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Andrey Zinchuk, MD, MHS

Assistant Professor
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Additional Titles

Director, Advanced Apnea Management Program

Director, Yale Sleep Fellowship Didactic and Research Curriculum, Internal Medicine, PCCSM

Director, Upper Airway Neurostimulation Program

Section of Pulmonary, Critical Care and Sleep Medicine

About

Titles

Assistant Professor

Director, Advanced Apnea Management Program; Director, Yale Sleep Fellowship Didactic and Research Curriculum, Internal Medicine, PCCSM; Director, Upper Airway Neurostimulation Program; Section of Pulmonary, Critical Care and Sleep Medicine

Biography

After working as a chemical engineer, I completed my medical school training at University of Connecticut and have found the intersection between disciplines to be an exciting area for patient care and research. I have trained in internal medicine, neurology, pulmonary, critical care and sleep medicine and am now focused on caring for patients with sleep disorders and those who are critically ill.

Patient care: My goal is to provide the kind of care that I would want for my own family. I believe in taking the time to hear the patient and being a guide in their journey in health and illness. In the clinic, my focus is on caring for patients with sleep disorders and in particular, individuals with complex sleep disordered breathing.

Research: My aim is to improve the lives of people with sleep disordered breathing. My colleagues and I hope to do so by identifying subgroups (phenotypes) of sleep apnea patients with unique physiology, prognoses and treatment responsiveness, as well as through development of novel, effective and tolerable treatments.

Service: I am working to mitigate the consequences of Russia's war on the health of Ukrainian people. Along with other Yale colleagues with Ukrainian roots, we co-founded Doctors United for Ukraine, a non-profit organization focused on critical care, mental and women's health of vulnerable populations in Ukraine. Doctors United for Ukraine – Dwight Hall at Yale

Mentors: Klar Yaggi MD, MPH, Andrew Wellman, MD, PhD (Harvard), Scott Sands, PhD (Harvard), Nancy Redeker, RN, PhD (UCONN)

Appointments

Other Departments & Organizations

Education & Training

MHS
Yale University (2018)
Fellow, Sleep Medicine
Yale University (2017)
Fellow, Pulmonary & Critical Care
Yale University (2016)
Chief Medical Resident
Beth Israel Deaconess Medical Center and Boston Veterans Affairs Medical Center (2013)
Resident, Internal Medicine
Beth Israel Deaconess Medical Center, Harvard University (2012)
Resident, Neurology
Beth Israel Deaconess Medical Center, Harvard University (2010)
Intern, Internal Medicine
Beth Israel Deaconess Medical Center, Harvard University (2009)
MD
University of Connecticut (2008)
BS
Lehigh University (2000)

Research

Overview

We conduct NIH-sponsored research to identify physiological characteristics of individuals with sleep apnea that predict the effectiveness of treatment. Many individuals with sleep apnea can not tolerate first-line therapy: continuous positive airway pressure (CPAP). We find that traits such as the ease with which individuals arouse from sleep and the biological clock are key factors in someone's success with CPAP therapy. We aim to use this understanding to personalized approaches to treatment, for example, in those with easy arousability, using medications or non-pharmacological treatments.
We also hope to understand phenotypes of sleep apnea and how they influence incident cardiovascular disease or death. For example, the propensity for oxygen desaturation during an apnea or the heart rate response to an apnea may identify those at most risk for heart disease or death. Understanding these phenotypes can help identify individuals in which sleep apnea treatment may prevent heart disease.

Mentors: Klar Yaggi MD (Yale), Andrew Wellman MD, PhD (Harvard), Scott Sands, PhD (Harvard)

Medical Research Interests

Cardiovascular Diseases; Continuous Positive Airway Pressure; Endophenotypes; Polysomnography; Precision Medicine; Sleep; Sleep Apnea Syndromes; Sleep Apnea, Central

Research at a Glance

Yale Co-Authors

Frequent collaborators of Andrey Zinchuk's published research.

Publications

2024

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Academic Achievements & Community Involvement

  • activity

    Yale School of Medicine/Yale New Haven Hospital Internal Medicine Residency Mentor-Advisor-Coach committee

    CommitteesMember
  • activity

    Guilford Center for Children

    Public ServiceVolunteer
  • activity

    Guilford Free Public Library

    Public ServiceVolunteer
  • activity

    Yale University, Sleep Fellowship Didactic and Research Educational Curriculum

    CommitteesDirector
  • activity

    Yale University and Yale New Haven Hospital, Advanced Apnea Management Program

    CommitteesDirector
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Clinical Care

Overview

Andrey Zinchuk, MD, MHS, is a pulmonary, critical care and sleep physician.

In the hospital’s intensive care unit, he cares for people who are critically ill. In the clinic, he helps patients with sleep disorders, particularly those with complex sleep-disordered breathing. “My goal is to provide the kind of care that I would want for my own family,” Dr. Zinchuk says. “I believe in taking the time to hear the patient, and being a guide in their journey in health and illness.”

Before he decided to pursue medicine, Dr. Zinchuk worked as a chemical engineer, devising new ways to deliver medications to the right parts of the human body at the right time. “I loved the complexity of engineering and how physical systems interact, but I wanted to apply this passion for complex systems to directly improve people’s lives,” he says.

Both of Dr. Zinchuk’s parents were doctors, and he decided to follow in their footsteps. He began his training in neurology, but transitioned to internal medicine, ultimately specializing in pulmonary and sleep medicine. “I find sleep to be a perfect intersection between engineering, the science of breathing, neurology, and mental health.” He now directs the Advances Apnea Management Program (AAMP) at Yale, specializing in cutting-edge treatments for sleep apnea.

In addition to directly caring for patients, Dr. Zinchuk conducts research to help personalize therapy for sleep disorders. “We are finding that sleep apnea patients who have certain physiological characteristics (phenotypes) respond to some treatments but not others.” His most recent work describes how certain phenotypes may help predict whether a patient suffering from sleep apnea will succeed with continuous positive airway pressure (CPAP) or another sleep apnea therapy.

Clinical Specialties

Sleep Medicine; Critical Care Medicine

Fact Sheets

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Board Certifications

  • Sleep Medicine (Internal Medicine)

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    2017

  • Critical Care Medicine (Internal Medicine)

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    2016

  • Pulmonary Disease

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    2015

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