2025
A sibling study of the prenatal and perinatal risks for cerebral palsy
Zhuo H, Rogne T, Liew Z. A sibling study of the prenatal and perinatal risks for cerebral palsy. Pediatric Research 2025, 1-8. PMID: 40316681, DOI: 10.1038/s41390-025-04055-4.Peer-Reviewed Original ResearchSibling comparison designCerebral palsyLow Apgar scoreMaternal pregnancy complicationsSibling designPerinatal factorsAssociated with CPApgar scoreComparison designPregnancy complicationsOdds ratioPreterm birthAttenuated to nullConfidence intervalsPre-pregnancy overweightLifestyle-related factorsCP riskSibling comparison studiesSibling-comparison designGestational ageMaternal cigarette smokingSingleton birthsCP etiologyInterpretation of findingsPre-pregnancySpatial single-cell analysis identifies placental villi structuraland immune remodeling across gestation
Velagala S, Phan L, Eke C, Fernandes A, Rice T, Olaloye O, Konnikova L. Spatial single-cell analysis identifies placental villi structuraland immune remodeling across gestation. Mucosal Immunology 2025 PMID: 40288579, DOI: 10.1016/j.mucimm.2025.04.005.Peer-Reviewed Original ResearchVascular smooth muscle cellsPlacental villiSmooth muscle cellsMid-gestationMyeloid-derived suppressor cellsMuscle cellsMechanisms of preterm birthMaternal immune systemInnate lymphoid cellsRare T cellsFull-term samplesTolerogenic statePreterm birthSuppressor cellsImmune remodelingPregnancy complicationsDendritic cellsActivation markersT cellsImaging Mass CytometryLymphoid cellsImmune populationsMacrophage subtypesSyncytial trophoblastImmune systemOccupational Prenatal Radiation Exposure and Occupational Safety: Position Paper for Pregnant and breastfeeding Personnel in Interventional Procedures with Ionizing Radiation
Becker L, Stein T, Frisch A, Dewald C, Blum S, Wintergerst C, Torsello G, Peperhove M, Pöhler G, Staudacher E, Franke M, Tritt S, Westphalen K, Bruners P, Rohde S, Gebauer B, Das M, Jungnickel K, Fiebich M, Katoh M, Paprottka P, Uder M, Wacker F, Uller W, Bruners P, Gebauer B, Katoh M, Paprottka P, Das M, Rohde S, Uller W, Wacker F, Westphalen K, Adam G, Antoch G, Bamberg F, Barkhausen J, Beer M, Bley T, Bücker A, Borggrefe J, Denecke T, Eisenblätter M, Forsting M, Hamm B, Heindel W, Hoffmann R, Jansen O, Kauczor H, Krombach G, Kröncke T, Kuhl C, Lotz J, Mahnken A, Maintz D, Makowski M, Maurer M, Nikolaou K, Pech M, Ricke J, Schönberg S, Schreyer A, Stroszczynski C, Teichgräber U, Uder M, Vogl T, Wacker F, Weber M, Wohlgemuth W. Occupational Prenatal Radiation Exposure and Occupational Safety: Position Paper for Pregnant and breastfeeding Personnel in Interventional Procedures with Ionizing Radiation. RöFo 2025 PMID: 40148103, DOI: 10.1055/a-2536-7206.Peer-Reviewed Original ResearchProtection lawRadiation protection lawPrenatal radiation exposureOccupational safety regulationsGerman legislationLegal frameworkSurgical professionOccupational SafetyRadiation exposureScientific CommissionCommissionSafety regulationsLawProtection measuresRisk of pregnancy complicationsProtectionIonizing RadiationInterventional proceduresInternational CommissionContext of pregnancyRelevant sourcesEffects of Atomic RadiationRisk assessmentSpecial attentionPregnancy complicationsBuprenorphine induces human fetal membrane sterile inflammation
Lynn T, Kelleher M, Georges H, McCauley E, Logan R, Yonkers K, Abrahams V. Buprenorphine induces human fetal membrane sterile inflammation. Journal Of Reproductive Immunology 2025, 168: 104445. PMID: 39914058, PMCID: PMC11890952, DOI: 10.1016/j.jri.2025.104445.Peer-Reviewed Original ResearchConceptsOpioid-use disorderPreterm birthToll-like receptor 4Prostaglandin E2Sterile inflammationRate of preterm birthAssociated with pregnancy complicationsInnate immune toll-like receptor 4Maternal-fetal interfaceNeutrophil chemokine IL-8Induce sterile inflammationM-opioid receptorCytokines IL-1bInflammatory cytokines IL-6Chemokine IL-8Cytokines IL-6Maternal morbidityPregnancy complicationsOpioid useOpioid-usersHuman FMInflammatory profileMembrane weakeningIL-1BPretermAssociations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two‐Sample Mendelian Randomization Analysis
de La Harpe R, Rogne T, Nyberg M, Cronjé H, Burgess S, Karhunen V, Gill D. Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two‐Sample Mendelian Randomization Analysis. International Journal Of Hypertension 2025, 2025: 9972031. PMID: 40406480, PMCID: PMC12097871, DOI: 10.1155/ijhy/9972031.Peer-Reviewed Original ResearchGenome-wide association studiesMendelian randomizationTwo-sample Mendelian randomization analysisRisk of preeclampsiaTwo-sample MR analysisGenetic association estimatesGenetic instrumental variablesPreeclampsia riskMendelian randomization analysisFemale participantsC-type natriuretic peptideIndividual-level dataEffects of C-type natriuretic peptideGenetic instrumentsMR analysisUK BiobankRandomization analysisAssociation estimatesMR paradigmAssociation studiesGenetic variantsPregnancy complicationsProtective effects of C-type natriuretic peptideTwo-sampleInstrumental variables
2024
Phenylalanine hydroxylase deficiency diagnosis and management: A 2023 evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG)
Smith W, Berry S, Bloom K, Brown C, Burton B, Demarest O, Jenkins G, Malinowski J, McBride K, Mroczkowski H, Scharfe C, Vockley J, Board of Directors A. Phenylalanine hydroxylase deficiency diagnosis and management: A 2023 evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG). Genetics In Medicine 2024, 27: 101289. PMID: 39630157, DOI: 10.1016/j.gim.2024.101289.Peer-Reviewed Original ResearchAmerican College of Medical Genetics and GenomicsRecent American College of Medical GeneticsPractice guidelinesEvidence-based clinical guidelinesEvidence-to-decision frameworkAmerican College of Medical GeneticsClinical practice guidelinesEvidence-based guidelinesPrevent pregnancy complicationsPhenylalanine hydroxylasePhenylalanine hydroxylase deficiencyIntellectual outcomeEvidence summaryStandard of careRecommendations AssessmentGuideline workgroupClinical guidelinesPregnancy complicationsSystematic reviewGenetic testingMedical GeneticsAmerican CollegeConfirm diagnosisPractice recommendationsPAH variants
2023
Effects of air pollution on adverse birth outcomes and pregnancy complications in the U.S. state of Kansas (2000–2015)
Hao H, Yoo S, Strickland M, Darrow L, D’Souza R, Warren J, Moss S, Wang H, Zhang H, Chang H. Effects of air pollution on adverse birth outcomes and pregnancy complications in the U.S. state of Kansas (2000–2015). Scientific Reports 2023, 13: 21476. PMID: 38052850, PMCID: PMC10697947, DOI: 10.1038/s41598-023-48329-5.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusAdverse birth outcomesLow birth weightGestational hypertensionBirth outcomesBirth weightPregnancy complicationsPreterm birthFirst trimesterRisk of GDMMaternal medical complicationsSingleton live birthsWeeks of pregnancyO3 exposureAdverse pregnancyPregnancy exposurePregnancy outcomesDiabetes mellitusMedical complicationsAdverse birthThird trimesterNeonatal mortalityResidential census tractsSocio-economic status factorsDiscrete-time survivalWomen with Preexisting CKD and a History of Preeclampsia Have a High Rate of Subsequent Pregnancy Complications but Are Seldom Linked to Adequate Care
Gupta S, Jim B, Golestaneh L. Women with Preexisting CKD and a History of Preeclampsia Have a High Rate of Subsequent Pregnancy Complications but Are Seldom Linked to Adequate Care. Journal Of The American Society Of Nephrology 2023, 34: 644-644. DOI: 10.1681/asn.20233411s1644d.Peer-Reviewed Original ResearchBirth weight influences cardiac structure, function, and disease risk: evidence of a causal association
Ardissino M, Morley A, Slob E, Schuermans A, Rayes B, Raisi-Estabragh Z, de Marvao A, Burgess S, Rogne T, Honigberg M, Ng F. Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association. European Heart Journal 2023, 45: 443-454. PMID: 37738114, PMCID: PMC10849320, DOI: 10.1093/eurheartj/ehad631.Peer-Reviewed Original ResearchLow birth weightAdverse intrauterine environmentCoronary artery diseaseBirth weightIntrauterine environmentCardiac structureArtery diseaseFoetal effectsCardiovascular disease prevention strategiesDisease riskAdverse cardiac structureCardiovascular disease riskCommon pregnancy complicationLower stroke volumeDisease prevention strategiesMendelian randomization studyBenjamini-Hochberg correctionPregnancy complicationsIschemic strokeHeart failureAtrial fibrillationCardiometabolic diseasesIntrauterine influencesStroke volumeCardiovascular diseaseAppraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association
Alexander B, South A, August P, Bertagnolli M, Ferranti E, Grobe J, Jones E, Loria A, Safdar B, Sequeira-Lopez M, Health O. Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association. Hypertension 2023, 80: e75-e89. PMID: 36951054, PMCID: PMC10242542, DOI: 10.1161/hyp.0000000000000227.Peer-Reviewed Original ResearchConceptsAldosterone systemCardiovascular healthCardiovascular diseaseLong-term cardiovascular healthAntenatal risk factorsRisk of hypertensionAdverse cardiovascular healthAmerican Heart AssociationMaternal-fetal healthTranslational research studiesPregnancy complicationsRenin-AngiotensinPreclinical evidenceComplicated pregnanciesPlacental interfaceHeart AssociationRisk factorsSystem dysregulationNovel therapiesClinical careRisk individualsHealth outcomesLife courseDiseaseScientific evidenceUse of family history of cardiovascular disease or chronic hypertension to better identify who needs postpartum cardiovascular risk screening
Ackerman-Banks C, Pudwell J, Lundsberg L, Lipkind H, Smith G. Use of family history of cardiovascular disease or chronic hypertension to better identify who needs postpartum cardiovascular risk screening. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 100850. PMID: 36640863, DOI: 10.1016/j.ajogmf.2022.100850.Peer-Reviewed Original ResearchConceptsPositive family historyFirst-degree family historyChronic hypertensionHypertensive disordersCardiovascular riskFamily historyCardiovascular diseaseUncomplicated pregnanciesControl individualsCardiovascular disease risk scoreBody mass indexDisease risk scoreFirst-degree relativesPregnancy complicationsTerm pregnancyMetabolic syndromeMass indexMyocardial infarctionHypertensionRisk scorePregnancyDiseaseIdentifies individualsDisordersRisk
2022
Circulating miRNAs in the first trimester and pregnancy complications: a systematic review
Subramanian A, Weiss D, Nyhan K, Dewan A, Jukic A. Circulating miRNAs in the first trimester and pregnancy complications: a systematic review. Epigenetics 2022, 18: 2152615. PMID: 36503407, PMCID: PMC9980650, DOI: 10.1080/15592294.2022.2152615.Peer-Reviewed Original ResearchConceptsPregnancy complicationsSystematic reviewFirst trimesterMiR-520hPlacental originMiR-518bFuture pregnancy complicationsMost pregnancy complicationsFirst-trimester serumFirst trimester biomarkersPotential early biomarkersGestational hypertensionPreterm birthPlacental pathologyEarly biomarkersComplicationsEarly placentationPotential biomarkersPlasma miRNAsPreeclampsiaMiR-125bEarly detectionBiomarkersMiR-365aMost evidenceNAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone
Sunderji S, Peyvandi S, Jaeggi E, Szwast A, Ryan G, Tessier F, Siddiqui S, Cuneo B, Sheth S, Treadwell M, Frommelt M, Turan S, Copel J, Emery S, Rand L, Moon-Grady AJ, Network F. NAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone. The Journal Of Maternal-Fetal & Neonatal Medicine 2022, 35: 9263-9270. PMID: 35014577, DOI: 10.1080/14767058.2022.2025536.Peer-Reviewed Original ResearchConceptsPositive pregnanciesPrimary outcomePregnancy complicationsPregnancy outcomesPremature deliverySecondary outcomesNorth American Fetal Therapy Network (NAFTNet) centersRo/SSA-positive pregnanciesRetrospective multi-center cohort studyAnti-Ro/SSAMulti-center cohort studyFetal heart blockOverall pregnancy complicationsBetter pregnancy outcomesPoor pregnancy outcomesUse of dexamethasoneTerms of efficacyHigh rateFetal dyadsMaternal comorbiditiesAntibody positivityExpectant managementMaternal diseaseNeonatal morbidityPreterm deliveryChapter 23 Polycystic ovarian syndrome and reproductive failure
Duero J, Tal R. Chapter 23 Polycystic ovarian syndrome and reproductive failure. 2022, 351-378. DOI: 10.1016/b978-0-323-90805-4.00009-2.ChaptersPolycystic ovarian syndromeInsulin resistanceOvarian syndromeEndometrial receptivityUterine abnormalitiesReproductive dysfunctionPathophysiology of PCOSRecurrent pregnancy lossReproductive-age womenAbnormal follicular developmentRisk of obesityComplex endocrine disorderEndometrial gene expressionMajority of womenType II diabetesPregnancy complicationsPolycystic ovariesPreterm birthPlacental dysfunctionChronic inflammationClinical manifestationsEndocrine disordersImplantation failurePregnancy lossCardiovascular disease
2021
Pregnancy Outcomes among Women with Class III Obesity with Pre-diabetic Early Hemoglobin A1C
Dillon J, Mitchell CJ, Ellett T, Siegel A, Denoble AE, Dotters-Katz SK. Pregnancy Outcomes among Women with Class III Obesity with Pre-diabetic Early Hemoglobin A1C. American Journal Of Perinatology 2021, 39: 238-242. PMID: 34891200, DOI: 10.1055/s-0041-1739358.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusClass III obesityBody mass indexPre-diabetic rangeGestational diabetesA1C 5.7Normal A1CPrimary outcomeGestational ageDevelopment of GDMClass III obese womenDelivery body mass indexNon-anomalous singleton pregnanciesMaternal body mass indexLow-A1C groupFetal growth restrictionInduction of laborHigh-risk populationA1c groupMedian A1CPregnancy complicationsBaseline demographicsCesarean deliveryMultiple gestationsObese womenDistance matters: barriers to antenatal care and safe childbirth in a migrant population on the Thailand-Myanmar border from 2007 to 2015, a pregnancy cohort study
Steinbrook E, Min M, Kajeechiwa L, Wiladphaingern J, Paw M, Pimanpanarak M, Hiranloetthanyakit W, Min A, Tun N, Gilder M, Nosten F, McGready R, Parker D. Distance matters: barriers to antenatal care and safe childbirth in a migrant population on the Thailand-Myanmar border from 2007 to 2015, a pregnancy cohort study. BMC Pregnancy And Childbirth 2021, 21: 802. PMID: 34856954, PMCID: PMC8638435, DOI: 10.1186/s12884-021-04276-5.Peer-Reviewed Original ResearchConceptsAntenatal carePregnancy outcomesFirst trimesterSkilled childbirth servicesPregnancy cohort studyPoor pregnancy outcomesPlasmodium falciparum malariaPredictors of lossMultivariable negative binomial regressionHealth-related factorsThailand-Myanmar borderEvidence-based interventionsSingleton childbirthPregnancy complicationsAntenatal clinicCohort studyFalciparum malariaAntenatal servicesBirth outcomesThird trimesterMalaria infectionMaternal healthMaternal healthcareConclusionsThis analysisChildbirth servicesMaternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface
Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Team Y, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionMaternal-fetal interfaceACE2 expressionNatural killerPregnant womenPlacental cellsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2-infected womenTerm placentaSyndrome coronavirus 2 infectionCoronavirus 2 infectionPotential immune mechanismsRobust inflammatory responseRobust immune responseCoronavirus disease 2019Detectable viral RNAInterferon-related genesLower ACE2 expressionMajority of placentasPregnancy complicationsPlacental histologyHofbauer cellsEarly pregnancyImmune activationPregnancy outcomes among women with class III obesity with normal early glucola
Ellett T, Mitchell CJ, Dillon J, Siegel A, Denoble AE, Dotters-Katz S. Pregnancy outcomes among women with class III obesity with normal early glucola. The Journal Of Maternal-Fetal & Neonatal Medicine 2021, 35: 5834-5839. PMID: 33818267, DOI: 10.1080/14767058.2021.1895741.Peer-Reviewed Original ResearchConceptsBody mass indexRate of GDMGlucose challenge testGestational diabetesObese womenPrimary outcomeGestational ageChallenge testDelivery body mass indexNon-anomalous singleton pregnanciesMaternal body mass indexOral glucose challenge testClass 3 obesityDevelopment of GDMClass III obesityGestational diabetes mellitusFetal growth restrictionInduction of laborNeonatal birthweightPregnancy complicationsBaseline demographicsCesarean deliveryMultiple gestationsPregnancy outcomesRetrospective cohort962 Miami mother-baby COVID collaborative: a prospective study linking circulating factors, placental findings and pregnancy complications
Colon-Aponte C, Ndubizu C, Jayakumar A, Saad A, Galli J, Potter J, Pahwa S, Ahn H, Abhari P, Cruz N, Spiliopoulos M, Covarrubias A, Pallikkuth S, Duara S, Bandstra E, Burkett G, Paidas M, Sfakianaki A. 962 Miami mother-baby COVID collaborative: a prospective study linking circulating factors, placental findings and pregnancy complications. American Journal Of Obstetrics And Gynecology 2021, 224: s597-s598. PMCID: PMC9991406, DOI: 10.1016/j.ajog.2020.12.987.Peer-Reviewed Original Research
2020
NLRP3 inflammasome function and pyroptotic cell death in human placental Hofbauer cells
Abrahams VM, Tang Z, Mor G, Guller S. NLRP3 inflammasome function and pyroptotic cell death in human placental Hofbauer cells. Journal Of Reproductive Immunology 2020, 142: 103214. PMID: 33152658, PMCID: PMC7770077, DOI: 10.1016/j.jri.2020.103214.Peer-Reviewed Original ResearchConceptsHofbauer cellsCaspase-1 activationIL-1β processingIL-1βInflammasome activationFetal inflammatory response syndromeSubsequent pregnancy complicationsInflammatory response syndromeCell deathNLRP3 inflammasome activationInterleukin-1 betaIL-1β secretionInhibition of P2X7Human term placentaGasdermin D cleavageNLRP3 knockdownPlacental inflammationPyroptotic cell deathFetal inflammationHistologic chorioamnionitisPregnancy complicationsResponse syndromeNLRP3 inflammasomeProtein/gene expressionInflammatory form
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