About
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Director, Analytical Core
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Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Terence Wu's published research.
Publications Timeline
A big-picture view of Terence Wu's research output by year.
Karl Insogna, MD, FACP
John Wysolmerski, MD
10Publications
890Citations
Publications
2012
Alzheimer disease periventricular white matter lesions exhibit specific proteomic profile alterations
Castaño E, Maarouf C, Wu T, Leal M, Whiteside C, Lue L, Kokjohn T, Sabbagh M, Beach T, Roher A. Alzheimer disease periventricular white matter lesions exhibit specific proteomic profile alterations. Neurochemistry International 2012, 62: 145-156. PMID: 23231993, PMCID: PMC3568229, DOI: 10.1016/j.neuint.2012.12.001.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAlzheimer's diseaseWhite matterNDC subjectsPeriventricular white matter lesionsCourse of ADGlial fibrillary acidic proteinPeriventricular white matterCollapsin response mediator protein 2White matter lesionsResponse mediator protein 2Fibrillary acidic proteinGray matter functionΕ3/3 genotypeAxonal lossMyelin lossAD dementiaDementia pathogenesisMatter lesionsMean ageAD pathologyCalcium metabolismPeriventricular WMPathologic basisAD subjectsWM alterationsCerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson’s disease subjects
Maarouf C, Beach T, Adler C, Shill H, Sabbagh M, Wu T, Walker D, Kokjohn T, Roher A, Consortium A. Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson’s disease subjects. Neurological Research 2012, 34: 669-676. PMID: 22889670, PMCID: PMC3681206, DOI: 10.1179/1743132812y.0000000063.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsParkinson's diseaseCerebrospinal fluidPostmortem ventricular cerebrospinal fluidCerebrospinal fluid biomarkersNormal control subjectsYears of ageVentricular cerebrospinal fluidPD patientsFluid biomarkersControl subjectsConsensus panelDefinitive biomarkersApolipoprotein EPD casesPD pathogenesisPotential biomarkersClinical diagnosisNeurodegenerative disordersApolipoprotein ADiseaseModifying treatmentsTwo-dimensional difference gel electrophoresisBiomarkersDiagnostic toolDifference gel electrophoresisCollapsin response mediator protein‐2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non‐lethal oxidative stress
Fernández‐Gamba A, Leal M, Maarouf C, Richter‐Landsberg C, Wu T, Morelli L, Roher A, Castaño E. Collapsin response mediator protein‐2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non‐lethal oxidative stress. Journal Of Neurochemistry 2012, 121: 985-995. PMID: 22443207, PMCID: PMC3371108, DOI: 10.1111/j.1471-4159.2012.07742.x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntioxidantsBlotting, WesternFluorescent Antibody TechniqueHumansImmunohistochemistryIntercellular Signaling Peptides and ProteinsMutagenesis, Site-DirectedNerve Tissue ProteinsOligodendrogliaOxidative StressPhosphorylationPolymerase Chain ReactionRatsRats, WistarReactive Oxygen SpeciesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTransfectionConceptsNon-lethal oxidative stressOxidative stressCollapsin response mediator protein 2 (CRMP2) phosphorylationOLN-93 cellsCRMP-2Collapsin response mediator protein 2Response mediator protein 2Rho-kinaseWhite matter pathologyCandidate effector moleculesProtein 2 phosphorylationVehicle-exposed cellsCell line cellsAxonal contactHuman dementiaAdult brainNeurodegenerative conditionsProcess retractionOligodendrocytesEndogenous reactive oxygen speciesReactive oxygen speciesPrimary oligodendrocytesPrecursor cellsExtension of processesEffector molecules
1989
Synthetic Parathyroid Hormone-Like Protein-(1–74): Biochemical and Physiological Characterization*
STEWART A, ELLIOT J, BURTIS W, WU T, INSOGNA K. Synthetic Parathyroid Hormone-Like Protein-(1–74): Biochemical and Physiological Characterization*. Endocrinology 1989, 124: 642-648. PMID: 2912692, DOI: 10.1210/endo-124-2-642.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAmino acid compositionDirect amino acid sequencingAmino acid sequencingAcid compositionPhysiological characterizationN-terminusParathyroid hormone-like proteinRenal cortical adenylate cyclaseFetal rat long bonesInternal sequencesTransduction mechanismsCortical adenylate cyclasePhysiological comparisonPTH-like proteinHormone-like proteinProteolytic fragmentsRat long bonesAdenylate cyclase assayBovine PTHProteinPTH receptorFull-length peptidePeptide hormonesSynthetic peptidesNovel class
1988
Adenylate cyclase-stimulating, bone-resorbing and B TGF-like activities in canine apocrine cell adenocarcinoma of the anal sac
Weir E, Centrella M, Matus R, Brooks M, Wu T, Insogna K. Adenylate cyclase-stimulating, bone-resorbing and B TGF-like activities in canine apocrine cell adenocarcinoma of the anal sac. Calcified Tissue International 1988, 43: 359-365. PMID: 3146425, DOI: 10.1007/bf02553279.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAdenylate cyclase-stimulating activityBone-resorbing activityTGF-like activityControl tumorsCell adenocarcinomaAnal sacDose-response curve parallelCyclase-stimulating activityC18 reverse-phase high-pressure liquid chromatographyResponsible mediatorsTumor extractsHigh-pressure liquid chromatographyReverse-phase high-pressure liquid chromatographyTumorsPressure liquid chromatographyAdenocarcinomaC18 RP-HPLCCurve parallelSacExtractHypercalcemiaLiquid chromatographyBPTHActivityResorptionSynthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats.
Stewart AF, Mangin M, Wu T, Goumas D, Insogna KL, Burtis WJ, Broadus AE. Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats. Journal Of Clinical Investigation 1988, 81: 596-600. PMID: 3339131, PMCID: PMC329608, DOI: 10.1172/jci113358.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBone-resorbing agentsMicrograms/hParathyroid hormone-like proteinFetal rat long bonesAdenylate cyclasePotent bone-resorbing agentHormone-like proteinRat long bonesMembrane adenylate cyclaseSerum calciumHumoral hypercalcemiaOsmotic minipumpsBone resorptionPotent agonistLong bonesSuch synthetic peptidesHypercalcemiaRatsDlVivo bioactivityCyclaseSynthetic peptidesAgentsMinipumpsPatients
1987
Two forms of parathyroid hormone‐like adenylate cyclase‐stimulating protein derived from tumors associated with humoral hypercalcemia of malignancy
Stewart A, Burtis W, Wu T, Goumas D, Broadus A. Two forms of parathyroid hormone‐like adenylate cyclase‐stimulating protein derived from tumors associated with humoral hypercalcemia of malignancy. Journal Of Bone And Mineral Research 1987, 2: 587-593. PMID: 3455636, DOI: 10.1002/jbmr.5650020616.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsN-Terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: Identification of parathyroid hormone-like and parathyroid hormone-unlike domains
Stewart A, Wu T, Goumas D, Burtis W, Broadus A. N-Terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: Identification of parathyroid hormone-like and parathyroid hormone-unlike domains. Biochemical And Biophysical Research Communications 1987, 146: 672-678. PMID: 3619898, DOI: 10.1016/0006-291x(87)90581-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsIdentification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.
Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. Journal Of Biological Chemistry 1987, 262: 7151-7156. PMID: 3584110, DOI: 10.1016/s0021-9258(18)48217-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsThe relative potency of a human tumor‐derived PTH‐like adenylate cyclase‐stimulating preparation in three bioassays
Stewart A, Wu T, Burtis W, Weir E, Broadus A, Insogna K. The relative potency of a human tumor‐derived PTH‐like adenylate cyclase‐stimulating preparation in three bioassays. Journal Of Bone And Mineral Research 1987, 2: 37-43. PMID: 3455155, DOI: 10.1002/jbmr.5650020107.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFetal bone resorptionRat osteosarcomaPTH standardRelative potencyCyclase assaysPTH target tissuesAdenylate cyclase assayHumoral hypercalcemiaBone resorptionPTH receptorBPTH 1Target tissuesDistinct subpopulationsPotencyAssaysHypercalcemiaPrevious studiesMalignancyOsteosarcomaTumorsResorptionReceptors
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