Kalpana Raja, PhD, MRSB, CSci
Instructor of Biomedical Informatics and Data ScienceCards
Contact Info
Biomedical Informatics & Data Science
100 College St
New Haven, CT 06510
United States
About
Titles
Instructor of Biomedical Informatics and Data Science
Biography
Kalpana Raja, PhD joined the Section of Biomedical Informatics & Data Science (BIDS) at Yale School of Medicine in February of 2023. Before moving to New Haven, CT, Kalpana worked as an assistant professor at the School of Biomedical Informatics, University of Texas Health Science Center (UTHealth) at Houston, TX. She also worked as a scientist at Sema4, a patient centered healthcare company located in Stamford, CT. Kalpana completed her bachelor’s degree in pharmacy from Tamil Nadu Dr. M.G.R. Medical University at Chennai, India. She is a registered pharmacist with the Indian Pharmacy Council. With a vision to develop software for biological applications, she completed her master’s degree in computing with a focus in software technology from The Robert Gordon University, Aberdeen, UK. She developed ProfileSKiM, an intelligent document retrieval tool, and submitted the findings in her MSc thesis. ProfileSKiM received a reward from the Robert Gordon University in 2005 and the Technology Award from the British Computer Society, London, UK in 2006. Kalpana completed her second master’s degree in bioinformatics and her PhD in computing: software technology – bioinformatics (inter-disciplinary) from Bharathiar University, Coimbatore, India. She presented her findings from the PhD research work at the 2012 Asia Pacific Bioinformatics Conference (APBC) held in Melbourne, Australia, and BioCreative Conference V held at Washington DC.
Kalpana’s research interests include natural language processing (NLP) and machine learning. She developed methodologies and software for information retrieval, information extraction, knowledge summarization, literature-based discovery, and automated hypothesis generation. She applied her approaches on various biological domains such as protein-protein interaction, protein phosphorylation, drug-drug interactions, adverse drug events, drug repurposing, and disease comorbidity. She also provided the NLP support for various genomics and transcriptomics projects. Kalpana has published more than 70 articles in peer reviewed journals, books, and conference proceedings. She has reviewed several research articles submitted to prestigious journals such as Briefings in Bioinformatics and serves as an associate editor in the Journal of Embryology & Stem Cell Research.
Kalpana was elected as a “Member of Royal Society of Biology” (MRSB) in 2019 by the Royal Society of Biology, London, UK. Recently, she was honored as the “Chartered Scientist” (CSci) by the Royal Society of Biology, London, UK. Kalpana also received the “2019 Women Scientist Award” from the Society for Bioinformatics and Biological Sciences, a non-profit professional society based in India.
Areas of Expertise
- Natural Language Processing
- Artificial Intelligence (AI)
- Large Language Models (LLMs)
- Deep Learning
- Machine Learning
- Biomedical informatics
Google scholar
Appointments
Biomedical Informatics & Data Science
InstructorPrimary
Other Departments & Organizations
Education & Training
- PhD
- Bharathiar University
- MSc
- Bharathiar University
- MSc
- The Robert Gordon University
- BPharm
- Tamilnadu Dr M G R Medical University
Research
Overview
Medical Research Interests
Research at a Glance
Publications Timeline
Publications
2022
Integrated Approaches to Identify miRNA Biomarkers Associated with Cognitive Dysfunction in Multiple Sclerosis Using Text Mining, Gene Expression, Pathways, and GWAS.
Prabahar A, Raja K. Integrated Approaches to Identify miRNA Biomarkers Associated with Cognitive Dysfunction in Multiple Sclerosis Using Text Mining, Gene Expression, Pathways, and GWAS. Diagnostics (Basel) 2022, 12 PMID: 36010264, DOI: 10.3390/diagnostics12081914.Peer-Reviewed Original ResearchExtracting Significant Comorbid Diseases from MeSH Index of PubMed.
Anand D, Manoharan S, Iyyappan OR, Anand S, Raja K. Extracting Significant Comorbid Diseases from MeSH Index of PubMed. Methods Mol Biol 2022, 2496: 283-299. PMID: 35713870, DOI: 10.1007/978-1-0716-2305-3_15.Peer-Reviewed Original Research
2021
Advancement in predicting interactions between drugs used to treat psoriasis and its comorbidities by integrating molecular and clinical resources.
Patrick MT, Bardhi R, Raja K, He K, Tsoi LC. Advancement in predicting interactions between drugs used to treat psoriasis and its comorbidities by integrating molecular and clinical resources. J Am Med Inform Assoc 2021, 28: 1159-1167. PMID: 33544847, DOI: 10.1093/jamia/ocaa335.Peer-Reviewed Original ResearchA summary on up-to-date research on fungal siderophores on disease, treatment and pathogenicity based on text mining, bioinformatics and experts’ opinion
Prabahar, A., Shanmugam, L., Jose, M.A., Radhakrishnan, K.M., & Raja, K. A summary on up-to-date research on fungal siderophores on disease, treatment and pathogenicity based on text mining, bioinformatics and experts’ opinion. Springer Nature: Fungal siderophores – From Mineral-Microbe Interactions to Anti-pathogenecity. 2021, 187-210.Chapters
2020
Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeutics.
Paul D, Chipurupalli S, Justin A, Raja K, Mohankumar SK. Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeutics. J Pharmacol Toxicol Methods 2020, 106: 106932. PMID: 33091537, DOI: 10.1016/j.vascn.2020.106932.Peer-Reviewed Original ResearchAutomated Extraction and Visualization of Protein-Protein Interaction Networks and Beyond: A Text-Mining Protocol.
Raja K, Natarajan J, Kuusisto F, Steill J, Ross I, Thomson J, Stewart R. Automated Extraction and Visualization of Protein-Protein Interaction Networks and Beyond: A Text-Mining Protocol. Methods Mol Biol 2020, 2074: 13-34. PMID: 31583627, DOI: 10.1007/978-1-4939-9873-9_2.Peer-Reviewed Original Research
2019
Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus.
Tsoi LC, Hile GA, Berthier CC, Sarkar MK, Reed TJ, Liu J, Uppala R, Patrick M, Raja K, Xing X, Xing E, He K, Gudjonsson JE, Kahlenberg JM. Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus. J Immunol 2019, 202: 2121-2130. PMID: 30745462, DOI: 10.4049/jimmunol.1800650.Peer-Reviewed Original ResearchDrug Repurposing Prediction for Immune-Mediated Cutaneous Diseases using a Word-Embedding-Based Machine Learning Approach.
Patrick MT, Raja K, Miller K, Sotzen J, Gudjonsson JE, Elder JT, Tsoi LC. Drug Repurposing Prediction for Immune-Mediated Cutaneous Diseases using a Word-Embedding-Based Machine Learning Approach. J Invest Dermatol 2019, 139: 683-691. PMID: 30342048, DOI: 10.1016/j.jid.2018.09.018.Peer-Reviewed Original Research
2018
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients.
Patrick MT, Stuart PE, Raja K, Gudjonsson JE, Tejasvi T, Yang J, Chandran V, Das S, Callis-Duffin K, Ellinghaus E, Enerbäck C, Esko T, Franke A, Kang HM, Krueger GG, Lim HW, Rahman P, Rosen CF, Weidinger S, Weichenthal M, Wen X, Voorhees JJ, Abecasis GR, Gladman DD, Nair RP, Elder JT, Tsoi LC. Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients. Nat Commun 2018, 9: 4178. PMID: 30301895, DOI: 10.1038/s41467-018-06672-6.Peer-Reviewed Original ResearchMining protein phosphorylation information from biomedical literature using NLP parsing and Support Vector Machines.
Raja K, Natarajan J. Mining protein phosphorylation information from biomedical literature using NLP parsing and Support Vector Machines. Comput Methods Programs Biomed 2018, 160: 57-64. PMID: 29728247, DOI: 10.1016/j.cmpb.2018.03.022.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor Full Member
National AwardSigma Xi, NC, USADetails12/04/2023honor Outstanding Reviewer
International AwardMultidisciplinary Digital Publishing Institute (MDPI), Basel, SwitzerlandDetails11/30/2023Switzerlandhonor Chartered Scientist (CSci)
International AwardThe Royal Society, London, UKDetails04/01/2022United Kingdomhonor 2019 Women Scientist Award
International AwardThe Society for Bioinformatics and Biological Sciences, IndiaDetails12/18/2020honor Chair Person
International AwardInternational Conference on Agriculture and Biological Sciences at Kathmandu (Lalitpur), NepalDetails12/14/2020
News
News
- October 21, 2024
Yale BIDS Presenting at the AMIA 2024 Annual Symposium
- September 27, 2024
Biomedical Informatics and Data Science (BIDS) Secures a $7.88 Million NIH Grant to Advance Mental Health Research Using AI Technology
- June 17, 2024
Hot off the Press: Natural Language Processing in Biomedicine
- June 25, 2021Source: Morgridge Institute for Research
Raja awarded the “Women Scientist Award” for achievements in bioinformatics
Get In Touch
Contacts
Biomedical Informatics & Data Science
100 College St
New Haven, CT 06510
United States