2024
Therapeutic management in women with a diminished ovarian reserve: a systematic review and meta-analysis of randomized controlled trials
Conforti A, Carbone L, Di Girolamo R, Iorio G, Guida M, Campitiello M, Ubaldi F, Rienzi L, Vaiarelli A, Cimadomo D, Ronsini C, Longobardi S, D'Hooghe T, Esteves S, Alviggi C. Therapeutic management in women with a diminished ovarian reserve: a systematic review and meta-analysis of randomized controlled trials. Fertility And Sterility 2024 PMID: 39332623, DOI: 10.1016/j.fertnstert.2024.09.038.Peer-Reviewed Original ResearchDiminished ovarian reserveLive birth rateOvarian reserveRandomized controlled trialsClinical management of womenHigher live birth ratesAssociated with higher live birth ratesMeta-analysis of randomized controlled trialsControlled trialsInvestigate adjuvant treatmentsManagement of womenLow-dose gonadotropinsLuteal phase stimulationBirth ratePOSEIDON criteriaCorifollitropin alfaAdjuvant treatmentGonadotropin regimensGnRH antagonistClomiphene citrateLuteinizing hormoneTherapeutic managementTestosterone supplementationClinical managementRandomized trialsGonadotropin Activity during Early Folliculogenesis and Implications for Polycystic Ovarian Syndrome and Premature Ovarian Insufficiency: A Narrative Review
Longobardi S, Klinger F, Zheng W, Campitiello M, D’Hooghe T, La Marca A. Gonadotropin Activity during Early Folliculogenesis and Implications for Polycystic Ovarian Syndrome and Premature Ovarian Insufficiency: A Narrative Review. International Journal Of Molecular Sciences 2024, 25: 7520. PMID: 39062762, PMCID: PMC11277126, DOI: 10.3390/ijms25147520.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromePremature ovarian insufficiencyFollicle-stimulating hormoneEarly folliculogenesisOvarian reservePolycystic ovarian syndromeOvarian insufficiencyLuteinizing hormoneOvarian syndromePool of primordial folliclesFemale fertilityPrimordial follicle activationPrimordial follicle developmentStages of folliculogenesisResponse to gonadotropinsMolecular pathway alterationsInfluence of LHYears of ageGonadotropin-independentGonadotropin-dependentPrimordial folliclesAntral stageAntiepileptic treatmentPathway alterationsFolliculogenesisCirculating microRNAs as Non-Invasive Biomarkers in Endometriosis Diagnosis—A Systematic Review
Vanhie A, Caron E, Vermeersch E, O D, Tomassetti C, Meuleman C, Mestdagh P, D'Hooghe T. Circulating microRNAs as Non-Invasive Biomarkers in Endometriosis Diagnosis—A Systematic Review. Biomedicines 2024, 12: 888. PMID: 38672242, PMCID: PMC11048084, DOI: 10.3390/biomedicines12040888.Peer-Reviewed Original ResearchDose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatment
Cottell E, Michalet D, Lispi M, Araujo T, Gleixner R, Longobardi S, D’Hooghe T. Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatment. Expert Opinion On Drug Delivery 2024, 21: 337-346. PMID: 38299472, DOI: 10.1080/17425247.2024.2311127.Peer-Reviewed Original Research
2023
Response to Individualized vs. conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial
Longobardi S, D'Hooghe T. Response to Individualized vs. conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial. Fertility And Sterility 2023, 121: 706. PMID: 38147958, DOI: 10.1016/j.fertnstert.2023.12.024.Peer-Reviewed Original ResearchHome Monitoring of Art Cycles
Zheng W, Gerris J, Dancet E, D'Hooghe T. Home Monitoring of Art Cycles. 2023, 539-546. DOI: 10.1201/9781003268611-49.Peer-Reviewed Original ResearchAssisted reproductive technologyControlled ovarian stimulationOvarian hyperstimulation syndromeHormone testClinic-based monitoringLoss of incomeHyperstimulation syndromeCycle monitoringOvarian responseOvarian stimulationSerum hormone assaysAssess ovarian responseReproductive technologyVaginal ultrasoundHealth approachHormone assaysPrevent complicationsBlood withdrawalTailored treatmentTele-counselingUltrasoundOffice hoursTreatmentIncomeEffectiveness of recombinant human FSH: recombinant human LH combination treatment versus recombinant human FSH alone for assisted reproductive technology in women aged 35–40 years
Bielfeld A, Schwarze J, Verpillat P, Lispi M, Fischer R, Hayward B, Chuderland D, D'Hooghe T, Krussel J. Effectiveness of recombinant human FSH: recombinant human LH combination treatment versus recombinant human FSH alone for assisted reproductive technology in women aged 35–40 years. Reproductive BioMedicine Online 2023, 48: 103725. PMID: 38593745, DOI: 10.1016/j.rbmo.2023.103725.Peer-Reviewed Original ResearchAdvanced maternal ageWomen of advanced maternal ageR-hLHR-hFSHRecombinant human FSHLive birthsClinical pregnancyOvarian stimulationHuman FSHPost hoc analysis of womenRecombinant human LHLive birth rateNormal ovarian reserveNon-interventional studyAssisted reproductive technologyAnalysis of womenPost hoc analysisOvarian reserveMaternal ageEffects of treatmentHuman LHAlone groupPatient groupClinical trialsART treatmentImproving trustworthiness in research in Women's Health: A collective effort by OBGYN Editors
Berghella V, Aviram A, Chescheir N, de Costa C, Dicker P, Goggins A, Gupta J, D'Hooghe T, Odibo A, Papageorghiou A, Saade G, Geary M. Improving trustworthiness in research in Women's Health: A collective effort by OBGYN Editors. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2023, 292: 71-74. PMID: 37976768, DOI: 10.1016/j.ejogrb.2023.11.001.Peer-Reviewed Original ResearchPreface: Health economics and outcomes research in reproductive medicine: Methods and comparative effectiveness of treatment protocols
D'Hooghe T. Preface: Health economics and outcomes research in reproductive medicine: Methods and comparative effectiveness of treatment protocols. Best Practice & Research Clinical Obstetrics & Gynaecology 2023, 92: 102424. PMID: 37952324, DOI: 10.1016/j.bpobgyn.2023.102424.Peer-Reviewed Original ResearchPreface: Emerging importance of real world evidence in reproductive medicine
D'Hooghe T. Preface: Emerging importance of real world evidence in reproductive medicine. Best Practice & Research Clinical Obstetrics & Gynaecology 2023, 92: 102423. PMID: 37952325, DOI: 10.1016/j.bpobgyn.2023.102423.Peer-Reviewed Original ResearchP-238 Non-interventional study comparing the effectiveness and safety of r-hFSH:r-hLH versus r-hFSH in women aged 35-42 years with normal ovarian reserve undergoing GnRH antagonist ART treatment
Arvis P, Lehert P, Chuderland D, Schwarze J, Helwig C, Bidet M, Guivarc'h Leveque A, Lispi M, D'Hooghe T. P-238 Non-interventional study comparing the effectiveness and safety of r-hFSH:r-hLH versus r-hFSH in women aged 35-42 years with normal ovarian reserve undergoing GnRH antagonist ART treatment. Human Reproduction 2023, 38 DOI: 10.1093/humrep/dead093.596.Peer-Reviewed Original ResearchNormal ovarian reserveR-hLHR-hFSHLive birth rateOvarian stimulationOvarian reserveNon-interventional studyART treatmentFrench centersLive birthsPregnancy rateOS cyclesClinical pregnancy rateAdvanced maternal ageOngoing pregnancy rateOvarian reserve biomarkersLow ovarian reserveAnalysis of clinical dataSubgroup of patientsFollow-up periodPregnancy failure rateBirth rateSecondary analysis of clinical dataClinical pregnancyAMH levels
2022
P-635 The impact of force-degraded variants of recombinant human follicle stimulating hormone alfa (r-hFSH alfa) on in-vitro and in-vivo biological activity
Nevelli F, Peroglio F, Gleixner R, Dadone A, Palmese A, Lispi M, D'Hooghe T, D’Acunto C. P-635 The impact of force-degraded variants of recombinant human follicle stimulating hormone alfa (r-hFSH alfa) on in-vitro and in-vivo biological activity. Human Reproduction 2022, 37: deac107.584. DOI: 10.1093/humrep/deac107.584.Peer-Reviewed Original ResearchOvarian weight increaseR-hFSH-alfaBiological activity in vitroActivity in vitroIn vivoFSH-RIn vivo rat bioassayAbstract Study questionIn vitro bioassaysIn vivo bioassayEndogenous FSHSialic acid levelsHFSH receptorWIDER IMPLICATIONSUntreated samplesFollitropin alfaIn vivo biological activityWeight increaseRatsIn vitro assaysIn vitroP-598 Dose accuracy of the follitropin-alfa, follitropin-alfa/lutropin-alfa and choriogonadotropin-alfa pen injectors used for fertility treatment
Lispi M, Cottell E, Michalet D, Araujo T, Gleixner R, D'Hooghe T. P-598 Dose accuracy of the follitropin-alfa, follitropin-alfa/lutropin-alfa and choriogonadotropin-alfa pen injectors used for fertility treatment. Human Reproduction 2022, 37: deac107.550. DOI: 10.1093/humrep/deac107.550.Peer-Reviewed Original Research
2013
The Role of Scientists and Clinicians in Raising Public Support for Animal Research in Reproductive Biology and Medicine1
Dancet E, Brännström M, Brasky K, Chai D, Chan A, Conn P, Else J, Falconer H, Fazleabas A, Farah I, Goddeeris B, Golos T, Hau J, Hearn J, Kariuki T, Kyama C, Lebovic D, Mwenda J, Ndung'u J, Nyachieo A, Parker J, Slayden O, Stouffer R, Strauss J, Taylor H, Vanderpoel S, Westergaard J, Zelinski M, D'Hooghe T. The Role of Scientists and Clinicians in Raising Public Support for Animal Research in Reproductive Biology and Medicine1. Biology Of Reproduction 2013, 88: 33, 1-3. PMID: 23255340, DOI: 10.1095/biolreprod.112.105908.Peer-Reviewed Original Research