David Silverstone, MD
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Appointments
About
Titles
Professor of Ophthalmology and Visual Science
Biography
Dr. Silverstone received his undergraduate degree from Columbia College and his M.D. from New York Medical College. He completed his ophthalmology residency, a glaucoma research fellowship, and a chief residency in ophthalmology at Yale. He did a fellowship in Intraocular Lens Implantation at New York Medical College. Dr. Silverstone has been the Assistant Chief of Ophthalmology at Yale-New Haven Hospital since 1988. He has also served as the Chief of Ophthalmology at the West Haven, Connecticut VA Medical Center.
Dr. Silverstone was part of the Yale team, under Dr. Marvin Sears, that developed Timolol, the first modern medication for the treatment of glaucoma. His pharmaceutical research interests include the medical treatment of glaucoma and the role of anti-inflammatory medications in post-surgical patient management. Dr. Silverstone has played a leading role in the development of Medical Information Technology. His research interests have included the development of electronic medical record technology, decision support software strategies and assuring data integrity in electronic health records. He has also worked on the development of visual field testing devices and co-authored a book on visual field testing with Yale neuroscientist Dr. Joy Hirsch.
Dr. Silverstone has served as both the Director of Continuing Medical Education and the Chair of the Health Information Technology Subcommittee of the American Society of Cataract and Refractive Surgery. He has served on the Governing Board of the American Society of Ophthalmic Administrators and was a founding member of the National Board for Certified Ophthalmic Executives. He is a fellow of the American Academy of Ophthalmology, which has awarded him its Senior Honor Award, has served on its Medical Information Technology Committee, and is currently a member of the Academy’s IRIS Disease Registry Operations Task Force.
Appointments
Ophthalmology
ProfessorPrimary
Other Departments & Organizations
- Cataracts
- Comprehensive (General) Eye Care
- Ophthalmology
- Purple College Affiliates
- Yale Medicine
Education & Training
- MD
- New York Medical College (1973)
Research
Research at a Glance
Publications Timeline
Publications
2012
Cloud Based EHRs — Hope or Hype?
SILVERSTONE D. Cloud Based EHRs — Hope or Hype? Ophthalmology Management 2012, 16: 45-47. DOI: 10.1097/01.omd.0000412772.34016.30.Peer-Reviewed Original Research
1999
Ketorolac tromethamine 0.5% ophthalmic solution in the treatment of moderate to severe ocular inflammation after cataract surgery: A randomized, vehicle-controlled clinical trial
Heier J, Cheetham J, DeGryse R, Dirks M, Caldwell D, Silverstone D, Rosenthal A. Ketorolac tromethamine 0.5% ophthalmic solution in the treatment of moderate to severe ocular inflammation after cataract surgery: A randomized, vehicle-controlled clinical trial. American Journal Of Ophthalmology 1999, 127: 253-259. PMID: 10088733, DOI: 10.1016/s0002-9394(98)00413-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAgedAged, 80 and overAnterior ChamberAnti-Inflammatory Agents, Non-SteroidalDouble-Blind MethodFemaleHumansKetorolac TromethamineLens Implantation, IntraocularMaleMiddle AgedOphthalmic SolutionsPain, PostoperativePhacoemulsificationSafetyTolmetinTreatment OutcomeTromethamineUveitis, AnteriorConceptsSevere anterior segment inflammationAnterior segment inflammationIntraocular lens implantationCataract surgeryVehicle solutionOphthalmic solutionLens implantationSubstantial anti-inflammatory activityVehicle-controlled clinical trialSafety of ketorolacAnterior chamber cellsParallel-group studyEye four timesUnilateral cataract surgerySevere ocular inflammationLack of efficacyAnti-inflammatory activityCiliary flushKetorolac groupTopical ketorolacAdverse eventsOcular inflammationOnly patientsVisual acuityIntraocular pressure
1992
Prophylactic Use of Apraclonidine for Intraocular Pressure Increase After Nd:YAG Capsulotomies: Reply
SILVERSTONE D, BRINT S, OLANDER K, TAYLOR R, McCARTY G, deFALLER J, BURK L. Prophylactic Use of Apraclonidine for Intraocular Pressure Increase After Nd:YAG Capsulotomies: Reply. American Journal Of Ophthalmology 1992, 114: 378-379. DOI: 10.1016/s0002-9394(14)71816-1.Peer-Reviewed Original ResearchConceptsProphylactic Use of Apraclonidine for Intraocular Pressure Increase After Nd:YAG Capsulotomies
Silverstone D, Brint S, Olander K, Taylor R, McCarty G, deFaller J, Burk L. Prophylactic Use of Apraclonidine for Intraocular Pressure Increase After Nd:YAG Capsulotomies. American Journal Of Ophthalmology 1992, 113: 401-405. PMID: 1348396, DOI: 10.1016/s0002-9394(14)76162-8.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsVehicle-treated groupIntraocular pressurePosterior capsulotomyYAG laser posterior capsulotomyIncidence of increaseMean maximal changeMasked clinical trialIntraocular pressure increaseLaser posterior capsulotomyYAG posterior capsulotomyTreatment armamentariumProphylactic effectYAG capsulotomyProphylactic useAdverse reactionsClinical trialsVisual functionRelative safetyCapsulotomyMaximal changeApraclonidineGroupMulticenterPatientsArmamentarium
1991
Evaluation of Once-Daily Levobunolol 0.25% and Timolol 0.25% Therapy for Increased Intraocular Pressure
Silverstone D, Zimmerman T, Choplin N, Mundorf T, Rose A, Stoecker J, Kelley E, Lue J. Evaluation of Once-Daily Levobunolol 0.25% and Timolol 0.25% Therapy for Increased Intraocular Pressure. American Journal Of Ophthalmology 1991, 112: 56-60. PMID: 1882923, DOI: 10.1016/s0002-9394(14)76213-0.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsOpen-angle glaucomaLevobunolol groupTimolol groupOcular hypertensionIntraocular pressureThree-month study periodIncreased Intraocular PressureOcular hypotensive efficacyOverall mean decreaseMean heart rateHypotensive efficacyBlood pressureClinical trialsHeart rateMean decreaseTreatment groupsThree monthsPatientsStudy periodHypertensionGlaucomaGroupLevobunololTimololTherapy
1989
Effect of varying drop size on the efficacy and safety of a topical beta blocker.
Charap A, Shin D, Petursson G, Cinotti D, Wortham E, Brown R, Silverstone D, Atkins J, Eto C, Lue J. Effect of varying drop size on the efficacy and safety of a topical beta blocker. Annals Of Ophthalmology - Glaucoma 1989, 21: 351-7. PMID: 2683937.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAdministration, TopicalAdultBlood PressureDosage FormsDose-Response Relationship, DrugDouble-Blind MethodElectrocardiographyExercise TestFollow-Up StudiesGlaucoma, Open-AngleHeart RateHumansIntraocular PressureLevobunololMiddle AgedMulticenter Studies as TopicRandom AllocationTime FactorsVisual AcuityConceptsIntraocular pressureBeta blockersHeart rateMicroL of vehicleTopical beta blockersMean intraocular pressureElevated intraocular pressureMean heart rateLevobunolol 0.5Levobunolol groupBlood pressureAcute studyTopical solutionVehicle groupChronic studiesMean decreaseControl groupOne hourEfficacyLevobunololBlockersSafetyGroupMicroLPatients
1988
Prophylactic Treatment of intraocular Pressure Elevations after Neodymium:YAG Laser Posterior Capsulotomies and Extracapsular Cataract Extractions with Levobunolol
Silverstone D, Novack G, Kelley E, Chen K. Prophylactic Treatment of intraocular Pressure Elevations after Neodymium:YAG Laser Posterior Capsulotomies and Extracapsular Cataract Extractions with Levobunolol. Ophthalmology 1988, 95: 713-718. PMID: 3062528, DOI: 10.1016/s0161-6420(88)33124-6.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsYAG laser posterior capsulotomyExtracapsular cataract extractionLaser posterior capsulotomyIntraocular pressure elevationLevobunolol groupPosterior capsulotomyVehicle groupMean IOPPressure elevationProphylactic treatmentCataract extractionPosterior chamber intraocular lensVehicle 1 hourPlacebo-controlled studyUnilateral NDElevated IOPIOP elevationProphylactic effectIntraocular lensLevobunololCapsulotomyMmHgIOPPatientsElevation
1985
Levobunolol A Beta-adrenoceptor Antagonist Effective in the Long-term Treatment of Glaucoma
Group T, Berson F, Epstein D, Partamian L, Cinotti A, Cohen H, Fries P, David R, Gurion B, Duzman E, Novack G, Lue J, Foerster R, Galin M, Lass J, Ober M, Scharrer A, Shin D, Silverstone D. Levobunolol A Beta-adrenoceptor Antagonist Effective in the Long-term Treatment of Glaucoma. Ophthalmology 1985, 92: 1271-1276. PMID: 2865710, DOI: 10.1016/s0161-6420(85)33887-3.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsLong-term treatmentDouble-masked studyOcular hypotensive efficacyOcular hypotensive effectOpen-angle glaucomaMean heart rateConcentrations of levobunololTest medicationOcular hypertensionBlood pressureMean IOPSystemic reactionsOcular safetyEffective therapyHeart rateOphthalmic solutionGlaucomaLevobunololPatientsTwo-year periodTimololTreatmentHypertensionMedicationsIOPLevobunolol vs Timolol for Open-Angle Glaucoma and Ocular Hypertension
Galin M, Cinotti A, Cinotti D, Grant W, Jacobs I, Silverstone D, Shin D, Esters J, Lee J, Bouchey R, Novack G, Duzman E, Lue J. Levobunolol vs Timolol for Open-Angle Glaucoma and Ocular Hypertension. American Journal Of Ophthalmology 1985, 99: 11-17. PMID: 3881032, DOI: 10.1016/s0002-9394(14)75859-3.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsOpen-angle glaucomaIntraocular pressureOcular hypertensionMean reductionChronic open-angle glaucomaPercent of patientsTopical ophthalmic solutionOverall mean reductionLife-table estimatesSuccessful treatmentLevobunololOphthalmic solutionPatientsTimololHypertensionSignificant differencesGlaucomaHgMonths
1977
Iris-supported lens implantation v. simple cataract extraction. An analysis of data.
Galin M, Obstbaum S, Boniuk V, Galin A, Silverstone D. Iris-supported lens implantation v. simple cataract extraction. An analysis of data. Transactions Of The Ophthalmological Societies Of The United Kingdom 1977, 97: 74-7. PMID: 271407.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCataract extractionPosterior segment changesIntracapsular cataract extractionVisual acuity levelsRatio of implantationCystic maculopathyPostoperative drugsCorneal degenerationRetinal detachmentSegment changesAcuity levelsAppropriate useAppropriate casesIncidenceMaculopathySurgeryGroupAnteriorDegenerationAnalysis of data
Clinical Care
Overview
David Silverstone, MD, a board-certified ophthalmologist, specializes in cataract surgery, glaucoma and general ophthalmology.
“I think of myself as a geriatric ophthalmologist—I see a lot of patients with glaucoma, which is prevalent in that age group,” he says.
Dr. Silverstone has been the assistant chief of ophthalmology at Yale-New Haven Hospital since 1988. He has also served as the chief of ophthalmology at the Veteran Affairs Connecticut Healthcare System in West Haven, Conn.
A clinical professor of ophthalmology for Yale School of Medicine, his research interests include the medical treatment of glaucoma and the role of anti-inflammatory medications in post-surgical patient management. He has also worked on the development of visual-field testing devices for glaucoma and is the co-author of a book on visual-field testing. He is a fellow of the American Academy of Ophthalmology, which has awarded him its Senior Honor Award, has served on its Medical Information Technology Committee, and is currently a member of the Academy’s IRIS Disease Registry Operations Task Force.
Clinical Specialties
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Ocular Hypertension
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Board Certifications
Ophthalmology
- Certification Organization
- AB of Ophthalmology
- Original Certification Date
- 1977
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