2022
Unexplained post-acute infection syndromes
Choutka J, Jansari V, Hornig M, Iwasaki A. Unexplained post-acute infection syndromes. Nature Medicine 2022, 28: 911-923. PMID: 35585196, DOI: 10.1038/s41591-022-01810-6.Peer-Reviewed Original ResearchConceptsPost-acute sequelaeMyalgic encephalomyelitis/chronic fatigue syndromeSARS-CoV-2 infectionCertain acute infectionsMinority of patientsChronic fatigue syndromeSubstantial healthcare burdenSimilar symptom profilesSARS-CoV-2Common etiopathogenesisAcute infectionInfection syndromeClinical featuresFatigue syndromeChronic disabilityHealthcare burdenChronic illnessSymptom profilesInfectious agentsInfectionPotential involvementSequelaeSyndromeField of medicinePatients
2015
Tissue instruction for migration and retention of TRM cells
Iijima N, Iwasaki A. Tissue instruction for migration and retention of TRM cells. Trends In Immunology 2015, 36: 556-564. PMID: 26282885, PMCID: PMC4567393, DOI: 10.1016/j.it.2015.07.002.Peer-Reviewed Original ResearchConceptsTissue-resident memory T cellsMemory lymphocyte clustersTRM cellsT cellsCD4 tissue-resident memory T cellsRobust local immune responseCD8 TRM cellsEffector T cellsLocal immune responseMemory T cellsNon-lymphoid tissuesLymphocyte clustersImmune responseInfectious agentsIncoming pathogensCell homingRecent findingsCellsInfectionFindingsNo Viral Association Found in a Set of Differentiated Vulvar Intraepithelial Neoplasia Cases by Human Papillomavirus and Pan-Viral Microarray Testing
Saglam O, Samayoa E, Somasekar S, Naccache S, Iwasaki A, Chiu CY. No Viral Association Found in a Set of Differentiated Vulvar Intraepithelial Neoplasia Cases by Human Papillomavirus and Pan-Viral Microarray Testing. PLOS ONE 2015, 10: e0125292. PMID: 25894343, PMCID: PMC4404153, DOI: 10.1371/journal.pone.0125292.Peer-Reviewed Original ResearchConceptsVulvar squamous cell carcinomaVulvar intraepithelial neoplasiaDVIN casesHuman papillomavirusHigh-grade vulvar intraepithelial neoplasiaUsual-type vulvar intraepithelial neoplasiaUsual-type VINSquamous cell carcinomaHPV infectionIntraepithelial neoplasiaCell carcinomaPrecursor lesionsSmall biopsiesInfectious agentsDifferentiated typeGermline mutationsP53 geneInfectionDVINBiopsyCarcinomaPapillomavirusNeoplasiaLesionsCases
2004
Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments
Sato A, Iwasaki A. Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 16274-16279. PMID: 15534227, PMCID: PMC528964, DOI: 10.1073/pnas.0406268101.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationCaspase 1Cell DifferentiationCell MovementDendritic CellsFemaleHerpesvirus 2, HumanImmunity, InnateInterleukin-12Membrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88Receptors, Cell SurfaceReceptors, ImmunologicReceptors, InterferonSignal TransductionStromal CellsTh1 CellsToll-Like ReceptorsConceptsToll-like receptorsT cell responsesPattern recognition receptorsViral infectionContribution of TLRsRecognition receptorsCell responsesEffector T cell responsesHerpes simplex virus type 2Simplex virus type 2Antiviral adaptive immunityDendritic cell compartmentEffector T cellsDendritic cell maturationMost viral infectionsVirus type 2Infected epithelial cellsMucosal infectionsT cellsAdaptive immunityAntiviral immunityInfectious agentsType 2Immune recognitionStromal cells