Sheng Gao
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2024
Nipocalimab, an anti-FcRn monoclonal antibody, in participants with moderate to severe active rheumatoid arthritis and inadequate response or intolerance to anti-TNF therapy: results from the phase 2a IRIS-RA study
Taylor P, Schett G, Huizinga T, Wang Q, Ibrahim F, Zhou B, Liva S, Shaik J, Xiong Y, Leu J, Panchakshari R, Loza M, Ma K, Dhatt H, Cella R, Karyekar C, Cuff C, Gao S, Fei K. Nipocalimab, an anti-FcRn monoclonal antibody, in participants with moderate to severe active rheumatoid arthritis and inadequate response or intolerance to anti-TNF therapy: results from the phase 2a IRIS-RA study. RMD Open 2024, 10: e004278. PMID: 38942592, PMCID: PMC11227837, DOI: 10.1136/rmdopen-2024-004278.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAnticitrullinated protein antibodiesModerate to severe active rheumatoid arthritisSevere active rheumatoid arthritisPatient-reported outcomesActive rheumatoid arthritisRheumatoid arthritisPrimary endpointAntitumour necrosis factor agentsInadequate responseModerate to severe active RAReduced serum immunoglobulin GAmerican College of Rheumatology (ACR) criteriaCirculating immune complex levelsPhase 2a studySevere active RAAnti-TNF therapyImmune complex levelsSerum inflammatory markersSerious adverse eventsStatistical significanceDAS28-CRP remissionSerum immunoglobulin GEfficacy endpointClinical improvementEfficacy benefitsModulation of Interleukin‐23 Signaling With Guselkumab in Biologic‐Naive Patients Versus Tumor Necrosis Factor Inhibitor–Inadequate Responders With Active Psoriatic Arthritis
Siebert S, Coates L, Schett G, Raychaudhuri S, Chen W, Gao S, Seridi L, Chakravarty S, Shawi M, Lavie F, Sharaf M, Zimmermann M, Kollmeier A, Xu X, Rahman P, Mease P, Deodhar A. Modulation of Interleukin‐23 Signaling With Guselkumab in Biologic‐Naive Patients Versus Tumor Necrosis Factor Inhibitor–Inadequate Responders With Active Psoriatic Arthritis. Arthritis & Rheumatology 2024, 76: 894-904. PMID: 38253404, DOI: 10.1002/art.42803.Peer-Reviewed Original ResearchAltmetricConceptsBD-2 levelsTNFi-IRIL-23 signalingIL-22Clinical responseIL-17AInadequate response to tumor necrosis factor inhibitorsResponse to tumor necrosis factor inhibitorsTumor necrosis factor inhibitorsAmerican College of Rheumatology criteriaBiomarker levelsTNFi-IR patientsBD-2Serum biomarker levelsC-reactive proteinBaseline biomarker levelsActive PsAFactor inhibitorsPsA patientsWeek-24ACR20 respondersGuselkumabIL-17FRheumatology criteriaPharmacodynamic effects