2015
Cerebellar associative sensory learning defects in five mouse autism models
Kloth A, Badura A, Li A, Cherskov A, Connolly S, Giovannucci A, Bangash M, Grasselli G, Peñagarikano O, Piochon C, Tsai P, Geschwind D, Hansel C, Sahin M, Takumi T, Worley P, Wang S. Cerebellar associative sensory learning defects in five mouse autism models. ELife 2015, 4: e06085. PMID: 26158416, PMCID: PMC4512177, DOI: 10.7554/elife.06085.Peer-Reviewed Original Research
2014
Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism
Piochon C, Kloth A, Grasselli G, Titley H, Nakayama H, Hashimoto K, Wan V, Simmons D, Eissa T, Nakatani J, Cherskov A, Miyazaki T, Watanabe M, Takumi T, Kano M, Wang S, Hansel C. Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism. Nature Communications 2014, 5: 5586. PMID: 25418414, PMCID: PMC4243533, DOI: 10.1038/ncomms6586.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMotor learningDelay eyeblink conditioningSocial behavior deficitsSpectrum disorderCerebellum-dependent motor learningEyeblink conditioningSurplus climbing fibresAutismLong-term depressionMotor problemsMajority of childrenMotor behaviorMotor controlBehavior deficitsCerebellar functionCerebellar plasticityMouse modelDeficitsSynaptic plasticitySynaptic pruningLearningParallel fiber-Purkinje cell synapsesFiber-Purkinje cell synapsesCerebellar synaptic plasticity