2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometrium
2024
Müllerian anomalies and endometriosis: associations and phenotypic variations
Bhamidipaty-Pelosi S, Kyei-Barffour I, Volpert M, O’Neill N, Grimshaw A, Eriksson L, Vash-Margita A, Pelosi E. Müllerian anomalies and endometriosis: associations and phenotypic variations. Reproductive Biology And Endocrinology 2024, 22: 157. PMID: 39702195, PMCID: PMC11656925, DOI: 10.1186/s12958-024-01336-1.Peer-Reviewed Original ResearchConceptsMullerian anomaliesObstructive Mullerian anomaliesAdverse pregnancy outcomesDevelopment of endometriosisAbsence of obstructionFemale reproductive tractHeterogeneity of phenotypesPregnancy outcomesRetrograde menstruationSurgical correctionCongenital conditionEndometriosisAnatomical variationsHigh riskReproductive tractCardiovascular systemVariable comorbiditiesClinical researchIncomplete developmentLack of genetic informationMalformationsComorbiditiesObstructionInfertilityMenstruationMood lability and depression limit oral contraceptive therapy in endometriosis
Cevik E, Taylor H. Mood lability and depression limit oral contraceptive therapy in endometriosis. Fertility And Sterility 2024, 123: 838-845. PMID: 39672361, DOI: 10.1016/j.fertnstert.2024.12.011.Peer-Reviewed Original ResearchProgestin-only oral contraceptivesOral contraceptivesOC discontinuationOC useDiagnosis of depressionMood labilityEffects of oral contraceptivesOral contraceptive (OCDocumented diagnosis of depressionDiscontinued OC useEffect of OC useInternational Classification of Diseases-10 codesSide effects of OC useElectronic medical record reviewTreated with OCCourse of treatmentMedical record reviewIncreased incidence of depressionUniversity affiliated hospitalTreatment discontinuationIncidence of depressionEndometriosisStudy cohortPrimary outcomeIncreased incidenceWomen with endometriosis in the United States: National Survey of Family Growth, 2011–2019
Al-Lami R, Taha S, Jalloul R, Taylor H. Women with endometriosis in the United States: National Survey of Family Growth, 2011–2019. Journal Of Endometriosis And Uterine Disorders 2024, 8: 100081. DOI: 10.1016/j.jeud.2024.100081.Peer-Reviewed Original ResearchNational Survey of Family GrowthAssociated with infertilityFamily GrowthRates of functional impairmentQuality of lifeNational surveyWeighted prevalencePrevalence of infertilityPain associated with endometriosisLongitudinal population-based studyAssociated with endometriosisPrevalence of endometriosisFunctional impairmentNationally Representative SamplePopulation-based studyDiminished quality of lifeLogistic regression analysisSample of womenCross-sectional studyCharacteristics of womenInfertile womenEndometriosisReproductive factorsU.S. womenAnalytic sampleTET3-overexpressing macrophages promote endometriosis
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael G, Li D, Taylor H, Huang Y. TET3-overexpressing macrophages promote endometriosis. Journal Of Clinical Investigation 2024, 134: e181839. PMID: 39141428, PMCID: PMC11527447, DOI: 10.1172/jci181839.Peer-Reviewed Original ResearchDisease-associated macrophagesTET3 overexpressionHuman endometriosis lesionsPathophysiology of endometriosisPro-inflammatory cytokine productionChronic inflammatory diseaseReproductive age womenEndometriosis lesionsE3 ubiquitin ligasePathogenic macrophagesCytokine productionEndometriosisInflammatory diseasesTET3 knockdownEndometriosis progressionPathogenic contributorsLet-7 miRNA expressionAge womenMacrophagesMouse macrophagesTherapeutic targetUbiquitin ligaseTET3MiceDiseaseIs There an Association Between Endometriosis, Early Menopause, and Cardiovascular Disease?
Younis J, Taylor H. Is There an Association Between Endometriosis, Early Menopause, and Cardiovascular Disease? The Journal Of Clinical Endocrinology & Metabolism 2024, 109: e1946-e1949. PMID: 39083665, DOI: 10.1210/clinem/dgae508.Peer-Reviewed Original ResearchEarly menopauseEndometriotic cystectomyNatural menopauseCardiovascular riskCardiovascular diseaseEndometriosis-associated pelvic painIncreased risk of cardiovascular diseaseLaparoscopically diagnosed endometriosisRisk of cardiovascular diseaseEarly natural menopauseLarge-scale cohort studyPelvic painOvarian reserveBilateral casesMenopause onsetMultiple surgeriesEndometriosisCohort studyHazard ratioIncreased riskMenopauseCystectomyRisk factorsEstimates of associationConfounding factorsMedical Management of Endometriosis in Adolescent and Young Adult Women: A Review of 91 Cases of Biopsy-Confirmed Endometriosis
Li H, Esencan E, Song Y, Taylor H, Cho Y, Vash-Margita A. Medical Management of Endometriosis in Adolescent and Young Adult Women: A Review of 91 Cases of Biopsy-Confirmed Endometriosis. Journal Of Obstetrics And Gynaecology Canada 2024, 46: 102562. PMID: 38759792, DOI: 10.1016/j.jogc.2024.102562.Peer-Reviewed Original ResearchCombined oral contraceptivesBiopsy-proven endometriosisLNG-IUDManagement of endometriosisOral progestinInitial treatmentRetrospective chart review of womenChart review of womenMedical management of endometriosisProgestin-only formulationsLevonorgestrel intrauterine deviceReview of womenRetrospective chart reviewYoung adult patientsTertiary hospital systemPelvic painIntrauterine deviceOral contraceptivesTreatment regimensYounger patientsAdult patientsHormonal managementEndometriosisTreatment planningCurrent treatmentThe effect of acute estrogen suppression on cutaneous endothelium-dependent vasodilation in women with endometriosis
Colburn A, Leone C, Alexander L, Stachenfeld N. The effect of acute estrogen suppression on cutaneous endothelium-dependent vasodilation in women with endometriosis. Physiology 2024, 39: 421. DOI: 10.1152/physiol.2024.39.s1.421.Peer-Reviewed Original ResearchEndothelium-dependent vasodilationEstrogen suppressionHealthy controlsLDF/mean arterial pressureSodium nitroprusside perfusionDose-response curveLaser Doppler flowmetryCardiovascular disease riskCutaneous vascular conductanceACh doseEndometriosis patientsPerfusion of acetylcholineMenstrual cycleIntradermal microdialysisSuppress estrogenEndothelial functionArterial pressureEndometriosisVasodilatory functionDoppler flowmetryVascular conductanceVasodilationMaximal vasodilationGraded perfusionEstrogenVilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial
Taylor H, Dong L, Haikonen J, Oppelt P, Tamussino K, Wenzl R, Faustmann T, Groettrup-Wolfers E, Ren X, Seitz C. Vilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial. F&S Reports 2024, 5: 189-196. PMID: 38983729, PMCID: PMC11228778, DOI: 10.1016/j.xfre.2024.03.002.Peer-Reviewed Original ResearchPelvic painSymptomatic endometriosisTreatment of symptomatic endometriosisEndometriosis-associated pelvic painBaseline to month 3Use of pain medicationAverage pain scoreMonths of treatmentPhase 2b randomized controlled trialAssess treatment effectsOutcome measures Primary outcomesPlacebo recipientsRandomized Controlled TrialsPain scoresMonth 3Pain medicationIncreased painVilaprisanPlaceboPrimary outcomeEndometriosisToxicity findingsIntervention participantsClinical relevanceBleeding intensity
2023
Corrigendum to “Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis” [BBA - Mol. Basis of Dis. 1869 (2023) 166784]
Grande J, Jones T, Sun Z, Chanana P, Jaiswal I, Leontovich A, Carapanceanu N, Carapanceanu V, Saadalla A, Osman A, Famuyide A, Daftary G, Khan Z, Khazaie K. Corrigendum to “Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis” [BBA - Mol. Basis of Dis. 1869 (2023) 166784]. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2023, 1870: 166923. PMID: 37949756, DOI: 10.1016/j.bbadis.2023.166923.Peer-Reviewed Original ResearchProgress on the Endometrium
Frankfurter D, Kliman H. Progress on the Endometrium. Obstetrics And Gynecology Clinics Of North America 2023, 50: 677-694. PMID: 37914487, DOI: 10.1016/j.ogc.2023.09.002.Peer-Reviewed Original ResearchConceptsAbsence of pregnancyEvidence-based approachEndometrial assessmentStromal maturationEndometrial proliferationEndometrial pathologyInflammatory mediatorsOvarian steroidsImplantation failureBlastocyst implantationEndometrial sloughingDiagnostic measuresEndometriumOffer hopeDynamic tissueDevelopmental markersSingle testTissueInternal reproductionMaturationEndometriosisPregnancyDecidualizationInfertilityUterusCHARACTERIZATION OF PROGESTERONE RESISTANCE IN A PROSPECTIVE COHORT OF SURGICALLY CONFIRMED PATIENTS WITH OR WITHOUT ENDOMETRIOSIS
Singh B, Courtright L, Brennan J, Chen L, Wu H, Patzkowsky K, Wang K, Simpson K, Wang T, Shih I, Cope L, Schepisi L, Taylor H, Segars J. CHARACTERIZATION OF PROGESTERONE RESISTANCE IN A PROSPECTIVE COHORT OF SURGICALLY CONFIRMED PATIENTS WITH OR WITHOUT ENDOMETRIOSIS. Fertility And Sterility 2023, 120: e224. DOI: 10.1016/j.fertnstert.2023.08.639.Peer-Reviewed Original ResearchEffects Of A Randomized Placebo-Controlled Oral Salsalate Intervention On Flow-Mediated Dilation In Women With Endometriosis
Kirby N, Williams A, Content V, Wolf S, Dillon G, Stachenfeld N, Alexander L. Effects Of A Randomized Placebo-Controlled Oral Salsalate Intervention On Flow-Mediated Dilation In Women With Endometriosis. Medicine & Science In Sports & Exercise 2023, 55: 398-399. DOI: 10.1249/01.mss.0000983544.89010.be.Peer-Reviewed Original ResearchFolate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium
Gersekowski K, Ibiebele T, Group F, Doherty J, Harris H, Goodman M, Terry K, Wu A, Bandera E, Qin B, Ong J, Tyrer J, Dixon-Suen S, Modugno F, Risch H, Webb P. Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium. Cancer Epidemiology Biomarkers & Prevention 2023, 32: of1-of10. PMID: 37220873, PMCID: PMC10390886, DOI: 10.1158/1055-9965.epi-23-0121.Peer-Reviewed Original ResearchConceptsOvarian cancer riskHigh dietary folate intakeDietary folate intakeCase-control studyFolate intakeOvarian cancerOvarian Cancer Association ConsortiumCancer riskOdds ratioMendelian randomizationSelf-reported endometriosisSupplemental folate intakeHigh folate intakeHigh folate dietCancer-promoting effectsPooled analysisFolate dietPrecancerous lesionsFolate statusEndometriosisIncrease riskCancerCancer typesLogistic regressionIntakeSurgical management of inguinal endometriosis: Case report and surgical video
Beroukhim G, Esencan E, Manrai P, Azodi M, K Cho Y. Surgical management of inguinal endometriosis: Case report and surgical video. Journal Of Case Reports And Images In Obstetrics And Gynecology 2023, 9: 11-16. DOI: 10.5348/100136z08gb2023cr.Peer-Reviewed Original ResearchInguinal endometriosisInguinal massDiagnostic laparoscopySurgical managementCase reportPainful right inguinal massExtra-pelvic endometriosisRight inguinal massAbsence of symptomsInternal inguinal ringStep surgical approachNulligravid womenExcisional surgeryRound ligamentSurgical approachEndometriosisTissue biopsiesInguinal ringRare typeMultidisciplinary teamLaparoscopyWorkupSurgical videosAccompanying videoReportClinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine
Saleh F, Taylor H. Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine. F&S Reports 2023, 4: 83-87. PMID: 37223759, PMCID: PMC10201293, DOI: 10.1016/j.xfre.2023.01.008.Peer-Reviewed Original ResearchHormone analogueGonadotropin-releasing hormone analogueOral GnRH antagonistCommon gynecologic conditionOvarian hormone productionClinical applicationGnRH antagonistPituitary responseGnRH activityGnRH analoguesGynecologic conditionsTreatment optionsGonadal axisReproductive axisRapid onsetGynecologic practiceHormone productionReproductive medicineReproductive technologiesDiverse clinical applicationsGonadotropinEndometriosisFibroidsGnRHAntagonistEpidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders
Koller D, Pathak G, Wendt F, Tylee D, Levey D, Overstreet C, Gelernter J, Taylor H, Polimanti R. Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. JAMA Network Open 2023, 6: e2251214. PMID: 36652249, PMCID: PMC9856929, DOI: 10.1001/jamanetworkopen.2022.51214.Peer-Reviewed Original ResearchConceptsPsychiatric comorbidityMAIN OUTCOMEMental healthIrritable bowel syndromeBody mass indexAssociation of endometriosisOdds of depressionSevere physical symptomsPain-related phenotypesWomen's mental healthMultivariate regression analysisOdds of endometriosisBowel syndromeGenetic associationMass indexGynecologic pathologyMillion Veteran ProgramEndometriosisPsychiatric disordersWomen's healthFemale controlsPleiotropic mechanismsPhysical symptomsComorbiditiesFinnGen study
2022
Endometriosis-associated infertility: From pathophysiology to tailored treatment
Bonavina G, Taylor H. Endometriosis-associated infertility: From pathophysiology to tailored treatment. Frontiers In Endocrinology 2022, 13: 1020827. PMID: 36387918, PMCID: PMC9643365, DOI: 10.3389/fendo.2022.1020827.Peer-Reviewed Original ResearchConceptsEndometriosis-associated infertilityRole of surgeryCurrent treatment optionsNon-invasive diagnostic toolLevel of impairmentInfertile womenRelated infertilityEndometrial receptivitySystemic diseaseTreatment optionsClinical managementDysfunctional alterationsEndometriosisSystemic effectsClinical situationsInfertilityPelvic anatomyClinical settingEndometriosis subtypesPrecise diagnosisPatient phenotypesReproductive technologiesDiagnostic toolTreatmentPhenotypePre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial
Taylor H, Li HJ, Carson S, Flores V, Pal L, Robbins J, Santoro NF, Segars JH, Seifer D, Huang H, Young S, Zhang H. Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial. BMJ Open 2022, 12: e052043. PMID: 35715184, PMCID: PMC9207753, DOI: 10.1136/bmjopen-2021-052043.Peer-Reviewed Original ResearchConceptsEndometriosis-associated infertilityPlacebo-controlled trialGnRH antagonistFertility treatmentOral GnRH antagonistEndometriosis-related infertilityFertilization-embryo transferLive birth rateUse of gonadotropinsEtiology of infertilityInstitutional review boardAntagonist pretreatmentCommon complicationObstetrical outcomesPeer-reviewed journalsSecondary outcomesIVF treatmentPrimary outcomeHormone agonistImplantation ratePregnancy rateLive birthsEndometriosisLocal protocolsOocyte numberVesical clear cell adenocarcinoma of Müllerian origin treated conservatively with partial cystectomy
Harold JA, Casilla-Lennon M, Kenney PA, Ratner ES. Vesical clear cell adenocarcinoma of Müllerian origin treated conservatively with partial cystectomy. BMJ Case Reports 2022, 15: e245015. PMID: 35383096, PMCID: PMC8984011, DOI: 10.1136/bcr-2021-245015.Peer-Reviewed Original ResearchConceptsClear cell adenocarcinomaPartial cystectomyCell adenocarcinomaMüllerian originPAX-8 stainingExtensive endometriosisAdjuvant therapyFinal pathologyTotal hysterectomyTransurethral resectionBladder massResidual tumorCystectomyAdenocarcinomaHysterectomyEndometriosisResectionTherapyTumorsPathologyWomen
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply