2025
1109-P: Physician Referral Pathway to a Commercially Marketed Digital Exercise Resource for Type 1 Diabetes—Implementation Metrics from a Clinical Trial
ASH G, MAK S, (ELIAS) SPANAKIS I, LUKASIK J, NALLY L, FUCITO L, WEINZIMER S. 1109-P: Physician Referral Pathway to a Commercially Marketed Digital Exercise Resource for Type 1 Diabetes—Implementation Metrics from a Clinical Trial. Diabetes 2025, 74 DOI: 10.2337/db25-1109-p.Peer-Reviewed Original ResearchPrimary care providersHome-based exerciseExercise prescriptionReferral pathwaysParticipating primary care providersPCP responsesClinical trial participationExercise intensityCare providersTrials of participantsCoach appVigorous exerciseNon-HispanicEligible participantsPortal messagesClinical trials of participantsLatent autoimmune diabetes of adulthoodModerate exerciseHealthcare systemTrial participantsSnowball samplingExercisePain symptomsClinical trialsUncontrolled hypertension
2024
Psychological stress, cardiovascular disease and somatic pain in asylum seekers: a retrospective cross-sectional study
Lurie J, Pietz H, Hatef C, Taki F, Lee A, Virk S, Oren T, Gbekie C, Milewski A, Boyer R, Kaur G. Psychological stress, cardiovascular disease and somatic pain in asylum seekers: a retrospective cross-sectional study. Nature Mental Health 2024, 2: 1442-1450. DOI: 10.1038/s44220-024-00312-3.Peer-Reviewed Original ResearchSymptoms of psychological stressSomatic painCross-sectional studyCardiovascular diseasePsychological stressRetrospective cross-sectional studyStress symptomsCardiovascular disease symptomsChest painPain symptomsHealth outcomesCVD symptomsPainRisk factorsStroke symptomsMedical evaluationSymptomsAsylum seekersComorbidityPrevalenceAssociations Between Reductions in Depressive Symptoms and Reductions in Pain and Anxiety Symptoms and Substance Use: Emulation of a Randomized Trial
Khan M, Acri M, Ban K, Scheidell J, Stevens E, Manandhar-Sasaki P, Charles D, Chichetto N, Crystal S, Gordon A, Marshall B, Edelman E, Justice A, Braithwaite S, Caniglia E. Associations Between Reductions in Depressive Symptoms and Reductions in Pain and Anxiety Symptoms and Substance Use: Emulation of a Randomized Trial. AJPM Focus 2024, 3: 100258. PMID: 39290574, PMCID: PMC11407062, DOI: 10.1016/j.focus.2024.100258.Peer-Reviewed Original ResearchUnhealthy alcohol useDepressive symptomsAnxiety symptomsIllicit opioid useOdds ratioAlcohol useVeterans Aging Cohort StudyPain symptomsConfidence intervalsTarget trial emulation frameworkElevated depressive symptomsAssociated with reductionsReducing depressive symptomsAging Cohort StudySubstance useOpioid useMultisite observational studyDepressive symptom reductionNext follow-up visitUS veteransReduce painFollow-up visitCohort studyAntidepressant medicationComparing individualsThe Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome
Koo B, Abdelfattah A, Eysa A, Lu L. The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome. Annals Of Neurology 2024, 95: 688-699. PMID: 38308537, DOI: 10.1002/ana.26876.Peer-Reviewed Original ResearchRestless legs syndromeRestless legs syndrome patientsRestless legs syndrome severityAdrenocorticotropin hormoneCerebrospinal fluidB-endorphinPro-opiomelanocortinA-MSHPlasma adrenocorticotropin hormoneRLS participantsInternational RLS Study Group Severity ScaleRLS patientsAssessed plasmaPain symptomsLumbar punctureA-melanocyte-stimulating hormoneMatched ControlsPatientsHormoneSeverity ScaleSensory discomfortPlasmaSeverityMelanocortin hormonesHyperalgesia
2023
Sex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial Infarction
Brush J, Chaudhry S, Dreyer R, D'Onofrio G, Greene E, Hajduk A, Lu Y, Krumholz H. Sex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial Infarction. The American Journal Of Cardiology 2023, 197: 101-107. PMID: 37062667, PMCID: PMC10198892, DOI: 10.1016/j.amjcard.2023.03.009.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionD2B timeSymptom complexityYoung womenChest painBalloon timeST-elevation myocardial infarctionSILVER-AMI StudySymptom phenotypeSex differencesPain symptomsCoronary interventionOlder patientsMyocardial infarctionOlder womenSTEMIOlder menSymptom patternsPresentation delayPatientsSymptom clustersLogistic regressionSymptomsWomenMean number
2022
Objective Sleep-Wake Characteristics Are Associated With Diabetes Symptoms in Young Adults With Type 1 Diabetes
Griggs S, Grey M, Ash GI, Li CR, Crawford SL, Hickman RL. Objective Sleep-Wake Characteristics Are Associated With Diabetes Symptoms in Young Adults With Type 1 Diabetes. The Science Of Diabetes Self-Management And Care 2022, 48: 149-156. PMID: 35446182, PMCID: PMC9157415, DOI: 10.1177/26350106221094521.Peer-Reviewed Original ResearchConceptsBody mass indexSleep-wake characteristicsTotal symptom burdenSleep onset latencySymptom burdenDiabetes symptomsYoung adultsOnset latencyHigher total symptom burdenDistress symptomsDescriptive cross-sectional studyDistress ScaleHigh sleep variabilityShorter total sleep timeType 1 diabetesCross-sectional studyLonger sleep onset latencyPoor sleep efficiencyTotal sleep timeYoung adults ages 18Adults ages 18Pain symptomsT1D durationDiabetes clinicEmotional Distress Scale
2021
Innovation in the treatment of persistent pain in adults with Neurofibromatosis Type 1 (NF1): Implementation of the iCanCope mobile application
Buono FD, Lalloo C, Larkin K, Zempsky WT, Ball S, Grau LE, Pham Q, Stinson J. Innovation in the treatment of persistent pain in adults with Neurofibromatosis Type 1 (NF1): Implementation of the iCanCope mobile application. Contemporary Clinical Trials Communications 2021, 25: 100883. PMID: 35036627, PMCID: PMC8743203, DOI: 10.1016/j.conctc.2021.100883.Peer-Reviewed Original ResearchNeurofibromatosis type 1Pain symptomsNF1 populationType 1Chronic pain symptomsSelf-management treatmentPersistent painTreatment satisfactionTreatment optionsControl studySix weeksPainPsychometric evaluationContingency managementInitial effectivenessGenetic disordersThird groupSymptomsAdultsTreatmentPopulationDifferent populationsGroupParticipants' experiencesGreater reachCounseling Veterans with Chronic Pain During the COVID-19 Pandemic: A Secondary Analysis of a Randomized Controlled Trial
Lazar CM, Rosen MI, Sellinger J, Mattocks K, Navarra L, Ross KA, Martino S. Counseling Veterans with Chronic Pain During the COVID-19 Pandemic: A Secondary Analysis of a Randomized Controlled Trial. Pain Medicine 2021, 23: 1434-1441. PMID: 34958381, PMCID: PMC8755363, DOI: 10.1093/pm/pnab349.Peer-Reviewed Original ResearchConceptsChronic painMental health issuesComprehensive pain management approachCOVID-19 pandemicVeterans' mental health issuesPain management servicesMultimodal pain treatmentPain management approachesOngoing clinical trialsCounseling sessionsQuality of lifeSample of veteransPain symptomsPain treatmentControlled TrialsPain managementClinical trialsPain experiencePainVeterans' useBrief counselingAdaptive coping skillsSecondary analysisVeterans AffairsHealth issuesFunctional Abdominal Pain
Drossman D, Deutsch J. Functional Abdominal Pain. 2021, 1191-1202. DOI: 10.1007/978-3-030-30192-7_99.Peer-Reviewed Original ResearchFunctional gastrointestinal disordersIrritable bowel syndromeCentral nervous systemAbdominal painCognitive behavioral therapyPain symptomsFunctional dyspepsiaOlder adultsAbdominal pain syndromeChronic abdominal painFunctional abdominal painGut-brain interactionGut motility disordersImprovement of symptomsChronic pain conditionsRed flagsQuality of lifePain syndromeBowel syndromeElderly patientsGastrointestinal painPain modulationPain conditionsMotility disordersGastrointestinal disordersAnti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats
Ishikura T, Kinoshita M, Shimizu M, Yasumizu Y, Motooka D, Okuzaki D, Yamashita K, Murata H, Beppu S, Koda T, Tada S, Shiraishi N, Sugiyama Y, Miyamoto K, Kusunoki S, Sugimoto T, Kumanogoh A, Okuno T, Mochizuki H. Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats. Journal Of Neuroinflammation 2021, 18: 181. PMID: 34419102, PMCID: PMC8380350, DOI: 10.1186/s12974-021-02232-w.Peer-Reviewed Original ResearchConceptsNeuromyelitis optica spectrum disorderIgG-treated ratsMechanical allodyniaNeuropathic painSpinal cordATP receptorsATP releaseSymptoms of neuromyelitis optica spectrum disorderDevelopment of mechanical allodyniaDevelopment of neuropathic painPharmacological inhibitionDevelopment of painful symptomsAnti-AQP4 autoantibodiesPeripheral neuropathic painAnti-AQP4 antibodyRelease of extracellular ATPExtracellular ATP releaseRat spinal cordDamage-associated molecular patternsAnti-AQP4Pain mechanismsMechanical painInvolvement of ATPPain symptomsRemission phaseQuality of life, functioning, and symptoms in patients with previously treated locally advanced or metastatic urothelial carcinoma from EV-301: A randomized phase 3 trial of enfortumab vedotin versus chemotherapy.
Mamtani R, Rosenberg J, Powles T, Sonpavde G, Loriot Y, Duran I, Lee J, Matsubara N, Vulsteke C, Castellano D, Sridhar S, Pappot H, Valderrama B, Gurney H, Bedke J, Van Der Heijden M, Wu C, Hepp Z, McKay C, Petrylak D. Quality of life, functioning, and symptoms in patients with previously treated locally advanced or metastatic urothelial carcinoma from EV-301: A randomized phase 3 trial of enfortumab vedotin versus chemotherapy. Journal Of Clinical Oncology 2021, 39: 4539-4539. DOI: 10.1200/jco.2021.39.15_suppl.4539.Peer-Reviewed Original ResearchMetastatic urothelial carcinomaUrothelial carcinomaOpen-label phase 3 studyCompliance rateGlobal health status scaleRandomized phase 3 trialSymptom scales/itemsLife Questionnaire Core 30Median overall survivalQuestionnaire compliance ratesPhase 3 studyPhase 3 trialCancer Core QualityWeeks of treatmentHealth status scalesRisk of deathQLQ-C30 scoresQLQ-C30 domainsQuality of lifeBenefit/riskScales/itemsPain symptomsAppetite lossLiver metastasesOverall survivalMyotonic Muscular Dystrophy Type 2 in CT, USA: A Single-Center Experience With 50 Patients.
Roy B, Wu Q, Whitaker C, Felice K. Myotonic Muscular Dystrophy Type 2 in CT, USA: A Single-Center Experience With 50 Patients. Journal Of Clinical Neuromuscular Disease 2021, 22: 135-146. PMID: 33595997, DOI: 10.1097/cnd.0000000000000340.Peer-Reviewed Original ResearchConceptsClinicopathological findingsSymptom onsetNonischemic dilated cardiomyopathySingle-center experienceProximal lower extremityType 2Medical Research Council scoreAutosomal dominant disorderMuscle pathological changesAge of symptom onsetMyotonic dystrophy type 2Cardiac transplantationPain symptomsDilated CardiomyopathySingle-centerClinical myotoniaCardiac abnormalitiesDominant disorderLimb weaknessCNBP geneMuscular dystrophyPatientsMyotonic dischargesLower extremitiesPathological changes
2020
Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes
Salerno S, Zhao Z, Sankar S, Salvatore M, Gu T, Fritsche L, Lee S, Lisabeth L, Valley T, Mukherjee B. Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes. Journal Of Internal Medicine 2020, 289: 726-737. PMID: 33253457, PMCID: PMC7753604, DOI: 10.1111/joim.13213.Peer-Reviewed Original ResearchConceptsAssociated with repeat testingFalse-negative rateNeighborhood poverty levelPre-existing type 2 diabetesSevere COVID-19-related outcomesDiagnostic testsPatient characteristicsPre-existing kidney diseaseBody mass indexICU-level careHealth outcomesCOVID-19-related outcomesCharacteristics of patientsCOVID-19 diagnostic testsType 2 diabetesMichigan MedicineMass indexCOVID-19Pain symptomsPatient agePoverty levelDownstream outcomesKidney diseaseRepeated TestingLiver diseasePrevalence, Patterns, and Correlates of Pain in Medically Hospitalized Pediatric Patients With Somatic Symptom and Related Disorders
Ibeziako P, Randall E, Vassilopoulos A, Choi C, Thomson K, Ribeiro M, Fernandes S, Thom R, Bujoreanu S. Prevalence, Patterns, and Correlates of Pain in Medically Hospitalized Pediatric Patients With Somatic Symptom and Related Disorders. Journal Of The Academy Of Consultation-Liaison Psychiatry 2020, 62: 46-55. PMID: 32641234, DOI: 10.1016/j.psym.2020.05.008.Peer-Reviewed Original ResearchConceptsPrevalence of painWidespread painPain symptomsPediatric patientsPrior Child Protective Services (CPS) involvementDiagnostic tests/proceduresRelated disordersSomatic symptomsHospitalized youthCorrelates of painWidespread pain symptomsRetrospective chart reviewPsychiatry consultation serviceTertiary pediatric hospitalTests/proceduresFamily psychiatric historyStressor-related disordersChild protective services involvementChart reviewOpioid usePediatric hospitalPediatric populationComorbid depressionLimited painMedical conditionsEstrogen receptor-α immunoreactivity predicts symptom severity and pain recurrence in deep endometriosis
Pluchino N, Mamillapalli R, Wenger JM, Ramyead L, Drakopoulos P, Tille JC, Taylor HS. Estrogen receptor-α immunoreactivity predicts symptom severity and pain recurrence in deep endometriosis. Fertility And Sterility 2020, 113: 1224-1231.e1. PMID: 32416979, DOI: 10.1016/j.fertnstert.2020.01.036.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersConstipationCross-Sectional StudiesDysmenorrheaDyspareuniaEndometriosisEstrogen Receptor alphaFemaleHumansImmunohistochemistryMiddle AgedPain MeasurementPredictive Value of TestsProgestinsRecurrenceRisk AssessmentRisk FactorsSeverity of Illness IndexTissue Array AnalysisTreatment OutcomeYoung AdultConceptsER-α expressionNumerical rating scaleProgesterone receptorAndrogen receptorDeep dyspareuniaDeep endometriosisImmunoreactive scoreProgestin therapyReceptor expressionTissue microarrayExpression of PRMultivariate logistic regression analysisER-α levelsSteroid receptor expressionTime of surgerySeverity of dysmenorrheaSeverity of symptomsLogistic regression analysisNonmenstrual painPain recurrencePain symptomsSevere dysmenorrheaPain persistencePain severityProgestin treatmentMusculoskeletal Pain Symptoms and Injuries Among Endoscopists Who Perform ERCP
Campbell EV, Muniraj T, Aslanian HR, Laine L, Jamidar P. Musculoskeletal Pain Symptoms and Injuries Among Endoscopists Who Perform ERCP. Digestive Diseases And Sciences 2020, 66: 56-62. PMID: 32144599, DOI: 10.1007/s10620-020-06163-z.Peer-Reviewed Original ResearchConceptsEndoscopic retrograde cholangiopancreatographyMusculoskeletal pain symptomsPain symptomsRisk factorsMusculoskeletal injuriesPrevalent musculoskeletal injuriesDe Quervain's tenosynovitisPotential risk factorsRisk of injuryAnonymous electronic surveyNeck painBack painQuervain's tenosynovitisRetrograde cholangiopancreatographyResultsA totalPreventative strategiesConclusionsThe majorityInjurySymptomsEndoscopistsProtective gearMultiple studiesHalf reportTenosynovitisElectronic surveyElagolix in the treatment of endometriosis: impact beyond pain symptoms
Archer DF, Soliman AM, Agarwal SK, Taylor HS. Elagolix in the treatment of endometriosis: impact beyond pain symptoms. Therapeutic Advances In Reproductive Health 2020, 14: 2633494120964517. PMID: 33294846, PMCID: PMC7708701, DOI: 10.1177/2633494120964517.Peer-Reviewed Original ResearchPain symptomsSystemic manifestationsOral gonadotropin-releasing hormone receptor antagonistGonadotropin-releasing hormone receptor antagonistTreatment of endometriosisHormone receptor antagonistQuality of lifePelvic painSevere painCommon symptomsReceptor antagonistEndometriosisElagolixBeneficial effectsSymptomsPainManifestationsOutcomesPatientsWorkplace effectsAntagonistDiseaseWomen
2019
Functional Abdominal Pain
Drossman D, Deutsch J. Functional Abdominal Pain. 2019, 1-12. DOI: 10.1007/978-3-319-90761-1_99-1.Peer-Reviewed Original ResearchFunctional gastrointestinal disordersIrritable bowel syndromeCentral nervous systemAbdominal painCognitive behavioral therapyPain symptomsFunctional dyspepsiaOlder adultsAbdominal pain syndromeChronic abdominal painFunctional abdominal painGut-brain interactionGut motility disordersImprovement of symptomsChronic pain conditionsRed flagsQuality of lifePain syndromeBowel syndromeElderly patientsGastrointestinal painPain modulationPain conditionsMotility disordersGastrointestinal disordersAchieving clinically meaningful response in endometriosis pain symptoms is associated with improvements in health-related quality of life and work productivity: analysis of 2 phase III clinical trials
Pokrzywinski RM, Soliman AM, Chen J, Snabes MC, Coyne KS, Surrey ES, Taylor HS. Achieving clinically meaningful response in endometriosis pain symptoms is associated with improvements in health-related quality of life and work productivity: analysis of 2 phase III clinical trials. American Journal Of Obstetrics And Gynecology 2019, 222: 592.e1-592.e10. PMID: 31759891, DOI: 10.1016/j.ajog.2019.11.1255.Peer-Reviewed Original ResearchConceptsEndometriosis Health Profile-30Nonmenstrual pelvic painHealth-related qualityEndometriosis-associated painPelvic painMonth 3Clinical responseClinical respondersPain symptomsMeaningful improvementsEndometriosis-related pain symptomsSevere endometriosis-associated painSevere endometriosis-related painGonadotropin-releasing hormone antagonistPhase III clinical trialsPain reduction scoresPain responder statusSelf-reported bleedingPlacebo-controlled studyEndometriosis-related painSelf-reported painWork productivityReceiver-operating characteristic analysisNumber of symptomsProductivity QuestionnaireClinical evaluation of the oral gonadotropin-releasing hormone-antagonist elagolix for the management of endometriosis-associated pain
Taylor HS, Dun EC, Chwalisz K. Clinical evaluation of the oral gonadotropin-releasing hormone-antagonist elagolix for the management of endometriosis-associated pain. Pain Management 2019, 9: 497-515. PMID: 31434540, DOI: 10.2217/pmt-2019-0010.Peer-Reviewed Original ResearchConceptsEndometriosis-associated painPain symptomsEstrogen-dependent chronic inflammatory diseaseSevere endometriosis-associated painCurrent medical treatment optionsNonmenstrual pelvic painPelvic pain symptomsMedical treatment optionsChronic inflammatory diseasePathophysiology of endometriosisRole of estrogenEstrogen suppressionCentral sensitizationPelvic painTreatment optionsClinical evaluationInflammatory diseasesPainClinical developmentHigh dosesLow dosesElagolixUS FDAEndometriosisSymptoms
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