2025
Acute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021
Koo A, Zhou L, Hameed I, Rivier C, Clocchiatti-Tuozzo S, Kamel H, Falcone G, Ney J, Sharma R, Matouk C, Yaghi S, Sheth K, de Havenon A. Acute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021. Neurology 2025, 105: e213766. PMID: 40493873, PMCID: PMC12165311, DOI: 10.1212/wnl.0000000000213766.Peer-Reviewed Original ResearchConceptsIntervention hospitalsSurvey weightsNon-Hispanic black ethnicityNIH Stroke ScaleStroke riskIschemic strokeFactors associated with ischemic strokeAssociated with female sexCardiac interventionsIschemic stroke riskIncidence of ischemic strokeVariables associated with riskRate of ischemic strokeNational Inpatient SampleHigh-risk populationDiagnosis-related groupsIntervention patientsCross-sectional cohortUnited StatesAcute ischemic stroke riskIn-Hospital DeathRisk of strokeSecondary analysisBlack ethnicityInpatient mortalityIncidence Trends and Risk of Recurrent Stroke of Cervical Artery Dissections in the United States Between 2005 and 2019
Shu L, Strelecky L, de Havenon A, Nguyen T, Henninger N, Keser Z, Khan M, Siegler J, Penckofer M, Omran S, Field T, Zhou L, Xiao H, Jacobson A, Goldstein E, Stretz C, Khan F, Perelstein E, Furie K, Yaghi S. Incidence Trends and Risk of Recurrent Stroke of Cervical Artery Dissections in the United States Between 2005 and 2019. Neurology 2025, 104: e213548. PMID: 40173376, PMCID: PMC11966527, DOI: 10.1212/wnl.0000000000213548.Peer-Reviewed Original ResearchConceptsAverage annual percent changeClinical Modification</i>State-level dataAcute ischemic strokeIncidence trendsUS Census dataCervical artery dissectionVertebral artery dissectionArtery dissectionRacial minoritiesCensus dataAnnual percent changeUnique patient identifiersSecondary prevention strategiesRisk of ischemic strokeIschemic stroke riskIschemic strokeHispanic populationRisk of acute ischemic strokeCeAD casesNational Inpatient SampleConcurrent acute ischemic strokeJoinpoint regressionEstimated annual incidenceAcute ischemic stroke riskObstructive Sleep Apnea is Associated With Increased Rates of Acute Respiratory Failure, Length of Stay, and Hospital Costs in Patients Undergoing Elective Single-Level Anterior Cervical Discectomy and Fusion.
Mastrokostas P, Said M, Cassar C, Mastrokostas L, Lavi A, Varthi A, Bou Monsef J, Razi A, Ng M. Obstructive Sleep Apnea is Associated With Increased Rates of Acute Respiratory Failure, Length of Stay, and Hospital Costs in Patients Undergoing Elective Single-Level Anterior Cervical Discectomy and Fusion. Global Spine Journal 2025, 21925682251333324. PMID: 40152967, PMCID: PMC11954374, DOI: 10.1177/21925682251333324.Peer-Reviewed Original ResearchObstructive sleep apneaRates of acute respiratory failureSingle-level anterior cervical discectomyLength of staySingle-level ACDFAcute respiratory failureAnterior cervical discectomyNational Inpatient SampleSleep apneaCervical discectomyRespiratory failureHospital costsAssociated with increased respiratory complicationsObstructive sleep apnea cohortObstructive sleep apnea patientsYear of surgeryProlonged length of stayAssociated with increased ratesHigh-risk populationHigher hospital costsMethodsThe National Inpatient SamplePropensity score matchingChi-square testPostoperative complicationsPostoperative outcomesRacial and Ethnic Disparities in Ischemic Stroke Severity in the National Inpatient Sample Between 2018 and 2021
Fayed M, Peng T, Skolarus L, Sheth K, Wong K, de Havenon A. Racial and Ethnic Disparities in Ischemic Stroke Severity in the National Inpatient Sample Between 2018 and 2021. Stroke 2025, 56: 1290-1294. PMID: 40099374, DOI: 10.1161/strokeaha.124.048532.Peer-Reviewed Original ResearchConceptsNational Institutes of Health Stroke ScaleHealth Stroke ScaleNational Inpatient SampleStroke severityStroke ScaleAge- and sex-adjusted estimatesInpatient SampleIschemic stroke severityNational InstituteAcute ischemic strokeIschemic strokeNationally Representative SampleSelf-reported racePrimary discharge diagnosisNon-white raceAdult hospital dischargesHealth disparitiesHigher stroke severityEthnic disparitiesStroke dischargesLinear regression modelsHispanic patientsSocioeconomic factorsCharlson Comorbidity IndexEvaluate stroke severity
2024
Inflammatory bowel disease is associated with greater odds of complications following posterior lumbar fusion and further amplified for patients exposed to monoclonal antibody biologics
Seddio A, Katsnelson B, Smith-Voudouris J, Gouzoulis M, Day W, Jabbouri S, Vasudevan R, Rubio D, Grauer J. Inflammatory bowel disease is associated with greater odds of complications following posterior lumbar fusion and further amplified for patients exposed to monoclonal antibody biologics. North American Spine Society Journal (NASSJ) 2024, 20: 100574. PMID: 39759221, PMCID: PMC11697407, DOI: 10.1016/j.xnsj.2024.100574.Peer-Reviewed Original ResearchPosterior lumbar fusionInflammatory bowel diseaseOdds ratioNational Inpatient SampleElixhauser Comorbidity IndexLumbar fusionBowel diseaseKaplan-Meier survival analysisEmergency departmentInflammatory bowel disease patientsLog-rank testMinor adverse eventsNon-IBD patientsIn-hospital dataMultivariate logistic regressionAssociated with greater oddsElevated odds ratiosReoperation rateSurgical complicationsSpine surgeryInferior outcomesPearlDiver databasePost-discharge outcomesAdult patientsAdverse eventsS2118 Association Between Congenital Birth Defects and Development of MASH Cirrhosis: Insights From the National Inpatient Sample
Boateng S, Ezeani C, Ameyaw P, Njei B. S2118 Association Between Congenital Birth Defects and Development of MASH Cirrhosis: Insights From the National Inpatient Sample. The American Journal Of Gastroenterology 2024, 119: s1512-s1513. DOI: 10.14309/01.ajg.0001037840.47400.fc.Peer-Reviewed Original ResearchHospital Transfers for Digit Replants as Cost Saving and Safe While Access to Replantation Procedures Remains Limited
Hauc S, Ihnat J, Hu K, Parikh N, Rivera J, Alperovich M. Hospital Transfers for Digit Replants as Cost Saving and Safe While Access to Replantation Procedures Remains Limited. Annals Of Plastic Surgery 2024, 93: 597-600. PMID: 39293070, DOI: 10.1097/sap.0000000000004099.Peer-Reviewed Original ResearchHospital transferTraumatic finger amputationsNational Inpatient SampleIncome quartileReplantation outcomesImprove health equityPatient factorsFinger amputationsHealth equityAmputation patientsChronic conditionsHospital characteristicsInjury characteristicsAttempted replantationHispanic patientsFinger replantationReplantation success rateInpatient SampleLogistic regressionWhite patientsTop income quartileAmputationOlder ageHospitalPatient genderAtrial Fibrillation: Prevalence and Association With Outcome in Patients With Stroke Undergoing Mechanical Thrombectomy in the United States
Otite F, Patel S, Hoffman H, Aneni E, Anikpezie N, Akano E, Wee C, Burke D, Albright K, Beutler T, Latorre J, Sonig A, Singla A, Morris N, Chaturvedi S, Khandelwal P. Atrial Fibrillation: Prevalence and Association With Outcome in Patients With Stroke Undergoing Mechanical Thrombectomy in the United States. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.123.001248.Peer-Reviewed Original ResearchAcute ischemic strokeAF prevalenceJoinpoint regressionAtrial fibrillationIn-Hospital DeathIn-Hospital OutcomesMechanical thrombectomyDemographic subgroupsMultivariable-adjusted generalized linear modelsDemographic subgroups of patientsOdds of in-hospital deathCross-sectional studyNegative binomial regressionPrevalence of atrial fibrillationRoutine home dischargeNational Inpatient SampleAcute ischemic stroke populationAssociation of AFUnited StatesSubgroup of patientsHome dischargeBinomial regressionMultivariable adjustmentRacial subgroupsInpatient SampleEndovascular thrombectomy versus medical management for acute basilar artery occlusion stroke in the elderly
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Endovascular thrombectomy versus medical management for acute basilar artery occlusion stroke in the elderly. American Journal Of Neuroradiology 2024, 46: ajnr.a8473. PMID: 39181691, PMCID: PMC11878975, DOI: 10.3174/ajnr.a8473.Peer-Reviewed Original ResearchPropensity score matchingBasilar artery occlusionIntracranial hemorrhageAssociated with higher ratesIn-Hospital MortalityEndovascular thrombectomyIntravenous thrombolysisMedical managementAssociated with increased risk of ICHTreated with medical managementPatients treated with endovascular thrombectomyRisk of intracranial hemorrhageSafety of endovascular thrombectomyBasilar artery occlusion strokeFavorable hospital outcomesTreated with intravenous thrombolysisHome dischargeAssociated with increased riskEndovascular thrombectomy groupArtery occlusion strokeNational Inpatient SampleNIH Stroke ScalePropensity score-matched controlsStroke patientsHigher RatesFor whom the bell tolls: assessing the incremental costs associated with failure to rescue after elective colorectal surgery
Schultz K, Moore M, Pantel H, Mongiu A, Reddy V, Schneider E, Leeds I. For whom the bell tolls: assessing the incremental costs associated with failure to rescue after elective colorectal surgery. Journal Of Gastrointestinal Surgery 2024, 28: 1812-1818. PMID: 39181234, DOI: 10.1016/j.gassur.2024.08.019.Peer-Reviewed Original ResearchFailure-to-rescueMedian total hospital costTotal hospital costsColorectal surgeryNational Inpatient SampleUneventful recoveryRetrospective study of adult patientsFailure-to-rescue patientsAssociated with increased healthcare costsStudy of adult patientsElective colorectal resectionHospital costsElective colorectal surgeryNationally Representative CohortColorectal resectionElective colectomyPostoperative complicationsRetrospective studyAdult patientsRescue attemptsMedical futilityElective surgeryRepresentative cohortHealthcare costsPrimary outcomeEndovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke
Chen H, Khunte M, Malhotra A, Gandhi D, Colasurdo M. Endovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke. Journal Of Neurology 2024, 271: 6247-6254. PMID: 39085619, DOI: 10.1007/s00415-024-12582-z.Peer-Reviewed Original ResearchAssociated with higher oddsAnterior cerebral arteryAssociated with higher ratesIntracranial hemorrhageEndovascular thrombectomyMedical managementHigher oddsEfficacy of endovascular thrombectomyFavorable short-term outcomesRetrospective cohort studyPatient selection criteriaShort-term outcomesEndovascular thrombectomy patientsIn-Hospital MortalityMultivariate logistic regressionHome dischargeArtery occlusion strokeNational Inpatient SampleHigher RatesNeurological outcomeCohort studyPrimary outcomeCerebral arterySecondary outcomesOcclusion strokeRacial, ethnic and sex disparity in acute heart failure patients with COVID-19: A nationwide analysis
Hashem A, Khalouf A, Mohamed M, Nayfeh T, Elkhapery A, Zahid S, Altibi A, Thyagaturu H, Kashou A, Anavekar N, Gulati M, Balla S. Racial, ethnic and sex disparity in acute heart failure patients with COVID-19: A nationwide analysis. Heliyon 2024, 10: e34513. PMID: 39157311, PMCID: PMC11327804, DOI: 10.1016/j.heliyon.2024.e34513.Peer-Reviewed Original ResearchAcute heart failureImpact of raceNational Inpatient SampleCOVID-19 infectionWhite malesHispanic malesDiagnosis of acute heart failureOutcomes of acute heart failureOdds of cardiac arrestAcute heart failure patientsCOVID-19Sex disparitiesWhite femalesOdds of in-hospital mortalityEthnicityRaceDisparitiesMultivariate logistic regression modelIn-Hospital MortalityIn-Hospital OutcomesHeart failure patientsLogistic regression modelsHispanic ethnicityHeart failureCardiac arrestRegional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis
Sayeed S, Theriault B, Hengartner A, Serrato P, Sadeghzadeh S, Belkasim S, Ahsan N, Elsamadicy E, DiLuna M, Elsamadicy A. Regional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis. Child's Nervous System 2024, 40: 3571-3580. PMID: 38955900, DOI: 10.1007/s00381-024-06514-5.Peer-Reviewed Original ResearchNational Inpatient SampleIntraoperative variablesLong-term neurodevelopmental outcomesLow gestational ageMultivariate logistic regression analysisPermanent CSF shuntNational database analysisLow birth weightPercentage of patientsRetrospective cohort studyAssociated with decreased oddsImpact of insurance statusAssociated with reduced oddsMedian total costAssociated with mortalityLogistic regression analysisBackgroundIntraventricular hemorrhageNeonatal IVHGestational ageIntraventricular hemorrhageNeurodevelopmental outcomesCSF diversionCSF shuntingCost of admissionBirth weightA Nationwide Analysis on Major Upper Extremity Amputations and Replantations.
Stögner V, Hauc S, Hosseini H, Williams M, Boroumand S, Huelsboemer L, Kauke-Navarro M, Pomahac B, Colen D. A Nationwide Analysis on Major Upper Extremity Amputations and Replantations. Hand 2024, 15589447241259189. PMID: 38907654, PMCID: PMC11571424, DOI: 10.1177/15589447241259189.Peer-Reviewed Original ResearchUpper extremity amputationExtremity amputationTraumatic upper extremity amputationsUtilization Project's National Inpatient SampleProportion of amputationsUrban teaching hospitalLevel of injuryNational Inpatient SampleNontraumatic amputationsUnited StatesHospital typeLength of stayInternational ClassificationTraumatic amputationHealthcare costsHighest burdenUpper extremityAlcohol useTeaching hospitalInpatient SamplePool of casesAmputationNational trendsNationwide analysisLow likelihoodAssociation of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) With an Increased Risk of Congestive Heart Failure in Hospitalized Patients With Cirrhosis: A Propensity Score-Matched Analysis
Ugwendum D, Mohamed M, Al-Ajlouni Y, Nso N, Njei B. Association of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) With an Increased Risk of Congestive Heart Failure in Hospitalized Patients With Cirrhosis: A Propensity Score-Matched Analysis. Cureus 2024, 16: e62441. PMID: 39011212, PMCID: PMC11249195, DOI: 10.7759/cureus.62441.Peer-Reviewed Original ResearchCongestive heart failureIn-Hospital MortalityCongestive heart failure riskOdds ratioMortality odds ratioCirrhotic patientsHeart failureClinical practice implicationsIn-patient mortalityLiver diseaseIncreased risk of congestive heart failureNational Inpatient SampleRisk of congestive heart failurePrevalence of congestive heart failureSteatotic liver diseaseHealth outcomesHospitalized cirrhotic patientsPost-matchPropensity Score Matching AnalysisHospital stay lengthStudy of patientsObese/overweight individualsInpatient SampleLogistic regressionDischarge statusAssociation Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock
Jamil Y, Park D, Rao S, Ahmad Y, Sikand N, Bosworth H, Coles T, Damluji A, Nanna M, Samsky M. Association Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock. JACC Advances 2024, 3: 100949. PMID: 38938859, PMCID: PMC11198471, DOI: 10.1016/j.jacadv.2024.100949.Peer-Reviewed Original ResearchAcute myocardial infarctionAMI-CSIn-Hospital OutcomesDo-not-resuscitate statusPatients admitted with acute myocardial infarctionOdds of in-hospital mortalitySkilled nursing facilityPrevalence of frailtyProportion of hospitalsAssociated with in-hospital outcomesIn-Hospital Adverse EventsCompare in-hospital outcomesRisk score cut-offNational Inpatient SampleNursing facilitiesIn-Hospital MortalityScore cut-offAssociated with adverse outcomesInpatient SampleFrailtyCardiogenic shockIn-hospital morbidityMyocardial infarction complicationsNonfrail groupOddsNationwide Assessment of Chronic Pain among Hospitalized Individuals with Co-occurring Post Traumatic Stress Disorder and Substance Use Disorder in the United States
Olayinka O, Alemu B, Nkemjika S, Barry D. Nationwide Assessment of Chronic Pain among Hospitalized Individuals with Co-occurring Post Traumatic Stress Disorder and Substance Use Disorder in the United States. Journal Of Dual Diagnosis 2024, 20: 340-349. PMID: 38704860, DOI: 10.1080/15504263.2024.2347489.Peer-Reviewed Original ResearchSubstance use disordersIncreased oddsChronic painPosttraumatic stress disorderNational Inpatient SampleIncreased odds of depressionFactors associated with CPIncreased risk of CPAssessment of chronic painOdds of depressionOdds of anxietyIncreased odds of anxietyMental health disordersRisk of CPMultivariate logistic regression modelOdds of insomniaManagement of CPLogistic regression modelsStress disorderAssociated with substance use disordersHospitalized AmericansEvidence-based managementPost-traumatic stress disorderHospital resource usageDecreased oddsImpact of anemia on outcomes and resource utilization in patients with myocardial infarction: A national database analysis
Jhand A, Abusnina W, Tak H, Ahmed A, Ismayl M, Altin S, Sherwood M, Alexander J, Rao S, Abbott J, Carson J, Goldsweig A. Impact of anemia on outcomes and resource utilization in patients with myocardial infarction: A national database analysis. International Journal Of Cardiology 2024, 408: 132111. PMID: 38697401, DOI: 10.1016/j.ijcard.2024.132111.Peer-Reviewed Original ResearchLength of stayNational Inpatient SampleMyocardial infarctionDiagnosis codesAnemic patientsAdverse eventsPatients admitted with MIAssociated with higher in-hospital mortalityAssociated with high mortalityAssociated with increased mortalityNational database analysisHigher In-Hospital MortalityAssociation of anemiaHigher mortalityImpact of anemiaIn-Hospital Adverse EventsPrimary diagnosis codeSecondary diagnosis codesLonger length of stayMultivariate logistic regressionIn-Hospital MortalityIn-Hospital OutcomesMI hospitalizationConcomitant anemiaBlood transfusionThrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data.
Chen H, Khunte M, Colasurdo M, Malhotra A, Gandhi D. Thrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data. Neurology 2024, 102: e209315. PMID: 38626383, PMCID: PMC11175628, DOI: 10.1212/wnl.0000000000209315.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhagePosterior cerebral arteryAssociated with higher oddsNational Inpatient SampleEndovascular thrombectomyHigher oddsMedical managementCohort studyFunctional independencePosterior cerebral artery strokeSafety of endovascular thrombectomyOdds of symptomatic intracranial hemorrhageAssociated with significantly higher ratesOxford Centre for Evidence-Based Medicine criteriaRates of in-hospital mortalityCentre for Evidence-Based Medicine criteriaMeta-analysisRate of ICHAssociated with different oddsHigher odds of deathRate of subarachnoid hemorrhageIn-Hospital MortalityAssociated with lower ratesClass III evidenceLevel of evidenceFrailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction
Park D, Jamil Y, Ahmad Y, Coles T, Bosworth H, Sikand N, Davila C, Babapour G, Damluji A, Rao S, Nanna M, Samsky M. Frailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction. Journal Of Clinical Medicine 2024, 13: 2078. PMID: 38610842, PMCID: PMC11012362, DOI: 10.3390/jcm13072078.Peer-Reviewed Original ResearchDo-not-resuscitate statusOdds of in-hospital mortalitySkilled nursing facilityIn-Hospital Adverse EventsRelationship of frailtyCompare in-hospital outcomesNon-frail groupRisk score cut-offNational Inpatient SampleAssociated with increased rates of morbidityNursing facilitiesMyocardial infarctionAssociated with increased ratesFrail adultsIn-Hospital MortalityIn-Hospital OutcomesAcute myocardial infarctionFrail groupScore cut-offFrailtyInpatient SampleCardiogenic shockRisk factorsCardiovascular diseaseHospital
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