2024
Pla2g12b drives expansion of triglyceride-rich lipoproteins
Thierer J, Foresti O, Yadav P, Wilson M, Moll T, Shen M, Busch-Nentwich E, Morash M, Mohlke K, Rawls J, Malhotra V, Hussain M, Farber S. Pla2g12b drives expansion of triglyceride-rich lipoproteins. Nature Communications 2024, 15: 2095. PMID: 38453914, PMCID: PMC10920679, DOI: 10.1038/s41467-024-46102-4.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumAccumulation of intracellular lipidsSubcellular localizationTriglyceride-rich lipoproteinsEvolutionary tradeoffsInteraction partnersNascent lipoproteinsFunctional domainsLipoprotein homeostasisPLA2G12BIntracellular lipidsResistant to atherosclerosisMutant miceVertebratesReticulumTriglyceride incorporationLipid secretionCardiovascular disease riskCalcium-dependentExcessive accumulationDisease riskTriglyceride transportLipoproteinTriglyceridesLipid
2023
A model for collagen secretion by intercompartmental continuities
Bunel L, Pincet L, Malhotra V, Raote I, Pincet F. A model for collagen secretion by intercompartmental continuities. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 121: e2310404120. PMID: 38147551, PMCID: PMC10769856, DOI: 10.1073/pnas.2310404120.Peer-Reviewed Original Research