Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsJonas Christian Schupp, MD
Assistant Professor AdjunctAbout
Research
Publications
2025
PDE-4 Inhibition in Sarcoidosis Patients: A Retrospective Single-Center Analysis of 51 Patients
Feineis M, Terschluse C, Jouanjan L, Soriano D, Agarwal P, Schupp J, Müller-Quernheim J, Stolz D, Frye B. PDE-4 Inhibition in Sarcoidosis Patients: A Retrospective Single-Center Analysis of 51 Patients. Pharmaceuticals 2025, 18: 1729. PMID: 41304973, PMCID: PMC12654997, DOI: 10.3390/ph18111729.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseSarcoidosis patientsModerate gastrointestinal side effectsNo severe AEsRetrospective single-center analysisSide effectsAssociated with numerous side effectsSingle-center analysisTreatment of chronic obstructive pulmonary diseaseEscalation of therapyDepartment of PneumologySevere adverse eventsGastrointestinal side effectsDetrimental to patientsNumerous side effectsObstructive pulmonary diseaseUniversity Hospital FreiburgTherapy escalationTherapeutic optionsAdverse eventsLung function lossSarcoidosisOff-labelOrgan damageControl symptomsSegDecon bridges histology and transcriptomics through AI-based nuclei segmentation and image-informed spatial deconvolution
Xi Y, Jiang X, Schupp J, Xu C, Li Y. SegDecon bridges histology and transcriptomics through AI-based nuclei segmentation and image-informed spatial deconvolution. Computational And Structural Biotechnology Journal 2025, 27: 4586-4596. PMID: 41234485, PMCID: PMC12605641, DOI: 10.1016/j.csbj.2025.10.041.Peer-Reviewed Original ResearchFrom spatial transcriptomics to mouse model: the (re-)emergence of ductal myofibroblasts as a new cellular target in idiopathic pulmonary fibrosis
Justet A, Schupp J. From spatial transcriptomics to mouse model: the (re-)emergence of ductal myofibroblasts as a new cellular target in idiopathic pulmonary fibrosis. European Respiratory Journal 2025, 66: 2501466. PMID: 41057218, DOI: 10.1183/13993003.01466-2025.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisExtracellular matrix componentsPulmonary fibrosisExcessive deposition of extracellular matrix componentsIdiopathic interstitial lung diseaseDeposition of extracellular matrix componentsPathological wound-healing responsePotential therapeutic targetExcessive depositionInterstitial lung diseaseCellular targetsImpaired gas exchangeWound healing responseGas exchangeMatrix componentsTherapeutic targetRespiratory failureCell populationsLung diseaseFatal disorderMouse modelSevere formLung parenchymaIrreversible remodelingFibrosisDifferential effects of antifibrotic treatment on outcome prediction via serial CRPM levels in IPF
Seeliger B, Ruwisch J, Bülow Sand J, Simões F, Jessen H, Boerner E, Fuge J, Sewald K, Welte T, Wendel-Garcia P, Schupp J, Leeming D, Bonella F, Prasse A. Differential effects of antifibrotic treatment on outcome prediction via serial CRPM levels in IPF. Chest 2025 PMID: 41033547, DOI: 10.1016/j.chest.2025.08.047.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisAntifibrotic treatmentSerum concentrationsAssociated with worse 5-year survivalMarkers of local inflammationGerman tertiary centerEndothelial cellsTreatment-naive patientsTransplant-free survivalTreated with nintedanibPatients' mean ageHuman umbilical vein-derived endothelial cellsUmbilical vein-derived endothelial cellsC-reactive proteinAnti-fibrotic therapiesCell culture experimentsCRPM levelsPropensity score matchingPirfenidone treatmentTertiary centerSerum levelsPulmonary fibrosisNintedanibMean ageLocal inflammationSingle-cell analysis of cryobiopsy samples from patients with early IPF reveals loss of alveolar epithelial cells, and emergence of aberrant basaloid cells
Justet A, Adams T, Khoury J, Balayev A, Schupp J, Manning E, Zhao A, Ahangari F, Yan X, Ravaglia C, Poletti V, Tomasseti S, Kaminski N. Single-cell analysis of cryobiopsy samples from patients with early IPF reveals loss of alveolar epithelial cells, and emergence of aberrant basaloid cells. 2025, oa1196. DOI: 10.1183/13993003.congress-2025.oa1196.Peer-Reviewed Original ResearchThe PPFE atlas reveals distinct profibrotic and elastotic mesenchymal cellular archetypes in pleuroparenchymal fibroelastosis
Ruwisch J, Cazes A, Leiber L, Borie R, Christian L, Mal H, Langer L, De Montpréville V, Kamp J, Greer M, Wrede C, Hegermann J, Gottlieb J, Seeliger B, Bernaudin J, Knudsen L, Mordant P, Neubert L, Crestani B, Prasse A, Kaminski N, Justet A, Schupp J. The PPFE atlas reveals distinct profibrotic and elastotic mesenchymal cellular archetypes in pleuroparenchymal fibroelastosis. 2025, oa4324. DOI: 10.1183/13993003.congress-2025.oa4324.Peer-Reviewed Original ResearchNovel autoantibody profiles in primary Sjögren’s disease with Interstitial Lung Disease
Gras J, Ruwisch J, Engelke F, Graalmann T, Schupp J, Fuge J, Dettmer S, Witte T, Seeliger B. Novel autoantibody profiles in primary Sjögren’s disease with Interstitial Lung Disease. 2025, pa1882. DOI: 10.1183/13993003.congress-2025.pa1882.Peer-Reviewed Original ResearchThe clinical significance of bronchiectasis in IPF and RA-ILD: a retrospective analysis
Raith J, Ruwisch J, Knegendorf L, Schupp J, Graalmann T, Fuge J, Dettmer S, Ringshausen F, Rademacher J, Seeliger B. The clinical significance of bronchiectasis in IPF and RA-ILD: a retrospective analysis. 2025, pa6106. DOI: 10.1183/13993003.congress-2025.pa6106.Peer-Reviewed Original ResearchA deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases
Zheng Y, Schupp J, Adams T, Clair G, Justet A, Ahangari F, Yan X, Hansen P, Carlon M, Cortesi E, Vermant M, Vos R, De Sadeleer L, Rosas I, Pineda R, Sembrat J, Königshoff M, McDonough J, Vanaudenaerde B, Wuyts W, Kaminski N, Ding J. A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases. Nature Biomedical Engineering 2025, 9: 2155-2180. PMID: 40542107, PMCID: PMC12705450, DOI: 10.1038/s41551-025-01423-7.Peer-Reviewed Original ResearchComplex cellular dynamicsCellular dynamicsSingle-cell transcriptomic dataIn silico drug discoverySingle-cell transcriptomicsTranscriptome dataPotential therapeutic drug candidateComplex diseasesHuman diseasesIdiopathic pulmonary fibrosisTherapeutic drug candidateCell embeddingDrug discoveryPulmonary fibrosisDrug candidatesDisease progressionHuman tissuesHuman precision-cut lung slicesDynamic analysisPrecision-cut lung slicesPathological landscapeComputational toolsAnti-fibrotic effectsUnagiTranscriptomeTranscriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease
Fließer E, Jandl K, Chen S, Wang M, Schupp J, Kuebler W, Baker A, Kwapiszewska G. Transcriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease. JCI Insight 2025, 10: e191059. PMID: 40401523, PMCID: PMC12128986, DOI: 10.1172/jci.insight.191059.Peer-Reviewed Original ResearchConceptsEndothelial cellsCardiopulmonary vasculatureImmune responseImmune cell recruitmentRegulation of immune responsesFunction of endothelial cellsImmunoregulatory roleAntigen presentationCytokine secretionCell recruitmentCardiopulmonary healthDelivery of oxygenSingle-cell RNA sequencingImmunomodulatory propertiesCardiopulmonary diseaseClearance functionDisease pathogenesisTherapy targetTranscriptional signatureEC subpopulationsImmunomodulatory activityDiseaseLungVasculatureHeart