Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsDustin R. Wakeman, PhD
Adjunct Assistant Professor, Dept. of Psychiatry, School of MedicineDownloadHi-Res Photo
About
Copy Link
Titles
Adjunct Assistant Professor, Dept. of Psychiatry, School of Medicine
Biography
Dr. Wakeman’s research goals are directed at developing stem cell based therapeutics to treat neurodevelopmental and neurodegenerative disease. His career interests include disease modeling, neural transplantation, and morphological and molecular changes in neurodegenerative diseases and aging. Dr. Wakeman’s research is primarily focused on drug discovery, preclinical safety & pharmacology assessments, and clinical development using a rationale course of animal models to predict translational clinical outcome. He is utilizing pluripotent stem cells to develop new strategies to model and treat disorders of the central nervous system. The goal is to use patient derived iPSCs as an in vitro platform to model disease-specific phenotypes and develop new drugable targets, as well as in vivo to mimic human disease in the rodent and nonhuman primate brain. Dr. Wakeman has active research programs investigating Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and several rare genetic neurological disorders.
Last Updated on May 08, 2024.
Education & Training
- PhD
- University of California at San Diego, Biomedical Sciences (2010)
- BS
- University of Illinois at Urbana-Champaign, Biology (2003)
Research
Copy Link
Overview
Medical Research Interests
Alzheimer Disease; Central Nervous System Diseases; Huntington Disease; Lewy Body Disease; Parkinsonian Disorders; Stroke
Research at a Glance
Yale Co-Authors
Frequent collaborators of Dustin R. Wakeman's published research.
Publications Timeline
A big-picture view of Dustin R. Wakeman's research output by year.
Research Interests
Research topics Dustin R. Wakeman is interested in exploring.
Matthew Lawrence, MD, PhD
John Elsworth, PhD
28Publications
2,744Citations
Stroke
Parkinsonian Disorders
Alzheimer Disease
Huntington Disease
Publications
2025
Proteomic Signatures of Epigenetic Age in African Green Monkey Cerebrospinal Fluid and Plasma
Elsworth J, Neutzner A, Roux J, Gordevicius J, Milciute M, Dzikiti L, Wakeman D, Danielsson B, Agca C, Lawrence M. Proteomic Signatures of Epigenetic Age in African Green Monkey Cerebrospinal Fluid and Plasma. Aging Cell 2025, 24: e70168. PMID: 40729555, PMCID: PMC12507418, DOI: 10.1111/acel.70168.Peer-Reviewed Original ResearchCitationsAltmetricLong-Term Engraftment of Cryopreserved Human Neurons for In Vivo Disease Modeling in Neurodegenerative Disease
Marmion D, Deng P, Hiller B, Lewis R, Harms L, Cameron D, Nolta J, Kordower J, Fink K, Wakeman D. Long-Term Engraftment of Cryopreserved Human Neurons for In Vivo Disease Modeling in Neurodegenerative Disease. Biology 2025, 14: 217. PMID: 40001985, PMCID: PMC11852092, DOI: 10.3390/biology14020217.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Intrathecal amyloid‐beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease
Wakeman DR, Weed MR, Perez SE, Cline EN, Viola KL, Wilcox KC, Moddrelle DS, Nisbett EZ, Kurian AM, Bell AF, Pike R, Jacobson PB, Klein WL, Mufson EJ, Lawrence MS, Elsworth JD. Intrathecal amyloid‐beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease. Neuropathology And Applied Neurobiology 2022, 48: e12800-e12800. PMID: 35156715, PMCID: PMC10902791, DOI: 10.1111/nan.12800.Peer-Reviewed Original ResearchCitationsAltmetric
2020
The Future of GDNF in Parkinson's Disease
Manfredsson F, Polinski N, Subramanian T, Boulis N, Wakeman D, Mandel R. The Future of GDNF in Parkinson's Disease. Frontiers In Aging Neuroscience 2020, 12: 593572. PMID: 33364933, PMCID: PMC7750181, DOI: 10.3389/fnagi.2020.593572.Peer-Reviewed Original ResearchCitationsAltmetricChemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration
Lee J, Zhang R, Yan M, Duggineni S, Wakeman D, Niles W, Feng Y, Chen J, Hamblin M, Han E, Gonzalez R, Fang X, Zhu Y, Wang J, Xu Y, Wenger D, Seyfried T, An J, Sidman R, Huang Z, Snyder E. Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 31177-31188. PMID: 33219123, PMCID: PMC7733796, DOI: 10.1073/pnas.1911444117.Peer-Reviewed Original ResearchCitationsAltmetricMitomycin-C treatment during differentiation of induced pluripotent stem cell-derived dopamine neurons reduces proliferation without compromising survival or function in vivo
Hiller B, Marmion D, Gross R, Thompson C, Chavez C, Brundin P, Wakeman D, McMahon C, Kordower J. Mitomycin-C treatment during differentiation of induced pluripotent stem cell-derived dopamine neurons reduces proliferation without compromising survival or function in vivo. Stem Cells Translational Medicine 2020, 10: 278-290. PMID: 32997443, PMCID: PMC7848297, DOI: 10.1002/sctm.20-0014.Peer-Reviewed Original ResearchCitationsAltmetricA Biomarker for Predicting Responsiveness to Stem Cell Therapy Based on Mechanism-of-Action: Evidence from Cerebral Injury
Hartman R, Nathan N, Ghosh N, Pernia C, Law J, Nuryyev R, Plaia A, Yusof A, Tone B, Dulcich M, Wakeman D, Dilmac N, Niles W, Sidman R, Obenaus A, Snyder E, Ashwal S. A Biomarker for Predicting Responsiveness to Stem Cell Therapy Based on Mechanism-of-Action: Evidence from Cerebral Injury. Cell Reports 2020, 31: 107622. PMID: 32402283, DOI: 10.1016/j.celrep.2020.107622.Peer-Reviewed Original ResearchCitationsAltmetric
2017
Cell Replacement Strategies for Parkinson’s Disease
Chatterjee D, Wakeman D, Kordower J. Cell Replacement Strategies for Parkinson’s Disease. Molecular And Translational Medicine 2017, 73-83. DOI: 10.1007/978-3-319-57153-9_4.Peer-Reviewed Original ResearchCitationsCryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo
Wakeman D, Hiller B, Marmion D, McMahon C, Corbett G, Mangan K, Ma J, Little L, Xie Z, Perez-Rosello T, Guzman J, Surmeier D, Kordower J. Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo. Stem Cell Reports 2017, 9: 149-161. PMID: 28579395, PMCID: PMC5511045, DOI: 10.1016/j.stemcr.2017.04.033.Peer-Reviewed Original ResearchCitationsAltmetric
2015
Autologous iPSC‐derived dopamine neuron grafts show considerable promise in a nonhuman primate model of Parkinson's disease
Wakeman D. Autologous iPSC‐derived dopamine neuron grafts show considerable promise in a nonhuman primate model of Parkinson's disease. Movement Disorders 2015, 30: 1034-1034. PMID: 26095814, DOI: 10.1002/mds.26267.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Copy Link
Honors
honor Young Investigator Award
12/05/2015International AwardStem Cell Translational MedicineDetailsUnited States
Get In Touch
Copy Link