2025
Serum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study
Hinchcliff M, Khanna D, De Lorenzis E, Di Donato S, Carriero A, Ross R, Huang S, Aren K, Bernstein E, Carns M, Castelino F, Domsic R, Frech T, Gordon J, Hant F, Shah A, Shanmugam V, Steen V, Assassi S, Del Galdo F. Serum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study. The Lancet Rheumatology 2025, 7: e403-e414. PMID: 40179922, PMCID: PMC12107440, DOI: 10.1016/s2665-9913(24)00403-x.Peer-Reviewed Original ResearchConceptsDiffuse cutaneous systemic sclerosisCutaneous systemic sclerosisHealth Assessment Questionnaire-Disability IndexForced Vital CapacitySystemic sclerosisRetrospective cohort studyHealthy controlsIFN scoreIncident cohortDisease activityCohort studyModified Rodnan skin scoreCumulative 5-year mortalityEarly systemic sclerosisRodnan skin scoreSevere systemic sclerosisBaseline forced vital capacityMedian disease durationCohort of patientsDisease activity biomarkersHigh disease activityShorter median disease durationMinimal Clinically Important DifferenceKennedy Trust for Rheumatology ResearchConcentrations of CCL2Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults
Guo X, Ren H, Zhang J, Ma X, Tong S, Tang S, Mao C, Shi X. Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults. Biomedical And Environmental Sciences 2025, 38: 144-153. PMID: 40159168, DOI: 10.3967/bes2025.015.Peer-Reviewed Original ResearchConceptsLung functionInflammatory factorsIL-13Hormone groupThyroid hormonesEffects of IL-2Organochlorine exposureHealthy older adultsInterleukin (IL)-2Thyroid hormone levelsAssociated with forced vital capacityOlder adultsForced Vital CapacityIL-7IL-2Hormone levelsIL-8Wearable passive samplersEffects of organochlorinesAssociated with changesVital capacityLungMediation analysisParticipants' lung functionBlood samplesIdentifying Daytime Hypercapnia Using Transcutaneous Carbon Dioxide Monitoring in Patients With Amyotrophic Lateral Sclerosis
Morrison A, Jimenez J, Hsu J, Elman L, Choi P, Ackrivo J. Identifying Daytime Hypercapnia Using Transcutaneous Carbon Dioxide Monitoring in Patients With Amyotrophic Lateral Sclerosis. Muscle & Nerve 2025, 71: 611-619. PMID: 39936179, PMCID: PMC11887530, DOI: 10.1002/mus.28366.Peer-Reviewed Original ResearchConceptsPulmonary function testsMaximum inspiratory pressureForced Vital CapacityDaytime hypercapniaAmyotrophic lateral sclerosisClinical significanceValues of maximum inspiratory pressurePrevalence of hypercapniaTranscutaneous carbon dioxide monitoringTranscutaneous carbon dioxideRate of deathRespiratory failureCause of deathLateral sclerosisRetrospective studyProspective studyAmyotrophic lateral sclerosis clinicInspiratory pressurePatient's symptomsFunction testsClinical rolePatientsVital capacityHypercapniaCarbon dioxide monitoringContinued Treatment with Nintedanib in Patients with Progressive Pulmonary Fibrosis: Data from INBUILD-ON
Wuyts W, Bonella F, Chaudhuri N, Varone F, Antin-Ozerkis D, Song J, Miede C, Dumistracel M, Coeck C, Cottin V. Continued Treatment with Nintedanib in Patients with Progressive Pulmonary Fibrosis: Data from INBUILD-ON. Lung 2025, 203: 25. PMID: 39789408, PMCID: PMC11717875, DOI: 10.1007/s00408-024-00778-z.Peer-Reviewed Original ResearchConceptsProgressive pulmonary fibrosisForced Vital CapacityAdverse eventsSafety profilePulmonary fibrosisConclusionThe safety profileDiscontinuation of nintedanibExposure to nintedanibSafety of nintedanibOpen-label extensionBaseline to weekFrequent adverse eventsFatal adverse eventsLong-term treatmentLonger-term treatmentNintedanib groupGastrointestinal eventsINBUILD trialNintedanibMethodsAdverse eventsModerate severityPatientsContinuous treatmentVital capacityINBUILD
2024
Assessing Respiratory Function in the Patient with Neuromuscular Disease
Jimenez J, Choi P. Assessing Respiratory Function in the Patient with Neuromuscular Disease. Respiratory Medicine 2024, 37-57. DOI: 10.1007/978-3-031-65335-3_2.Peer-Reviewed Original ResearchSniff nasal inspiratory pressureSlow vital capacityMuscle force testsForced Vital CapacityEvaluation of diaphragm functionVital capacityRespiratory functionAccessory muscle useRespiratory muscle strengthNasal inspiratory pressureAbnormal breathing patternsHistory of symptomsNeuromuscular diseaseLongitudinal assessmentSimple spirometryNoninvasive ventilationDiaphragm functionInspiratory pressurePhysical examinationBlood carbon dioxideBreathing patternPatientsMuscle strengthMuscle useSpirometryPersonal exposure to airborne organic pollutants and lung function changes among healthy older adults
Guo X, Ren H, Sun P, Ding E, Fang J, Fang K, Ma X, Li C, Li C, Xu Y, Cao K, Lin E, Guo P, Pollitt K, Tong S, Tang S, Shi X. Personal exposure to airborne organic pollutants and lung function changes among healthy older adults. Environmental Research 2024, 258: 119411. PMID: 38876423, DOI: 10.1016/j.envres.2024.119411.Peer-Reviewed Original ResearchCross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana
Laskaris Z, O'Neill M, Batterman S, Mukherjee B, Fobil J, Robins T. Cross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana. Frontiers In Public Health 2024, 12: 1368112. PMID: 38784567, PMCID: PMC11111984, DOI: 10.3389/fpubh.2024.1368112.Peer-Reviewed Original ResearchConceptsE-waste workersExposure to particulate matterE-wasteParticulate matterAgbogbloshie e-waste siteInhalation exposure to particulate matterE-waste sitesBurning e-wasteConcentrations of PMHealth-based guidelinesExposure to airborne pollutantsExposure to PMOccupational exposure to particulate matterCross-shift changesElectronic-wasteForced Vital CapacityPersonal PMPM exposureAirborne pollutantsLinear mixed modelsBreathing zone concentrationsPulmonary functionComparison populationRecovery workersMixed modelsExploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function
Seo J, Gaddis N, Patchen B, Xu J, Barr R, O’Connor G, Manichaikul A, Gharib S, Dupuis J, North K, Cassano P, Hancock D. Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function. American Journal Of Clinical Nutrition 2024, 119: 1227-1237. PMID: 38484975, PMCID: PMC11130669, DOI: 10.1016/j.ajcnut.2024.03.007.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide interactionsGWAS meta-analysesGenome-wide genotypingGenetic variant associationsPathway enrichment analysisGenetic architectureVariant associationsP38 MAPK pathwayAssociation studiesGene-environment interactionsBiological insightsGenetic variantsEnrichment analysisVariant signalsMeta-analyzed resultsMAPK pathwayBiological relevancePathwayForced Vital CapacityEvaluate interactive effectsMeta-analysesVariantsSmoking historyAssociated with FEV<sub>1</sub> an
2023
A systematic review and meta‐analysis of long‐term sequelae of COVID‐19 2‐year after SARS‐CoV‐2 infection: A call to action for neurological, physical, and psychological sciences
Rahmati M, Udeh R, Yon D, Lee S, Dolja‐Gore X, McEVoy M, Kenna T, Jacob L, Sánchez G, Koyanagi A, Shin J, Smith L. A systematic review and meta‐analysis of long‐term sequelae of COVID‐19 2‐year after SARS‐CoV‐2 infection: A call to action for neurological, physical, and psychological sciences. Journal Of Medical Virology 2023, 95: e28852. PMID: 37288652, DOI: 10.1002/jmv.28852.Peer-Reviewed Original ResearchConceptsSystematic reviewConfidence intervalsMeta-analysisPooled effect sizeRisk of long COVIDHealth-related consequencesPotential risk factorsPre-existing medical comorbiditiesComprehensive Meta-AnalysisLong-term sequelaeCOVID-19 survivorsEvent ratesPsychological sequelaeSleep difficultiesEffect sizeIntervention strategiesForced Vital CapacityRisk factorsMedical comorbiditiesSARS-CoV-2 infectionLongitudinal trajectoriesRisk of long-term sequelaeHigh riskLong COVIDCOVID-19
2020
Safety and efficacy of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis and carrying a telomere-related gene mutation
Justet A, Klay D, Porcher R, Cottin V, Ahmad K, Molina Molina M, Nunes H, Reynaud-Gaubert M, Naccache J, Manali E, Froidure A, Jouneau S, Wemeau L, Andrejak C, Gondouin A, Hirschi S, Blanchard E, Bondue B, Bonniaud P, Tromeur C, Prévot G, Marchand-Adam S, Funke-Chambour M, Gamez A, Ba I, Papiris S, Grutters J, Crestani B, van Moorsel C, Kannengiesser C, Borie R. Safety and efficacy of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis and carrying a telomere-related gene mutation. European Respiratory Journal 2020, 57: 2003198. PMID: 33214205, DOI: 10.1183/13993003.03198-2020.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosis patientsIdiopathic pulmonary fibrosisTelomere-related genesDecline of forced vital capacityFamilial pulmonary fibrosisInterstitial lung diseaseForced Vital CapacityPulmonary fibrosisGene mutationsSporadic idiopathic pulmonary fibrosisEfficacy of nintedanibEfficacy of pirfenidoneEffect of pirfenidoneGermline pathogenic variationOccurrence of idiopathic pulmonary fibrosisFVC declineRetrospective studyProspective studyAssess safetyNintedanibLung diseasePirfenidoneFamilial occurrencePatientsGenetic susceptibility traitsGenetically Determined Omega-3 Polyunsaturated Fatty Acids and Lung Function: A Mendelian Randomization Analysis
Patchen B, Xu J, Hancock D, Cassano P. Genetically Determined Omega-3 Polyunsaturated Fatty Acids and Lung Function: A Mendelian Randomization Analysis. Current Developments In Nutrition 2020, 4: nzaa061_101. PMCID: PMC7259102, DOI: 10.1093/cdn/nzaa061_101.Peer-Reviewed Original ResearchAssociated with FEV1Multivariable MRMendelian randomizationForced Vital CapacityHeart and Aging ResearchInverse variance weighted methodHealth training programsMendelian randomization analysisVariance weighted methodGenome-wide association dataImprove causal inferenceCross-sectional studyLung functionNational InstituteWald ratioDigestive and Kidney DiseasesSample MRUnivariable MREpidemiology ConsortiumUK BiobankResidual confoundingNational Institute of DiabetesRandomization analysisTraining programForced expiratory volume
2019
Positive Associations of Dietary Marine Omega-3 Polyunsaturated Fatty Acids with Lung Function: A Meta-analysis (P18-087-19)
Patchen B, Xu J, Barr R, van Eekelen E, Dupuis J, North K, Gharib S, Lahousse L, Lemaitre R, Manichaikul A, de Mutsert R, Houston D, Saccone N, Steffen L, Terzikhan N, Xu H, Wojczynski M, Hancock D, Cassano P. Positive Associations of Dietary Marine Omega-3 Polyunsaturated Fatty Acids with Lung Function: A Meta-analysis (P18-087-19). Current Developments In Nutrition 2019, 3: nzz039.p18-087-19. PMCID: PMC6579416, DOI: 10.1093/cdn/nzz039.p18-087-19.Peer-Reviewed Original ResearchForced Vital CapacityN-3 PUFAFormer smokersLung functionHeart and Aging ResearchMeta-analysisAlpha-linolenic acidDietary intakeFish intakeGenomic Epidemiology ConsortiumFixed-effect meta-analysisPositive associationAssociated with forced expiratory volumeAssociated with higher lung functionHigher forced vital capacityDocosahexaenoic acidSD higher intakeAssociated with FEV1Higher lung functionDocosapentaenoic acidEicosapentanoic acidMarine n-3 PUFADietary n-3 PUFASmoking status interactionAssociation of docosahexaenoic acid
2018
Performance of Forced Vital Capacity and Lung Diffusion Cutpoints for Associated Radiographic Interstitial Lung Disease in Systemic Sclerosis
Showalter K, Hoffmann A, Rouleau G, Aaby D, Lee J, Richardson C, Dematte J, Agrawal R, Chang RW, Hinchcliff M. Performance of Forced Vital Capacity and Lung Diffusion Cutpoints for Associated Radiographic Interstitial Lung Disease in Systemic Sclerosis. The Journal Of Rheumatology 2018, 45: 1572-1576. PMID: 30275265, PMCID: PMC6214765, DOI: 10.3899/jrheum.171362.Peer-Reviewed Original ResearchConceptsScl-70 autoantibodiesPulmonary function testsNegative predictive valueInterstitial lung diseaseSSc-ILDVital capacityLung diseaseSystemic sclerosis-associated interstitial lung diseaseRadiographic interstitial lung diseaseHigh negative predictive valueReceiver-operating characteristic curveForced Vital CapacityILD evaluationChest HRCTSystemic sclerosisFunction testsTomography scanAmerican CollegeFVCDLCOPatientsAutoantibodiesPredictive valueSSc criteriaThoracic radiologistsMeta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function
Xu J, Bartz T, Chittoor G, Eiriksdottir G, Manichaikul A, Sun F, Terzikhan N, Zhou X, Booth S, Brusselle G, de Boer I, Fornage M, Frazier-Wood A, Graff M, Gudnason V, Harris T, Hofman A, Hou R, Houston D, Jacobs D, Kritchevsky S, Latourelle J, Lemaitre R, Lutsey P, O’Connor G, Oelsner E, Pankow J, Psaty B, Rohde R, Rich S, Rotter J, Smith L, Stricker B, Voruganti V, Wang T, Zillikens M, Barr R, Dupuis J, Gharib S, Lahousse L, London S, North K, Smith A, Steffen L, Hancock D, Cassano P. Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. British Journal Of Nutrition 2018, 120: 1159-1170. PMID: 30205856, PMCID: PMC6263170, DOI: 10.1017/s0007114518002180.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAgingBlack or African AmericanBlack PeopleCross-Sectional StudiesFemaleForced Expiratory VolumeGenome, HumanHeartHeart DiseasesHumansLungLung DiseasesMaleMiddle AgedMolecular EpidemiologyProspective StudiesRegression AnalysisRespiratory Function TestsSmokingVital CapacityVitamin DWhite PeopleConceptsHeart and Aging ResearchForced Vital CapacityEuropean ancestryVitamin DNever smokersMeta-analysisAfrican ancestryHigher 25(OH)DPulmonary functionGenomic Epidemiology ConsortiumSerum 25-hydroxyvitamin DAssociation of serum vitamin DSerum vitamin DEpidemiology ConsortiumForced expiratory volumeEffect modificationFormer smokersSmoking statusSerum 25(OH)DVulnerable populationsAging ResearchSmokersEpidemiological studiesExpiratory volumeVital capacityEffect of Recombinant Human Pentraxin 2 vs Placebo on Change in Forced Vital Capacity in Patients With Idiopathic Pulmonary Fibrosis: A Randomized Clinical Trial
Raghu G, van den Blink B, Hamblin MJ, Brown AW, Golden JA, Ho LA, Wijsenbeek MS, Vasakova M, Pesci A, Antin-Ozerkis DE, Meyer KC, Kreuter M, Santin-Janin H, Mulder GJ, Bartholmai B, Gupta R, Richeldi L. Effect of Recombinant Human Pentraxin 2 vs Placebo on Change in Forced Vital Capacity in Patients With Idiopathic Pulmonary Fibrosis: A Randomized Clinical Trial. JAMA 2018, 319: 2299-2307. PMID: 29800034, PMCID: PMC6134440, DOI: 10.1001/jama.2018.6129.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPentraxin 2Placebo groupPulmonary fibrosisWeek 28FVC percentageWalk distanceLung volumeProgressive fibrotic lung diseaseEnd pointVital capacity percentageCommon adverse eventsPlacebo-controlled trialPrimary end pointSecondary end pointsFibrotic lung diseaseForced Vital CapacityTotal lung volumeSignificant treatment differencesEligible patientsMeasurements of DLCOStudy drugAdverse eventsLung functionPoor prognosisSafety and efficacy of pirfenidone in patients carrying telomerase complex mutation
Justet A, Thabut G, Manali E, Molina M, Kannengiesser C, Cadranel J, Cottin V, Gondouin A, Nunes H, Magois E, Tromeur C, Prevot G, Papiris S, Marchand-Adam S, Gamez A, Reynaud-Gaubert M, Wemeau L, Crestani B, Borie R. Safety and efficacy of pirfenidone in patients carrying telomerase complex mutation. European Respiratory Journal 2018, 51: 1701875. PMID: 29449422, DOI: 10.1183/13993003.01875-2017.Peer-Reviewed Original ResearchConceptsFamilial pulmonary fibrosisIdiopathic pulmonary fibrosisEfficacy of pirfenidoneMutation carriersForced Vital CapacityRetrospective studyPulmonary fibrosisTreatment of idiopathic pulmonary fibrosisReduced FVC declineProgression-free survivalMulticentre retrospective studyEffect of pirfenidoneLung function declineTERC mutationsFVC declineMultidisciplinary diagnosisAssociated with bloodPatient carriersFrequent mutationsPirfenidoneSynthetic androgenDiffusing capacitySkin disordersPatientsVital capacity
2017
[18F]FDG PET/CT predicts progression-free survival in patients with idiopathic pulmonary fibrosis
Justet A, Laurent-Bellue A, Thabut G, Dieudonné A, Debray M, Borie R, Aubier M, Lebtahi R, Crestani B. [18F]FDG PET/CT predicts progression-free survival in patients with idiopathic pulmonary fibrosis. Respiratory Research 2017, 18: 74. PMID: 28449678, PMCID: PMC5408423, DOI: 10.1186/s12931-017-0556-3.Peer-Reviewed Original ResearchConceptsStandardized uptake value maxStandardized uptake valueProgression-free survivalStandardized uptake value meanHigh-resolution CTForced Vital CapacityRisk of deathSUV meanIPF patientsPulmonary fibrosisAssociated with progression-free survivalSingle-center retrospective studyMultivariate Cox proportional-hazards modelSeverity of lung involvementAssessed clinical dataGastrointestinal neuroendocrine tumorsGround-glass scoreDisease activity markersIdiopathic pulmonary fibrosisBackgroundIdiopathic pulmonary fibrosisPredictors of deathCox proportional-hazards modelProportional-hazards modelHigher TLGIPF groupMeta‐Analysis of the Association of Omega‐3 Fatty Acids Biomarkers with Pulmonary Function
Xu J, Bartz T, Eiriksdottir G, Frazier‐Wood A, Gudnason V, Lahousse L, Manichaikul A, Rohde R, Sun F, Terzikhan N, Zhou X, Barr R, Brusselle G, Dupuis J, Gharib S, London S, North K, Psaty B, Smith A, Steffen L, Hancock D, Cassano P. Meta‐Analysis of the Association of Omega‐3 Fatty Acids Biomarkers with Pulmonary Function. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.167.5.Peer-Reviewed Original ResearchHigher forced vital capacityEA groupSmoking statusForced Vital CapacityNo significant associationMeta-analysisHeart and Aging ResearchEuropean ancestryAncestry groupsCohort-specific resultsFEV 1Genomic Epidemiology ConsortiumYears of cigarette smokingPopulation-based studyPlasma docosahexaenoic acidAfrican ancestryPulmonary function testsPulmonary functionEpidemiology ConsortiumEffect modificationNever smokersLinear regression modelsPack-yearsFEV 1 /FVCEffect estimates
2008
Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study
Lampe B, Park S, Robins T, Mukherjee B, Litonjua A, Amarasiriwardena C, Weisskopf M, Sparrow D, Hu H. Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study. Environmental Health Perspectives 2008, 116: 1226-1230. PMID: 18795167, PMCID: PMC2535626, DOI: 10.1289/ehp.11265.Peer-Reviewed Original ResearchConceptsSmoking statusCommunity-based study of agingAssessed effect modificationForced Vital CapacityPulmonary functionCommunity-based studyAssociated with forced expiratory volumeStudy of agingFEV(1)/FVC ratioCadmium exposureUrinary cadmiumNormative Aging StudyEffect modificationEnvironmental cadmium exposureLevels of cadmium exposureAssociated with reduced pulmonary functionTests of pulmonary functionMixed-effects modelsAging StudyChronic cadmium exposureSmokingCadmium body burdenForced expiratory volumeCigarette smokingLog unit increase
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