Yuan Lu, ScD
Assistant Professor of Medicine (Cardiology) and of Biomedical Informatics and Data Science and of Epidemiology (Chronic Diseases)Cards
Appointments
Contact Info
About
Titles
Assistant Professor of Medicine (Cardiology) and of Biomedical Informatics and Data Science and of Epidemiology (Chronic Diseases)
Biography
Dr. Lu was trained in epidemiology and global health, with a particular focus on cardiovascular diseases. She obtained both of her ScD and MSc Degrees in Global Health and Population at the Harvard School of Public Health. She works in the intersection of cardiovascular disease prevention, health equity, and digital health, using implementation science methods to resolve real-world issues. Her long-term goal is to improve care, outcomes, and equity of cardiovascular diseases by designing and implementing technology-based interventions.
She successfully completed an NHLBI K12 career development award in implementation science. During this award, she harnessed electronic health records from the Yale New Haven Health System to identify patients with persistent hypertension and designing decision support systems to improve their care. Currently, Dr. Lu serves as the Principal Investigator for an NIH R01 grant, where she leverages real-world data from five electronic health record databases encompassing over 100 million US adults. The goal of this endeavor is to generate real-world evidence that informs decisions regarding hypertension treatment escalation.
In addition to her domestic contributions, Dr. Lu has engaged in groundbreaking collaborative projects between Yale University and the Chinese National Center for Cardiovascular Diseases in Beijing. These include the Millions Persons Project that assembles remarkable population health and biomedical resources from 5 million individuals across China. Moreover, she has collaborated with the NCD Risk Factor Collaboration (NCD-RisC) on global analyses examining the impact of risk factors on the worldwide burden of cardiovascular diseases.
She has authored over 150 peer-reviewed publications, including first author articles in leading journals such as The Lancet, JAMA, BMJ, Circulation, and JACC, and her work has been cited more than 50,000 times. Dr. Lu is the recipient of the 2022 John H. Laragh Research Award of the American Journal of Hypertension for her contribution to the field of hypertension. She is a Fellow of the American Heart Association and the American College of Cardiology, and currently serves as an Executive Associate Editor at JACC.
Appointments
Cardiovascular Medicine
Assistant ProfessorPrimaryBiomedical Informatics & Data Science
Assistant ProfessorSecondaryChronic Disease Epidemiology
Assistant ProfessorSecondary
Other Departments & Organizations
- Biomedical Informatics & Data Science
- Cardiovascular Medicine
- Center for Outcomes Research & Evaluation (CORE)
- Chronic Disease Epidemiology
- Internal Medicine
- Janeway Society
- Preventive Cardiovascular Health Program at Yale
- Yale UNRAVEL Study
Education & Training
- ScD
- Harvard School of Public Health, Global Health and Population (2015)
Research
Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-5264-2169- View Lab Website
Yale/YNHH Center for Outcomes Research and Evaluation (CORE)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Harlan Krumholz, MD, SM
Erica Spatz, MD, MHS
Rohan Khera, MD, MS
Shiwani Mahajan, MBBS, MHS
Yuntian Liu, MPH
Karthik Murugiah, MBBS, MHS
Cardiovascular Diseases
Chronic Disease
Publications
2025
Floods and cause-specific mortality in the United States applying a triply robust approach
Chu L, Warren J, Spatz E, Lowe S, Lu Y, Ma X, Ross J, Krumholz H, Chen K. Floods and cause-specific mortality in the United States applying a triply robust approach. Nature Communications 2025, 16: 2853. PMID: 40122917, PMCID: PMC11930965, DOI: 10.1038/s41467-025-58236-0.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCDC's National Center for Health StatisticsNational Center for Health StatisticsCause-specific mortality ratesCenter for Health StatisticsCause-specific mortalityHealth impacts of floodingExcess all-cause deathsLong-term health risksFlood daysLong-term associationDeath recordsHealth StatisticsConfounder adjustmentExternal causesStorm Events DatabaseAll-cause deathHealth impactsImpact of floodsPropensity scorePost‐flood yearMortality rateMyocardial infarctionPost-floodContiguous U.S.Respiratory diseaseShort‐Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study
Zhang S, Chu L, Lu Y, Wei J, Dubrow R, Chaudhry S, Spatz E, Krumholz H, Chen K. Short‐Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study. GeoHealth 2025, 9: e2024gh001234. PMID: 39968338, PMCID: PMC11833228, DOI: 10.1029/2024gh001234.Peer-Reviewed Original ResearchConceptsAcute myocardial infarction subtypeShort-term associationsAcute myocardial infarctionAcute myocardial infarction onsetAMI riskEffect modificationAssociated with increased AMI riskParticipant's home addressNon-Hispanic blacksNon-ST-segment elevation acute myocardial infarctionNon-Hispanic whitesCase-crossover designType 1 AMIConditional logistic regressionIncreased AMI riskMyocardial infarction onsetType 2 AMIAcute myocardial infarction patientsST-segment elevation acute myocardial infarctionLifestyle factorsSociodemographic statusHome addressUS hospitalsStratified analysisSpatiotemporal deep learning approachDepression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D’Onofrio G, Pilote L, Lichtman J. Depression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction. 2025, 87: 129-137. PMID: 39909011, DOI: 10.1097/psy.0000000000001363.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsLow social supportCardiac-specific quality of lifeNatural direct effectSocial supportMonths post-AMIQuality of lifeAcute myocardial infarctionMarital stressComprehensive secondary preventive strategySignificant depressive symptomsPost-AMISecondary prevention strategiesYoung adultsMyocardial infarctionSociodemographic factorsDepressive symptomsAMI survivorsCovariate adjustmentPrevention strategiesSelf-reportContinuous scoresQoLBaseline QoLCategorical depressionDepressionWildfires, Compound Extreme Events, Climate Change, and Cardiovascular Health
Chen K, Lu Y, Krumholz H. Wildfires, Compound Extreme Events, Climate Change, and Cardiovascular Health. Journal Of The American College Of Cardiology 2025, 85: 1379-1381. PMID: 39927913, DOI: 10.1016/j.jacc.2025.01.009.Peer-Reviewed Original ResearchClosing the Gap: Digital Innovations to Address Hypertension Disparities
Shanab B, Gaffey A, Schwamm L, Zawalich M, Sarpong D, Pérez-Escamilla R, Dorney J, Cooperman C, Schafer R, Lipkind H, Lu Y, Onuma O, Spatz E. Closing the Gap: Digital Innovations to Address Hypertension Disparities. Current Cardiology Reports 2025, 27: 23. PMID: 39812880, DOI: 10.1007/s11886-024-02171-x.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHypertension disparitiesCare teamSocial determinants of healthCommunity health workersDeterminants of healthRemote blood pressure monitoringIncrease patient empowermentBlood pressure controlMultidisciplinary care teamBlood pressure machineIntegration of servicesHealth equityHealth inequalitiesHealth disparitiesPatient empowermentPatient engagementInfluence blood pressure controlSocial determinantsHealth workersTelehealth visitsPayment modelsHypertension managementPressure controlHypertension DetectionPatient outcomesA failure to launch: blood pressure control after stroke in a regional health system
Forman R, Xin X, Kim C, Kernan W, Sheth K, Krumholz H, de Havenon A, Spatz E, Lu Y. A failure to launch: blood pressure control after stroke in a regional health system. Journal Of Hypertension 2025, 43: 715-718. PMID: 39995224, DOI: 10.1097/hjh.0000000000003961.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsYale New Haven Health SystemRegional health systemHealth systemSystolic blood pressureDiastolic blood pressureMonths post strokeAverage proportion of patientsBP controlPost strokeBlood pressureProfessional visitsPrimary outcomeBlood pressure controlProportion of patientsAverage proportionVisitsSBP valuesEpic systemPressure controlStrokePatientsGlobal budgetNavigating the 2024 ESC Hypertension Guidelines What Is New, Context, and Future Directions
Lu Y, Spatz E, Krumholz H. Navigating the 2024 ESC Hypertension Guidelines What Is New, Context, and Future Directions. Journal Of The American College Of Cardiology 2025, 85: 556-559. PMID: 39745405, DOI: 10.1016/j.jacc.2024.10.114.Peer-Reviewed Original Research
2024
Utilizing the Electronic Health Record to Evaluate Lipoprotein(a) Testing Within a Large Regional Health System
Faridi K, Wu Q, Kim C, Spatz E, Desai N, Krumholz H, Lu Y. Utilizing the Electronic Health Record to Evaluate Lipoprotein(a) Testing Within a Large Regional Health System. JACC Advances 2024, 4: 101441. PMID: 39720580, PMCID: PMC11666933, DOI: 10.1016/j.jacadv.2024.101441.Peer-Reviewed Original ResearchHealth status outcomes after acute myocardial infarction in patients without standard modifiable risk factors
Ikemura N, Chan P, Gosch K, Nguyen D, Iv C, Khan M, Lu Y, Sawano M, Krumholz H, Spertus J. Health status outcomes after acute myocardial infarction in patients without standard modifiable risk factors. American Heart Journal 2024, 281: 123-132. PMID: 39638274, PMCID: PMC11810589, DOI: 10.1016/j.ahj.2024.11.018.Peer-Reviewed Original ResearchConceptsSeattle Angina QuestionnaireModifiable risk factorsHealth status outcomesBaseline SAQ scoresAcute myocardial infarctionStatus outcomesHealth statusRisk factorsSequential adjustmentSAQ scoresModifiable cardiovascular risk factorsHistory of coronary diseaseSAQ Summary ScoreHierarchical linear mixed modelsAcute myocardial infarction patientsCardiovascular risk factorsMyocardial infarctionSummary scoreSociodemographic characteristicsAngina QuestionnaireLinear mixed modelsDepressive symptomsU.S. hospitalsLong-term mortalitySecondary preventionUsing Electronic Health Records to Evaluate Treatment Gaps and Disparities in Severe Hypertension
Lu Y, Liu Y, Kim C, Sussman S, Deshpande O, Krumholz H. Using Electronic Health Records to Evaluate Treatment Gaps and Disparities in Severe Hypertension. JACC Advances 2024, 4: 101428. PMID: 39697770, PMCID: PMC11650125, DOI: 10.1016/j.jacadv.2024.101428.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity National Institutes of Health (NIH)
Peer Review Groups and Grant Study SectionsReviewerDetails06/01/2023 - Presentactivity JACC
Journal ServiceAssociate EditorDetails02/01/2024 - Presentactivity American Heart Association
Professional OrganizationsFellowDetails07/01/2021 - Presentactivity JACC
Journal ServiceAssociate EditorDetails07/01/2024 - Presentactivity Unraveling the Interplay between Age, Obesity, and Mortality across Adulthood: Insights from National Health and Nutrition Examination Survey 1999-2018
Poster PresentationAmerican Heart Association Scientific Sessions 2023Details11/11/2023 - 11/13/2023Philadelphia, PA, United States
News
News
- April 17, 2025
Lower Blood Pressure May Offer Benefits Even for the Very Elderly
- March 19, 2025Source: HealthDay
Seniors Benefit from Tight Blood Pressure Control
- January 22, 2025
In California Wildfires, Climate and Health Collide
- September 24, 2024
Long-term exposure to wildfire smoke associated with higher risk of death
Get In Touch
Contacts
Locations
Yale Center for Outcomes Research and Evaluation
Academic Office
195 Church Street, Rm 5th Floor
New Haven, CT 06510