2016
Whole genome sequencing shows sleeping sickness relapse is due to parasite regrowth and not reinfection
Richardson JB, Evans B, Pyana PP, Van Reet N, Sistrom M, Büscher P, Aksoy S, Caccone A. Whole genome sequencing shows sleeping sickness relapse is due to parasite regrowth and not reinfection. Evolutionary Applications 2016, 9: 381-393. PMID: 26834831, PMCID: PMC4721075, DOI: 10.1111/eva.12338.Peer-Reviewed Original ResearchSame patientHuman African trypanosomiasisHigh incidencePatientsTrypanosoma brucei gambienseHAT casesDrug resistanceDisease controlRelapseSingle nucleotide polymorphismsBrucei gambienseWhole-genome sequencingAfrican trypanosomiasisPathogenic levelsSaharan AfricaNucleotide polymorphismsOriginal strainRecent studiesTreatmentPromising new setFunctional studiesNovel insightsReinfectionFuture functional studiesNew strain
2013
Genetically Distinct Glossina fuscipes fuscipes Populations in the Lake Kyoga Region of Uganda and Its Relevance for Human African Trypanosomiasis
Echodu R, Sistrom M, Hyseni C, Enyaru J, Okedi L, Aksoy S, Caccone A. Genetically Distinct Glossina fuscipes fuscipes Populations in the Lake Kyoga Region of Uganda and Its Relevance for Human African Trypanosomiasis. BioMed Research International 2013, 2013: 614721. PMID: 24199195, PMCID: PMC3807537, DOI: 10.1155/2013/614721.Peer-Reviewed Original ResearchConceptsSex-biased dispersalMicrosatellite DNA dataLack of admixtureAgents of humanVicariant barrierGenetic differentiationSouthern populationsDNA dataTrypanosoma bruceiCompetitive exclusionMain vector speciesSole vectorsContact zonePopulation clustersVector speciesEnvironmental conditionsTsetse fliesDistinct groupsAnimal trypanosomiasisHuman African trypanosomiasisGlossinaAfrican trypanosomiasisIntrogressionSympatryDispersalGlossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda
Aksoy S, Caccone A, Galvani AP, Okedi LM. Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda. Trends In Parasitology 2013, 29: 394-406. PMID: 23845311, PMCID: PMC3772539, DOI: 10.1016/j.pt.2013.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiodiversityDNA, MitochondrialFemaleGene FlowGenetics, PopulationHost-Pathogen InteractionsHumansInsect VectorsMaleMicrobiotaMicrosatellite RepeatsPest Control, BiologicalSymbiosisTrypanosoma brucei gambienseTrypanosoma brucei rhodesienseTrypanosomiasis, AfricanTsetse FliesUgandaConceptsOccurrence of polyandryGene flowPopulation geneticsPopulation structureGenetic applicationsHuman African trypanosomiasisMajor vectorMicrobiome compositionTsetse control programsTrypanosomiasis transmissionRecent spreadPotential rolePresent knowledgeGlossinaAfrican trypanosomiasisPolyandryHuman African trypanosomiasis transmissionInfection outcomesGeneticsFuscipesDiversityPopulation
2012
Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance
Symula RE, Beadell JS, Sistrom M, Agbebakun K, Balmer O, Gibson W, Aksoy S, Caccone A. Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance. PLOS Neglected Tropical Diseases 2012, 6: e1728. PMID: 22802982, PMCID: PMC3393672, DOI: 10.1371/journal.pntd.0001728.Peer-Reviewed Original ResearchConceptsTrypanosome lytic factorHuman serum resistanceGroup 2Group 1Serum resistanceHaptoglobin-hemoglobin receptorHuman serumHuman African trypanosomiasisInnate immunityTrypanosoma brucei rhodesienseUnique amino acid substitutionsAltered activityLytic factorCausative agentLytic activityHemoglobin receptorTLF-1African trypanosomiasisBrucei rhodesienseSerumReceptorsAmino acid substitutionsFurther evidenceHpHbRTBR
2008
Multiple-strain infections of Trypanosoma brucei across Africa
Balmer O, Caccone A. Multiple-strain infections of Trypanosoma brucei across Africa. Acta Tropica 2008, 107: 275-279. PMID: 18671933, PMCID: PMC2582348, DOI: 10.1016/j.actatropica.2008.06.006.Peer-Reviewed Original Research