2018
The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome
Hayashi K, Taura M, Iwasaki A. The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome. Science Signaling 2018, 11 PMID: 29717061, PMCID: PMC6462218, DOI: 10.1126/scisignal.aan4144.Peer-Reviewed Original ResearchConceptsInterferon regulatory factor 7Autophagy protein LC3Type I IFN productionI interferonI IFN productionMicrotubule-associated proteinsPutative LC3Type I interferon productionEndosomal vesiclesAutophagosome formationNoncanonical autophagyToll-like receptor 9Production of IFNStimulation of TLR9Regulatory factor 7Protein LC3Direct bindingI interferon productionIFN productionEndosomesChain 3Type I interferonKinase IKKαLC3Lap formation
2010
Innate Immunity to Viruses
Iwasaki A. Innate Immunity to Viruses. 2010, 183-196. DOI: 10.1128/9781555816872.ch15.Peer-Reviewed Original ResearchDNA virusesEndosomal trafficking eventsHost cell machineryMechanism of RNAiAbsence of VpuInnate immunityTrafficking eventsEndonuclease familyCell machineryCytoplasmic DNAE3 ubiquitinLipid raftsCaspase-1 inflammasomeAnalysis of animalCell surfaceViral dsRNADistinct rolesNeighboring cellsAntiviral stateBillions of yearsLike receptorsI IFN productionComplementary sequencesViral RNARNA