2017
Theory, practice, and conservation in the age of genomics: The Galápagos giant tortoise as a case study
Gaughran S, Quinzin M, Miller J, Garrick R, Edwards D, Russello M, Poulakakis N, Ciofi C, Beheregaray L, Caccone A. Theory, practice, and conservation in the age of genomics: The Galápagos giant tortoise as a case study. Evolutionary Applications 2017, 11: 1084-1093. PMID: 30026799, PMCID: PMC6050186, DOI: 10.1111/eva.12551.Peer-Reviewed Original ResearchGalápagos giant tortoisesSingle nucleotide polymorphismsGenetic differentiationPopulation structureGiant tortoisesRecent single nucleotide polymorphismGenomewide single nucleotide polymorphismsGenomic single nucleotide polymorphismsGiant tortoise speciesHigh-throughput DNA sequencingStructured natural populationsHundreds of SNPsThousands of SNPsPopulation genetics theoryTraditional genetic markersAge of genomicsMitochondrial DNA analysisNonmodel organismsNonmodel speciesEvolutionary historyNatural populationsGenetic theoryTortoise speciesUnnatural groupingGenomic data
2016
Vectors as Epidemiological Sentinels: Patterns of Within-Tick Borrelia burgdorferi Diversity
Walter KS, Carpi G, Evans BR, Caccone A, Diuk-Wasser MA. Vectors as Epidemiological Sentinels: Patterns of Within-Tick Borrelia burgdorferi Diversity. PLOS Pathogens 2016, 12: e1005759. PMID: 27414806, PMCID: PMC4944968, DOI: 10.1371/journal.ppat.1005759.Peer-Reviewed Original ResearchConceptsPathogen diversityPositive selectionVertebrate hostsHost pathogen diversityLyme disease bacteriaNatural transmission cycleNatural populationsPathogen evolutionGenomic variationHost diversityMajority of ticksHost processesDiverse inoculumUndocumented levelEvolutionary processesTick diversityDisease vectorsMixed strain infectionsImmune complementIndividual ticksDiversityEpidemiological sentinelsTick vectorTransmission cycleHost
2015
Description of a New Galapagos Giant Tortoise Species (Chelonoidis; Testudines: Testudinidae) from Cerro Fatal on Santa Cruz Island
Poulakakis N, Edwards D, Chiari Y, Garrick R, Russello M, Benavides E, Watkins-Colwell G, Glaberman S, Tapia W, Gibbs J, Cayot L, Caccone A. Description of a New Galapagos Giant Tortoise Species (Chelonoidis; Testudines: Testudinidae) from Cerro Fatal on Santa Cruz Island. PLOS ONE 2015, 10: e0138779. PMID: 26488886, PMCID: PMC4619298, DOI: 10.1371/journal.pone.0138779.Peer-Reviewed Original ResearchConceptsMultiple independent evolutionary lineagesGiant tortoise speciesIndependent evolutionary lineagesCompelling genetic evidenceGalapagos tortoisesRank of speciesSanta Cruz IslandGenetic distinctivenessAnalysis of DNAEvolutionary lineagesEvolutionary relationshipsNatural populationsDNA charactersDistinct lineagesIsland of originTaxonomic revisionMorphological charactersMuseum specimensNew speciesGenetic evidenceTortoise speciesLineagesSpeciesTortoisesType specimen
2012
Limited Usefulness of Microsatellite Markers from the Malaria Vector Anophelesgambiae When Applied to the Closely Related Species Anopheles melas
Deitz K, Reddy V, Reddy M, Satyanarayanah N, Lindsey M, Overgaard H, Jawara M, Caccone A, Slotman M. Limited Usefulness of Microsatellite Markers from the Malaria Vector Anophelesgambiae When Applied to the Closely Related Species Anopheles melas. Journal Of Heredity 2012, 103: 585-593. PMID: 22593601, DOI: 10.1093/jhered/ess025.Peer-Reviewed Original Research
2010
Anopheles Immune Genes and Amino Acid Sites Evolving Under the Effect of Positive Selection
Parmakelis A, Moustaka M, Poulakakis N, Louis C, Slotman MA, Marshall JC, Awono-Ambene PH, Antonio-Nkondjio C, Simard F, Caccone A, Powell JR. Anopheles Immune Genes and Amino Acid Sites Evolving Under the Effect of Positive Selection. PLOS ONE 2010, 5: e8885. PMID: 20126662, PMCID: PMC2811201, DOI: 10.1371/journal.pone.0008885.Peer-Reviewed Original ResearchConceptsPositive selectionImmune genesGambiae complexDN/dS ratiosLineage-specific evolutionPopulation genetics frameworkAmino acid sitesAnopheles gambiae complexSpecific amino acidsInnate immunity genesAncestral polymorphismComparative phylogeneticsGene diversityEvolutionary historyNatural populationsGenetic diversityGenetic frameworkNatural selectionImmunity genesVector biologyDS ratiosGenesAmino acidsDiversityGenetic knowledge
2004
Genetic analysis of a successful repatriation programme: giant Galpagos tortoises
Milinkovitch M, Monteyne D, Gibbs J, Fritts T, Tapia W, Snell H, Tiedemann R, Caccone A, Powell J. Genetic analysis of a successful repatriation programme: giant Galpagos tortoises. Proceedings Of The Royal Society B 2004, 271: 341-345. PMID: 15101691, PMCID: PMC1691607, DOI: 10.1098/rspb.2003.2607.Peer-Reviewed Original ResearchConceptsGenetic variationIsland of EspañolaGiant Galápagos tortoisesMicrosatellite DNA markersNatural populationsGalápagos tortoisesDNA markersNatural habitatsSitu reproductionBreeding programsGenetic analysisRepatriation programBreedersTortoisesOffspringFurther lossHabitatsTaxaPaternitySpeciesCaptivityReproductionPopulationIslandsVariation
2003
The origin of captive Galápagos tortoises based on DNA analysis: implications for the management of natural populations
Burns C, Ciofi C, Beheregaray L, Fritts T, Gibbs J, Márquez C, Milinkovitch M, Powell J, Caccone A. The origin of captive Galápagos tortoises based on DNA analysis: implications for the management of natural populations. Animal Conservation 2003, 6: 329-337. DOI: 10.1017/s1367943003003408.Peer-Reviewed Original ResearchNatural populationsMtDNA haplotypesCaptive individualsMtDNA control region haplotypesDistinct mtDNA haplotypesControl region haplotypesMultilocus microsatellite genotypesCaptive breeding programsSpecies management plansNumber of breedersLonesome GeorgeCharles Darwin Research StationCR haplotypesEvolutionary originGalápagos tortoisesIsland populationsMicrosatellite genotypesRegion haplotypesGiant tortoisesGalápagos IslandsGalápagos ArchipelagoGeographic originMolecular techniquesHaplotypesCaptive tortoises