The Role of Immune Factors in Shaping Fetal Neurodevelopment
Lu-Culligan A, Iwasaki A. The Role of Immune Factors in Shaping Fetal Neurodevelopment. Annual Review Of Cell And Developmental Biology 2020, 36: 1-28. PMID: 32722920, PMCID: PMC9034439, DOI: 10.1146/annurev-cellbio-021120-033518.Peer-Reviewed Original ResearchConceptsMaternal immune activationImmune factorsFetal neurodevelopmentMaternal immunityPoor neurological outcomeMaternal-fetal interfaceNeurological outcomeNormal pregnancyImmune activationImmune pathwaysPostnatal lifeNeurological disordersExperimental modelNeurodevelopmentNormal physiologyPregnancyVivo roleImmunityCritical participantsMaternal pathwayFactorsSequence of eventsPathogenesisUteroFetusesContributions of maternal and fetal antiviral immunity in congenital disease
Yockey LJ, Lucas C, Iwasaki A. Contributions of maternal and fetal antiviral immunity in congenital disease. Science 2020, 368: 608-612. PMID: 32381717, DOI: 10.1126/science.aaz1960.Peer-Reviewed Original ResearchConceptsViral infectionCongenital diseaseDirect viral toxicityMaternal immune responseMaternal immune activationFetal developmental defectsFuture treatment strategiesImmune defense mechanismsPregnancy outcomesFetal demiseImmune activationUncontrolled inflammationMaternal healthChronic infectionTreatment strategiesImmune responseAntiviral immunityRange of syndromesFetal developmentTissue damagePathological effectsInfectionViral toxicityDevastating consequencesPregnancy