2019
Heart-Kidney and Heart-Liver Transplantation Provide Immunoprotection to the Cardiac Allograft
Chou AS, Habertheuer A, Chin AL, Sultan I, Vallabhajosyula P. Heart-Kidney and Heart-Liver Transplantation Provide Immunoprotection to the Cardiac Allograft. The Annals Of Thoracic Surgery 2019, 108: 458-466. PMID: 30885846, DOI: 10.1016/j.athoracsur.2019.02.012.Peer-Reviewed Original ResearchConceptsHeart-kidney transplantationHeart-liver transplantationHT patientsPrior single-center studiesTen-year patient survivalAcute rejection episodesCardiac allograft survivalEquivalent postoperative outcomesFirst posttransplant yearOrgan Sharing databaseSingle-center studyKaplan-Meier curvesChi-square testAllograft survivalHLT patientsRejection episodesSimultaneous kidneyCardiac allograftsHeart transplantationImmunologic outcomesLiver allograftsLiver transplantationPosttransplant yearPostoperative outcomesSimultaneous transplantation
2015
The Impact of Donor and Recipient Renal Dysfunction on Cardiac Allograft Survival: Insights Into Reno-Cardiac Interactions
Laur O, Brisco MA, Kula AJ, Cheng SJ, Mangi AA, Bellumkonda L, Jacoby DL, Coca S, Tang WH, Parikh CR, Testani JM. The Impact of Donor and Recipient Renal Dysfunction on Cardiac Allograft Survival: Insights Into Reno-Cardiac Interactions. Journal Of Cardiac Failure 2015, 22: 368-375. PMID: 26616578, PMCID: PMC4904299, DOI: 10.1016/j.cardfail.2015.11.009.Peer-Reviewed Original ResearchConceptsRenal dysfunctionCardiac transplantationAdverse recipient outcomesCardiac allograft survivalOrgan Sharing registryGlomerular filtration ratePotent risk factorImpact of donorAllograft survivalCardiac allograftsRecipient deathRecipient outcomesUnited NetworkAdverse outcomesFiltration rateMyocardial necrosisRisk factorsCardiovascular diseaseHigh riskDonor characteristicsOlder ageRetransplantationDeathTransplantationDysfunction
2009
27: Targeting of the Histone Acetyltransferase, Myst1, Enhances Foxp3+ Regulatory T Cell Function and Prolongs Cardiac Allograft Survival
Gruber P, Wang L, de Zoeten E, Granger A, Zhou D, Hancock W. 27: Targeting of the Histone Acetyltransferase, Myst1, Enhances Foxp3+ Regulatory T Cell Function and Prolongs Cardiac Allograft Survival. The Journal Of Heart And Lung Transplantation 2009, 28: s74. DOI: 10.1016/j.healun.2008.11.033.Peer-Reviewed Original Research
2008
Novel Immunosuppression: R348, a JAK3- and Syk-Inhibitor Attenuates Acute Cardiac Allograft Rejection
Deuse T, Velotta J, Hoyt G, Govaert J, Taylor V, Masuda E, Herlaar E, Park G, Carroll D, Pelletier M, Robbins R, Schrepfer S. Novel Immunosuppression: R348, a JAK3- and Syk-Inhibitor Attenuates Acute Cardiac Allograft Rejection. Transplantation 2008, 85: 885-892. PMID: 18360272, DOI: 10.1097/tp.0b013e318166acc4.Peer-Reviewed Original ResearchConceptsCombination regimensAllograft survivalAcute cardiac allograft rejectionPrevention of acute rejectionCardiac allograft survivalCardiac allograft rejectionPostoperative day 5Th2 immune responseInflammatory cytokine upregulationAnimals treated with different dosesEnzyme-linked immunosorbent assayEvaluate drug interactionsGraft infiltrationAcute rejectionAllograft rejectionGraft functionInhibition of JAK3Immune cellsPlasma levelsCytokine upregulationTacrolimusDrug interactionsPharmacokinetic dataCellular Th1Treatment period
2007
Is the Malononitrilamide FK778 Better for the Prevention of Acute or Chronic Rejection?
Deuse T, Schrepfer S, Pelletier M, Fischbein M, Robbins R, Reichenspurner H. Is the Malononitrilamide FK778 Better for the Prevention of Acute or Chronic Rejection? Transplantation Proceedings 2007, 39: 569-572. PMID: 17362784, DOI: 10.1016/j.transproceed.2006.12.020.Peer-Reviewed Original ResearchConceptsObliterative airway diseaseUntreated recipientsLuminal obliterationComplete luminal obliterationEfficacy of FK778Rat cardiac transplantsTracheal luminal obliterationCardiac allograft survivalProlonged graft survivalChronic allograft rejectionAcute heart rejectionMalononitrilamide FK778Mycophenolate mofetilAllograft survivalChronic rejectionCardiac transplantationImmunosuppressive agentsAllograft rejectionGraft survivalFK778Heart rejectionAirway diseaseTacrolimusTracheal transplantationIntense infiltration
2002
Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys1
Kawai T, Cosimi A, Wee S, Houser S, Andrews D, Sogawa H, Phelan J, Boskovic S, Nadazdin O, Abrahamian G, Colvin R, Sach D, Madsen J. Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys1. Transplantation 2002, 73: 1757-1764. PMID: 12084998, DOI: 10.1097/00007890-200206150-00011.Peer-Reviewed Original ResearchConceptsDonor bone marrow transplantationKidney allograft recipientsCell-mediated lympholysisBone marrow transplantationAllograft recipientsAllograft survivalMultilineage chimerismCardiac allograftsHematopoietic chimerismMarrow transplantationLong-term acceptancePosttransplant courseIn vitro mixed leukocyte reactionLong-term heart allograft survivalLow-dose total body irradiationInduction of mixed chimerismMHC-mismatched nonhuman primatesDay 0Tolerance to cardiac allograftsImmunological responseMHC-mismatched donorsHeart allograft survivalCardiac allograft survivalHeart allograft recipientsDonor-specific hyporesponsiveness
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply