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Peter Moore, PhD

Professor Emeritus of Chemistry

Appointments

Chemistry
Primary

About

Titles

Professor Emeritus of Chemistry

Appointments

  • Chemistry

    Emeritus
    Primary

Other Departments & Organizations

Education & Training

Postdoctoral Fellow
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK (1969)
Postdoctoral Fellow
Institut de Biologie Moleculaire, University of Geneva, Switzerland (1967)
PhD
Harvard University (1966)

Research

Overview

By protein standards, our understanding of RNA structure and function is primitive because it was technically difficult to determine RNA structures for many years. Consequently, even though the technical problems have been overcome, there are lots of RNAs—many of them recently discovered—for which we do not have structures, and hence cannot fully explain their functional properties. The Moore group studies RNA structure/function using NMR and X-ray crystallography as well as molecular biological techniques. The structures being investigated today include: 1) those that form when box H/ACA snoRNAs interact with the rRNA sequences they target for pseudouridylation; and 2) the ribosomal proteins/mRNA complexes responsible for the autogenous regulation of ribosomal protein synthesis. We are also trying to identify the sources of the species specificity shown by many of the antibiotics that inhibit ribosome activity by binding to highly conserved rRNA sequences, and to determine the three-dimensional structure of the eukaryotic ribosome.

Research at a Glance

Yale Co-Authors

Frequent collaborators of Peter Moore's published research.

Publications

2021

2009

2008

2007

2006

2005

Get In Touch

Contacts

Locations

  • SCL 117

    Academic Office

    Sterling Chemistry Lab

    225 Prospect Street

    New Haven, CT 06511