2020
Seasonality of Respiratory Viral Infections
Moriyama M, Hugentobler WJ, Iwasaki A. Seasonality of Respiratory Viral Infections. Annual Review Of Virology 2020, 7: 1-19. PMID: 32196426, DOI: 10.1146/annurev-virology-012420-022445.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCoronavirus InfectionsCOVID-19HumansHumidityInfectious Disease Incubation PeriodInfluenza, HumanOrthomyxoviridaePandemicsPicornaviridae InfectionsPneumonia, ViralRespiratory Tract InfectionsRhinovirusSARS-CoV-2SeasonsSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusSeverity of Illness IndexTemperatureConceptsRespiratory viral infectionsViral infectionSevere acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusViral respiratory infectionsAdaptive immune responsesRespiratory viral diseasesRespiratory infectionsRespiratory virusesInfluenza diseaseRespiratory tractImmune responseAnnual epidemicsHost responseInfectionMajor contributing factorViral diseasesDiseaseContributing factorVirus stabilityVirusEpidemicRecent studiesYearsHuman population
2013
Generating protective immunity against genital herpes
Shin H, Iwasaki A. Generating protective immunity against genital herpes. Trends In Immunology 2013, 34: 487-494. PMID: 24012144, PMCID: PMC3819030, DOI: 10.1016/j.it.2013.08.001.Peer-Reviewed Original ResearchConceptsGenital herpesHerpes simplex virus infectionSimplex virus infectionSignificant risk factorsClinical vaccine trialsRecurrent symptomsHSV infectionProtective immunityViral sheddingVaccine trialsRisk factorsChronic diseasesVirus infectionHIV-1Clear infectionAntiviral drugsHost responseHerpesVaccine designInfectionMillions of peopleSpread of diseaseDiseaseRecent studiesVaccine
2012
Unique features of antiviral immune system of the vaginal mucosa
Kumamoto Y, Iwasaki A. Unique features of antiviral immune system of the vaginal mucosa. Current Opinion In Immunology 2012, 24: 411-416. PMID: 22673876, PMCID: PMC3423557, DOI: 10.1016/j.coi.2012.05.006.Peer-Reviewed Original ResearchConceptsVaginal mucosaVirus-specific CD4Development of vaccinesAntiviral immune systemHuman papillomavirusGenital tractT cellsImmune responseAdaptive immunityHuman vaccinesMucosal organsImmune systemVaccineAntiviral defenseMucosaVaginaVirusRecent studiesWide spectrumVast majorityCurrent understandingCD8CD4PapillomavirusImmunobiologySkin TRM mediates distributed border patrol
Shin H, Iwasaki A. Skin TRM mediates distributed border patrol. Cell Research 2012, 22: 1325-1327. PMID: 22565287, PMCID: PMC3434347, DOI: 10.1038/cr.2012.75.Peer-Reviewed Original Research
2011
Mitoxosome: a mitochondrial platform for cross‐talk between cellular stress and antiviral signaling
Tal MC, Iwasaki A. Mitoxosome: a mitochondrial platform for cross‐talk between cellular stress and antiviral signaling. Immunological Reviews 2011, 243: 215-234. PMID: 21884179, PMCID: PMC3170140, DOI: 10.1111/j.1600-065x.2011.01038.x.Peer-Reviewed Original ResearchConceptsCellular stressMitochondrial functionCell biologic analysesViral recognitionInnate immune signalingDynamic relocalizationAntiviral signalingImmune signalingMitochondriaAntiviral responseMultiple pathwaysAntiviral immunityCurrent understandingRecent findingsSignalingViral replicationInnate responseIntegrated viewBiologic analysisRecent studiesSignalosomeRelocalizationKey componentStressIntegral platform
2008
Autophagy and antiviral immunity
Lee HK, Iwasaki A. Autophagy and antiviral immunity. Current Opinion In Immunology 2008, 20: 23-29. PMID: 18262399, PMCID: PMC2271118, DOI: 10.1016/j.coi.2008.01.001.Peer-Reviewed Original ResearchConceptsViral infectionViral replicationAdaptive antiviral immune responsesEndogenous viral antigensCD4 T cellsMHC class II loading compartmentsAntiviral immune responseCritical effector mechanismAdaptive immune systemViral antigensEffector mechanismsT cellsImmune responseAntiviral immunityImmune systemLoading compartmentCertain virusesInfectionAutophagyRecent studiesCellsAntigenImmunityCellular homeostasis
2007
Role of Autophagy in Innate Viral Recognition
Iwasaki A. Role of Autophagy in Innate Viral Recognition. Autophagy 2007, 3: 354-356. PMID: 17404496, DOI: 10.4161/auto.4114.Peer-Reviewed Original ResearchConceptsPlasmacytoid dendritic cellsToll-like receptorsI interferonViral recognitionLive viral infectionType I interferonRole of autophagyPDC responsesDendritic cellsViral infectionViral replicationTLR7Pathogen signaturesVirusSuch virusesVirus detectionAutophagyRNA virusesRecent studiesInterferonInfectionSsRNA virusesSecretionReceptors
2005
Intestinal epithelial barrier and mucosal immunity
Sato A, Iwasaki A. Intestinal epithelial barrier and mucosal immunity. Cellular And Molecular Life Sciences 2005, 62: 1333. PMID: 15971108, DOI: 10.1007/s00018-005-5037-z.Peer-Reviewed Original ResearchConceptsDendritic cellsMucosal immunityPeyer's patchesMajor inductive siteMucosal dendritic cellsPP dendritic cellsResident dendritic cellsMucosal immune systemIntestinal epithelial barrierFood antigensInductive sitesGastrointestinal mucosaT cellsImmune inductionImmune responseRecent studiesEpithelial barrierImmune systemCommensal microbesSmall intestineA responsesInfectious pathogensImmunityAntigenInduction
2004
Toll-like receptor control of the adaptive immune responses
Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nature Immunology 2004, 5: 987-995. PMID: 15454922, DOI: 10.1038/ni1112.Peer-Reviewed Original ResearchConceptsToll-like receptorsAdaptive immune responsesImmune responseMechanisms of TLRToll-like receptor controlHost defense responsesDendritic cell functionDendritic cell populationsMicrobial infectionsInnate immune systemDistinct anatomical locationsInflammatory reactionAdaptive immunityImmune systemAnatomical locationReceptor controlCell functionCell populationsMultiple mechanismsInfectionRecent studiesResponseInitiationSystemic defenseImportant clues
1999
I. Mucosal dendritic cells: their specialized role in initiating T cell responses*
Iwasaki A, Kelsall B. I. Mucosal dendritic cells: their specialized role in initiating T cell responses*. American Journal Of Physiology 1999, 276: g1074-g1078. PMID: 10329996, DOI: 10.1152/ajpgi.1999.276.5.g1074.Peer-Reviewed Original ResearchConceptsT cell responsesMucosal dendritic cellsDendritic cellsCell responsesCompetent antigen-presenting cellsPrimary T cell responsesTissue-resident dendritic cellsResident dendritic cellsAntigen-presenting cellsDC populationsLymphoid tissueRecent studiesCellsFunctional studiesResponseMucosaIsolation procedureSpecialized role