2021
Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice
Sadleir K, Popovoic J, Zhu W, Reidel C, Do H, Silverman R, Vassar R. Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice. Current Alzheimer Research 2021, 18: 283-297. PMID: 34259145, PMCID: PMC9527523, DOI: 10.2174/1567205018666210713125333.Peer-Reviewed Original ResearchConceptsVoltagegated calcium channelsPlacebo-treated miceNeuropathic painPregabalin treatmentStatistically significant positive correlationCalcium channelsCalcium influxAb levelsDecreased markersPregabalinSignificant positive correlationCerebral concentrationsEffective treatmentAmyloid depositsCausative roleDystrophyCalcium dysregulationMiceNeuritic dystrophyProgression of amyloid pathologyPathologyImmunofluorescence imagingNeuronal processesPlaqueTreatment
2008
From Basic Science to Blockbuster Drug: The Discovery of Lyrica
Silverman R. From Basic Science to Blockbuster Drug: The Discovery of Lyrica. Angewandte Chemie International Edition 2008, 47: 3500-3504. PMID: 18307181, DOI: 10.1002/anie.200704280.Peer-Reviewed Original Research