2017
The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry
Lipovsky A, Erden A, Kanaya E, Zhang W, Crite M, Bradfield C, MacMicking J, DiMaio D, Schoggins JW, Iwasaki A. The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry. Journal Of General Virology 2017, 98: 2821-2836. PMID: 29058661, PMCID: PMC5845663, DOI: 10.1099/jgv.0.000954.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapsid ProteinsCell LineHuman papillomavirus 16HumansKeratinocytesNeuropeptidesOncogene Proteins, ViralProtein BindingVirus InternalizationConceptsHuman papillomavirusEntry of HPVVirus entryImportant infectious causeL1 major capsid proteinHPV typesTrans-Golgi networkInfectious causesProphylactic vaccinesHPV16 infectionL2 minor capsid proteinHPV entryDeadly cancerHPV16 entryBasal levelsInfectionVirus uptakeRetrograde transportHuman keratinocytesCapsid proteinHPV16PapillomavirusVirus uncoatingNon-enveloped virusesVirus
2013
High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells
Iijima N, Goodwin EC, DiMaio D, Iwasaki A. High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells. Virology 2013, 444: 257-262. PMID: 23871219, PMCID: PMC3755085, DOI: 10.1016/j.virol.2013.06.020.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCells, CulturedCoculture TechniquesFemaleHumansImmune EvasionLangerhans CellsMonocytesOncogene Proteins, ViralPapillomaviridaeConceptsHigh-risk human papillomavirusLangerhans cellsHigh-risk HPVCompetent antigen presenting cellsHPV-positive cancer cellsKey antigen-presenting cellsHPV-positive cervical cancer cellsCancer cellsHuman peripheral blood monocytesAntigen-presenting cellsAntigen presenting cellsImmune evasion strategiesPeripheral blood monocytesVariety of malignanciesCervical cancer cellsContact-dependent mannerDifferentiation of monocytesHuman papillomavirusPresenting cellsImmune surveillanceSquamous epitheliumBlood monocytesMucosal epitheliumHPV E6HPV16 E6
2010
Influenza virus activates inflammasomes via its intracellular M2 ion channel
Ichinohe T, Pang IK, Iwasaki A. Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nature Immunology 2010, 11: 404-410. PMID: 20383149, PMCID: PMC2857582, DOI: 10.1038/ni.1861.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCells, CulturedCytokinesDendritic CellsGenetic EngineeringGolgi ApparatusHydrogen-Ion ConcentrationIon ChannelsMacrophagesMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutMonensinNLR Family, Pyrin Domain-Containing 3 ProteinOncogene Proteins, ViralOrthomyxoviridaeOrthomyxoviridae InfectionsPotassium ChlorideProtein TransportProtonsSequence DeletionToll-Like Receptor 7Viral Matrix ProteinsVirus Replication