2025
Current management of hypertrophic cardiomyopathy
Sikand N, Stendahl J, Sen S, Lampert R, Day S. Current management of hypertrophic cardiomyopathy. The BMJ 2025, 389: e077274. PMID: 40425241, DOI: 10.1136/bmj-2023-077274.Peer-Reviewed Original ResearchConceptsOutflow tract gradientObstructive hypertrophic cardiomyopathyHypertrophic cardiomyopathyAtrial fibrillationLeft ventricular outflow tract gradientNon-obstructive hypertrophic cardiomyopathyManagement of hypertrophic cardiomyopathyRisk of sudden deathCardiac sarcomere genesImplantable cardioverter-defibrillator implantationSeptal reduction therapyNon-obstructive diseaseSymptomatic atrial fibrillationCardiac myosin inhibitorLeft ventricular hypertrophySurgical treatment optionsCardioverter-defibrillator implantationAdvanced heart failureStructural heart conditionsArrhythmic riskCardiac transplantationImprove patient outcomesRhythm controlMedical therapyVentricular hypertrophyDiagnosis of Cardiac Transplant Rejection Using Point-of-Care Ultrasound
Li J, Boivin Z, Boyer W, Liu R. Diagnosis of Cardiac Transplant Rejection Using Point-of-Care Ultrasound. Journal Of Emergency Medicine 2025 DOI: 10.1016/j.jemermed.2025.04.011.Peer-Reviewed Original ResearchPoint-of-care ultrasoundAcute cellular rejectionCellular rejectionEmergency departmentRight ventricular (RV) dilatationDiagnosis of transplant rejectionYear post cardiac transplantationPoint-of-care ultrasound findingsEmergency physiciansIncreased tricuspid regurgitationPost-cardiac transplantationCardiac allograft vasculopathyRight heart catheterizationEnd-stage heart failureShortness of breathAllograft vasculopathyConfirmatory biopsyRV dysfunctionDiastolic abnormalitiesEndomyocardial biopsyTricuspid regurgitationHeart catheterizationCardiac transplantationTransplant-related issuesNonspecific symptoms
2024
Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy
Jadam S, Gaballa A, Alashi A, Xu B, Thamilarasan M, Rodriguez E, Tan C, Ospina S, Smedira N, Popovic Z, Desai M. Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy. JACC Heart Failure 2024, 13: 631-640. PMID: 39545888, DOI: 10.1016/j.jchf.2024.10.006.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathySurgical myectomyLong-term outcomesMyocyte hypertrophyInterstitial fibrosisHistological findingsHypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathy patientsHistological scoresAssociated with long-term outcomesSevere histological findingsHypertrophic cardiomyopathy patientsKaplan-Meier analysisMultivariate Cox analysisLeft ventricular hypertrophyComposite of deathPrimary eventDiastolic dysfunctionCardiac transplantationPrimary endpointTertiary centerCardiomyopathy patientsMicrovascular ischemiaVentricular hypertrophyCox analysis
2023
PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study
Kramer R, Fatahian A, Chan A, Mortenson J, Osher J, Sun B, Parker L, Rosamilia M, Potter K, Moore K, Atkins S, Rosenfeld J, Birjiniuk A, Jones E, Howard T, Kim J, Scott D, Lalani S, Rouzbehani O, Kaplan S, Hathaway M, Cohen J, Asaki S, Martinez H, Boudina S, Landstrom A. PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study. Circulation Genomic And Precision Medicine 2023, 16: 390-400. PMID: 37395136, PMCID: PMC10528350, DOI: 10.1161/circgen.122.003912.Peer-Reviewed Original ResearchConceptsConditional knockout miceKnockout miceCardiac transplantationCardiac mortalityRetrospective cohortIncreased risk of cardiomyopathyVentricular assist deviceDeletion syndromeAssociated with increased risk of deathMulti-institutional cohort studyReview cohortPediatric-onset cardiomyopathiesAssociated with increased riskRisk of cardiomyopathyPrevalence of cardiomyopathyRisk of deathSeverity of contractile dysfunctionPrognostic impactAssess fibrosisContractile dysfunctionCohort studyCardiomyopathyCardiac diseaseIncreased riskAssist deviceLeft Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry
Alaiwi S, Roston T, Marstrand P, Claggett B, Parikh V, Helms A, Ingles J, Lampert R, Lakdawala N, Michels M, Owens A, Rossano J, Saberi S, Abrams D, Ashley E, Semsarian C, Stendahl J, Ware J, Miller E, Ryan T, Russell M, Day S, Olivotto I, Vissing C, Ho C. Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry. Circulation 2023, 148: 394-404. PMID: 37226762, PMCID: PMC10373850, DOI: 10.1161/circulationaha.122.062517.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic dysfunctionHypertrophic cardiomyopathyMedian ageHCM diagnosisVentricular assist device implantationCox proportional hazards modelComposite of deathVentricular systolic dysfunctionAssist device implantationVentricular ejection fractionProportional hazards modelCardiac transplantationSystolic dysfunctionEjection fractionHCM cohortPediatric cohortDevice implantationPoor outcomeSubsequent prognosisEchocardiographic reportsHazards modelPatientsAdult cohortPrognosisCohort
2022
Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation
Chouairi F, Mullan C, Ahmed A, Bhinder J, Guha A, Miller P, Jastreboff A, Fuery M, Chiravuri M, Geirsson A, Desai N, Maulion C, Sen S, Ahmad T, Anwer M. Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation. PLOS ONE 2022, 17: e0273111. PMID: 36516178, PMCID: PMC9750001, DOI: 10.1371/journal.pone.0273111.Peer-Reviewed Original ResearchConceptsPost-transplant mortalityType 2 diabetesAllocation system changeOld allocation systemsHeart transplant recipientsOutcomes of patientsOrgan Sharing databaseProportion of patientsHeart transplantation outcomesLower likelihoodLikelihood of transplantationHigher likelihoodNew allocation systemCardiac transplantationHeart transplantationTransplant recipientsT2D patientsHeart failureSharing databaseCox regressionTransplantation outcomesUnited NetworkWorse outcomesT2DPatientsPrognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy
Hutt E, Mentias A, Alashi A, Wadhwa R, Fava A, Lever HM, Thamilarasan M, Popovic ZB, Smedira NG, Desai MY. Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy. Progress In Cardiovascular Diseases 2022, 74: 11-18. PMID: 35952727, DOI: 10.1016/j.pcad.2022.08.002.Peer-Reviewed Original ResearchConceptsSeptal reduction therapyBNP ratioNT-proBNP ratioPrimary outcomeAsymptomatic patientsPrognostic valueObstructive hypertrophic cardiomyopathy patientsIncremental prognostic valueNormal NT-proBNPNT-pro BNPObstructive hypertrophic cardiomyopathyLong-term outcomesHypertrophic cardiomyopathy patientsCardiac transplantationNT-proBNPPrimary endpointCardiomyopathy patientsHypertrophic cardiomyopathyReduction therapyHigh riskPatientsDefibrillator dischargeSpline analysisOutcomesBNPThe impact of induction therapy on mortality and treated rejection in cardiac transplantation: A retrospective study
Bellumkonda L, Oikonomou EK, Hsueh C, Maulion C, Testani J, Patel J. The impact of induction therapy on mortality and treated rejection in cardiac transplantation: A retrospective study. The Journal Of Heart And Lung Transplantation 2022, 41: 482-491. PMID: 35094919, DOI: 10.1016/j.healun.2022.01.008.Peer-Reviewed Original ResearchConceptsInduction therapyCause mortalityOutcome measuresLeft ventricular assist device therapyT-cell depleting agentsVentricular assist device therapyDual organ transplantsRoutine induction therapySecondary outcome measuresTime of transplantationPrimary outcome measureCox regression modelPropensity score adjustmentRisk of rejectionPrior transplantCardiac transplantationHeart transplantationUNOS databaseAdult patientsOverall survivalDevice therapyMedian ageRetrospective studyReceptor antagonistReduced odds
2021
Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
Fuery MA, Chouairi F, Natov P, Bhinder J, Rose Chiravuri M, Wilson L, Clark KA, Reinhardt SW, Mullan C, Miller PE, Davis RP, Rogers JG, Patel CB, Sen S, Geirsson A, Anwer M, Desai N, Ahmad T. Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates. Journal Of The American Heart Association 2021, 10: e023662. PMID: 34743559, PMCID: PMC9075266, DOI: 10.1161/jaha.121.023662.Peer-Reviewed Original ResearchConceptsLow-urgency patientsHigh-urgency patientsUrgency patientsCardiac transplantationAllocation system changeLonger waitlist timesOrgan Sharing databaseTime of transplantationCardiac transplantation candidatesNew allocation systemBaseline recipientPosttransplantation outcomesPosttransplantation survivalAdditional comorbiditiesClinical characteristicsConclusions PatientsHepatitis CIschemic timeTransplantation candidatesSharing databaseWaitlist timeWaitlist survivalUnited NetworkRetrospective analysisPatientsEvaluation of Racial and Ethnic Disparities in Cardiac Transplantation
Chouairi F, Fuery M, Clark KA, Mullan CW, Stewart J, Caraballo C, Clarke J, Sen S, Guha A, Ibrahim NE, Cole RT, Holaday L, Anwer M, Geirsson A, Rogers JG, Velazquez EJ, Desai NR, Ahmad T, Miller PE. Evaluation of Racial and Ethnic Disparities in Cardiac Transplantation. Journal Of The American Heart Association 2021, 10: e021067. PMID: 34431324, PMCID: PMC8649228, DOI: 10.1161/jaha.120.021067.Peer-Reviewed Original ResearchConceptsWhite patientsHispanic patientsBlack patientsCardiac transplantationHeart transplantationHigh riskEthnic disparitiesAdult heart recipientsAllocation system changePost-transplant deathPost-transplant mortalityOrgan Sharing databasePost-transplantation deathNew allocation systemHeart recipientsDiabetes mellitusRenal diseaseSharing databaseTransplantation ratesUnited NetworkContemporary outcomesPatientsTransplantationDonor characteristicsStudy periodCardiac allograft vasculopathy: current review and future research directions
Pober JS, Chih S, Kobashigawa J, Madsen JC, Tellides G. Cardiac allograft vasculopathy: current review and future research directions. Cardiovascular Research 2021, 117: 2624-2638. PMID: 34343276, PMCID: PMC8783389, DOI: 10.1093/cvr/cvab259.Peer-Reviewed Original ResearchConceptsCardiac allograft vasculopathyAllograft vasculopathyImmune-mediated vasculopathyLate graft lossGraft lossCardiac transplantationOrgan graftsTransplanted heartsCurrent therapiesVascular remodellingVasculopathyMajor causeCurrent reviewRemodellingTransplantationPathogenesisGraftTherapyPerfusionIncidenceDiagnosisVasculatureMyotonic Muscular Dystrophy Type 2 in CT, USA: A Single-Center Experience With 50 Patients.
Roy B, Wu Q, Whitaker C, Felice K. Myotonic Muscular Dystrophy Type 2 in CT, USA: A Single-Center Experience With 50 Patients. Journal Of Clinical Neuromuscular Disease 2021, 22: 135-146. PMID: 33595997, DOI: 10.1097/cnd.0000000000000340.Peer-Reviewed Original ResearchConceptsClinicopathological findingsSymptom onsetNonischemic dilated cardiomyopathySingle-center experienceProximal lower extremityType 2Medical Research Council scoreAutosomal dominant disorderMuscle pathological changesAge of symptom onsetMyotonic dystrophy type 2Cardiac transplantationPain symptomsDilated CardiomyopathySingle-centerClinical myotoniaCardiac abnormalitiesDominant disorderLimb weaknessCNBP geneMuscular dystrophyPatientsMyotonic dischargesLower extremitiesPathological changes
2020
Transition to Advanced Therapies in Elderly Patients Supported by Extracorporeal Membrane Oxygenation Therapy
Chouairi F, Vallabhajosyula S, Mullan C, Mori M, Geirsson A, Desai NR, Ahmad T, Miller PE. Transition to Advanced Therapies in Elderly Patients Supported by Extracorporeal Membrane Oxygenation Therapy. Journal Of Cardiac Failure 2020, 26: 1086-1089. PMID: 32777479, DOI: 10.1016/j.cardfail.2020.07.019.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationOrthotopic cardiac transplantationCardiogenic shockAdvanced therapiesVentricular assist device implantationNational Inpatient Sample databaseExtracorporeal membrane oxygenation therapyYounger groupStudy periodAssist device implantationMembrane oxygenation therapyProportion of patientsSurvival of patientsHospitalizations of peopleOlder age groupsHospital mortalityCardiac transplantationECMO supportMultivariable adjustmentElderly patientsLVAD implantationMembrane oxygenationOxygenation therapyPrimary outcomeDevice implantationAssociation of Race With Disease Expression and Clinical Outcomes Among Patients With Hypertrophic Cardiomyopathy
Eberly LA, Day SM, Ashley EA, Jacoby DL, Jefferies JL, Colan SD, Rossano JW, Semsarian C, Pereira AC, Olivotto I, Ingles J, Seidman CE, Channaoui N, Cirino AL, Han L, Ho CY, Lakdawala NK. Association of Race With Disease Expression and Clinical Outcomes Among Patients With Hypertrophic Cardiomyopathy. JAMA Cardiology 2020, 5: 83-91. PMID: 31799990, PMCID: PMC6902181, DOI: 10.1001/jamacardio.2019.4638.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAtrial FibrillationBlack or African AmericanCardiomyopathy, HypertrophicCohort StudiesDeath, Sudden, CardiacDefibrillators, ImplantableFemaleGenetic TestingHealth Services AccessibilityHealthcare DisparitiesHeart FailureHeart SeptumHeart TransplantationHeart-Assist DevicesHumansMaleMiddle AgedMortalityPhenotypeQuality of Health CareStrokeUnited StatesWhite PeopleConceptsNYHA class IIIAssociation of raceVentricular assist device implantationOverall composite outcomeSeptal reduction therapyAssist device implantationHeart failureBlack patientsHypertrophic cardiomyopathyCause mortalityWhite patientsAtrial fibrillationClass IIICardiac transplantationGenetic testingComposite outcomeClinical outcomesDisease expressionDevice implantationReduction therapyNew York Heart Association functional class IIIMultivariable Cox proportional hazards regressionInvasive septal reduction therapySarcomeric Human Cardiomyopathy RegistryImplantable cardioverter-defibrillator therapy
2019
Impact of Obesity on Ventricular Assist Device Outcomes
Jaiswal A, Truby LK, Chichra A, Jain R, Myers L, Patel N, Topkara VK. Impact of Obesity on Ventricular Assist Device Outcomes. Journal Of Cardiac Failure 2019, 26: 287-297. PMID: 31618696, PMCID: PMC7141964, DOI: 10.1016/j.cardfail.2019.10.001.Peer-Reviewed Original ResearchConceptsBody mass indexImpact of obesityObese patientsVAD implantationSignificant weight lossVentricular assist deviceClinical outcomesWeight lossHeart transplantationBMI groupsCardiac arrhythmiasMechanically Assisted Circulatory Support registryPatients warrants further investigationVentricular assist device outcomesWorld Health Organization classificationAdvanced heart failureWarrants further investigationBleeding riskCardiac transplantationInteragency RegistryRelative contraindicationHeart failureHospital readmissionVAD therapyMass indexShort‐term results in infants with multiple left heart obstructive lesions
Steele JM, Komarlu R, Worley S, Alsaied T, Statile C, Erenberg FG. Short‐term results in infants with multiple left heart obstructive lesions. Congenital Heart Disease 2019, 14: 1193-1198. PMID: 31489778, DOI: 10.1111/chd.12829.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresChild, PreschoolEchocardiographyFemaleHeart Defects, CongenitalHeart VentriclesHumansInfantInfant, NewbornMalePalliative CareRecovery of FunctionRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeVentricular Function, LeftVentricular Function, RightConceptsHeart obstructive lesionsVentricular septal defectObstructive lesionsMultiple left heart obstructive lesionsAortic valve z-scoreLeft heart obstructive lesionsHybrid stage 1Mitral valve atresiaCritical aortic stenosisInitial surgical procedureSingle ventricle physiologySeptal defect closureSuccessful biventricular repairTricuspid valve annulus sizeShort-term resultsYears of ageEchocardiographic predictorsInitial echocardiogramBiventricular repairCardiac transplantationCoarctation repairVentricle physiologyAortic stenosisArch reconstructionClinical outcomes
2018
Tricuspid Valve Regurgitation Immediately After Heart Transplant and Long-Term Outcomes
Bishawi M, Zanotti G, Shaw L, MacKenzie M, Castleberry A, Bartels K, Schroder J, Velazquez E, Swaminathan M, Rogers J, Milano C. Tricuspid Valve Regurgitation Immediately After Heart Transplant and Long-Term Outcomes. The Annals Of Thoracic Surgery 2018, 107: 1348-1355. PMID: 30529215, PMCID: PMC7256852, DOI: 10.1016/j.athoracsur.2018.10.065.Peer-Reviewed Original ResearchConceptsSignificant tricuspid valve regurgitationTricuspid valve regurgitationLong-term outcomesHeart transplantationCardiopulmonary bypassTR gradeValve regurgitationSurgical repairValve repairCommon findingOrthotropic heart transplantationPostoperative plasma creatininePulmonary vascular resistanceTricuspid valve repairEarly surgical repairEarly morbidityPostoperative stayCardiac transplantationMultiorgan transplantsVascular resistanceTransplant databaseHeart transplantAdjusted survivalPlasma creatinineTransplant
2015
The Impact of Donor and Recipient Renal Dysfunction on Cardiac Allograft Survival: Insights Into Reno-Cardiac Interactions
Laur O, Brisco MA, Kula AJ, Cheng SJ, Mangi AA, Bellumkonda L, Jacoby DL, Coca S, Tang WH, Parikh CR, Testani JM. The Impact of Donor and Recipient Renal Dysfunction on Cardiac Allograft Survival: Insights Into Reno-Cardiac Interactions. Journal Of Cardiac Failure 2015, 22: 368-375. PMID: 26616578, PMCID: PMC4904299, DOI: 10.1016/j.cardfail.2015.11.009.Peer-Reviewed Original ResearchConceptsRenal dysfunctionCardiac transplantationAdverse recipient outcomesCardiac allograft survivalOrgan Sharing registryGlomerular filtration ratePotent risk factorImpact of donorAllograft survivalCardiac allograftsRecipient deathRecipient outcomesUnited NetworkAdverse outcomesFiltration rateMyocardial necrosisRisk factorsCardiovascular diseaseHigh riskDonor characteristicsOlder ageRetransplantationDeathTransplantationDysfunctionDefibrillator implantations for primary prevention in the United States: Inappropriate care or inadequate documentation: Insights from the National Cardiovascular Data ICD Registry
Kaiser DW, Tsai V, Heidenreich PA, Goldstein MK, Wang Y, Curtis J, Turakhia MP, Registry C. Defibrillator implantations for primary prevention in the United States: Inappropriate care or inadequate documentation: Insights from the National Cardiovascular Data ICD Registry. Heart Rhythm 2015, 12: 2086-2093. PMID: 25982720, PMCID: PMC4770888, DOI: 10.1016/j.hrthm.2015.05.010.Peer-Reviewed Original ResearchConceptsMulticenter Unsustained Tachycardia TrialMulticenter Automatic Defibrillator Implantation TrialICD RegistryPrimary preventionICD implantationInclusion criteriaNational Cardiovascular Data Registry ICD RegistryMultivariate analysisImplantable cardioverter defibrillator implantationAtrioventricular conduction diseaseFirst-time ICDPrimary prevention ICDsPrior cardiac transplantationHeart Failure TrialPrimary prevention trialsProportion of patientsCardioverter-defibrillator implantationAppropriate use criteriaSudden cardiac deathCardiac transplantationDefibrillator implantationMADIT-IIPatient characteristicsYounger patientsCardiac deathHeart Transplantation in Adults With Congenital Heart Disease: 100% Survival With Operations Performed by a Surgeon Specializing in Congenital Heart Disease in an Adult Hospital
Mori M, Vega D, Book W, Kogon BE. Heart Transplantation in Adults With Congenital Heart Disease: 100% Survival With Operations Performed by a Surgeon Specializing in Congenital Heart Disease in an Adult Hospital. The Annals Of Thoracic Surgery 2015, 99: 2173-2178. PMID: 25921255, DOI: 10.1016/j.athoracsur.2015.03.001.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseHeart diseaseCongenital heart conditionsHeart transplantationAdult patientsAdult hospitalsCardiac transplantationPostoperative coursePostoperative careMedian cardiopulmonary bypass timeMedian total operating timeDonor ischemic timePostoperative management strategiesCardiopulmonary bypass timeRetrospective cohort studyConsecutive adult patientsComplicated postoperative courseDifficult patient populationMajority of patientsComplex patient cohortIntensive care unitCongenital cardiac diseaseHeart conditionsBypass timeProlonged ventilation
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