2025
Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
Dribin T, Sampson H, Zhang Y, Boyd S, Zhang N, Michelson K, Neuman M, Brousseau D, Mistry R, Freedman S, Aronson P, Bergmann K, Boswell B, Chinta S, Chua W, Cohen A, Cohen J, Daggett A, Davis J, Freeman J, Khanna K, Knoles C, Kwan K, Larsen C, Lee J, Lubell T, Metcalf A, Moake M, Nesiama J, Ngo T, Pulcini C, Russo C, Singh N, Srivastava G, Strutt J, Thapar V, Vander Wyst C, Walsh P, Wolnerman Y, Schnadower D, Academy of Pediatrics P, Kanngiesser A, McGarghan F, Dulchavsky A, Costalez J, DesPain A, Armanious M, Haghnazarian E, Brown-Whitehorn T, Weigert R, Dayan P, Meltzer J, Chowdhury N, Benedetti J, Sinziana C, Handorf A, Ruthford M, Devens M, Mecham C, Holland J, Casas T, Brown J, Panda P, Morrow A, Maready M, Nathani Y, Stevens M, Abraham G, Yen K, Cooper-Sood J, Woolf S. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 484-496. PMID: 40506197, DOI: 10.1016/s2352-4642(25)00139-7.Peer-Reviewed Original ResearchConceptsElectronic medical recordsEmergency departmentRetrospective cohort studyCohort studyMedical recordsDocumentation of symptomsCardiovascular involvementHealth-care facilitiesEpinephrine doseAcute allergic reactionsNational Institutes of HealthCumulative incidenceNational Center for Advancing Translational SciencesInstitutes of HealthChildren Aged 6 MonthsClinical ModificationHospital wardsIncidence rateICD-10Observation periodPrimary outcomeAllergic reactionsSecondary to medicationsInitiation to discontinuationKaplan-Meier analysisPrediction Model for Safe Contrast Volume Thresholds to Prevent Postcontrast Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair
Bader J, Li Y, Lee C, Li J, Said S, Slade M, Huang Y, Kuwayama D, Guzman R, Ochoa Chaar C. Prediction Model for Safe Contrast Volume Thresholds to Prevent Postcontrast Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair. Journal Of Vascular Surgery 2025 PMID: 40490161, DOI: 10.1016/j.jvs.2025.05.041.Peer-Reviewed Original ResearchElective endovascular abdominal aortic aneurysm repairEndovascular abdominal aortic aneurysm repairRisk of PC-AKIAbdominal aortic aneurysm repairMultivariate logistic regression analysisAortic aneurysm repairPC-AKIAcute kidney injuryLogistic regression analysisPerioperative mortalityAneurysm repairKidney injuryComplication of endovascular abdominal aortic aneurysm repairPatient characteristicsIncidence of preoperative comorbiditiesPost-contrast acute kidney injuryPostcontrast acute kidney injuryAssociated with development of chronic kidney diseaseAssociated with perioperative mortalityDevelopment of chronic kidney diseaseVascular Quality Initiative databasePreoperative patient characteristicsKaplan-Meier analysisProlonged hospital stayRenal artery stentingClinical outcomes following brachytherapy for endometrial cancer patients with narrow vaginal anatomy
Adefres B, Tien C, Gueble S, Damast S. Clinical outcomes following brachytherapy for endometrial cancer patients with narrow vaginal anatomy. Brachytherapy 2025 PMID: 40447531, DOI: 10.1016/j.brachy.2025.04.002.Peer-Reviewed Original ResearchHigh-dose-rateVaginal brachytherapyVaginal recurrenceEndometrial cancerClinical outcomesStage I-II diseaseClinical outcome of EC patientsHigher surface doseIn-field recurrenceOutcome of EC patientsExcellent local controlIRB-approved databaseKaplan-Meier analysisEndometrial cancer patientsVaginal cylinderUrinary toxicityVaginal stenosisCTCAE v4.0Dose heterogeneityVaginal scarringVaginal anatomyMedian ageRecurrence rateSurface dosePatient demographicsUnplanned Readmission Rate Before Interval Appendectomy After Nonoperative Management of Complicated Appendicitis.
Hellmann Z, Rehman S, Hornick M, Solomon D. Unplanned Readmission Rate Before Interval Appendectomy After Nonoperative Management of Complicated Appendicitis. Journal Of The American College Of Surgeons 2025, 240: 908-913. PMID: 39655815, DOI: 10.1097/xcs.0000000000001255.Peer-Reviewed Original ResearchNonoperative management of complicated appendicitisManagement of complicated appendicitisPediatric Health Information SystemComplicated appendicitisNonoperative managementInterval appendectomyIndex admissionRecurrent appendicitisReadmission ratesRisk of recurrent appendicitisKaplan-Meier survival analysisKaplan-Meier analysisConsecutive daysICD-10 diagnosis codesReceiving antibioticsAppendectomyAppendicitisClinical equipoisePatientsSurvival analysisNatural historyDay patientsDiagnosis codesAdmissionICD-10Decoding Recurrence in Early-Stage and Locoregionally Advanced Non–Small Cell Lung Cancer: Insights From Electronic Health Records and Natural Language Processing
Lee K, Liu Z, Huang Q, Corrigan D, Kalsekar I, Jun T, Stolovitzky G, Oh W, Rajaram R, Wang X. Decoding Recurrence in Early-Stage and Locoregionally Advanced Non–Small Cell Lung Cancer: Insights From Electronic Health Records and Natural Language Processing. JCO Clinical Cancer Informatics 2025, 9: e2400227. PMID: 40249880, PMCID: PMC12011440, DOI: 10.1200/cci-24-00227.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerDistant metastasis-free survivalRecurrence-free survivalLocoregionally advanced non-small cell lung cancerAdvanced non-small cell lung cancerCell lung cancerStage I-IIIA non-small cell lung cancerNatural language processingLung cancerRecurrence-free survival ratesNon-small cell lung cancer recurrenceRisk factorsEarly-stageCox proportional hazards analysisStage IB patientsMetastasis-free survivalKaplan-Meier analysisNatural language processing systemsLikelihood of recurrenceAnalyze risk factorsProportional hazards analysisLocal/regional recurrenceRFS ratesCurative resectionStage IAPostoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study
Stannard B, Epstein R, Gabel E, Nadkarni G, Ouyang Y, Lin H, Salari V, Hofer I. Postoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study. BJA Open 2025, 14: 100384. PMID: 40129614, PMCID: PMC11930183, DOI: 10.1016/j.bjao.2025.100384.Peer-Reviewed Original ResearchPostoperative acute kidney injuryGlomerular filtration rateAcute kidney injuryRenal functionKidney injuryRates of postoperative acute kidney injuryOccurrence of postoperative acute kidney injuryAcute Kidney Injury Network classificationLong-term renal functionRetrospective propensity-matched studyCox modelPropensity-matched cohort studyPersistent renal dysfunctionIncreased hazardKaplan-Meier analysisFollow-up outpatient visitsFollow-up glomerular filtration ratePropensity-Matched StudyTertiary care hospitalHaemodialysis requirementRenal dysfunctionAdult patientsFiltration rateCohort studyHazard ratioSurvival of patients with metastatic renal cell carcinoma with or without brain metastases.
Hurwitz M, Considine B, Hasson N, Savion Gaiger N, Nelson M, Chiang V, Kluger H, Braun D, Schoenfeld D, Sznol M, Leapman M. Survival of patients with metastatic renal cell carcinoma with or without brain metastases. Journal Of Clinical Oncology 2025, 43: 476-476. DOI: 10.1200/jco.2025.43.5_suppl.476.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaImmune checkpoint inhibitorsClear cell RCCRenal cell carcinomaImmune checkpoint inhibitor therapyMetastatic clear cell RCCBrain metastasesOverall survivalCell carcinomaImmune checkpoint inhibitor eraPrevalence of brain metastasesMultivariate Cox proportional hazards modelAssociated with poor survivalMedian overall survivalAssociated with poor prognosisCompare overall survivalImproved overall survivalAdverse prognostic indicatorDevelopment of BMSurvival of patientsKaplan-Meier analysisYale Cancer CenterRetrospective cohort studyCox proportional hazards modelsProportional hazards modelLobectomy vs Sublobar Resection in The Society of Thoracic Surgeons Database: Importance of Patient Factors and Lymph Node Evaluation
Woodard G, Grau-Sepulveda M, Onaitis M, Udelsman B, David E, Jacobs J, Kosinski A, Blasberg J, Boffa D. Lobectomy vs Sublobar Resection in The Society of Thoracic Surgeons Database: Importance of Patient Factors and Lymph Node Evaluation. The Annals Of Thoracic Surgery 2025, 119: 1071-1081. PMID: 39864772, DOI: 10.1016/j.athoracsur.2025.01.004.Peer-Reviewed Original ResearchNon-small cell lung cancerSublobar resectionCell lung cancerLung cancerNodal upstagingImproved survivalHealthy patientsNode-negative non-small cell lung cancerThe Society of Thoracic Surgeons databaseRandomized trialsSociety of Thoracic Surgeons databaseAssociated with improved survivalEarly-stage lung cancerFewer lymph nodesInferior to survivalSublobar resection groupLymph node resectionThoracic Surgeons databaseLymph node evaluationProspective randomized trialsKaplan-Meier analysisForced expiratory volumeCT1 N0Pathologic upstagingNodal evaluationCefazolin Alone Versus Cefazolin With Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Total Joint Arthroplasty
Dhodapkar M, Halperin S, Radford Z, Rubin L, Grauer J, Li M. Cefazolin Alone Versus Cefazolin With Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Total Joint Arthroplasty. Arthroplasty Today 2025, 31: 101613. PMID: 39911247, PMCID: PMC11794179, DOI: 10.1016/j.artd.2024.101613.Peer-Reviewed Original ResearchFive-year implant survivalTotal knee arthroplastyElixhauser Comorbidity IndexProphylactic cefazolinImplant survivalAdverse outcomesComorbidity indexTotal hip arthroplastyAntibiotic prophylaxis regimensIntraoperative antibiotic prophylaxisStandard prophylactic antibioticsKaplan-Meier analysisLog-rank testPerioperative adverse outcomesPostoperative adverse outcomesProsthetic joint infectionMultivariate logistic regressionAntibiotic prophylaxisProphylaxis regimensTotal knee arthroplasty patientsProphylactic antibioticsSSI ratesComplication of total knee arthroplastyJoint infectionCefazolin
2024
Comparison of EndoSuture vs fenestrated aortic aneurysm repair in treatment of abdominal aortic aneurysms with unfavorable neck anatomy
Fereydooni A, Satam K, Dossabhoy S, Trogolo-Franco C, Sorondo S, Arya S, Ullery B, Lee J. Comparison of EndoSuture vs fenestrated aortic aneurysm repair in treatment of abdominal aortic aneurysms with unfavorable neck anatomy. Journal Of Vascular Surgery 2024, 81: 856-865.e1. PMID: 39603282, PMCID: PMC11967903, DOI: 10.1016/j.jvs.2024.11.020.Peer-Reviewed Original ResearchFenestrated endovascular aortic repairSac regressionInfrarenal angulationAneurysm repairNeck anatomyAortic aneurysmHostile aortic neck anatomyLong-term renal functionTreatment of abdominal aortic aneurysmsAneurysm-related reinterventionsAortic neck anatomyUnfavorable neck anatomyThoracoabdominal aortic aneurysmsAneurysm-related mortalityShorter neck lengthType Ia endoleakEndovascular aortic repairAortic aneurysm repairPre-operative eGFRKaplan-Meier analysisTreatment of AAARandomized prospective trialAssociated with reduced freedomBranch vessel patencyPropensity-matched cohortLong-term outcomes of IgA nephropathy in China
Shen X, Chen P, Liu M, Liu L, Shi S, Zhou X, Lv J, Zhang H. Long-term outcomes of IgA nephropathy in China. Nephrology Dialysis Transplantation 2024, 40: 1137-1146. PMID: 39557651, DOI: 10.1093/ndt/gfae252.Peer-Reviewed Original ResearchConceptsEnd-stage kidney diseaseLong-term outcomesTime-averaged proteinuriaKidney outcomesPrognosis of immunoglobulin A nephropathyFollow-upMonths of follow-upKidney failureOutcome of IgA nephropathyAssociated with kidney failureKidney survival ratesPeking University First HospitalRestricted cubic spline analysisRisk of end-stage kidney diseaseLong-term kidney survivalBiopsy-proven IgANOutcome of IgANKaplan-Meier analysisAnnual event rateLong-term prognosisCurrent treatment strategiesImmunoglobulin A nephropathyRisk of kidney failureCubic spline analysisProteinuria remissionAssociation of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy
Jadam S, Gaballa A, Alashi A, Xu B, Thamilarasan M, Rodriguez E, Tan C, Ospina S, Smedira N, Popovic Z, Desai M. Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy. JACC Heart Failure 2024, 13: 631-640. PMID: 39545888, DOI: 10.1016/j.jchf.2024.10.006.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathySurgical myectomyLong-term outcomesMyocyte hypertrophyInterstitial fibrosisHistological findingsHypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathy patientsHistological scoresAssociated with long-term outcomesSevere histological findingsHypertrophic cardiomyopathy patientsKaplan-Meier analysisMultivariate Cox analysisLeft ventricular hypertrophyComposite of deathPrimary eventDiastolic dysfunctionCardiac transplantationPrimary endpointTertiary centerCardiomyopathy patientsMicrovascular ischemiaVentricular hypertrophyCox analysisOpen and endovascular treatment of the common femoral artery in a tertiary care center
Wells N, Hundito A, Tuttle M, Alameddine D, Aboian E, Arhuidese I, Fischer U, Perez Lozada J, Guzman R, Ochoa Chaar C. Open and endovascular treatment of the common femoral artery in a tertiary care center. Journal Of Vascular Surgery 2024, 81: 386-396.e2. PMID: 39442735, PMCID: PMC11748354, DOI: 10.1016/j.jvs.2024.10.027.Peer-Reviewed Original ResearchLower extremity revascularizationTreated with open surgeryPeripheral arterial diseaseCFA endarterectomyEndovascular therapyOpen surgeryEndovascular treatmentEndovascular lower extremity revascularizationTreated with endovascular therapyCompared to open surgeryAssociated with higher perioperative complicationsLower extremity revascularization proceduresPost-operative bleedingFemoral arteryImprove patient selectionKaplan-Meier analysisTertiary care centerTertiary-care centerLong-term outcomesEndovascular treatment of peripheral arterial diseaseLonger hospital lengthMALE-free survivalMultivariate logistic regressionTreatment of peripheral arterial diseaseCommon femoral arteryLenalidomide in Transfusion-Dependent IPSS Low- or Intermediate-1-Risk Myelodysplastic Syndromes and Isolated Del(5q): Results of a European Postauthorization Safety Surveillance Study
Poloni A, Raaschou-Jensen K, Mohedo F, Paolini S, Oliva E, Buccisano F, Vasconcelos A, Kim I, Makwana A, Bernasconi D, Rosettani B, Prebet T, Santini V. Lenalidomide in Transfusion-Dependent IPSS Low- or Intermediate-1-Risk Myelodysplastic Syndromes and Isolated Del(5q): Results of a European Postauthorization Safety Surveillance Study. Clinical Lymphoma Myeloma & Leukemia 2024, 25: e131-e142. PMID: 39516085, DOI: 10.1016/j.clml.2024.10.007.Peer-Reviewed Original ResearchInternational Prognostic Scoring SystemDose of lenalidomideMyelodysplastic syndromeIsolated del(5qAcute myeloid leukemiaBenefit-risk profileSafety populationTransfusion-DependentOverall survivalCumulative incidenceCumulative incidence of acute myeloid leukemiaGrade 3/4 treatment-emergent adverse eventsNon-interventional post-authorization safety studyInternational Prognostic Scoring System low-Intermediate-1-risk myelodysplastic syndromeIncidence of acute myeloid leukemiaLower-risk myelodysplastic syndromesTreatment-emergent adverse eventsEffects of lenalidomidePrognostic scoring systemKaplan-Meier analysisPost-authorization safety studyRoutine careClinical trial dataSafety surveillance studyThe Incidence and Impact of Cardiac Function Decline after Lower Extremity Revascularization
Jamil Y, Huttler J, Alameddine D, Wu Z, Mena-Hurtado C, Velazquez E, Guzman R, Ochoa Chaar C. The Incidence and Impact of Cardiac Function Decline after Lower Extremity Revascularization. Annals Of Vascular Surgery 2024, 110: 414-423. PMID: 39343374, DOI: 10.1016/j.avsg.2024.07.119.Peer-Reviewed Original ResearchCardiac functional declineStable cardiac functionLower extremity revascularizationPeripheral arterial diseaseCardiac functionFollow-upExtremity revascularizationFunctional declineElectronic records of patientsKaplan-Meier analysisRecords of patientsMode of revascularizationAdverse limb eventsLower-extremity revascularizationTransthoracic echocardiogramReintervention rateHeart failureDiabetes mellitusPeriprocedural bleedingPatient characteristicsArtery diseasePatientsLimb eventsIncreased MortalityRevascularizationPrognosis of IgA nephropathy patient with proteinuria remission by supportive therapy: cohort from screening failed Chinese patients in TESTING study
Guo Y, Shi S, Zhao J, Wang C, Liu Z, Fu S, Chen N, Li G, Wang L, Ni Z, Zhang H, Lai L, Lv J, Zhang H. Prognosis of IgA nephropathy patient with proteinuria remission by supportive therapy: cohort from screening failed Chinese patients in TESTING study. Renal Failure 2024, 46: 2398826. PMID: 39248402, PMCID: PMC11385640, DOI: 10.1080/0886022x.2024.2398826.Peer-Reviewed Original ResearchConceptsRelapse of proteinuriaImmunosuppressive therapyComposite kidney outcomeKaplan-Meier analysisProteinuria remissionKidney outcomesFollow-upSupportive therapyKidney outcomes of patientsLong-term kidney outcomesRenin-angiotensin system blockersComposite kidney endpointRemission of proteinuriaOutcomes of patientsLong-term prognosisRun-in phaseIgA nephropathy patientsStages of follow-upIntensive supportive therapyEarly stage of follow-upPersistent remissionDialysis of patientsKidney survivalRenal transplantationKidney endpointsOmission of 5-Fluorouracil Bolus From Multidrug Regimens for Advanced Gastrointestinal Cancers: A Multicenter Cohort Study.
Peng C, Saffo S, Oberstein P, Shusterman M, Thomas C, Becker D, Berlin J, Leichman L, Boursi B, Nagar A, Yu S. Omission of 5-Fluorouracil Bolus From Multidrug Regimens for Advanced Gastrointestinal Cancers: A Multicenter Cohort Study. Journal Of The National Comprehensive Cancer Network 2024, 22: 521-527. PMID: 39236754, DOI: 10.6004/jnccn.2024.7029.Peer-Reviewed Original ResearchMultidrug regimensFOLFIRINOX regimensAdvanced colorectalGastrointestinal cancerAssociated with decreased survivalGranulocyte colony-stimulating factorCompare survival outcomesGastrointestinal cancer treatmentBaseline clinical factorsKaplan-Meier analysisFirst-line FOLFOXMulticenter cohort studyColony-stimulating factorInverse probability of treatmentAdvanced gastrointestinal cancerTreatment selection biasProbability of treatmentHealth care savingsCox proportional hazardsOverall survivalEffective regimenIPTW analysisSurvival outcomesPancreatic cancerAssociated with reductionsTotal Shoulder Arthroplasty in Patients With Hemophilia A: Greater Odds of Postoperative Bleeding and Thromboembolic Events but No Difference in 5-year Implant Survival
Gillinov S, Modrak M, Park N, Monahan P, Wilhelm C, Lee M, Mahatme R, Fong S, Moran J, Grauer J, Jimenez A. Total Shoulder Arthroplasty in Patients With Hemophilia A: Greater Odds of Postoperative Bleeding and Thromboembolic Events but No Difference in 5-year Implant Survival. Clinical Orthopaedics And Related Research® 2024, 483: 268-275. PMID: 39246053, PMCID: PMC11753735, DOI: 10.1097/corr.0000000000003209.Peer-Reviewed Original ResearchVenous thromboembolic eventsTotal shoulder arthroplastyHemophilia AImplant survivalMatched ControlsThromboembolic eventsElixhauser Comorbidity IndexMale patientsAdverse eventsShoulder arthroplastyProsthesis survivalThromboembolic adverse eventsVenous thromboembolic event prophylaxisKaplan-Meier analysisFactor VIII levelsRevers total shoulder arthroplastyIndividual patient basisOdds of postoperative bleedingPostoperative bleedingBleeding complicationsTranexamic acidNinety-dayPatient basisControl cohortComorbidity indexProphylaxis with recombinant factor IX Fc fusion protein reduces the risk of bleeding and delays time to first spontaneous bleed event in previously untreated patients with haemophilia B: A post hoc analysis of the PUPs B‐LONG study
Nolan B, Recht M, Rendo P, Falk A, Foster M, Casiano S, Rauch A, Shapiro A. Prophylaxis with recombinant factor IX Fc fusion protein reduces the risk of bleeding and delays time to first spontaneous bleed event in previously untreated patients with haemophilia B: A post hoc analysis of the PUPs B‐LONG study. European Journal Of Haematology 2024, 113: 485-492. PMID: 38922990, DOI: 10.1111/ejh.14252.Peer-Reviewed Original ResearchConceptsRecombinant FIX Fc fusion proteinSpontaneous bleedingRisk of bleedingHemophilia BPost Hoc AnalysisUntreated patientsRecombinant factor IX Fc fusion proteinBaseline ageHoc AnalysisInitial treatment regimensMedian time to eventKaplan-Meier analysisSpontaneous bleeding eventsFc fusion proteinTime to eventProphylaxis typeBleeding eventsTreatment regimenTreatment regimensTreatment patternsTreat ODBleedingProphylaxisFixed replacementSevere casesAdjuvant imatinib in high‐risk resected gastrointestinal stromal tumors: Merely delaying the inevitable?
Sutton T, Billingsley K, Johnson A, Corless C, Blanke C, Heinrich M, Mayo S. Adjuvant imatinib in high‐risk resected gastrointestinal stromal tumors: Merely delaying the inevitable? Journal Of Surgical Oncology 2024, 130: 40-46. PMID: 38924626, DOI: 10.1002/jso.27654.Peer-Reviewed Original ResearchHigh-risk gastrointestinal stromal tumorsRecurrence-free survivalGastrointestinal stromal tumorsResected gastrointestinal stromal tumorsAdjuvant imatinibOverall survivalStromal tumorsAdjuvant therapyDuration of adjuvant imatinibBenefit of adjuvant therapyMonths of postsurgical follow-upMultivariate Cox proportional hazards modelPostsurgical follow-upKaplan-Meier analysisCox proportional hazards modelsProportional hazards modelRadiographic recurrenceImatinib resistanceReviewed patientsFollow-upImatinibOncological treatmentCytocidal effectCancer CenterPatients
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