2017
Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo
Wakeman D, Hiller B, Marmion D, McMahon C, Corbett G, Mangan K, Ma J, Little L, Xie Z, Perez-Rosello T, Guzman J, Surmeier D, Kordower J. Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo. Stem Cell Reports 2017, 9: 149-161. PMID: 28579395, PMCID: PMC5511045, DOI: 10.1016/j.stemcr.2017.04.033.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDopamine neuronsMidbrain dopamine neuronsStem cell therapyGrafted neuronsHost striatumCell-based therapiesPluripotent stem cell therapyFunctional deficitsPrimate modelFiber innervationParkinsonian phenotypeTherapeutic efficacyTransplantation studiesCell therapyNeuronsSignificant reversalTranslational developmentBehavioral assessmentClinical applicationTherapyElectrophysiological signaturesRatsDiseaseMinimal manipulation
2014
Neonatal immune-tolerance in mice does not prevent xenograft rejection
Mattis V, Wakeman D, Tom C, Dodiya H, Yeung S, Tran A, Bernau K, Ornelas L, Sahabian A, Reidling J, Sareen D, Thompson L, Kordower J, Svendsen C. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Experimental Neurology 2014, 254: 90-98. PMID: 24440640, PMCID: PMC3954854, DOI: 10.1016/j.expneurol.2014.01.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnimals, Outbred StrainsCells, CulturedCorpus StriatumDisease Models, AnimalFemaleGraft RejectionGraft SurvivalHeterograftsHumansHuntingtin ProteinHuntington DiseaseImmune ToleranceMaleMiceMice, Inbred NODMice, SCIDMice, TransgenicNerve Tissue ProteinsNeural Stem CellsNuclear ProteinsTransplantation, HeterologousConceptsNeonatal toleranceRapid rejectionHuman stem cell transplantationImmune-intact miceSignificant immune rejectionStem cell transplantationHumanized mouse modelXenograft rejectionCell transplantationRodent modelsMouse modelImmune rejectionMiceConflicting resultsStem cell typesXenograftsRecent reportsCell typesRejectionTransplantationRatsDisease
2011
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
Kriks S, Shim J, Piao J, Ganat Y, Wakeman D, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal M, Surmeier D, Kordower J, Tabar V, Studer L. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Nature 2011, 480: 547-551. PMID: 22056989, PMCID: PMC3245796, DOI: 10.1038/nature10648.Peer-Reviewed Original Research