2023
2023 Vascular Research Initiatives Conference: Structural and Immune Cells in Vascular Disease
Thaxton C, Gallagher K, Dardik A. 2023 Vascular Research Initiatives Conference: Structural and Immune Cells in Vascular Disease. JVS Vascular Science 2023, 4: 100117. PMID: 37649474, PMCID: PMC10463243, DOI: 10.1016/j.jvssci.2023.100117.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsVascular diseaseImmune cellsNovel immunotherapeutic targetAtherosclerotic cardiovascular diseaseAmerican Heart AssociationBasic science researchersImmune checkpointsVenous diseaseImmunotherapeutic targetHeart AssociationCardiovascular diseaseVascular conditionsImmune systemDiseaseVascular regenerationVascular cliniciansFirst dayNational InstituteAtherosclerosisTranslational scienceStem cellsResident researchCellsTranslational fieldAortopathyEphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model
Langford J, Gonzalez L, Taniguchi R, Brahmandam A, Zhang W, Dardik A. EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model. JVS Vascular Science 2023, 4: 100109. PMID: 37519335, PMCID: PMC10372308, DOI: 10.1016/j.jvssci.2023.100109.Peer-Reviewed Original ResearchAortic transplant modelAllograft vasculopathyT cellsTransplant modelEphrin-B2Immune cell accumulationChronic graftCardiac transplantChronic rejectionTransplanted graftAortic allograftsNeointima formationCell accumulationTissue damageMonocyte adhesionLess neointima formationVasculopathyAdherent monocytesEndothelial surfaceReceptor EphB4MacrophagesGraftMonocytesImportant targetCells
2020
Stem Cell Delivery Techniques for Stroke and Peripheral Artery Disease
Lee S, Fereydooni A, Dardik A. Stem Cell Delivery Techniques for Stroke and Peripheral Artery Disease. 2020, 69-103. DOI: 10.1007/978-3-030-56954-9_3.ChaptersPeripheral artery diseaseArtery diseaseImpact of patientStem cellsVascular diseaseTherapeutic effectHuman trialsOptimal doseTarget organsPharmaceutic agentsCell therapyDiseaseCell delivery techniquesStrokeCell factorPatientsTherapyDelivery techniquesDiverse populationsDelivery methodsCellsDelivery optionsDoseTrialsInduced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing
Gorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A. Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing. Regenerative Medicine 2020, 15: 1277-1293. PMID: 32228292, PMCID: PMC7304438, DOI: 10.2217/rme-2019-0086.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsMuscle cellsDiabetic wound healingWound healingPro-angiogenic cytokinesMurine AdiposeStem cellsType macrophagesCollagen scaffoldsCultured mediumM2-type macrophagesCellsNumber of totalNew candidatesAngiogenesisNude miceDiabetic woundsPromising new candidateScaffoldsHealingCytokinesExpressionSecreteWoundsAdipose
2018
Molecular identity of arteries, veins, and lymphatics
Wolf K, Hu H, Isaji T, Dardik A. Molecular identity of arteries, veins, and lymphatics. Journal Of Vascular Surgery 2018, 69: 253-262. PMID: 30154011, PMCID: PMC6309638, DOI: 10.1016/j.jvs.2018.06.195.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsArteriesBiomarkersCOUP Transcription Factor IIEphrin-B2Gene Expression Regulation, DevelopmentalGestational AgeHomeodomain ProteinsHumansIntracellular Signaling Peptides and ProteinsLymphangiogenesisLymphatic VesselsMembrane ProteinsNeovascularization, PhysiologicReceptor, EphB4Receptors, NotchSignal TransductionTumor Suppressor ProteinsVascular Endothelial Growth Factor Receptor-2Vascular Surgical ProceduresVeinsConceptsMolecular identityEphrin-B2 expressionVessel identityVascular identityMolecular determinantsVenous identityArterial-venous identityCritical molecular determinantsEph-B4Specific molecular markersEmbryonic developmentMolecular mechanismsMolecular markersArterial identityUndifferentiated cellsEphrin-B2Adult vesselsDifferent functionsPostsurgical environmentExpressionEndothelial cellsStructural differencesCellsNew therapeutic approachesLymphatic vessels