2025
115,000 Miles and Counting: Extraordinary Athletic Activity After a Historic Total HipArthroplasty with 39-year Follow-up
Gilmore M, Khwaja A, Wiznia D, Rubin L. 115,000 Miles and Counting: Extraordinary Athletic Activity After a Historic Total HipArthroplasty with 39-year Follow-up. Arthroplasty Today 2025, 33: 101711. PMID: 40548308, PMCID: PMC12182318, DOI: 10.1016/j.artd.2025.101711.Peer-Reviewed Original ResearchAccelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers
Abraham S, Parekh J, Lee S, Afrin H, Rozenblit M, Blenman K, Perry R, Ferrucci L, Liu J, Irwin M, Lustberg M. Accelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers. Cancer Medicine 2025, 14: e70929. PMID: 40322791, PMCID: PMC12051034, DOI: 10.1002/cam4.70929.Peer-Reviewed Original ResearchConceptsBiological age of patientsLeukocyte telomere lengthInterleukin-6Treatment-related toxicityAge of patientsTherapy-induced toxicityExpression of p16INK4aPredictors of toxicityStatus of biomarkersMarkers of cellular senescenceRadiation therapyBiological ageCancer patientsCancer therapyFunctional reserveAging biomarkersPhysiological reserveCancer treatmentCancerConfirmatory studiesTherapyClinical practiceFunctional capacityPatientsFunctional status1089 Indications and Complications of Diagnostic Cerebral Angiogram in a Modern Academic Practice
Sujijantarat N, Jiang J, Shekhar A, Amllay A, Fathima B, Hengartner A, Gilmore E, Antonios J, Koo A, Nowicki K, Renedo D, Hebert R, King J. 1089 Indications and Complications of Diagnostic Cerebral Angiogram in a Modern Academic Practice. Neurosurgery 2025, 71: 160-160. DOI: 10.1227/neu.0000000000003360_1089.Peer-Reviewed Original ResearchDiagnostic cerebral angiographyComplication ratePost-procedural neurological complicationsFactors associated with complicationsDiagnostic cerebral angiogramAge of patientsProcedural complication rateAssociated with complicationsAccess site complicationsNon-atherosclerotic vasculopathyAtherosclerotic cerebrovascular diseaseShunt lesionsRetrospective reviewIntracranial hemorrhageCerebral angiographyNeurological complicationsTumor evaluationCerebral angiogramProcedure timeAtherosclerotic vasculopathySite complicationsProcedure indicationStatistically significant factorsMultivariate analysisCatheter technologyEP1.45 Patients Undergoing Hip Arthroscopy with Either Periportal or Puncture Capsulotomy Demonstrate Favorable Outcomes: A Systematic Review
Klug T, Fox J, Rosa R, Pettinelli N, Sabzevari S, Lee M, MacLeod J, Moran J, Park N, Mahatme R, Gillinov S, Jimenez A. EP1.45 Patients Undergoing Hip Arthroscopy with Either Periportal or Puncture Capsulotomy Demonstrate Favorable Outcomes: A Systematic Review. Journal Of Hip Preservation Surgery 2025, 12: i49-i49. PMCID: PMC11953805, DOI: 10.1093/jhps/hnaf011.155.Peer-Reviewed Original ResearchPatient-reported outcomesFollow-upHip arthroscopyPre-operativelyFollow-up patient-reported outcomesSystematic reviewPatient acceptable symptom stateClinical benefit rateMinimal Clinically Important DifferenceAge of patientsHip jointLow level of evidenceAcceptable symptom statePreferred Reporting ItemsClinically Important DifferencePeriportal capsulotomyFollow-up scoresLevel of evidenceAverage pre-operativeRandomized Controlled TrialsHarris hip scoreStatistically significant improvementBenefit rateClinical benefitFavorable outcomeEP6.47 Pericapsular Nerve Group Block Effectively Controls Pain After Hip Arthroscopy: A Systematic Review
Kothari T, Qureshi A, Rodriguez G, Lee M, MacLeod J, Pettinelli N, Rosa R, Park N, Gillinov S, Moran J, Norman M, Jimenez A. EP6.47 Pericapsular Nerve Group Block Effectively Controls Pain After Hip Arthroscopy: A Systematic Review. Journal Of Hip Preservation Surgery 2025, 12: i104-i105. PMCID: PMC11954087, DOI: 10.1093/jhps/hnaf011.336.Peer-Reviewed Original ResearchPericapsular nerve group blockPericapsular nerve groupPost-anesthesia care unitPain scoresCochrane Center Register of Controlled TrialsAnalgesic consumptionHip arthroscopySystematic reviewOpioid consumptionPreferred Reporting Items of Systematic ReviewsItems of Systematic ReviewsAverage VAS pain scoreMorphine Milligram EquivalentsPostoperative pain scoresPreferred Reporting ItemsVAS pain scoresAge of patientsEffective analgesic techniquePrimary research articlesControl groupRegister of Controlled TrialsAnterior hip capsuleAnesthesia care unitMilligram equivalentsPENG blockEP6.48 Sex-Based Differences in Hip Arthroscopy Outcomes: A Systematic Review
Mahatme R, Simington J, Lee A, Qureshi A, Zhu J, Patel S, Darby F, Lee M, MacLeod J, Park N, Surucu S, Jimenez A. EP6.48 Sex-Based Differences in Hip Arthroscopy Outcomes: A Systematic Review. Journal Of Hip Preservation Surgery 2025, 12: i105-i105. PMCID: PMC11954090, DOI: 10.1093/jhps/hnaf011.337.Peer-Reviewed Original ResearchSex-based outcome differencesMinimal Clinically Important DifferencePatient acceptable symptomatic stateNon-Arthritic Hip ScoreModified Harris Hip ScoreCochrane Controlled Register of TrialsPostoperative outcome scoresPatient-reported outcomesHip arthroscopy outcomesHip arthroscopySex-based differencesPostoperative outcomesFemale patientsMale patientsOutcome scoresInternational Hip Outcome Tool-12Arthroscopy outcomesOutcome differencesHip scoreAge of patientsPrimary hip arthroscopySystematic reviewCochrane Controlled RegisterClinically Important DifferenceRegister of Trials
2024
Pain, Substance Use Disorders, Mental Health, and Buprenorphine Treatment among Patients With and Without HIV
Miller E, McGinnis K, Edelman E, Feinberg T, Gordon K, Kerns R, Marshall B, Patterson J, McRae M. Pain, Substance Use Disorders, Mental Health, and Buprenorphine Treatment among Patients With and Without HIV. AIDS And Behavior 2024, 28: 3994-4004. PMID: 39264485, PMCID: PMC11586311, DOI: 10.1007/s10461-024-04494-w.Peer-Reviewed Original ResearchMental health classesSubstance use disordersOpioid use disorderHIV statusBuprenorphine initiationVeterans Aging Cohort StudyInitiate buprenorphineMental health diagnosesAging Cohort StudyBuprenorphine treatmentMultiple pain conditionsAssociated with HIV statusInfluence treatment retentionUse disorderTreatment of opioid use disorderHigher comorbidity burdenAge of patientsClinical encountersMental healthHealth diagnosisBlack veteransHealth classesLatent class analysisCohort studyPrescription dataInternational Prognostic Score for Nodular Lymphocyte–Predominant Hodgkin Lymphoma
Binkley M, Flerlage J, Savage K, Akhtar S, Steiner R, Zhang X, Dickinson M, Prica A, Major A, Hendrickson P, Hopkins D, Ng A, Casulo C, Baron J, Roberts K, Al Kendi J, Balogh A, Ricardi U, Torka P, Specht L, De Silva R, Pickard K, Blazin L, Henry M, Smith C, Halperin D, Brady J, Brennan B, Senchenko M, Reeves M, Hoppe B, Terezakis S, Talaulikar D, Picardi M, Kirova Y, Fergusson P, Hawkes E, Lee D, Doo N, Barraclough A, Cheah C, Ku M, Hamad N, Mutsando H, Gilbertson M, Marconi T, Viiala N, Maurer M, Eichenauer D, Hoppe R, Borchmann P, Fuchs M, Hartmann S, Eich H, Lo A, Skinnider B, Rauf M, Maghfoor I, Pinnix C, Milgrom S, Vega F, Alomari M, Collins G, Advani R, Metzger M, Wirth A, Tsang R, Smith S, Kelsey C, McKay P, Koenig J, Constine L, Sakthivel K, Plastaras J, Gao S, Al Rahbi N, Levis M, Sridhar A, Shah N, Osborne W, Chang I, Miall F, Mikhaeel G, Penn A, Volchkov E, Della Pepa R, Northend M, Opat S, Salvaris R, Tedjaseputra A, Palese M, Shankar A, Natkunam Y, Kelly K. International Prognostic Score for Nodular Lymphocyte–Predominant Hodgkin Lymphoma. Journal Of Clinical Oncology 2024, 42: 2271-2280. PMID: 38531001, DOI: 10.1200/jco.23.01655.Peer-Reviewed Original ResearchNodular lymphocyte-predominant Hodgkin lymphomaProgression-free survivalLymphocyte-predominant Hodgkin lymphomaInternational Prognostic ScoreImmunoarchitectural patternsOverall survivalHodgkin lymphomaPrognostic scoreSplenic involvementAssociated with worse progression-free survivalAssociated with progression-free survivalDe-escalation of therapyMedian Follow-UpAge of patientsProspective clinical trialHigh-risk patientsStage III-IVClinical risk factorsRisk of transformationStage I to IIB symptomsAdult patientsIII-IVActive surveillanceRare cancersOsteochondral Allograft or Autograft Transplantation of the Femoral Head Leads to Improvement in Outcomes but Variable Survivorship: A Systematic Review
Fong S, Lee M, Pettinelli N, Norman M, Park N, Gillinov S, Zhu J, Gagné J, Lee A, Mahatme R, Jimenez A. Osteochondral Allograft or Autograft Transplantation of the Femoral Head Leads to Improvement in Outcomes but Variable Survivorship: A Systematic Review. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2024, 41: 357-373.e1. PMID: 38365122, DOI: 10.1016/j.arthro.2024.02.008.Peer-Reviewed Original ResearchPatient-reported outcomesFollow-upAutograft transplantationAllograft transplantationOsteochondral autograftReview patient-reported outcomesAverage follow-up timePostoperative patient-reported outcomesSystematic reviewLevel of Evidence IVSystematic Review of Level IV StudiesAge of patientsFollow-up timeOsteochondral allograft transplantationOsteochondral autograft transplantationRegister of Controlled TrialsTwo-year follow-upFemoral headLevel IV studiesEvidence IVIV studyPreferred Reporting ItemsOsteochondral allograftsOsteochondral lesionsTransplantationAssociation between thymectomy and incidence of renal cell carcinoma (RCC).
Barragan-Carrillo R, Ebrahimi H, Chawla N, Salgia N, Castro D, Chehrazi-Raffle A, Dizman N, Hsu J, Meza L, Zengin Z, LeVee A, Tripathi A, Dorff T, Bergerot C, Bergerot P, Eilber K, Dallas K, Pal S. Association between thymectomy and incidence of renal cell carcinoma (RCC). Journal Of Clinical Oncology 2024, 42: 371-371. DOI: 10.1200/jco.2024.42.4_suppl.371.Peer-Reviewed Original ResearchRenal cell carcinomaIncidence of nephrectomyIncidence of renal cell carcinomaMedian age of patientsFrequency of nephrectomyAge of patientsT cell productionProportion of patientsRate of nephrectomyFisher's exact testGeneral populationAge-matched populationICD-9/10 codesPopulation-based cohortPopulation-based studyImmunogenic cancerPrior thymectomyChi-square testCell carcinomaMedian ageSurgical interventionNephrectomyThymectomyExact testOSHPD databasePsychosocial and socioeconomic factors are most predictive of health status in patients with claudication
Scierka L, Peri-Okonny P, Romain G, Cleman J, Spertus J, Fitridge R, Secemsky E, Patel M, Gosch K, Mena-Hurtado C, Smolderen K. Psychosocial and socioeconomic factors are most predictive of health status in patients with claudication. Journal Of Vascular Surgery 2024, 79: 1473-1482.e5. PMID: 38266885, PMCID: PMC11180544, DOI: 10.1016/j.jvs.2024.01.021.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral Artery Questionnaire summary scoresPeripheral arterial diseaseHealth statusSummary scoreSymptomatic peripheral arterial diseaseSocial supportInsurance statusPAD-specific health statusHierarchical multivariable linear regression modelSocioeconomic patient characteristicsLow social supportPeripheral artery disease cohortPeripheral artery questionnaire scoresImprove health statusComparative effectiveness researchDiagnosis of depressionPatient characteristicsMultivariate linear regression modelPrediction of health statusDepression scoresLinear regression modelsAge of patientsDuration of symptomsAnxiety scores
2023
Therapy for Chikungunya Arthritis: A Study of 133 Brazilian Patients.
Amaral J, Bingham C, Taylor P, Vilá L, Weinblatt M, Schoen R. Therapy for Chikungunya Arthritis: A Study of 133 Brazilian Patients. American Journal Of Tropical Medicine And Hygiene 2023, 109: 542-547. PMID: 37549898, PMCID: PMC10484246, DOI: 10.4269/ajtmh.23-0205.Peer-Reviewed Original ResearchConceptsChikungunya arthritisWeeks of treatmentSwollen joint countTender joint countJoint countDAS28-erythrocyte sedimentation rateAge of patientsTreated with methotrexateDisease Activity ScoreGroup of patientsMedical record reviewAcute chikungunyaPain scoresClinical improvementBrazilian patientsAssess painClinical criteriaBaseline visitActivity scoreMaintained 5 monthsPainPatientsRecord reviewSelf-limitingRheumatology practicePatient preferences, regret, and health-related quality of life among older adults with acute myeloid leukemia: A pilot longitudinal study
LoCastro M, Wang Y, Sanapala C, Jensen-Battaglia M, Wittink M, Norton S, Klepin H, Richardson D, Mendler J, Liesveld J, Huselton E, Loh K. Patient preferences, regret, and health-related quality of life among older adults with acute myeloid leukemia: A pilot longitudinal study. Journal Of Geriatric Oncology 2023, 14: 101529. PMID: 37244139, PMCID: PMC10288066, DOI: 10.1016/j.jgo.2023.101529.Peer-Reviewed Original ResearchConceptsHealth-related quality of lifeHealth-related qualityOlder adultsDecisional regretQuality of lifeAcute myeloid leukemiaBest-worst scalingPatient preferencesInitial treatment decisionsPreferences of older adultsDecisional Regret ScaleEQ-5D-5LMyeloid leukemiaTreatment decisionsLocation of treatmentPatient prioritiesHRQoL scoresAttributes of treatmentDiagnosed AMLIntensive treatmentAssociated with poor outcomesRegret ScaleAge of patientsHRQoLResponse to treatment
2022
Booster doses of COVID-19 vaccines for patients with haematological and solid cancer: a systematic review and individual patient data meta-analysis
Mai A, Lee A, Tay R, Shapiro L, Thakkar A, Halmos B, Grinshpun A, Herishanu Y, Benjamini O, Tadmor T, Shroff R, LaFleur B, Bhattacharya D, Peng S, Tey J, Lee S, Chai L, Soon Y, Sundar R, Lee M. Booster doses of COVID-19 vaccines for patients with haematological and solid cancer: a systematic review and individual patient data meta-analysis. European Journal Of Cancer 2022, 172: 65-75. PMID: 35753213, PMCID: PMC9163022, DOI: 10.1016/j.ejca.2022.05.029.Peer-Reviewed Original ResearchConceptsIndividual Patient Data Meta-AnalysisPatient data meta-analysisSolid cancersBooster doseNon-respondersData Meta-AnalysisHaematological cancersMeta-analysisAntibody titresBooster dose of COVID-19 vaccineAssociated with increased durationIncreased risk of severe diseaseResponse to booster vaccinationAge of patientsRisk of severe diseaseVaccine non-respondersDose of COVID-19 vaccineSystematic reviewJoanna Briggs Institute Critical Appraisal ChecklistGastrointestinal cancer patientsCOVID-19 vaccine booster doseReduced vaccine immunogenicityVaccine booster doseImproved seroconversionCritical Appraisal ChecklistClinical characteristics and treatments of multi-system inflammatory syndrome in children: a systematic review.
Lee K, Li H, Lee M, Park S, Kim J, Han Y, Cho K, Ha B, Kim S, Jacob L, Koyanagi A, Shin J, Kim J, Smith L. Clinical characteristics and treatments of multi-system inflammatory syndrome in children: a systematic review. European Review For Medical And Pharmacological Sciences 2022, 26: 3342-3350. PMID: 35587087, DOI: 10.26355/eurrev_202205_28754.Peer-Reviewed Original ResearchConceptsMIS-CSevere COVID-19Kawasaki diseaseInflammatory syndromeDiagnostic criteriaMulti-system inflammatory syndromeAtypical Kawasaki diseaseAge of patientsMultisystem inflammatory syndromeAssociated with coronavirus disease 2019Indicators of inflammationIntravenous immunoglobulinLaboratory characteristicsPresenting symptomsInotropic agentsMIS-C.D-dimerCase seriesClinical characteristicsCardiac injuryGastrointestinal symptomsTroponin IEarly diagnosisIL-6Average ageThrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis
Kim A, Woo W, Yon D, Lee S, Yang J, Kim J, Park S, Koyanagi A, Kim M, Lee S, Shin J, Smith L. Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis. International Journal Of Infectious Diseases 2022, 119: 130-139. PMID: 35339716, PMCID: PMC8942584, DOI: 10.1016/j.ijid.2022.03.034.Peer-Reviewed Original ResearchConceptsVaccine-induced immune thrombotic thrombocytopeniaCerebral venous thrombosisChAdOx1 nCoV-19 vaccineSplanchnic vein thrombosisThrombotic thrombocytopeniaVein thrombosisVenous thrombosisClinical outcomesMeta-analysisRate of cerebral venous thrombosisAge of patientsPooled incidence rateAdenoviral vector vaccinesSARS-CoV-2 vaccinesSite of thrombosisChAdOx1 nCoV-19Between-study heterogeneityAnticoagulant treatmentNo significant differenceFemale predominanceClinical manifestationsExtracranial thrombosisIntracranial haemorrhageFatal outcomeOverall mortality
2021
Real-World Effectiveness of Damoctocog Alfa Pegol in the Subgroup of Adolescent Hemophilia A Patients Aged 12-18 Years in the ATHNdataset
Chandler M, Recht M, He C, Moulton T, Charafi L. Real-World Effectiveness of Damoctocog Alfa Pegol in the Subgroup of Adolescent Hemophilia A Patients Aged 12-18 Years in the ATHNdataset. Blood 2021, 138: 4241. DOI: 10.1182/blood-2021-152345.Peer-Reviewed Original ResearchDamoctocog alfa pegolHemophilia treatment centersAdolescent patientsBleeding rateTreated twice-weeklyHistory of inhibitorsYear of therapyAmerican ThrombosisAge of patientsMonths of treatmentSevere hemophilia ASubgroup of patientsHemophilia A patientsProportion of patientsBaseline demographic dataPatient chart reviewReal-world studyHemostasis NetworkData cutoffA patientsBleeding eventsWeekly dosesHemophilia AChart reviewOregon Health & Science UniversityThree-Dimensional Osteosynthesis Plates for the Surgical Treatment of Mandibular Fractures
Khalil S, Khamis H, Kauke M, Iizuka T, Safi AF. Three-Dimensional Osteosynthesis Plates for the Surgical Treatment of Mandibular Fractures. Journal Of Craniofacial Surgery 2021, 32: e728-e735. PMID: 34172684, DOI: 10.1097/scs.0000000000007709.Peer-Reviewed Original ResearchConceptsAdditional surgical interventionMandibular fracturesPostoperative complicationsMajor complicationsRetrospective studySurgical interventionSystematic reviewPlate fractureAge of patientsEffective treatment modalityNumber of patientsRisk of biasComprehensive electronic searchCochrane HandbookSurgical treatmentClinical outcomesStability of osteosynthesisProspective studyWound dehiscenceOutcome parametersTreatment modalitiesMandible fracturesLower incidenceHigh riskFracture classification
2020
Implications of Sex Difference in CT Scan Findings and Outcome of Patients with COVID-19 Pneumonia
Moradi B, Ghanaati H, Kazemi M, Gity M, Hashemi H, Davari-Tanha F, Chavoshi M, Rouzrokh P, Kolahdouzan K. Implications of Sex Difference in CT Scan Findings and Outcome of Patients with COVID-19 Pneumonia. Radiology Cardiothoracic Imaging 2020, 2: e200248. PMID: 33778607, PMCID: PMC7370352, DOI: 10.1148/ryct.2020200248.Peer-Reviewed Original ResearchReceiver Operating CharacteristicCT scoreCT scanDisease severityDistribution of opacitiesCT scan findingsRisk of disease severityAge of patientsOutcomes of patientsChest CT scanThoracic CT scansPredicting poor prognosisCOVID-19 pneumoniaDiagnosing coronavirus disease 2019Intensive care unitReverse-transcription polymerase chain reactionAge cut-offCut-offChest CTCT findingsScan findingsHospital stayUnfavorable prognosisPoor prognosisPolymerase chain reaction
2019
Factors Associated With Use of Sipuleucel-T to Treat Patients With Advanced Prostate Cancer
Caram M, Ross R, Lin P, Mukherjee B. Factors Associated With Use of Sipuleucel-T to Treat Patients With Advanced Prostate Cancer. JAMA Network Open 2019, 2: e192589. PMID: 31002323, PMCID: PMC6481456, DOI: 10.1001/jamanetworkopen.2019.2589.Peer-Reviewed Original ResearchConceptsMinimally symptomatic metastatic castration-resistant prostate cancerSipuleucel-TProstate cancerSymptomatic metastatic castration-resistant prostate cancerDatabase of commercially insured patientsMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerAge of patientsRetrospective cohort studyFactors associated with useAssociated with patientsCommercially insured patientsPatterns of treatmentConcurrent therapyTreated patientsCohort studyMultivariate analysisCancer therapyTherapyPatientsPhysician factorsCancerBarriers to treatmentBinomial logistic regressionLogistic regression
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