2024
Cost-benefit analysis of intraoperative neuromonitoring for cardiac surgery
Jain B, Rahim F, Thirumala P, McGarvey M, Balzer J, Nogueira R, van der Goes D, de Havenon A, Sultan I, Ney J. Cost-benefit analysis of intraoperative neuromonitoring for cardiac surgery. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107576. PMID: 38232584, DOI: 10.1016/j.jstrokecerebrovasdis.2024.107576.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionCardiac surgeryIntraoperative neuromonitoringModified Rankin ScaleDetect large vessel occlusionHigh-risk patientsOne-way sensitivity analysesLifetime costsProbabilistic sensitivity analysesNeurological complicationsRankin ScaleSurgeryFunctional outcomesLifetime horizonVessel occlusionPatientsDecision-analysis treeSocietal perspectiveNeuromonitoringCost-saving
2023
Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study
Abou Karam G, Tharmaseelan H, Aboian M, Malhotra A, Gilmore E, Falcone G, de Havenon A, Sheth K, Payabvash S. Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107375. PMID: 37738914, PMCID: PMC10591892, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107375.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleSecondary brain injuryIntracerebral hemorrhagePerihematomal edemaSubacute intracerebral hemorrhageIntravoxel incoherent motion imagingAdmission NIHSSBrain injuryMedian baseline National InstitutesPilot studyBaseline National InstitutesHealth Stroke ScalePerfusion fractionSupratentorial intracerebral hemorrhageIVIM metricsIncoherent motion imagingStroke ScaleNeuroprotective therapiesParenchymal injuryRankin ScaleRisk patientsConsecutive patientsUnivariable analysisPoor outcomeICH volume
2022
Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization
Frontera J, Sabadia S, Yang D, de Havenon A, Yaghi S, Lewis A, Lord A, Melmed K, Thawani S, Balcer L, Wisniewski T, Galetta S, Agarwal S, Andino A, Arena V, Baskharoun S, Bauman K, Bell L, Berger S, Bhagat D, Bokhari M, Bondi S, Canizares M, Chervinsky A, Czeisler B, Dygert L, Fang T, Flusty B, Friedman D, Friedman D, Fuchs B, Granger A, Gratch D, Gurin L, Gutman J, Hasanaj L, Holmes M, Horng J, Huang J, Ishii H, Jauregui R, Ji Y, Kahn D, Koch E, Krieger P, Kvernland A, Lalchan R, Lillemoe K, Lin J, Liu S, Madhavan M, Medicherla C, Millar-Vernetti P, Morgan N, Olivera A, Omari M, Park G, Patel P, Ristic M, Rosenthal J, Sonson M, Snyder T, Stainman R, Sunwoo B, Talmasov D, Tamimi M, Thomas B, Valdes E, Zhou T, Zhu Y. Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization. Journal Of The Neurological Sciences 2022, 443: 120487. PMID: 36379135, PMCID: PMC9637014, DOI: 10.1016/j.jns.2022.120487.Peer-Reviewed Original ResearchConceptsModified Rankin ScalePost-acute symptomsLong-term outcomesCOVID-19 hospitalizationBaseline disabilityBarthel IndexPoor outcomeFemale sexLife stressorsCOVID-19Telephone Montreal Cognitive AssessmentOlder ageMultivariable logistic regressionStrong independent predictorCOVID-19 patientsLongitudinal cohort studyCOVID-19 severityWorse mRSMontreal Cognitive AssessmentProlonged symptomsRankin ScaleCohort studyIndependent predictorsMultivariable analysisNeuropsychiatric outcomes
2021
Variability of the Modified Rankin Scale Score Between Day 90 and 1 Year After Ischemic Stroke
de Havenon A, Tirschwell DL, Heitsch L, Cramer SC, Braun R, Cole J, Reddy V, Majersik JJ, Lindgren A, Worrall BB. Variability of the Modified Rankin Scale Score Between Day 90 and 1 Year After Ischemic Stroke. Neurology Clinical Practice 2021, 11: e239-e244. PMID: 34484897, PMCID: PMC8382369, DOI: 10.1212/cpj.0000000000000954.Peer-Reviewed Original ResearchModified Rankin ScaleTrial's primary outcomePrimary outcomeIschemic strokeDay 90Stroke onsetStroke trialsStroke (NINDS) rt-PA Stroke StudyModified Rankin Scale scoreAcute ischemic strokeProportion of patientsIschemic stroke onsetRankin Scale scoreClinical trial designTraditional outcome measuresMRS improvementMRS shiftStroke IIIRecurrent strokeRankin ScaleInterventional managementClinical evolutionStroke StudyRehabilitative therapyAlbumin treatmentPredicting 90-Day Outcome After Thrombectomy: Baseline-Adjusted 24-Hour NIHSS Is More Powerful Than NIHSS Score Change
Mistry EA, Yeatts S, de Havenon A, Mehta T, Arora N, La Rosa F, Starosciak AK, Siegler JE, Mistry AM, Yaghi S, Khatri P. Predicting 90-Day Outcome After Thrombectomy: Baseline-Adjusted 24-Hour NIHSS Is More Powerful Than NIHSS Score Change. Stroke 2021, 52: 2547-2553. PMID: 34000830, PMCID: PMC11261999, DOI: 10.1161/strokeaha.120.032487.Peer-Reviewed Original ResearchConceptsNIHSS scoreLong-term functional outcomeNIHSS score changeComprehensive stroke centerHealth Stroke ScaleProspective observational studyEarly time pointsStroke centersStroke ScaleEndovascular therapyMRS outcomesMRS scoreRankin ScaleStroke patientsFunctional outcomeSurrogate markerClinical studiesNIHSSMultivariable modelingObservational studyOutcome measuresPatientsPercent changeScore changeLogistic regressionEndovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion
Anadani M, Marnat G, Consoli A, Papanagiotou P, Nogueira RG, Spiotta AM, Bourcier R, Kyheng M, Labreuche J, Siddiqui AH, Ribo M, de Havenon A, Fischer U, Sibon I, Dargazanli C, Arquizan C, Cognard C, Olivot JM, Anxionnat R, Audibert G, Mazighi M, Blanc R, Lapergue B, Richard S, Gory B, Investigators T. Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion. Journal Of NeuroInterventional Surgery 2021, 14: 314-320. PMID: 33911016, DOI: 10.1136/neurintsurg-2020-017202.Peer-Reviewed Original ResearchConceptsCervical internal carotid arteryIntravenous thrombolysisAcute ischemic strokeTandem occlusionsEndovascular therapyInternal carotid arteryFavorable outcomeAcute strokeIschemic strokeCarotid arteryHigher oddsAnterior circulation tandem occlusionAcute tandem occlusionIschemic Stroke RegistrySignificant hemorrhagic complicationsIVT treatmentHemorrhagic complicationsStroke RegistrySuccessful reperfusionRankin ScaleConsecutive patientsIPTW analysisPrimary outcomeEndovascular treatmentPuncture time
2019
Increased blood pressure variability after acute ischemic stroke increases the risk of death: A secondary analysis of the Virtual International Stroke Trial Archive
de Havenon A, Stoddard G, Saini M, Wong KH, Tirschwell D, Bath P, . Increased blood pressure variability after acute ischemic stroke increases the risk of death: A secondary analysis of the Virtual International Stroke Trial Archive. JRSM Cardiovascular Disease 2019, 8: 2048004019856496. PMID: 31217966, PMCID: PMC6560789, DOI: 10.1177/2048004019856496.Peer-Reviewed Original ResearchBlood pressure variabilityVirtual International Stroke Trials ArchiveAcute ischemic strokePressure variabilityIschemic strokeStudy enrollmentAcute ischemic stroke patientsDiastolic blood pressure variabilitySystolic blood pressure variabilityIschemic stroke patientsOutcome of deathWorse neurologic outcomeDiastolic blood pressureRisk of deathBlood pressure readingsLogistic regression modelsNeurologic outcomeRankin ScaleStroke onsetBlood pressurePrimary outcomeClinical outcomesStroke patientsRetrospective analysisLarge cohort
2018
Increased Blood Pressure Variability Contributes to Worse Outcome After Intracerebral Hemorrhage
de Havenon A, Majersik JJ, Stoddard G, Wong KH, McNally JS, Smith AG, Rost NS, Tirschwell DL. Increased Blood Pressure Variability Contributes to Worse Outcome After Intracerebral Hemorrhage. Stroke 2018, 49: 1981-1984. PMID: 30012822, PMCID: PMC6202185, DOI: 10.1161/strokeaha.118.022133.Peer-Reviewed Original ResearchConceptsBlood pressure variabilitySystolic blood pressure variabilitySystolic blood pressureNeurological outcomeRankin ScaleBlood pressureAcute periodIntracerebral hemorrhageWorse outcomesPressure variabilityLong-term neurological outcomeUtility-weighted modified Rankin scaleWorse neurological outcomeAcute ischemic strokeModified Rankin ScaleBlood pressure meansATACH-2 trialProtocol-based approachATACH-2Ischemic strokeSecondary outcomesPrimary outcomeEarly identificationSecondary analysisConsistent association
2016
Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke
de Havenon A, Bennett A, Stoddard GJ, Smith G, Wang H, Wold J, Chung L, Tirschwell DL, Majersik JJ. Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke. Stroke Research And Treatment 2016, 2016: 7670161. PMID: 27974991, PMCID: PMC5126417, DOI: 10.1155/2016/7670161.Peer-Reviewed Original ResearchBlood pressure variabilityLower mean blood pressureSystolic blood pressure variabilityMean blood pressureWorse neurologic outcomeBlood pressureIschemic strokeNeurologic outcomeVessel occlusionPressure variabilityAcute anterior circulation ischemic strokeAnterior circulation ischemic strokeAcute ischemic stroke patientsDiastolic blood pressure variabilityProximal vessel occlusionAcute ischemic strokeAnterior circulation strokeIschemic stroke patientsLogistic regression modelsOrdinal logistic regression modelsRankin ScaleAcute settingThrombolytic therapyStroke patientsPatient population