Tailored assemblies of COPII proteins in secretion
Malhotra V. Tailored assemblies of COPII proteins in secretion. Journal Of Cell Biology 2024, 223: e202404013. PMID: 38958655, PMCID: PMC11222725, DOI: 10.1083/jcb.202404013.Peer-Reviewed Original ResearchTANGO1 inhibitors reduce collagen secretion and limit tissue scarring
Raote I, Rosendahl A, Häkkinen H, Vibe C, Küçükaylak I, Sawant M, Keufgens L, Frommelt P, Halwas K, Broadbent K, Cunquero M, Castro G, Villemeur M, Nüchel J, Bornikoel A, Dam B, Zirmire R, Kiran R, Carolis C, Andilla J, Loza-Alvarez P, Ruprecht V, Jamora C, Campelo F, Krüger M, Hammerschmidt M, Eckes B, Neundorf I, Krieg T, Malhotra V. TANGO1 inhibitors reduce collagen secretion and limit tissue scarring. Nature Communications 2024, 15: 3302. PMID: 38658535, PMCID: PMC11043333, DOI: 10.1038/s41467-024-47004-1.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulum exit sitesECM proteinsSecretion of ECM proteinsPeptide inhibitorFibrotic diseasesCollagen exportTANGO1Binding interfaceWound healingZebrafish resultsECM componentsReduced granulation tissue formationGranulation tissue formationEffective therapyCutaneous wound healingInhibitor treatmentFibrotic processUncontrolled secretionWidespread occurrenceProtein levelsExit siteExcessive scarringAmount of collagenTherapeutic modulationTissue scarringSorting of secretory proteins at the trans-Golgi network by human TGN46
Lujan P, Garcia-Cabau C, Wakana Y, Lillo J, Rodilla-Ramírez C, Sugiura H, Malhotra V, Salvatella X, Garcia-Parajo M, Campelo F. Sorting of secretory proteins at the trans-Golgi network by human TGN46. ELife 2024, 12: rp91708. PMID: 38466628, PMCID: PMC10928510, DOI: 10.7554/elife.91708.Peer-Reviewed Original ResearchConceptsSecretory proteinsSorting of secretory proteinsCargo-sorting functionsTrans-Golgi networkNascent carriersCargo sortingLumenal domainMutagenesis approachTGN46Quantitative fluorescence microscopyCellular functionsMolecular playersTGNTransport carriersProteinFluorescence microscopyMembrane carrierSorting functionFundamental processesSortingCargoMutagenesisExportPAUFReceptors