2025
Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice
Hoyt L, Liu E, Olson E, Jacobsen D, Siniscalco E, Krier-Burris R, Greenfield K, McBride C, Alfajaro M, Amat J, Zhao Z, Xu L, Philip V, Verma A, Fourati S, Senger D, Zhang L, Bunyavanich S, Glass S, Coffey R, Wilen C, Williams A, Eisenbarth S. Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice. Science 2025, 389: eadp0240. PMID: 40773557, PMCID: PMC12333546, DOI: 10.1126/science.adp0240.Peer-Reviewed Original ResearchConceptsFood-specific immunoglobulin ESensitivity to anaphylaxisFood-specific IgEResistant C57BL/6 miceFood allergensLife-threatening anaphylaxisStrains of miceGut absorptionOral anaphylaxisSusceptible miceResistant miceC57BL/6 miceCysteinyl leukotrienesAllergen consumptionAllergic sensitizationFood allergyImmunoglobulin EAllergen absorptionAnaphylaxisIntestinal epitheliumMiceIntestinal goblet cellsAllergen transportSynthesis inhibitorGoblet cells
2021
Prolonged Anaphylaxis to Pfizer Coronavirus Disease 2019 Vaccine: A Case Report and Mechanism of Action
Frank A, Radparvar S, Manasia A, Bassily-Marcus A, Kohli-Seth R. Prolonged Anaphylaxis to Pfizer Coronavirus Disease 2019 Vaccine: A Case Report and Mechanism of Action. Critical Care Explorations 2021, 3: e0397. PMID: 33834172, PMCID: PMC8021358, DOI: 10.1097/cce.0000000000000397.Peer-Reviewed Original ResearchMessenger RNA-based vaccinesEtiology of anaphylaxisRate of anaphylaxisCritical care managementCenters for Disease Control and PreventionEmergency use authorizationProtracted anaphylaxisDisease Control and PreventionIV steroidsRNA-based vaccinesMechanism of actionSafety profilePatient's anaphylaxisCase reportControl and PreventionRespiratory distressAnaphylactic reactionsClinical trialsEpinephrine infusionCoronavirus diseaseUnique caseAnaphylaxisAllergic reactionsPatientsVaccine prototype
2020
Flow cytometric identification of T fh 13 cells in mouse and human
Chen JS, Grassmann JDS, Gowthaman U, Olyha SJ, Simoneau T, Berin MC, Eisenbarth SC, Williams A. Flow cytometric identification of T fh 13 cells in mouse and human. Journal Of Allergy And Clinical Immunology 2020, 147: 470-483. PMID: 32709424, PMCID: PMC7854882, DOI: 10.1016/j.jaci.2020.04.063.Peer-Reviewed Original ResearchConceptsIgE antibodiesHigh affinity IgE antibodiesLife-threatening allergic reactionFollicular helper THigh-affinity IgEIgE productionHelper TAllergic reactionsMast cellsSevere reactionsMouse modelCytometric identificationCellular mechanismsBetter therapeuticsAllergyMiceAntibodiesCellsAnaphylaxisIgEPatientsHumansAeroallergensBasophils
2019
Prevalence of Errors in Anaphylaxis in Kids (PEAK): A Multicenter Simulation-Based Study
Maa T, Scherzer DJ, Harwayne-Gidansky I, Capua T, Kessler DO, Trainor JL, Jani P, Damazo B, Abulebda K, Diaz MCG, Sharara-Chami R, Srinivasan S, Zurca AD, Deutsch ES, Hunt EA, Auerbach M, the PEAK investigators of the International Network for Simulation-based Pediatric Innovation R, Song J, Wing R, Teman S, Rodriguez-Nunez A, Schneider C, Mercurio D, Gutierrez C, Gaba M, Joyner B, Vukin E, Henricksen J, Knight L, Wood T, England R, Cochran C, Andler C, Muñoz-Pareja J, Lordemann A, Biddell E. Prevalence of Errors in Anaphylaxis in Kids (PEAK): A Multicenter Simulation-Based Study. The Journal Of Allergy And Clinical Immunology In Practice 2019, 8: 1239-1246.e3. PMID: 31770652, DOI: 10.1016/j.jaip.2019.11.013.Peer-Reviewed Original ResearchConceptsMedication errorsEpinephrine administrationEpinephrine autoinjectorsLatent safety threatsInternational practice variationHealth care teamHealth care providersUse of protocolsEpinephrine deliveryReal medicationsAnaphylaxis guidelinesMedian timePediatric anaphylaxisAnaphylaxis managementInstitutional protocolCare teamAdministration errorsMedication formulariesPractice variationCare providersHealth care institutionsAnaphylaxisNursing experienceDemographic dataCare institutionsIdentification of a T follicular helper cell subset that drives anaphylactic IgE
Gowthaman U, Chen JS, Zhang B, Flynn WF, Lu Y, Song W, Joseph J, Gertie JA, Xu L, Collet MA, Grassmann JDS, Simoneau T, Chiang D, Berin MC, Craft JE, Weinstein JS, Williams A, Eisenbarth SC. Identification of a T follicular helper cell subset that drives anaphylactic IgE. Science 2019, 365 PMID: 31371561, PMCID: PMC6901029, DOI: 10.1126/science.aaw6433.Peer-Reviewed Original ResearchConceptsInterleukin-4B cellsFollicular Helper Cell SubsetsLow-affinity IgEFollicular helper cellsAllergen-specific IgEHelper cell subsetsIsotypes of antibodiesAlternative therapeutic targetsTranscription factor Bcl6Anaphylactic IgECytokine profileIgE productionCell subsetsHelper cellsImmunoglobulin ETherapeutic targetIgEAnaphylaxisAllergensCellular mechanismsRare populationCellsMiceGATA3
2018
Development and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database
Zhao Y, Lu H, Thai S, Li X, Hui J, Tang H, Zhai S, Sun L, Wang T. Development and validation of an algorithm to identify drug-induced anaphylaxis in the Beijing Pharmacovigilance Database. International Journal Of Clinical Pharmacy 2018, 40: 862-869. PMID: 29464448, DOI: 10.1007/s11096-018-0594-z.Peer-Reviewed Original ResearchConceptsDrug-induced anaphylaxisBeijing Pharmacovigilance DatabasePositive predictive valueAdverse drug eventsPharmacovigilance databaseAnaphylactic shockSpecific diagnosisSerious adverse drug eventsPhysician adjudicatorsChart abstractionAnaphylactic reactionsClinical criteriaDrug eventsAnaphylactoid reactionsMAIN OUTCOMEPredictive valueAnaphylaxisDiagnosisGold standardConfidence intervalsPatientsCriteria componentsHospitalDatabaseGreater number
2017
The vascular endothelial specific IL-4 receptor alpha–ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions
Yamani A, Wu D, Waggoner L, Noah T, Koleske AJ, Finkelman F, Hogan SP. The vascular endothelial specific IL-4 receptor alpha–ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions. Journal Of Allergy And Clinical Immunology 2017, 142: 1159-1172.e5. PMID: 29157947, PMCID: PMC5957775, DOI: 10.1016/j.jaci.2017.08.046.Peer-Reviewed Original ResearchConceptsIgE-mediated anaphylactic reactionsAnaphylactic reactionsFluid extravasationIL-4RαBarrier dysfunctionIL-4Food-induced anaphylactic reactionsIgE-induced anaphylaxisFood-induced anaphylaxisIgE-mediated anaphylaxisIL-4 receptor α chainIgE-mediated reactionsTreatment of miceSevere anaphylactic reactionsSeverity of anaphylaxisABL kinase inhibitor imatinibKinase inhibitor imatinibReceptor α chainVe cell linesVenous vasodilatationOral antigenHypovolemic shockInhibitor imatinibAnaphylaxisVe cellsSuccessful Graded Dose Challenge to Iodixanol Radiocontrast Media in a Patient With Delayed Anaphylaxis to Iohexol
Soffer G, Cohen B, Toh J, Edelman D, Garg K, Jariwala S. Successful Graded Dose Challenge to Iodixanol Radiocontrast Media in a Patient With Delayed Anaphylaxis to Iohexol. Vascular And Endovascular Surgery 2017, 52: 59-60. PMID: 29084492, DOI: 10.1177/1538574417736420.Peer-Reviewed Original ResearchConceptsDose challengeRadiocontrast media (RCM) hypersensitivityPostanesthesia care unitHospital coursePrednisone taperCare unitFinal doseSafe procedureAdverse reactionsLower extremitiesRight toeRadiocontrast mediaRadiographic studiesPatientsOperating roomAngiogramsLiterature reviewHoursRevascularizationGangreneAnaphylaxisHospitalDiphenhydramineExtremitiesHypersensitivity
2013
SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis
Zhou L, Oh SY, Zhou Y, Yuan B, Wu F, Oh MH, Wang Y, Takemoto C, Van Rooijen N, Zheng T, Zhu Z. SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis. PLOS ONE 2013, 8: e55763. PMID: 23390550, PMCID: PMC3563592, DOI: 10.1371/journal.pone.0055763.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAllergensAnaphylaxisAnimalsBasophilsCell DifferentiationCells, CulturedCytokinesGene ExpressionInflammationInjections, IntravenousLipopolysaccharidesLungMast CellsMiceMice, KnockoutOvalbuminProtein Tyrosine Phosphatase, Non-Receptor Type 6Respiratory HypersensitivitySignal TransductionTh2 CellsConceptsTh2 immune responseAllergic inflammationAirway inflammationMast cell functionImmune responseMast cellsDeficient bone marrow cellsMast cell-deficient miceCell-deficient miceCell functionSevere allergic reactionsWild-type miceSHP-1Bone marrow cellsAirway stimulationAdoptive transferSystemic anaphylaxisAnaphylactic responseClinical symptomsImmunological homeostasisDeficient miceAllergic reactionsType miceAnaphylaxisInflammation
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