Homing of Neural Stem Cells From the Venous Compartment Into a Brain Infarct Does Not Involve Conventional Interactions With Vascular Endothelium
Goncharova V, Das S, Niles W, Schraufstatter I, Wong A, Povaly T, Wakeman D, Miller L, Snyder E, Khaldoyanidi S. Homing of Neural Stem Cells From the Venous Compartment Into a Brain Infarct Does Not Involve Conventional Interactions With Vascular Endothelium. Stem Cells Translational Medicine 2014, 3: 229-240. PMID: 24396034, PMCID: PMC3925049, DOI: 10.5966/sctm.2013-0052.Peer-Reviewed Original ResearchConceptsHuman neural stem cellsNeural stem cellsIntravenous administrationStromal cell-derived factor-1αEx vivo fucosylationCutaneous lymphocyte antigenBlood-brain barrierStem cellsMortality of ratsHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsImplantation of cellsBrain infarctsVein endothelial cellsLymphocyte antigenVascular endotheliumIntracranial injectionVenous compartmentCell surface moietiesFactor-1αIntravascular spaceEndothelial cellsAdministrationLuminal surfaceRemoval of fucose