Peter S. Aronson, MD
C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular PhysiologyCards
About
Research
Overview
Our general goal is to characterize the mechanisms regulating sodium, acid-base, and anion excretion by the kidney. Our work is primarily focused on membrane transport proteins mediating ion exchange, namely NHE isoforms mediating Na+-H+ exchange, and SLC26 isoforms mediating anion exchange. One approach involves the generation of isoform- and phospho-specific polyclonal and monoclonal antibodies to identify the cellular and subcellular sites of expression of ion exchangers in the kidney and other tissues, and to study their regulation. A complementary approach uses mice with targeted gene disruption to elucidate the physiological roles of ion exchangers and associated proteins under in vivo conditions. For example, work with mice lacking anion exchanger Slc26a6, which can function as an oxalate transporter, revealed a phenotype of calcium oxalate kidney stones. This finding in turn has motivated studies on the mechanisms and regulation of oxalate transporters and their roles in oxalate homeostasis, urolithiasis, and crystal-induced inflammation in the kidney and other tissues.
Medical Research Interests
Academic Achievements & Community Involvement
News
News
- January 06, 2025
Request for Nominations: 2025 Iva Dostanic Award
- October 15, 2024
Meet Lonnette Diggs, Research Associate II, Nephrology
- October 02, 2024
How Diet Interacts with the Gut
- May 14, 2024
Students and Faculty Mentors Celebrated at Student Research Day
Get In Touch
Contacts
Administrative Support
Locations
Yale Nephrology
Academic Office
The Anlyan Center
300 Cedar Street, Ste Room S255C
New Haven, CT 06519