Endoplasmic reticulum exit sites are segregated for secretion based on cargo size
Saxena S, Foresti O, Liu A, Androulaki S, Pena Rodriguez M, Raote I, Aridor M, Cui B, Malhotra V. Endoplasmic reticulum exit sites are segregated for secretion based on cargo size. Developmental Cell 2024, 59: 2593-2608.e6. PMID: 38991587, DOI: 10.1016/j.devcel.2024.06.009.Peer-Reviewed Original ResearchEndoplasmic reticulum exit sitesProline-rich domainC-terminal proline-rich domainCOPII assemblyExit siteER membraneCargo exportJuxtanuclear regionU2OS cellsCargo moleculesBulky cargoSEC23AOptimal secretionCollagen VIIHuman osteosarcomaProlonged bindingComplex organismsCargoCargo sizeBindingCollagen ICTAGE5TANGO1COPIIERGIC53Tailored assemblies of COPII proteins in secretion
Malhotra V. Tailored assemblies of COPII proteins in secretion. Journal Of Cell Biology 2024, 223: e202404013. PMID: 38958655, PMCID: PMC11222725, DOI: 10.1083/jcb.202404013.Peer-Reviewed Original ResearchSorting of secretory proteins at the trans-Golgi network by human TGN46
Lujan P, Garcia-Cabau C, Wakana Y, Lillo J, Rodilla-Ramírez C, Sugiura H, Malhotra V, Salvatella X, Garcia-Parajo M, Campelo F. Sorting of secretory proteins at the trans-Golgi network by human TGN46. ELife 2024, 12: rp91708. PMID: 38466628, PMCID: PMC10928510, DOI: 10.7554/elife.91708.Peer-Reviewed Original ResearchConceptsSecretory proteinsSorting of secretory proteinsCargo-sorting functionsTrans-Golgi networkNascent carriersCargo sortingLumenal domainMutagenesis approachTGN46Quantitative fluorescence microscopyCellular functionsMolecular playersTGNTransport carriersProteinFluorescence microscopyMembrane carrierSorting functionFundamental processesSortingCargoMutagenesisExportPAUFReceptorsSorting of secretory proteins at the trans-Golgi network by human TGN46
Lujan P, Garcia-Cabau C, Wakana Y, Vera Lillo J, Rodilla-Ramírez C, Sugiura H, Malhotra V, Salvatella X, Garcia-Parajo M, Campelo F. Sorting of secretory proteins at the trans-Golgi network by human TGN46. ELife 2024, 12 DOI: 10.7554/elife.91708.3.Peer-Reviewed Original ResearchTrans Golgi networkSecretory proteinsSorting of secretory proteinsCargo-sorting functionsTrans-Golgi networkNascent carriersCargo sortingGolgi networkLumenal domainMutagenesis approachTGN46Quantitative fluorescence microscopyCellular functionsMolecular playersTransport carriersProteinFluorescence microscopyMembrane carrierSorting functionFundamental processesSortingCargoMutagenesisExportPAUF