Gabriel P. A. Costa, MD
Postdoctoral AssociateCards
About
Research
Overview
Public Health Interests
Clinical Trials; Behavioral Health; Statistical Computing; Mental Health; Randomized Trials; Substance Use, Addiction
Publications
2025
Internet-based cognitive behavioral therapy for alcohol use disorder: A systematic review of evidence and future potential.
Gushken F, Costa GPA, de Paula Souza A, Heringer D, Anand A. Internet-based cognitive behavioral therapy for alcohol use disorder: A systematic review of evidence and future potential. J Subst Use Addict Treat 2025, 171: 209627. PMID: 39870355, DOI: 10.1016/j.josat.2025.209627.Peer-Reviewed Original ResearchThe bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study
Costa G, Nunes J, Suh R, Sofuoglu M, Aquino J. The bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study. Drug And Alcohol Dependence 2025, 268: 112552. PMID: 39848133, PMCID: PMC11832315, DOI: 10.1016/j.drugalcdep.2025.112552.Peer-Reviewed Original ResearchConceptsDaily smokingDaily cigarette smokingChronic painDevelopment of painCigarette smokingTobacco smokePopulation Assessment of Tobacco and Health StudyBaseline painAlternative tobacco product usePersistent painTobacco product useDevelopment of persistent painYears of longitudinal dataHealth StudyTobacco useNo/low painPreventable causeSmoking outcomesBidirectional relationshipSurvival analysisSmokingPopulation AssessmentAge categoriesIncreased riskSurvey populationBuprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials
Hickey T, Costa G, Oliveira D, Podosek A, Abelleira A, Avila-Quintero V, De Aquino J. Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials. Regional Anesthesia & Pain Medicine 2025, rapm-2024-106014. PMID: 39753290, DOI: 10.1136/rapm-2024-106014.Peer-Reviewed Original ResearchAcute postoperative pain managementPostoperative pain managementAcute postoperative painDuration of analgesiaPain intensityPain managementRandomized controlled trialsRisk of biasAgonist opioidsPostoperative painControlled trialsRescue analgesiaMeta-analysis of randomized controlled trialsMean duration of analgesiaRescue analgesia useLong duration of actionCochrane Central Register of Controlled TrialsSafety of buprenorphineCentral Register of Controlled TrialsMeta-analysisRegister of Controlled TrialsRandom-effects meta-analysisAdverse effectsDuration of actionCochrane Central Register
2024
Racial and ethnic disparities in alcohol-associated liver disease hospitalizations in Brazil before and after the COVID-19 pandemic
Heringer D, Costa G, Weleff J, Rodrigues V, Sengupta S, Anand A. Racial and ethnic disparities in alcohol-associated liver disease hospitalizations in Brazil before and after the COVID-19 pandemic. Annals Of Hepatology 2024, 30: 101742. PMID: 39653118, DOI: 10.1016/j.aohep.2024.101742.Peer-Reviewed Original ResearchMonthly hospitalization ratesHospitalization ratesAlcohol-associated liver diseaseHealth-related inequalitiesInterrupted time series analysisIncidence of alcohol‐associated liver diseaseAge of hospitalized patientsPre-pandemic ratesEthnic groupsCOVID-19 pandemicEthnic disparitiesPublic hospitalsStatistically significant decreaseImpact of raceBlack populationHospitalLiver diseaseStudy periodCOVID-19Total populationSignificant decreaseCombined populationWhole populationConsecutive monthsPopulationWe Need to Rethink Our Strategy on Cannabis in the Overdose Crisis
Joao P. De Aquino and Gabriel P. A. Costa. Cannabis Needs Rethinking As a Strategy in the Overdose Crisis. Scientific American. Available at:Publications for non-academic audiencesAlcohol Use Disorder and Chronic Pain: An Overlooked Epidemic
De Aquino J, Sloan M, Nunes J, Costa G, Katz J, de Oliveira D, Ra J, Tang V, Petrakis I. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic. American Journal Of Psychiatry 2024, 181: 391-402. PMID: 38706339, PMCID: PMC11521207, DOI: 10.1176/appi.ajp.20230886.Peer-Reviewed Original ResearchConceptsAlcohol use disorderChronic painAUD studiesChronic pain disordersChronic pain outcomesRisk of relapseAlcohol withdrawal syndromeAssessment of painHigher levels of alcohol consumptionLevels of alcohol consumptionWithdrawal syndromePain disordersPain outcomesAcute toleranceNeurobiological changesClinical significanceUse disorderPainClinical relevanceSelf-reportAlcohol intoxicationAlcohol consumptionGeneral populationMedical conditionsNarrative reviewFrom taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder
Weleff J, Nunes J, Costa G, Sofuoglu M, MacLean R, De Aquino J. From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3036-3053. PMID: 38627909, PMCID: PMC11480258, DOI: 10.1111/bcp.16045.Peer-Reviewed Original ResearchOpioid use disorderChronic painLong-term opioid therapyManagement of chronic painPain management alternativeOpioid-induced analgesiaInnovative treatment optionsManagement of painReverse painCentral sensitizationOpioid therapyPain controlTreatment optionsClinical challengeClinical trialsPainPotential therapeutic applicationsPain experiencePotential of psychedelicsNovel therapeuticsHuman evidenceOpioid crisisNeurobiological substratesOpioidExploration of novel therapeuticsAssessing pain in persons with opioid use disorder: Approaches, techniques and special considerations
Nunes J, Costa G, Weleff J, Rogan M, Compton P, De Aquino J. Assessing pain in persons with opioid use disorder: Approaches, techniques and special considerations. British Journal Of Clinical Pharmacology 2024, 90: 2985-3002. PMID: 38556851, DOI: 10.1111/bcp.16055.Peer-Reviewed Original ResearchOpioid use disorderAssess painPain assessmentPain experienceConcomitant chronic painChronic opioid therapyQuantitative sensory testingVisual analogue scalePain assessment methodsPain assessment toolsComplex psychosocial backgroundImprove pain assessmentOpioid therapyOpioid usePain responseChronic painAnalogue scaleTraditional self-report methodsPainRisk factorsUse disorderOpioidNarrative reviewSelf-report methodsMultidisciplinary teamThe impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies
Costa G, Nunes J, Heringer D, Anand A, De Aquino J. The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies. The American Journal Of Drug And Alcohol Abuse 2024, 50: 12-26. PMID: 38225727, DOI: 10.1080/00952990.2023.2287406.Peer-Reviewed Original ResearchConceptsNon-medical opioid useOpioid use disorderOpioid useCannabis useOpioid use disorder pharmacotherapyUse disorderImpact of cannabis useAverage follow-up timeFollow-up timeMeta-analysisEvidence of moderate heterogeneityImpact of cannabisPooled odds ratioOpioids non-medicallyRandom-effects modelMeta-analysis of longitudinal studiesCannabis abstinenceTreatment modalitiesOdds ratioModerate heterogeneityPharmacotherapyCannabisOpioidComprehensive searchPublication bias