Genome-Wide Meta-Analysis Identifies Multiple Germline Genetic Variants Associated with Increased Risk of Follicular Lymphoma
Joseph V, Clay-Gilmour A, Park H, Breeze C, Sucheston-Campbell L, Arias J, Waller R, Güler M, Nieters A, Ekstroem Smedby K, Davídsson Ó, Wang S, Lan Q, Hjalgrim H, Slager S, McKay J, Cerhan J, Berndt S, Rothman N. Genome-Wide Meta-Analysis Identifies Multiple Germline Genetic Variants Associated with Increased Risk of Follicular Lymphoma. Blood 2024, 144: 4339-4339. DOI: 10.1182/blood-2024-211262.Peer-Reviewed Original ResearchGenome-wide association studiesTranscriptome wide association studyBlood cell traitsLeukocyte telomere lengthMendelian randomizationGermline genetic variantsB cell developmentClass II genesFollicular lymphomaAssociation studiesHLA class IRisk variantsGenetic variantsFL casesGenome-wide significant lociGenome-wide significant variantsWhole blood gene expression dataHLA regionII genesRegulation of B cell developmentBlood gene expression dataControls of European ancestryGene Ontology termsGene set analysisGenetically high-risk populationsHigh-throughput characterization of functional variants highlights heterogeneity and polygenicity underlying lung cancer susceptibility
Long E, Patel H, Golden A, Antony M, Yin J, Funderburk K, Feng J, Song L, Hoskins J, Amundadottir L, Hung R, Amos C, Shi J, Rothman N, Lan Q, Consortium I, Choi J. High-throughput characterization of functional variants highlights heterogeneity and polygenicity underlying lung cancer susceptibility. American Journal Of Human Genetics 2024, 111: 1405-1419. PMID: 38906146, PMCID: PMC11267514, DOI: 10.1016/j.ajhg.2024.05.021.Peer-Reviewed Original ResearchGenome-wide association studiesGenome-wide association study lociFunctional variantsTranscriptional activityAllelic transcriptional activityLung cancer susceptibilityRisk-associated lociPotential functional variantsCell type-specific expressionRisk-associated variantsLung cancer cell growthNon-protein-codingComprehensive functional analysisTranscription factor analysisCancer susceptibilityCancer cell growthGWAS lociEpigenomic dataCRISPR interferenceAssociation studiesLinkage disequilibriumAllelic effectsSignificant variantsGenetic variantsSusceptibility genes