2025
Estimated Theoretical Benefit of Aggressive LDL Lowering in Patients With Symptomatic Intracranial Atherosclerosis
Siegler J, Badillo Goicoechea E, Yaghi S, Morsi R, Arevalo A, Smith M, Kothari S, Desai H, Sehgal N, Rana R, Kellogg C, Jhaveri A, de Havenon A, Dunne T, Cameron K, Chaturvedi S, Ghannam M, Prabhakaran S, Coleman E, Brorson J, Mehendale R, Kass-Hout T. Estimated Theoretical Benefit of Aggressive LDL Lowering in Patients With Symptomatic Intracranial Atherosclerosis. Neurology 2025, 105: e213768. PMID: 40446174, DOI: 10.1212/wnl.0000000000213768.Peer-Reviewed Original ResearchConceptsProprotein convertase subtilisin/kexin type 9 inhibitorsIntracranial atherosclerotic diseasePrimary outcomeMyocardial infarctionStroke due to intracranial stenosisRecurrent strokeIntracranial stenosisPCSK9 inhibitor useClass IV evidenceCox proportional hazards regressionRecurrent cerebral infarctionSymptomatic intracranial atherosclerosisAggressive medical managementAssociated with lower ratesLow-density lipoprotein (LDLInterventional clinical trialsAtherosclerotic vascular eventsProportional hazards regressionSecondary analysisLDL improvementLipoprotein (LDLPreventing Recurrent StrokeIncidence rate differenceLDL reductionIV evidencePostoperative Angiotensin II Receptor Blocker Use Is Associated with Reduced Two-Year Reoperation Rates in Male Patients Undergoing Arthroscopic Rotator Cuff Repair
Fong S, Pettinelli N, Lee M, Macleod J, Gillinov S, Monahan P, Moran J, Jonnalagadda A, Mahatme R, Apostolakos J, Jimenez A. Postoperative Angiotensin II Receptor Blocker Use Is Associated with Reduced Two-Year Reoperation Rates in Male Patients Undergoing Arthroscopic Rotator Cuff Repair. JSES International 2025 DOI: 10.1016/j.jseint.2025.05.007.Peer-Reviewed Original ResearchArthroscopic rotator cuff repairSecondary surgery rateRotator cuff repairRevision rotator cuff repairCuff repairSurgery ratesOdds ratioRate of secondary surgeryAngiotensin II receptor blocker useSecondary shoulder surgeryRotator cuff repair patientsAssociated with lower ratesAssociated with reduced ratesArthroscopic shoulder proceduresMale-specific analysisStatistically significant differenceAssess outcome differencesRepair patientsBlocker useReoperation rateReceptor blockersSecondary surgeryMale patientsARB useShoulder surgery
2024
Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study
Chen H, Khunte M, Colasurdo M, Gunawardane S, Malhotra A, Gandhi D. Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022790. PMID: 39715667, DOI: 10.1136/jnis-2024-022790.Peer-Reviewed Original ResearchEndovascular arterial embolizationNasal packingSevere epistaxisPropensity score matchingNationwide Readmissions DatabaseArtery embolizationIschemic strokeCohort studyRates of patient morbidityHemorrhage risk factorsConservative management groupConservative managementRetrospective cohort studyNationwide cohort studyRate of ischemic strokeBalance patient characteristicsContemporary real-world dataAssociated with lower ratesPatients admitted to hospitalNon-routine dischargeRisk of ischemic strokeRecurrent epistaxisRecurrence ratePatient morbidityPatient characteristicsOncologic Outcomes of Sequential Intravesical Gemcitabine and Docetaxel Compared with Bacillus Calmette-Guérin in Patients with Bacillus Calmette-Guérin–Unresponsive Non–Muscle Invasive Bladder Cancer
Taylor J, Kamat A, Annapureddy D, Khene Z, Howard J, Tan W, McElree I, Facundo D, Yim K, Harrington S, Dyer E, Black A, Kanabur P, Roumiguié M, Lerner S, Black P, Raman J, Preston M, Steinberg G, Huang W, Li R, Packiam V, Woldu S, Lotan Y, O'Donnell M. Oncologic Outcomes of Sequential Intravesical Gemcitabine and Docetaxel Compared with Bacillus Calmette-Guérin in Patients with Bacillus Calmette-Guérin–Unresponsive Non–Muscle Invasive Bladder Cancer. European Urology Oncology 2024, 8: 469-476. PMID: 39694798, DOI: 10.1016/j.euo.2024.12.005.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdministration, IntravesicalAgedAntineoplastic Combined Chemotherapy ProtocolsBCG VaccineDeoxycytidineDocetaxelFemaleGemcitabineHumansMaleMiddle AgedNeoplasm InvasivenessNon-Muscle Invasive Bladder NeoplasmsRetrospective StudiesTreatment OutcomeUrinary Bladder NeoplasmsConceptsNon-muscle-invasive bladder cancerBCG-unresponsive NMIBCBacillus Calmette-GuerinOncological outcomesBladder cancerIntravesical gemcitabineNon-muscle invasive bladder cancerBacillus Calmette-Guerin treatmentHazard ratioBacillus Calmette-Guerin therapyBacillus Calmette-Guerin groupCompare oncologic outcomesInvasive bladder cancerCox proportional hazard ratiosKaplan-Meier methodNoninvasive bladder cancerRates of PFSProportional hazard ratiosAssociated with lower ratesFood and Drug Administration guidelinesBCG-unresponsiveDrug Administration guidelinesGemcitabine-docetaxelBCG therapyProgression-FreeAssociation of Homelessness and Unstable Housing With Cardiovascular Care Utilization Among Veterans
Sokoloff L, Wu J, Eberly L, Nathan A, Julien H, Kobayashi T, Damrauer S, Groeneveld P, Tsai J, Khatana S. Association of Homelessness and Unstable Housing With Cardiovascular Care Utilization Among Veterans. Circulation Cardiovascular Quality And Outcomes 2024, 17: e010993. PMID: 39492715, PMCID: PMC11576242, DOI: 10.1161/circoutcomes.124.010993.Peer-Reviewed Original ResearchEmergency department visitsCardiovascular disease managementDepartment visitsOutpatient visitsDisease managementCardiovascular diseaseUnstable housingRates of emergency department visitsDisproportionate burden of cardiovascular diseaseRate of outpatient visitsBurden of cardiovascular diseaseCardiovascular emergency department visitsAnnual outpatient visitsVeterans Affairs Corporate Data WarehouseAssociated with disparitiesRates of all-causeCorporate Data WarehouseChronic cardiovascular conditionsLogistic regression modelsCare accessCare utilizationInverse probability of treatment weightingAssociation of homelessnessAssociated with lower ratesCardiovascular careA Data-Driven Approach to Inguinal Hernia Repairs in Infants and Children
Hellmann Z, Shaughnessy M, Hornick M, Cowles R, Solomon D. A Data-Driven Approach to Inguinal Hernia Repairs in Infants and Children. Journal Of Laparoendoscopic & Advanced Surgical Techniques 2024, 34: 1128-1133. PMID: 39514238, DOI: 10.1089/lap.2024.0101.Peer-Reviewed Original ResearchInguinal hernia repairLaparoscopic inguinal hernia repairMetachronous contralateral herniaHernia repairOpen repairContralateral herniaCurrent Procedural TerminologyLaparoscopic repairRepair of bilateral herniasUnilateral inguinal hernia repairPediatric Health Information System databaseContralateral processus vaginalisPrimary laparoscopic repairHealth Information System databaseInfants 6 monthsPatients 6 monthsAssociated with lower ratesICD-10 procedure codeBilateral repairBilateral herniasProcessus vaginalisSurgical repairPatients 0Laparoscopic techniqueRecurrent herniaAssociation of patient socioeconomic status with outcomes after palliative treatment for disseminated cancer
Maduka R, Canavan M, Walters S, Ermer T, Zhan P, Kaminski M, Li A, Pichert M, Salazar M, Prsic E, Boffa D. Association of patient socioeconomic status with outcomes after palliative treatment for disseminated cancer. Cancer Medicine 2024, 13: e7028. PMID: 38711364, PMCID: PMC11074703, DOI: 10.1002/cam4.7028.Peer-Reviewed Original ResearchConceptsOptimal quality of careQuality of carePatient socioeconomic statusAssociated with improved qualityAssociated with improved quality of lifeEnd-of-lifeUS cancer populationPalliative treatmentQuality of lifeCox proportional hazards modelsMultivariate logistic regressionInformed decision makingProportional hazards modelFacility characteristicsNon-HispanicAssociated with lower ratesInsurance payer statusImproving informed decision makingCancer populationSocioeconomic statusHispanic ethnicityTreatment usePayer statusBlack raceLogistic regressionThrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data.
Chen H, Khunte M, Colasurdo M, Malhotra A, Gandhi D. Thrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data. Neurology 2024, 102: e209315. PMID: 38626383, PMCID: PMC11175628, DOI: 10.1212/wnl.0000000000209315.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhagePosterior cerebral arteryAssociated with higher oddsNational Inpatient SampleEndovascular thrombectomyHigher oddsMedical managementCohort studyFunctional independencePosterior cerebral artery strokeSafety of endovascular thrombectomyOdds of symptomatic intracranial hemorrhageAssociated with significantly higher ratesOxford Centre for Evidence-Based Medicine criteriaRates of in-hospital mortalityCentre for Evidence-Based Medicine criteriaMeta-analysisRate of ICHAssociated with different oddsHigher odds of deathRate of subarachnoid hemorrhageIn-Hospital MortalityAssociated with lower ratesClass III evidenceLevel of evidenceDapagliflozin and Mode of Death in Heart Failure With Improved Ejection Fraction
Vardeny O, Desai A, Jhund P, Fang J, Claggett B, de Boer R, Hernandez A, Inzucchi S, Kosiborod M, Lam C, Martinez F, Shah S, Mc Causland F, Petrie M, Vaduganathan M, McMurray J, Solomon S. Dapagliflozin and Mode of Death in Heart Failure With Improved Ejection Fraction. JAMA Cardiology 2024, 9: 283-289. PMID: 38265835, PMCID: PMC10809142, DOI: 10.1001/jamacardio.2023.5318.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionMode of deathEjection fractionCause-specific deathHeart failureCardiovascular deathNew York Heart Association class IIGuideline-directed medical therapyStudy case report formsSudden deathVentricular ejection fractionRate of sudden deathAssociated with lower ratesCox regression modelsImproved ejection fractionRandomized clinical trialsReduce cardiovascular mortalityCase report formsEnd-point committeeClinical end point committeePost Hoc AnalysisDapagliflozin EvaluationIV symptomsHFimpEFMedical therapy
2023
Use of Antipseudomonal Antibiotics is Not Associated With Lower Rates of Postoperative Drainage Procedures or More Favorable Culture Profiles in Children With Complicated Appendicitis
Cramm S, Graham D, Feng C, Allukian M, Blakely M, Chandler N, Cowles R, Kunisaki S, Lipskar A, Russell R, Santore M, Campbell B, Commander S, DeFazio J, Dukleska K, Echols J, Esparaz J, Gerall C, Griggs C, Hanna D, He K, Keane O, McLean S, Pace E, Scholz S, Sferra S, Tracy E, Zhang L, Rangel S, Network O. Use of Antipseudomonal Antibiotics is Not Associated With Lower Rates of Postoperative Drainage Procedures or More Favorable Culture Profiles in Children With Complicated Appendicitis. Annals Of Surgery 2023, 279: 1070-1076. PMID: 37970676, DOI: 10.1097/sla.0000000000006152.Peer-Reviewed Original ResearchConceptsComplicated appendicitisAntipseudomonal antibioticsDrainage proceduresPostoperative drainageSupplemental chart reviewRetrospective cohort studyAssociated with lower ratesMeasures of disease severityCompared to treatmentAntibiotic regimensNSQIP-Pediatric dataAntipseudomonal activityAntibiotic utilizationChart reviewCohort studyMulticenter dataAppendicitisCulture positivityDisease severityMultiple organsAntibioticsMixed-effects regressionPatientsLow rateCulture dataChanges in Opioid and Benzodiazepine Poisoning Deaths After Cannabis Legalization in the US: A County-level Analysis, 2002–2020
Castillo-Carniglia A, Rivera-Aguirre A, Santaella-Tenorio J, Fink D, Crystal S, Ponicki W, Gruenewald P, Martins S, Keyes K, Cerdá M. Changes in Opioid and Benzodiazepine Poisoning Deaths After Cannabis Legalization in the US: A County-level Analysis, 2002–2020. Epidemiology 2023, 34: 467-475. PMID: 36943813, PMCID: PMC10712490, DOI: 10.1097/ede.0000000000001609.Peer-Reviewed Original ResearchConceptsCannabis legalizationCannabis lawsRecreational cannabis lawsAvailability of cannabisMedical cannabis legalizationMedical cannabis lawsBenzodiazepine useBenzodiazepinesCannabisCannabis accessAssociated with higher ratesAssociated with increased deathAssociated with lower ratesOpioidSemi-synthetic opioidAssociated with fewer deathsSecondary analysisReducing opioidsCounty-level analysisAssociated with consistent reductionsPoisoning deathsLawRecreational dispensariesLegalitySynthetic opioidsCOVID-19 outcomes by cancer status, site, treatment, and vaccination
Salvatore M, Hu M, Beesley L, Mondul A, Pearce C, Friese C, Fritsche L, Mukherjee B. COVID-19 outcomes by cancer status, site, treatment, and vaccination. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 748-759. PMID: 36626383, DOI: 10.1158/1055-9965.epi-22-0607.Peer-Reviewed Original ResearchConceptsCOVID-19 outcomesCancer statusCancer diagnosisAssociated with higher ratesElectronic health record dataHealth record dataColorectal cancerIncreased riskAcademic medical centerKidney cancerCancer-free patientsIntensive care unit admissionCancer sitesAssociated with lower ratesChemotherapy receiptHigher RatesCOVID-19 precautionsRecord dataCOVID-19Logistic regressionMedical CenterUnit admissionRetrospective cohortVaccination statusLung cancer
2022
Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke
Bahit M, Vora A, Li Z, Wojdyla D, Thomas L, Goodman S, Aronson R, Jordan J, Kolls B, Dombrowski K, Vinereanu D, Halvorsen S, Berwanger O, Windecker S, Mehran R, Granger C, Alexander J, Lopes R. Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke. JAMA Cardiology 2022, 7: 682-689. PMID: 35612866, PMCID: PMC9134037, DOI: 10.1001/jamacardio.2022.1166.Peer-Reviewed Original ResearchConceptsVitamin K antagonistsAcute coronary syndromePercutaneous coronary interventionAtrial fibrillationTransient ischemic attackCRNM bleedingP2Y12 inhibitorsCoronary syndromeAssociated with numerically lower ratesIschemic eventsCoronary interventionEfficacy of apixabanHAS-BLED scoreNumerically lower ratesOral anticoagulant useRate of bleedingRisk of cerebrovascular ischemic eventsHigher CHA2DS2-VAScCox proportional hazards modelsCerebrovascular ischemic eventsAssociated with lower ratesRandomized clinical trialsProportional hazards modelHAS-BLEDK antagonists
2021
A Comparison of Clinical Outcomes of Endovascular Repair Versus Open Surgery for Ruptured Descending Thoracic Aorta
Xie X, Shu X, Zhang W, Guo D, Zhang W, Wang L, Fu W. A Comparison of Clinical Outcomes of Endovascular Repair Versus Open Surgery for Ruptured Descending Thoracic Aorta. Journal Of Endovascular Therapy 2021, 29: 307-318. PMID: 34779300, DOI: 10.1177/15266028211057087.Peer-Reviewed Original ResearchConceptsRe-intervention rateDescending Thoracic AortaOpen surgeryThoracic aortaRe-interventionPulmonary complicationsCardiac complicationsPerioperative mortalityPulmonary embolismAssociated with lower perioperative mortalityOdds ratioThoracic endovascular aortic repairYear mortalityEarly postoperative complicationsEndovascular aortic repairLow perioperative mortalityMeta-analysisRuptured thoracic aortaCochrane Library databasesAssociated with lower ratesConfidence intervalsTEVAR groupOS outcomesAortic repairPerioperative morbidityCharacterizing Prostate-Specific Antigen Levels at Death in Patients with Metastatic Castration-Resistant Prostate Cancer: Are We Underutilizing Imaging?
Bikkasani K, Qin Q, Zhong X, Lin J, Galsky M, Oh W, Tsao C. Characterizing Prostate-Specific Antigen Levels at Death in Patients with Metastatic Castration-Resistant Prostate Cancer: Are We Underutilizing Imaging? Clinical Genitourinary Cancer 2021, 19: e346-e351. PMID: 34011488, DOI: 10.1016/j.clgc.2021.04.003.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerProstate-specific antigen levelProstate-specific antigenCastration-resistant prostate cancerProstate cancerClinical outcomesDiagnosis of metastatic castration-resistant prostate cancerMetastatic castration-resistant prostate cancer patientsAssociated with lower Gleason scoreSingle-institution databaseHigher PSA levelsInstitutional review board approvalLow Gleason scoreClinical characteristics of diseaseReview board approvalMolecular phenotypic differencesAssociated with lower ratesDiagnosis to deathGenitourinary cancer patientsPSA levelsGleason scoreAntigen levelsPredictive biomarkersStratify patientsClinical characteristics
2020
Association of Antenatal Corticosteroids and Magnesium Sulfate Therapy With Neurodevelopmental Outcome in Extremely Preterm Children.
Gentle S, Carlo W, Tan S, Gargano M, Ambalavanan N, Chawla S, Bell E, Bann C, Hintz S, Heyne R, Tita A, Higgins R. Association of Antenatal Corticosteroids and Magnesium Sulfate Therapy With Neurodevelopmental Outcome in Extremely Preterm Children. Obstetrics And Gynecology 2020, 135: 1377-1386. PMID: 32459430, PMCID: PMC7278037, DOI: 10.1097/aog.0000000000003882.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesChild, PreschoolDatabases, FactualFemaleGestational AgeHumansInfantInfant MortalityInfant, Extremely PrematureInfant, NewbornLogistic ModelsMagnesium SulfateMaleNeurodevelopmental DisordersPregnancyPregnancy OutcomePrenatal CarePrenatal Exposure Delayed EffectsProspective StudiesUnited StatesConceptsSevere neurodevelopmental impairmentExposed to antenatal corticosteroidsExposure to antenatal corticosteroidsAntenatal corticosteroidsWeeks of gestationNeurodevelopmental impairmentMagnesium sulfateAssociation of antenatal corticosteroidsEunice Kennedy Shriver National Institute of Child HealthMagnesium sulfate therapyNational Institute of Child HealthInstitute of Child HealthAssociated with lower ratesExposure groupRate of deathPreterm childrenNeurodevelopmental outcomesLogistic regression modelsCorticosteroidsFollow-upPrimary outcomeSecondary outcomesTherapyGestationNetwork hospitalsInequity in selective referral to high-volume hospitals for genitourinary malignancies
Berg S, Tully K, Sahraoui A, Tan W, Krimphove M, Marchese M, Lipsitz S, Noldus J, Trinh Q. Inequity in selective referral to high-volume hospitals for genitourinary malignancies. Urologic Oncology Seminars And Original Investigations 2020, 38: 582-589. PMID: 32217041, DOI: 10.1016/j.urolonc.2020.02.013.Peer-Reviewed Original ResearchConceptsHigh-volume hospitalsBladder cancerPredictors of treatmentCancer patientsRadical prostatectomyProstate cancerMuscle-invasive urothelial bladder cancerNegative predictors of treatmentBlack raceNational Cancer DatabaseNonmetastatic prostate cancerUrothelial bladder cancerProstate cancer patientsBladder cancer patientsMultivariate logistic regression modelAssociated with lower ratesKidney cancer patientsPrivate insurance statusAssociated with lower oddsAssociated with greater oddsLow-volume hospitalsRadical cystectomyReceipt of treatmentGenitourinary malignanciesPerioperative morbidityEarly tracheostomy in patients with cervical spine injury reduces morbidity and improves resource utilization
Khan M, Prabhakaran K, Jehan F, Anderson P, Con J, Lombardo G, Rhee P, Latifi R. Early tracheostomy in patients with cervical spine injury reduces morbidity and improves resource utilization. The American Journal Of Surgery 2020, 220: 773-777. PMID: 32057414, DOI: 10.1016/j.amjsurg.2020.01.054.Peer-Reviewed Original ResearchConceptsShorter duration of mechanical ventilationDuration of mechanical ventilationC-spine injuriesEarly tracheostomyC-spineMechanical ventilationAssociated with shorter durationVentilator-associated pneumoniaAssociated with shorter duration of mechanical ventilationVentilator-associated-pneumoniaTiming of tracheostomyAssociated with lower ratesImpact of early tracheostomyRegression analysisCervical-spineMedian ISSMean ageTrauma patientsPatientsTracheostomyMortality rateICUHospitalShort durationInjury
2019
Impact of Age and Life-expectancy on Treatment Receipt in High-risk Prostate Cancer
Fei K, Lin J, Supoyo S, Franco R, Abramson S, Hoke G, Oh W, Stock R, Bickell N. Impact of Age and Life-expectancy on Treatment Receipt in High-risk Prostate Cancer. Journal Of Advances In Medicine And Medical Research 2019, 1-9. DOI: 10.9734/jammr/2019/v30i1130248.Peer-Reviewed Original ResearchHigh-risk prostate cancer patientsHigh-risk prostate cancerProstate cancer patientsProstate cancerTreatment decision-makingTreatment of high-risk prostate cancerHigh-risk localized prostate cancerCancer patientsClinically Significant Prostate CancerIncidence of prostate cancerImpact treatment decision-makingAndrogen deprivation therapySignificant prostate cancerLocalized prostate cancerOlder menAssociated with lower ratesMedical conditionsLife expectancyTreatment receiptPatient's life expectancyType of treatmentSurgical receiptDeprivation therapyRadical prostatectomyDefinitive therapyPrescription Drug Monitoring Programs and Opioid Overdoses
Castillo-Carniglia A, Ponicki W, Gaidus A, Gruenewald P, Marshall B, Fink D, Martins S, Rivera-Aguirre A, Wintemute G, Cerdá M. Prescription Drug Monitoring Programs and Opioid Overdoses. Epidemiology 2019, 30: 212-220. PMID: 30721165, PMCID: PMC6437666, DOI: 10.1097/ede.0000000000000950.Peer-Reviewed Original ResearchConceptsPrescription drug monitoring programsOnline prescription drug monitoring programsDrug monitoring programsNoncancer pain conditionsPrescription opioid overdoseMedication accessPain conditionsOpioid overdoseRate of hospital dischargeCounty-level ratesPrescription opioidsHeroin overdoseCounty levelRates of hospitalizationOpioid-related hospitalizationsAssociated with lower ratesMedical providersReduce harmHospital dischargeCounty-levelHierarchical Poisson modelsPrescriptionOpioidPoisson modelHospital
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