2025
114. FUNCTIONING AND DISABILITY IMPROVEMENT DURING AN ACUTE COURSE OF ECT IN GERIATRIC AND NON-GERIATRIC PATIENTS.
Mandell A, Kim J, Hong J, Park S, Touponse S, Crowell A, Hermida A, Kitay B, McDonald W, Posse P, Hershenberg R. 114. FUNCTIONING AND DISABILITY IMPROVEMENT DURING AN ACUTE COURSE OF ECT IN GERIATRIC AND NON-GERIATRIC PATIENTS. American Journal Of Geriatric Psychiatry 2025, 33: s83-s84. DOI: 10.1016/j.jagp.2025.04.116.Peer-Reviewed Original ResearchAcute course of ECTCourse of ECTTreatment-resistant depressed patientsElectroconvulsive therapyDepressed patientsAcute courseAcute seriesCharacteristics of depressionElectroconvulsive therapy researchSDS scoresGroup 2Group 1Depressive disorderHealth-related qualityBipolar disorderGeriatric populationCognitive functionClinical populationsNon-geriatric patientsDepressionNeuromodulation treatmentsNo significant differenceHealth-related quality of lifeSheehanElderly patientsRegional Versus General Anesthesia in the Elderly: A Nuanced Approach
Tseng L, Bartkowiak B, Lan H, Pejcic N, Munoz-Correa S, Mullin A, Moges Y, Brackett A, Li J. Regional Versus General Anesthesia in the Elderly: A Nuanced Approach. Current Anesthesiology Reports 2025, 15: 46. DOI: 10.1007/s40140-025-00701-z.Peer-Reviewed Original ResearchGeneral anesthesiaOutcome differencesHip fracture repairPeripheral nerve blocksHigher ASA statusRandomized Controlled TrialsBlood lossMultimodal analgesiaSpinal anesthesiaRetrospective studyClinical outcomesNerve blockElderly patientsASA statusAnesthetic modalityClinical significanceObservational cohortRegional anesthesiaFracture repairControlled TrialsGeriatric surgeryOrthopedic surgerySurgeryAnesthesiaEarly recoveryMechanical thrombectomy in centenarians for the treatment of acute stroke: Report of 4 patients and review of the literature
Arat A, Amllay A, Yilmaz E, Desai K, Matouk C, Schindler J. Mechanical thrombectomy in centenarians for the treatment of acute stroke: Report of 4 patients and review of the literature. Radiology Case Reports 2025, 20: 3938-3944. PMID: 40496084, PMCID: PMC12149959, DOI: 10.1016/j.radcr.2025.04.095.Peer-Reviewed Original ResearchIntracranial large vessel occlusionLarge vessel occlusionMechanical thrombectomyClinical outcomesAcute intracranial large vessel occlusionVessel occlusionPrestroke mRS scorePrestroke modified Rankin ScaleMechanical thrombectomy outcomesTreatment of acute strokeEndovascular treatmentArtery thrombectomyMRS scoreClinical complicationsElderly patientsRankin ScaleAcute infarctionPatientsThrombectomyResidual deficitsDistal embolizationAcute strokeCerebral thrombectomyThrombectomy outcomesUpper age limitEosinophilic esophagitis manifesting as intractable hiccups in an elderly patient: a case report
Jalloul S, Salem J, Karam K, Chamoun C, Chaptini L. Eosinophilic esophagitis manifesting as intractable hiccups in an elderly patient: a case report. Journal Of Medical Case Reports 2025, 19: 99. PMID: 40045389, PMCID: PMC11884032, DOI: 10.1186/s13256-025-05044-1.Peer-Reviewed Original ResearchConceptsDiagnosis of eosinophilic esophagitisEosinophilic esophagitisEosinophil infiltrationSymptoms related to esophageal dysfunctionComputed tomography of the chestSymptoms of eosinophilic esophagitisElevated peripheral eosinophil countPeripheral eosinophil countEsophagitis treatmentRefractory hiccupsBackgroundEosinophilic esophagitisConclusionThis caseEsophageal dysfunctionCase reportWeUpper endoscopyFood impactionIntermittent dysphagiaCase reportEndoscopic findingsDistal esophagusElderly patientsEosinophil countEsophageal mucosaComputed tomographyIntractable hiccupsMechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR
Cunningham C, Hubbard Z, Kasem R, Elawady S, Sowlat M, Matsukawa H, Maier I, Jabbour P, Kim J, Wolfe S, T A, Starke R, Psychogios M, Samaniego E, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Al Kasab S, Spiotta A. Mechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR. Journal Of NeuroInterventional Surgery 2025, 17: e206-e215. PMID: 39855673, DOI: 10.1136/jnis-2024-022677.Peer-Reviewed Original ResearchAlberta Stroke Program Early CT ScoreLow Alberta Stroke Program Early CT ScorePropensity score matchingSymptomatic intracranial hemorrhageEndovascular thrombectomyAnterior circulation large vessel occlusion acute ischemic strokeElderly patientsLVO-AISAssociated with 90-day mortalityRate of atrial fibrillationScore matchingLarge vessel occlusion acute ischemic strokeFirst-pass reperfusionAcute ischemic strokeCT scoreIntracranial hemorrhagePatient selectionMRS scoreAtrial fibrillationClinical factorsFavorable outcomeRecanalization ratePrimary outcomeMechanical thrombectomyPatientsPreparing for The Silver Tsunami: The Potential for use of Big Data and Artificial Intelligence in Geriatric Anesthesia
Chu L, Kurup V. Preparing for The Silver Tsunami: The Potential for use of Big Data and Artificial Intelligence in Geriatric Anesthesia. Current Anesthesiology Reports 2025, 15: 17. DOI: 10.1007/s40140-024-00674-5.Peer-Reviewed Original ResearchBig data analyticsData analyticsMachine learningPotential of big data analyticsAdoption of MLIntegration of MLData privacyBig dataData scientistsData-driven insightsArtificial intelligenceGeriatric anesthesiaAlgorithmic biasModel interpretationML modelsPreoperative risk stratificationPredicting postoperative complicationsIntraoperative anesthesia managementPostoperative complicationsRespiratory complicationsRisk stratificationElderly patientsDataAdverse outcomesAnesthesia management
2024
Perioperative Pain Management: An Update on Pharmacology with a Special Focus on the Opioid Tolerant Elderly
Chow R, Rajput K. Perioperative Pain Management: An Update on Pharmacology with a Special Focus on the Opioid Tolerant Elderly. Current Anesthesiology Reports 2024, 15: 6. DOI: 10.1007/s40140-024-00656-7.Peer-Reviewed Original ResearchElderly patientsOpioid toleranceChronic painPain managementModerate to high-risk patientsIncreasing use of opioidsOpioid-tolerant patientsSide effects of sedationOpioid sparing effectDoses of opioidsHigh-risk patientsUse of opioidsDrug-drug interactionsChronic opioidsOpioid requirementsTolerant patientsMultimodal analgesicsEffects of sedationPerioperative painRespiratory depressionHome dosePreexisting comorbiditiesPain surgeryRegional anestheticsPerioperative periodImpact of preoperative nutritional status on morbidity and mortality in elderly patients undergoing subdural hematoma evacuation: the role of the Geriatric Nutritional Risk Index.
Serrato P, Craft S, Sayeed S, Hengartner A, Belkasim S, Sadeghzadeh S, DiLuna M, Elsamadicy A. Impact of preoperative nutritional status on morbidity and mortality in elderly patients undergoing subdural hematoma evacuation: the role of the Geriatric Nutritional Risk Index. Journal Of Neurosurgery 2024, 142: 1035-1045. PMID: 39546774, DOI: 10.3171/2024.7.jns24875.Peer-Reviewed Original ResearchGeriatric Nutritional Risk IndexLength of hospital stayPreoperative nutritional statusSubdural hematoma evacuationAssociated with increased oddsNutritional Risk IndexProportion of patientsHematoma evacuationAdverse eventsShort-term outcomesMalnourished statusNutritional statusNonroutine dischargeElderly patientsImpact of preoperative nutritional statusAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseMultivariate logistic regression analysisExtended length of hospital staySevere adverse eventsRetrospective cohort studyPostoperative adverse eventsMinor adverse eventsVenetoclax-Based Therapy Versus Intensive Chemotherapy Followed By Allogeneic-Stem Cell Transplantation for High-Risk Elderly Acute Myeloid Leukemia
Iat A, Bewersdorf J, Gilhodes J, Liu Y, Shallis R, Boussi L, Zucenka A, Bystrom R, DeAngelo D, Berton G, Soua A, Ling K, Aguirre L, Stone R, Luskin M, Garcia J, Winer E, Chen E, Wadleigh M, Goldberg A, Zeidan A, Cluzeau T, Shimony S, Stahl M, Garciaz S. Venetoclax-Based Therapy Versus Intensive Chemotherapy Followed By Allogeneic-Stem Cell Transplantation for High-Risk Elderly Acute Myeloid Leukemia. Blood 2024, 144: 1508. DOI: 10.1182/blood-2024-207045.Peer-Reviewed Original ResearchCumulative incidence of relapseRelapse-free survivalAcute myeloid leukemiaOverall response rateAdverse risk cytogeneticsAllo-SCTVEN-based therapyNon-relapse mortalityIntensive chemotherapyComposite CROverall survivalIC groupMedian OSMyeloid leukemiaElderly patientsTherapy-related acute myeloid leukemiaHigh-risk acute myeloid leukemiaAllogeneic stem-cell transplantationMedian time to relapseElderly acute myeloid leukemiaLong-term disease controlResponse rateFrequent cytogenetic alterationsProspective validation trialVIALE-A trialDocetaxel Versus Androgen-Receptor Signaling Inhibitors (ARSI) as Second-Line Therapy After Failure of First-Line Alternative ARSI for the Elderly ≥ 75 Years Old With Metastatic Castration-Resistant Prostate Cancer (mCRPC): A SPARTACUSS—Meet-URO 26 Real-World Study
Patrikidou A, Saieva C, Lee-Ying R, Nuzzo P, Zarif T, McClure H, Davidsohn M, Eid M, Spinelli G, Catalano F, Cremante M, Fotia G, Rossetti S, Valenca L, Vauchier C, Ottanelli C, Andrade L, Gennusa V, Mestre R, Fornarini G, Pignata S, Procopio G, Santini D, Ravi P, Sweeney C, Heng D, De Giorgi U, Fizazi K, Russo A, Francini E, Group S. Docetaxel Versus Androgen-Receptor Signaling Inhibitors (ARSI) as Second-Line Therapy After Failure of First-Line Alternative ARSI for the Elderly ≥ 75 Years Old With Metastatic Castration-Resistant Prostate Cancer (mCRPC): A SPARTACUSS—Meet-URO 26 Real-World Study. Clinical Genitourinary Cancer 2024, 22: 102230. PMID: 39461026, DOI: 10.1016/j.clgc.2024.102230.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerAndrogen receptor signaling inhibitorsCastration-resistant prostate cancerAbiraterone acetateOverall survivalProstate cancerElderly patientsSignaling InhibitorsCohort of consecutive patientsSecond-line therapyStandard first-lineReal-world studySecond-lineConsecutive patientsTreatment toxicityFirst-lineD. CONCLUSIONSPatient comorbiditiesIdentified patientsRetrospective designToxicity outcomesD groupInternational cohortPatientsNo differenceTenecteplase versus alteplase for acute ischaemic stroke in the elderly patients: a post hoc analysis of the TRACE-2 trial
Xiong Y, Wang L, Pan Y, Wang M, Schwamm L, Duan C, Campbell B, Li S, Hao M, Wu N, Cao Z, Wu S, Li Z, Wang Y. Tenecteplase versus alteplase for acute ischaemic stroke in the elderly patients: a post hoc analysis of the TRACE-2 trial. Stroke And Vascular Neurology 2024, 10: 112-119. PMID: 38858097, PMCID: PMC11877429, DOI: 10.1136/svn-2023-003048.Peer-Reviewed Original ResearchSymptomatic intracranial haemorrhageAcute ischaemic strokeModified Rankin ScaleElderly patientsPost Hoc AnalysisAlteplase groupTenecteplase groupHoc AnalysisAlternative to alteplaseModified Rankin scale 0Ischaemic strokeRisk-benefit profileNon-inferiority clinical trialBenefit-risk profileEfficacy outcomesProportion of participantsReperfusion therapyIntracranial haemorrhageClinical trialsRankin ScaleSymptom onsetTenecteplaseAlteplaseIntravenous thrombolyticsSafety outcomesReal-World Treatment Patterns, Survival, and Economic Burden Among Elderly MCL Patients Previously Treated With cBTKis
Squires P, Puckett J, Ryland K, Kamal-Bahl S, Raut M, Doshi J, Huntington S. Real-World Treatment Patterns, Survival, and Economic Burden Among Elderly MCL Patients Previously Treated With cBTKis. Clinical Lymphoma Myeloma & Leukemia 2024, 24: e350-e358.e1. PMID: 39034204, DOI: 10.1016/j.clml.2024.05.023.Peer-Reviewed Original ResearchR/R MCLOverall survivalTreatment patternsRelapsed/refractory mantle cell lymphomaReal-world treatment patternsBruton tyrosine kinase inhibitorCovalent Bruton tyrosine kinase inhibitorMantle cell lymphomaTyrosine kinase inhibitorsDevelopment of novel therapeuticsMCL patientsCell lymphomaThird-lineRetrospective studyTreatment initiationResponse durationAdverse eventsElderly patientsKinase inhibitorsPatient subpopulationsPatientsAll-CauseNovel therapeuticsEconomic burdenSurvivalLiver and Kidney Transplantation in Elderly Patients
Guzzi J, Strand E, Ozturk B, Agarkov D, Deshpande R. Liver and Kidney Transplantation in Elderly Patients. Transplantology 2024, 5: 98-109. DOI: 10.3390/transplantology5020010.Peer-Reviewed Original ResearchPatients with a history of more than one cancer diagnosis: An opportunity to expand eligibility criteria?
Campos L, Peguero J, Koontz M, Trotter C, Svedman C, Paulson J, Chung W, Tucker V, McAneny B, Campbell Fontaine A. Patients with a history of more than one cancer diagnosis: An opportunity to expand eligibility criteria? Journal Of Clinical Oncology 2024, 42: e23019-e23019. DOI: 10.1200/jco.2024.42.16_suppl.e23019.Peer-Reviewed Original ResearchMedian ageCancer diagnosisIncreasing proportion of elderly patientsProportion of elderly patientsMedian time intervalHistory of 2Early-stage cancerCommunity oncology sitesAnalyzed patientsClinical characteristicsNSCLC diagnosisCure rateElderly patientsGenomic alterationsClinical trialsNSCLCPatientsExclusion criteriaCancerOncology sitesLonger life expectancyDiagnosisEligibility criteriaTesting ratesLife expectancy157 Minimally Invasive Treatment of Idiopathic Normal Pressure Hydrocephalus Using the Endovascular eShunt Implant
Lylyk P, Matouk C, Siddiqui A, Lylyk I, Bleise C, Scrivano E, Lylyk N, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. 157 Minimally Invasive Treatment of Idiopathic Normal Pressure Hydrocephalus Using the Endovascular eShunt Implant. Neurosurgery 2024, 70: 36-37. DOI: 10.1227/neu.0000000000002809_157.Peer-Reviewed Original ResearchNeurogenic Bladder Symptom ScoreComposite outcome scoreNormal pressure hydrocephalusIdiopathic normal pressure hydrocephalusOutcome scoresVentriculo-peritoneal shunt surgeryTimed Up &Treatment of idiopathic normal pressure hydrocephalusPressure hydrocephalusTreat communicating hydrocephalusFavorable risk profileFunctional outcome scoresMinimally invasive treatmentFollow-up dataMontreal Cognitive AssessmentCompared to baselineGait improvementFollow-up phaseShunt surgeryUrinary continenceCSF shuntingUrinary incontinenceElderly patientsPre-treatment scoresFollow-upImpact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography
Randazzo M, Elias P, Poterucha T, Sharir T, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Castillo M, Liang J, Miller R, Dey D, Berman D, Slomka P, Einstein A. Impact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography. European Heart Journal - Cardiovascular Imaging 2024, 25: 996-1006. PMID: 38445511, PMCID: PMC11210974, DOI: 10.1093/ehjci/jeae055.Peer-Reviewed Original ResearchSPECT myocardial perfusion imagingMyocardial perfusion imagingCoronary artery diseaseCardiac sizeDetect obstructive coronary artery diseasePerfusion imagingObstructive coronary artery diseaseDetection of coronary artery diseaseNegative predictive valueLeft ventricular volumeSolid-state scannersSmall cardiac sizeCoronary angiographyMale patientsYounger patientsElderly patientsMale sexDiagnostic performanceVentricular volumeArtery diseaseVisual assessmentPatientsPredictive valueElderly ageSPECTIn-hospital safety outcomes of left atrial appendage occlusion in octogenarians and nonagenarians
Ismayl M, Ahmed H, Goldsweig A, Freeman J, Alkhouli M. In-hospital safety outcomes of left atrial appendage occlusion in octogenarians and nonagenarians. EP Europace 2024, 26: euae055. PMID: 38391186, PMCID: PMC10927254, DOI: 10.1093/europace/euae055.Peer-Reviewed Original ResearchConceptsOutcomes of left atrial appendage occlusionLeft atrial appendage occlusionIn-hospital all-cause mortalityOdds of vascular complicationsLength of stayAll-Cause MortalityYounger patientsAppendage occlusionComposite of in-hospital all-cause mortalityOdds of in-hospital all-cause mortalityVascular complicationsSafety outcomesAcute kidney injuryNational Inpatient Sample databaseRetrospective cohort studyInpatient Sample databaseYears of ageCardiac tamponadeBlood transfusionProcedural complicationsSafety profileKidney injuryLogistic regression modelsElderly patientsCohort studyNeuromuscular manifestations of wild type transthyretin amyloidosis: a review and single center’s experience
Živković S, Lacomis D, Soman P. Neuromuscular manifestations of wild type transthyretin amyloidosis: a review and single center’s experience. Frontiers In Cardiovascular Medicine 2024, 11: 1345608. PMID: 38410247, PMCID: PMC10894993, DOI: 10.3389/fcvm.2024.1345608.Peer-Reviewed Original ResearchATTRwt patientsPeripheral neuropathyPrevalence of peripheral neuropathySuspected peripheral neuropathyCases of neuropathyDistal sensory lossTransthyretin amyloid depositionCardiomyopathy patientsClinical featuresTransthyretin genotypingMusculoskeletal manifestationsNeuropathy symptomsATTRwtTransthyretin amyloidosisElderly patientsHeart failureTransthyretin mutationFrequent comorbiditiesMultiple potential causesNeuropathySensory lossElderly menPatientsSenile amyloidosisPeripheral nervesClinical outcomes of hypomethylating agents plus Venetoclax as frontline treatment in patients 75 years and older with acute myeloid leukemia: Real‐world data from eight US academic centers
Abaza Y, Winer E, Murthy S, Shallis R, Matthews A, Badar T, Geramita E, Kota V, Swaroop A, Doukas P, Bradshaw D, Helenowski I, Liu Y, Zhang H, Im A, Litzow M, Perl A, Atallah E, Altman J. Clinical outcomes of hypomethylating agents plus Venetoclax as frontline treatment in patients 75 years and older with acute myeloid leukemia: Real‐world data from eight US academic centers. American Journal Of Hematology 2024, 99: 606-614. PMID: 38342997, DOI: 10.1002/ajh.27231.Peer-Reviewed Original ResearchAcute myeloid leukemiaHypomethylating agentsOverall survivalElderly patientsMedian OSMyeloid leukemiaTP53-mutated acute myeloid leukemiaNewly diagnosed acute myeloid leukemiaFailure of hypomethylating agentsMedian duration of responseDiagnosed AMLVIALE-A trialMedian overall survivalIncomplete count recoveryDuration of responseMulticenter retrospective studySingle-center studyTreatment of patientsStandard of careCR/CRi rateIntensive chemotherapyCount recoveryMedian durationFrontline treatmentRetrospective studyReal-World Survival, Healthcare Resource Utilization, and Costs Among U.S. Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL) Treated With R-GemOx in the Relapsed/Refractory Setting
Garg M, Puckett J, Kamal-Bahl S, Raut M, Ryland K, Doshi J, Huntington S. Real-World Survival, Healthcare Resource Utilization, and Costs Among U.S. Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL) Treated With R-GemOx in the Relapsed/Refractory Setting. Clinical Lymphoma Myeloma & Leukemia 2024, 24: e181-e190. PMID: 38433043, DOI: 10.1016/j.clml.2024.01.010.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaHealthcare resource utilizationR-GEMOXOverall survivalR/R settingR/R diffuse large B-cell lymphomaElderly patientsLarge B-cell lymphomaDLBCL diagnosisRates of healthcare resource utilizationCombination of rituximabMedian overall survivalR/R DLBCL patientsB-cell lymphomaStem cell transplantationReal-world survivalHealthcare resource useSample of patientsMicro AbstractRelapsed/refractory settingDLBCL patientsThird-lineSecond-lineCell transplantationPost-index
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