2022
Temporal Monitoring of the Floreana Island Galapagos Giant Tortoise Captive Breeding Program
Gray R, Fusco N, Miller J, Tapia W, Mariani C, Caccone A, Jensen E. Temporal Monitoring of the Floreana Island Galapagos Giant Tortoise Captive Breeding Program. Integrative And Comparative Biology 2022, 62: 1864-1871. PMID: 35906184, DOI: 10.1093/icb/icac129.Peer-Reviewed Original ResearchConceptsCaptive breeding programsBreeding programsEffective population sizeGalapagos giant tortoisesCaptive breedingGenetic diversityGenetic trackingReproductive outputSpecies restorationGiant tortoisesConservation managersBreeding outcomesMicrosatellite markersGenetic analysisMore foundersBreeding cyclePopulation sizeBreeding facilitiesTortoisesValue of hybridsParentageOffspringGenomeHybridsBreedingThe Galapagos giant tortoise Chelonoidis phantasticus is not extinct
Jensen E, Gaughran S, Fusco N, Poulakakis N, Tapia W, Sevilla C, Málaga J, Mariani C, Gibbs J, Caccone A. The Galapagos giant tortoise Chelonoidis phantasticus is not extinct. Communications Biology 2022, 5: 546. PMID: 35681083, PMCID: PMC9184544, DOI: 10.1038/s42003-022-03483-w.Peer-Reviewed Original ResearchConceptsGalapagos giant tortoisesGiant tortoisesMitochondrial DNA phylogenyDNA phylogenyMonophyletic groupCarapace morphologyPhylogeny GroupSame lineagePopulation sizeSpeciesTortoisesLineagesFemale tortoisesSingle specimenSingle individualPhylogenyCladeGenomeExtinctSaddlebackContinued existenceIslandsDiscovery
2019
Spatio-temporal distribution of Spiroplasma infections in the tsetse fly (Glossina fuscipes fuscipes) in northern Uganda
Schneider DI, Saarman N, Onyango MG, Hyseni C, Opiro R, Echodu R, O’Neill M, Bloch D, Vigneron A, Johnson TJ, Dion K, Weiss BL, Opiyo E, Caccone A, Aksoy S. Spatio-temporal distribution of Spiroplasma infections in the tsetse fly (Glossina fuscipes fuscipes) in northern Uganda. PLOS Neglected Tropical Diseases 2019, 13: e0007340. PMID: 31369548, PMCID: PMC6692048, DOI: 10.1371/journal.pntd.0007340.Peer-Reviewed Original ResearchGenetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana.
Orr AR, Quagraine JE, Suwondo P, George S, Harrison LM, Dornas FP, Evans B, Caccone A, Humphries D, Wilson MD, Cappello M. Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana. American Journal Of Tropical Medicine And Hygiene 2019, 100: 351-356. PMID: 30734697, PMCID: PMC6367626, DOI: 10.4269/ajtmh.18-0727.Peer-Reviewed Original ResearchConceptsMass drug administrationSoil-transmitted helminthsKintampo North MunicipalitySchool-aged childrenSingle nucleotide polymorphismsPolymerase chain reactionEffectiveness of MDAWild-type SNPsInfected study subjectsPeriodic mass drug administrationResistance-associated single nucleotide polymorphismsCross-sectional studyResistance-associated mutationsWorld Health OrganizationHookworm infectionDrug exposureHookworm eggsUnreported associationStudy subjectsDrug AdministrationPosttreatment samplesChemotherapeutic approachesGrowth delayHuman hookwormHealth Organization
2018
Genetic Differentiation of Glossina pallidipes Tsetse Flies in Southern Kenya.
Okeyo WA, Saarman NP, Bateta R, Dion K, Mengual M, Mireji PO, Ouma C, Okoth S, Murilla G, Aksoy S, Caccone A. Genetic Differentiation of Glossina pallidipes Tsetse Flies in Southern Kenya. American Journal Of Tropical Medicine And Hygiene 2018, 99: 945-953. PMID: 30105964, PMCID: PMC6159567, DOI: 10.4269/ajtmh.18-0154.Peer-Reviewed Original ResearchConceptsGenetic differentiationPopulation dynamicsDispersal patternsTsetse fliesLow genetic diversityGreater genetic differentiationEvidence of admixtureWestern clusterEastern clusterRecent anthropogenic influencesAnimal African trypanosomiasisGenetic connectivityWestern relativesGenetic diversityMicrosatellite lociPopulation structureGenotypic dataWidespread signalDisease vectorsMajor vectorVector control effortsGreat Rift ValleyDemographic parametersFliesVector control programsGenetic Pedigree Analysis of the Pilot Breeding Program for the Rediscovered Galapagos Giant Tortoise from Floreana Island
Miller J, Quinzin M, Scheibe E, Ciofi C, Villalva F, Tapia W, Caccone A. Genetic Pedigree Analysis of the Pilot Breeding Program for the Rediscovered Galapagos Giant Tortoise from Floreana Island. Journal Of Heredity 2018, 109: 620-630. PMID: 29490038, DOI: 10.1093/jhered/esy010.Peer-Reviewed Original ResearchConceptsReproductive skewGalapagos giant tortoisesBreeding programsFloreana IslandGiant tortoisesAssortative matingSelf-sustaining wild populationsGenetic pedigree analysisMajority of progenyCaptive breeding programsSmall breeding groupsOrigin of individualsPedigree analysisLarge breeding programsFounding individualsWild populationsAllelic diversityGenetic diversityExtinct tortoisesGenetic variationGenetic analysisC. nigerPopulation sizeRelated individualsBreeding groups
2017
Self-righting potential and the evolution of shell shape in Galápagos tortoises
Chiari Y, van der Meijden A, Caccone A, Claude J, Gilles B. Self-righting potential and the evolution of shell shape in Galápagos tortoises. Scientific Reports 2017, 7: 15828. PMID: 29192279, PMCID: PMC5709378, DOI: 10.1038/s41598-017-15787-7.Peer-Reviewed Original ResearchGenetic diversity and population structure of the tsetse fly Glossina fuscipes fuscipes (Diptera: Glossinidae) in Northern Uganda: Implications for vector control
Opiro R, Saarman NP, Echodu R, Opiyo EA, Dion K, Halyard A, Dunn AW, Aksoy S, Caccone A. Genetic diversity and population structure of the tsetse fly Glossina fuscipes fuscipes (Diptera: Glossinidae) in Northern Uganda: Implications for vector control. PLOS Neglected Tropical Diseases 2017, 11: e0005485. PMID: 28453513, PMCID: PMC5425221, DOI: 10.1371/journal.pntd.0005485.Peer-Reviewed Original ResearchConceptsAnimal African trypanosomiasisGenetic clustersEffective population size estimatesLake KyogaRecent population bottleneckMitochondrial DNA markersDistinct genetic clustersPolymorphic microsatellite lociNile drainagePopulation size estimatesGenetic structurePopulation bottlenecksMain haplogroupsGenetic diversityMicrosatellite lociGenetic assignmentDNA markersPopulation structureMtDNA analysisGenetic admixtureSampling sitesGenetic unitsMost populationsTrypanosoma parasitesHuman African trypanosomiasis
2016
Multiple Paternity in the Norway Rat, Rattus norvegicus , from Urban Slums in Salvador, Brazil
Costa F, Richardson JL, Dion K, Mariani C, Pertile AC, Burak MK, Childs JE, Ko AI, Caccone A. Multiple Paternity in the Norway Rat, Rattus norvegicus , from Urban Slums in Salvador, Brazil. Journal Of Heredity 2016, 107: 181-186. PMID: 26733693, PMCID: PMC5893012, DOI: 10.1093/jhered/esv098.Peer-Reviewed Original Research
2014
Lineage fusion in Galápagos giant tortoises
Garrick R, Benavides E, Russello M, Hyseni C, Edwards D, Gibbs J, Tapia W, Ciofi C, Caccone A. Lineage fusion in Galápagos giant tortoises. Molecular Ecology 2014, 23: 5276-5290. PMID: 25223395, DOI: 10.1111/mec.12919.Peer-Reviewed Original ResearchConceptsLineage fusionGiant tortoise speciesGalápagos giant tortoisesWidespread introgressive hybridizationLong generation timesWolf VolcanoCryptic lineagesReticulate evolutionIntrogressive hybridizationLineage splittingMicrosatellite dataGalápagos tortoisesPopulation geneticsEvolutionary phenomenaMate selectivityTortoise speciesGiant tortoisesLineagesGeneration timeRapid extinctionTortoisesPurebred femalesFusionIslandsHistorical reconstruction
2013
Genetically Distinct Glossina fuscipes fuscipes Populations in the Lake Kyoga Region of Uganda and Its Relevance for Human African Trypanosomiasis
Echodu R, Sistrom M, Hyseni C, Enyaru J, Okedi L, Aksoy S, Caccone A. Genetically Distinct Glossina fuscipes fuscipes Populations in the Lake Kyoga Region of Uganda and Its Relevance for Human African Trypanosomiasis. BioMed Research International 2013, 2013: 614721. PMID: 24199195, PMCID: PMC3807537, DOI: 10.1155/2013/614721.Peer-Reviewed Original ResearchConceptsSex-biased dispersalMicrosatellite DNA dataLack of admixtureAgents of humanVicariant barrierGenetic differentiationSouthern populationsDNA dataTrypanosoma bruceiCompetitive exclusionMain vector speciesSole vectorsContact zonePopulation clustersVector speciesEnvironmental conditionsTsetse fliesDistinct groupsAnimal trypanosomiasisHuman African trypanosomiasisGlossinaAfrican trypanosomiasisIntrogressionSympatryDispersalGlossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda
Aksoy S, Caccone A, Galvani AP, Okedi LM. Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda. Trends In Parasitology 2013, 29: 394-406. PMID: 23845311, PMCID: PMC3772539, DOI: 10.1016/j.pt.2013.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiodiversityDNA, MitochondrialFemaleGene FlowGenetics, PopulationHost-Pathogen InteractionsHumansInsect VectorsMaleMicrobiotaMicrosatellite RepeatsPest Control, BiologicalSymbiosisTrypanosoma brucei gambienseTrypanosoma brucei rhodesienseTrypanosomiasis, AfricanTsetse FliesUgandaConceptsOccurrence of polyandryGene flowPopulation geneticsPopulation structureGenetic applicationsHuman African trypanosomiasisMajor vectorMicrobiome compositionTsetse control programsTrypanosomiasis transmissionRecent spreadPotential rolePresent knowledgeGlossinaAfrican trypanosomiasisPolyandryHuman African trypanosomiasis transmissionInfection outcomesGeneticsFuscipesDiversityPopulationFive years of malaria control in the continental region, Equatorial Guinea
Rehman A, Mann A, Schwabe C, Reddy M, Roncon Gomes I, Slotman M, Yellott L, Matias A, Caccone A, Nseng Nchama G, Kleinschmidt I. Five years of malaria control in the continental region, Equatorial Guinea. Malaria Journal 2013, 12: 154. PMID: 23651490, PMCID: PMC3652729, DOI: 10.1186/1475-2875-12-154.Peer-Reviewed Original ResearchConceptsIndoor residual sprayingMalaria Indicator SurveyLow prevalenceIntervention coverageHealth information systemsCase managementP. falciparum prevalencePlasmodium falciparum infectionAnnual malaria indicator surveysProportion of childrenSuccessful malaria control programmesMalaria control programmesMinority of childrenPrevious nightFalciparum infectionChildren 1Malaria interventionsMalaria seasonInsecticidal netsMalaria transmissionP. falciparumMalaria controlLogistic regressionPrevalenceIndicator SurveyWolbachia association with the tsetse fly, Glossina fuscipes fuscipes, reveals high levels of genetic diversity and complex evolutionary dynamics
Symula RE, Alam U, Brelsfoard C, Wu Y, Echodu R, Okedi LM, Aksoy S, Caccone A. Wolbachia association with the tsetse fly, Glossina fuscipes fuscipes, reveals high levels of genetic diversity and complex evolutionary dynamics. BMC Ecology And Evolution 2013, 13: 31. PMID: 23384159, PMCID: PMC3574847, DOI: 10.1186/1471-2148-13-31.Peer-Reviewed Original ResearchConceptsMtDNA haplotypesDifferent WolbachiaGenetic diversityHost haplotypesSequence diversityMultiple WolbachiaArthropod host reproductionPopulation genetic differentiationComplex evolutionary dynamicsMitochondrial DNA haplotypesAssociation of WolbachiaLow reproductive outputHost population geneticsHost genetic diversityTsetse fliesMulti-locus sequence typingMost WolbachiaHost genetic compositionGenetic differentiationWolbachia evolutionWolbachia associationsHost reproductionDNA haplotypesMtDNA groupsΑ-proteobacteria
2012
The population structure of Glossina fuscipes fuscipes in the Lake Victoria basin in Uganda: implications for vector control
Hyseni C, Kato AB, Okedi LM, Masembe C, Ouma JO, Aksoy S, Caccone A. The population structure of Glossina fuscipes fuscipes in the Lake Victoria basin in Uganda: implications for vector control. Parasites & Vectors 2012, 5: 222. PMID: 23036153, PMCID: PMC3522534, DOI: 10.1186/1756-3305-5-222.Peer-Reviewed Original Research
2011
Genetic diversity and population structure of Glossina pallidipes in Uganda and western Kenya
Ouma JO, Beadell JS, Hyseni C, Okedi LM, Krafsur ES, Aksoy S, Caccone A. Genetic diversity and population structure of Glossina pallidipes in Uganda and western Kenya. Parasites & Vectors 2011, 4: 122. PMID: 21711519, PMCID: PMC3146932, DOI: 10.1186/1756-3305-4-122.Peer-Reviewed Original ResearchConceptsSex-biased dispersalGenetic diversityPopulation structureSource populationModern gene flowHigh genetic diversityMean genetic distanceAnalysis of mtDNAGene flowNuclear markersBayesian assignmentRelict populationsMtDNA haplotypesGenetic distanceMicrosatellite genotypesG. pallidipesGenetic variationPairwise relatednessMicrosatellite allelesMicrosatellite analysisDispersalSoutheastern UgandaFall populationPopulation comparisonsEffective control effortsPolyandry Is a Common Event in Wild Populations of the Tsetse Fly Glossina fuscipes fuscipes and May Impact Population Reduction Measures
Bonomi A, Bassetti F, Gabrieli P, Beadell J, Falchetto M, Scolari F, Gomulski LM, Regazzini E, Ouma JO, Caccone A, Okedi LM, Attardo GM, Guglielmino CR, Aksoy S, Malacrida AR. Polyandry Is a Common Event in Wild Populations of the Tsetse Fly Glossina fuscipes fuscipes and May Impact Population Reduction Measures. PLOS Neglected Tropical Diseases 2011, 5: e1190. PMID: 21666797, PMCID: PMC3110164, DOI: 10.1371/journal.pntd.0001190.Peer-Reviewed Original ResearchConceptsEffective population sizePopulation sizeInformative microsatellite lociNumber of matingsTsetse Fly GlossinaFemale rematingWild populationsReproductive biologyMicrosatellite lociFemale matesSterile malesDifferent matesFemale spermathecaeRematingReproductive potentialPolyandryDirect countsPopulation age structureFuscipesLake VictoriaSpermathecaeWildMatesDry seasonSpecies
2010
Genetic Differentiation between Marine Iguanas from Different Breeding Sites on the Island of Santa Fé (Galápagos Archipelago)
Lanterbecq D, Glaberman S, Vitousek M, Steinfartz S, Benavides E, Wikelski M, Caccone A. Genetic Differentiation between Marine Iguanas from Different Breeding Sites on the Island of Santa Fé (Galápagos Archipelago). Journal Of Heredity 2010, 101: 663-675. PMID: 20538757, DOI: 10.1093/jhered/esq067.Peer-Reviewed Original ResearchConceptsMarine iguanasGenetic diversitySex-biased dispersalMitochondrial control regionMitochondrial DNA markersGalápagos marine iguanasSanta FéDifferent breeding sitesSouthern sitesGenetic differentiationEvolutionary signalGenetic structureMicrosatellite lociDNA markersControl regionGenetic variationGenetic patternsBreeding sitesLittle differentiationBase pairsNeighboring islandsIguanasDiversitySampling sitesDifferentiation
2009
Progressive colonization and restricted gene flow shape island-dependent population structure in Galápagos marine iguanas (Amblyrhynchus cristatus)
Steinfartz S, Glaberman S, Lanterbecq D, Russello M, Rosa S, Hanley T, Marquez C, Snell H, Snell H, Gentile G, Dell'Olmo G, Powell A, Caccone A. Progressive colonization and restricted gene flow shape island-dependent population structure in Galápagos marine iguanas (Amblyrhynchus cristatus). BMC Ecology And Evolution 2009, 9: 297. PMID: 20028547, PMCID: PMC2807874, DOI: 10.1186/1471-2148-9-297.Peer-Reviewed Original ResearchConceptsComplete mitochondrial control regionMarine iguanasGene flowPopulation structureMarine iguana populationsHistorical gene flowNuclear gene flowMicrosatellite genetic diversityStrong genetic differentiationMale-biased dispersalMitochondrial control regionRecent population expansionBayesian cluster analysisGalápagos marine iguanasHaplotype distribution patternsDistinct genetic clustersPast genetic studiesGenetic differentiationWestern islandsFST estimatesIguana populationsFounder eventsFST analysisDifferent inheritance patternsGenetic clustersMorphometrics Parallel Genetics in a Newly Discovered and Endangered Taxon of Galápagos Tortoise
Chiari Y, Hyseni C, Fritts T, Glaberman S, Marquez C, Gibbs J, Claude J, Caccone A. Morphometrics Parallel Genetics in a Newly Discovered and Endangered Taxon of Galápagos Tortoise. PLOS ONE 2009, 4: e6272. PMID: 19609441, PMCID: PMC2707613, DOI: 10.1371/journal.pone.0006272.Peer-Reviewed Original ResearchConceptsGalápagos tortoisesGenetic variationGenetic distinctionTortoise populationsNon-neutral lociStrong genetic differentiationComplex heritable traitsDiagnostic morphological charactersShell morphologyShell shape variationGenetic differentiationMitochondrial dataMonophyletic lineageMorphological charactersGiant tortoisesHeritable traitGenetic dataMost islandsSanta CruzMolecular studiesShell shapeTurtle shellTortoisesLineagesParallel Genetic