemodialysis with peripheral artery disease.
Nishibe T, Kondo Y, Dardik A, Muto A, Koizumi J, Nishibe M. Stent placement in the superficial femoral artery for patients on chronic hemodialysis with peripheral artery disease. International Angiology 2009, 28: 484-9. PMID: 20087287.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiography, Digital SubtractionAngioplasty, BalloonAnkle Brachial IndexCase-Control StudiesChronic DiseaseFemaleFemoral ArteryHemodynamicsHumansIschemiaKaplan-Meier EstimateKidney DiseasesLimb SalvageMaleMiddle AgedPeripheral Vascular DiseasesRenal DialysisRisk AssessmentRisk FactorsStentsTime FactorsTreatment OutcomeUltrasonography, Doppler, DuplexVascular PatencyConceptsPeripheral artery diseaseSuperficial femoral arteryChronic hemodialysisStent placementNondialysis groupPrimary patencyDialysis groupLimb ischemiaSFA lesionsArtery diseaseLimb salvageFemoral arteryFirst-choice therapeutic optionSymptomatic limb ischemiaCritical limb ischemiaPrimary stent placementClinical outcomesTherapeutic optionsHigh prevalenceOutcome measuresHemodialysisLower limbsPatientsSurvival ratePatencyHybrid surgical and endovascular therapy in multifocal peripheral TASC D lesions: up to three-year follow-up.
Nishibe T, Kondo Y, Dardik A, Muto A, Koizumi J, Nishibe M. Hybrid surgical and endovascular therapy in multifocal peripheral TASC D lesions: up to three-year follow-up. The Journal Of Cardiovascular Surgery 2009, 50: 493-9. PMID: 19734834.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, BalloonArterial Occlusive DiseasesCombined Modality TherapyConstriction, PathologicEndarterectomyFemaleFemoral ArteryHemodynamicsHumansIliac ArteryIschemiaKaplan-Meier EstimateLimb SalvageLower ExtremityMaleMiddle AgedPeripheral Vascular DiseasesRadiographyReoperationStentsTime FactorsTreatment OutcomeVascular PatencyConceptsCommon femoral artery endarterectomyFemoral artery endarterectomyTASC D lesionsLimb salvage ratePrimary patency rateCritical limb ischemiaPeripheral artery diseaseCommon femoral arteryEndovascular therapySuperficial femoral arteryFemoral arteryPatency ratesArtery endarterectomyIntermittent claudicationArtery diseaseD lesionsLimb ischemiaSalvage rateLower limbsSurvival rateAssisted primary patencyVascular Surgery guidelinesThree-year experienceHemodynamic successPrimary patency
2003
Shear Stress and Cyclic Strain May Suppress Apoptosis in Endothelial Cells by Different Pathways
Haga M, Chen A, Gortler D, Dardik A, Sumpio B. Shear Stress and Cyclic Strain May Suppress Apoptosis in Endothelial Cells by Different Pathways. Endothelium 2003, 10: 149-157. PMID: 13129818, DOI: 10.1080/10623320390233463.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBcl-Associated Death ProteinCarrier ProteinsCattleCells, CulturedCulture Media, Serum-FreeEndothelial CellsEnzyme InhibitorsHemodynamicsPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPhosphorylationProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktSignal TransductionStress, MechanicalTranscription, GeneticConceptsPhosphorylation of AktEndothelial cellsPI3K inhibitionInhibition of apoptosisK inhibitionHemodynamic forcesAortic endothelial cellsBovine aortic endothelial cellsEffect of SSArterial levelsIntimal hyperplasiaDownstream target BadNormal endotheliumMaximal stimulationAkt phosphorylationLaminar shear stressApoptosisDownstream phosphorylationAktInhibitionCell survivalEC growthSerum withdrawalAlternate pathwayPhosphorylation of Bad