2023
Management of Bilateral Synchronous Knee Prosthetic Joint Infection in a Patient with Infected Heart Transplant
Jeong S, Yang A, Rubin L, Arsoy D. Management of Bilateral Synchronous Knee Prosthetic Joint Infection in a Patient with Infected Heart Transplant. JBJS Case Connector 2023, 13: e23.00182. PMID: 37506219, DOI: 10.2106/jbjs.cc.23.00182.Peer-Reviewed Original ResearchConceptsHeart transplantKnee prosthetic joint infectionProsthetic knee infectionProsthetic joint infectionResection arthroplastyKnee infectionRadical debridementSeptic shockEnterococcal endocarditisJoint infectionProsthetic knee jointRegular implantsKnee jointTransplantInfectionPatientsFirst reportEndocarditisDebridementArthroplastyPlacementMulticenter study of universal prophylaxis versus pre‐emptive therapy for patients at intermediate risk (R+) for CMV following heart transplantation
Lerman J, Green C, Molina M, Maharaj V, Ortega‐Legaspi J, Sen S, Flattery M, Maziarz E, Shah K, Martin C, Alexy T, Shah P, Morris A, DeVore A, Cole R. Multicenter study of universal prophylaxis versus pre‐emptive therapy for patients at intermediate risk (R+) for CMV following heart transplantation. Clinical Transplantation 2023, 37: e15065. PMID: 37392192, PMCID: PMC10592402, DOI: 10.1111/ctr.15065.Peer-Reviewed Original ResearchConceptsAcute cellular rejectionCardiac allograft vasculopathyUniversal prophylaxisPreemptive therapyHeart transplantHT recipientsGrade 2RIntermediate riskCMV-related complicationsIncidence of leukopeniaPre-emptive therapyAnti-CMV therapyEnd-organ diseaseInitiation/escalationAllograft vasculopathyCellular rejectionCMV DNAemiaCMV preventionGraft outcomeHeart transplantationCMV infectionSecondary outcomesPrimary outcomeProphylaxis strategiesSuch patients
2022
Trends and Outcomes of Patients With Amyloid Cardiomyopathy Listed for Heart Transplantation
Akintoye E, Salih M, Aje K, Alvarez P, Sellke F, Briasoulis A, Dorbala S. Trends and Outcomes of Patients With Amyloid Cardiomyopathy Listed for Heart Transplantation. Canadian Journal Of Cardiology 2022, 38: 1263-1270. PMID: 35525397, DOI: 10.1016/j.cjca.2022.04.023.Peer-Reviewed Original ResearchConceptsHeart transplantGraft survivalAmyloid cardiomyopathyWaitlist mortalityHeart transplantationRisk factorsSingle-organ heart transplantsStudy periodHeart transplant waitlistUnderwent heart transplantWorse graft survivalGraft survival ratesOutcomes of patientsPropensity-matched cohortOrgan Sharing databaseHigher waitlist mortalityNumber of patientsNumber of transplantsAmyloid recurrenceAdult patientsGraft failureRenal failureIndependent predictorsSharing databaseUnited NetworkWait List And Transplant Outcomes Of Diabetic Patients With Listed For Heart Transplantation: A Propensity-matched Analysis
Akintoye E, Alvarez P, Salih M, Briasoulis A. Wait List And Transplant Outcomes Of Diabetic Patients With Listed For Heart Transplantation: A Propensity-matched Analysis. Journal Of Cardiac Failure 2022, 28: s64. DOI: 10.1016/j.cardfail.2022.03.163.Peer-Reviewed Original ResearchDiabetic patientsWaitlist mortalityHeart transplantPost-transplant graft survivalEnd-stage heart failurePropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureHeart failureUnited NetworkRisk factorsOrgan SharingPatientsStudy periodTransplantMortalityFailureCohortWaitlistTrends in Survival for Pediatric Transplantation.
Hickner B, Anand A, Godfrey E, Dunson J, Reul R, Cotton R, Galvan N, O'Mahony C, Goss J, Rana A. Trends in Survival for Pediatric Transplantation. 2022, 149 PMID: 35079811, DOI: 10.1542/peds.2020-049632.Peer-Reviewed Original ResearchConceptsTreat survivalKidney transplantPosttransplant survivalHeart transplantPediatric transplantationMultivariable Cox regressionPercentage of patientsKaplan-Meier methodLog-rank testLiver transplantPosttransplant outcomesTreat analysisTransplant ratesCox regressionDonor poolPatient's perspectiveTransplantPatient careStudy periodΧ2 testLiverSurvivalTransplantationSignificant increaseChildrenOutcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis
Akintoye E, Alvarez P, Salih M, Sellke F, Briasoulis A. Outcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis. Clinical Transplantation 2022, 36: e14590. PMID: 35018661, DOI: 10.1111/ctr.14590.Peer-Reviewed Original ResearchConceptsDiabetic patientsWaitlist mortalityHeart transplantPost-transplant graft survivalEnd-stage heart failurePropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureHeart failureUnited NetworkRisk factorsOrgan SharingPatientsStudy periodTransplantMortalityFailureCohortWaitlist
2021
Impact of Obesity on Heart Transplantation Outcomes
Chouairi F, Milner A, Sen S, Guha A, Stewart J, Jastreboff AM, Mori M, Clark KA, Miller PE, Fuery MA, Rogers JG, Notarianni A, Jacoby D, Maulion C, Anwer M, Geirsson A, Desai NR, Ahmad T, Mullan CW. Impact of Obesity on Heart Transplantation Outcomes. Journal Of The American Heart Association 2021, 10: e021346. PMID: 34854316, PMCID: PMC9075353, DOI: 10.1161/jaha.121.021346.Peer-Reviewed Original ResearchConceptsBody mass indexHigher BMI categoriesImpact of obesityHeart transplantation outcomesBMI categoriesTransplantation outcomesHeart transplantationHigher Body Mass IndexAllocation system changeAdvanced heart failureOrgan Sharing databaseObese BMI categoriesVentricular assist deviceNew Organ ProcurementPosttransplant deathPosttransplantation deathPosttransplant mortalityBackground PatientsBMI 18.5Adult patientsCohort studyHeart failureHeart transplantSharing databaseWaitlist deathsOutcomes of diabetic patients with end-stage heart failure listed for heart transplantation: a propensity-matched analysis
Akintoye E, Alvarez P, Briasoulis A. Outcomes of diabetic patients with end-stage heart failure listed for heart transplantation: a propensity-matched analysis. European Heart Journal 2021, 42: ehab724.0967. DOI: 10.1093/eurheartj/ehab724.0967.Peer-Reviewed Original ResearchHeart transplantWaitlist mortalityPost-transplant graft survivalEnd-stage heart failureOutcomes of patientsPropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureDiabetic patientsHeart failureDiabetic cohortPoor outcomeUnited NetworkRisk factorsOrgan SharingPatientsTransplantStudy periodCohortMortalityOutcomesRiskPredictive value of NT-proBNP in non-obstructive hypertrophic cardiomyopathy
Hutt E, Mentias A, Alashi A, Fava A, Popovic Z, Thamilarasan M, Lever H, Desai M. Predictive value of NT-proBNP in non-obstructive hypertrophic cardiomyopathy. European Heart Journal 2021, 42: ehab724.0765. DOI: 10.1093/eurheartj/ehab724.0765.Peer-Reviewed Original ResearchNT-proBNP ratioLV ejection fractionSerum NT-proBNPNT-proBNPAsymptomatic patientsPrimary endpointSeptal myectomySudden cardiac death risk factorsNon-obstructive hypertrophic cardiomyopathyKaplan-Meier survival analysisDeath risk factorsEarly disease stagesHypertrophic cardiomyopathy patientsImplantable defibrillator dischargesEjection fractionHeart transplantPrimary outcomeRisk stratificationPrognostic valueAdverse outcomesDisease stageCardiomyopathy patientsRisk factorsEcho variablesHypertrophic cardiomyopathyTET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy
Ostriker AC, Xie Y, Chakraborty R, Sizer AJ, Bai Y, Ding M, Song WL, Huttner A, Hwa J, Martin KA. TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy. Circulation 2021, 144: 455-470. PMID: 34111946, PMCID: PMC8643133, DOI: 10.1161/circulationaha.120.050553.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsAnimalsApoptosisBiomarkersDioxygenasesDisease Models, AnimalDisease SusceptibilityDNA-Binding ProteinsHeart TransplantationHumansImmunohistochemistryInterferon-gammaMiceMice, KnockoutMyocytes, Smooth MuscleSignal TransductionSTAT1 Transcription FactorTunica IntimaVascular DiseasesConceptsCoronary allograft vasculopathyGraft arteriopathyIntimal thickeningCAV progressionRole of TET2VSMC apoptosisTransplant samplesGraft modelHigh-dose ascorbic acidTET2 expressionVSMC phenotypeContext of transplantCoronary blood flowEffect of IFNγTET2 activityTET2 depletionSmooth muscle cell apoptosisVascular smooth muscle cell apoptosisMuscle cell apoptosisAllograft vasculopathyDevastating sequelaeMedial thinningAortic graftHeart transplantTransplant failureRisk stratification of patients listed for heart transplantation while supported with extracorporeal membrane oxygenation
Ivey-Miranda JB, Maulion C, Farrero-Torres M, Griffin M, Posada-Martinez EL, Testani JM, Bellumkonda L. Risk stratification of patients listed for heart transplantation while supported with extracorporeal membrane oxygenation. Journal Of Thoracic And Cardiovascular Surgery 2021, 165: 711-720. PMID: 34167814, DOI: 10.1016/j.jtcvs.2021.05.032.Peer-Reviewed Original ResearchConceptsHeart transplantMajor risk factorRisk factorsPosttransplantation mortalityHT recipientsMembrane oxygenationGood long-term prognosisSevere cardiogenic shockOrgan Sharing databaseLong-term prognosisExtracorporeal membrane oxygenationMinor risk factorsVentricular assist deviceCardiogenic shockHeart transplantationRecipient ageIndependent predictorsPrimary outcomeSharing databaseMechanical ventilationRisk stratificationUnited NetworkAdult candidatesECMOAbsence of recoveryRacial Differences in In-Hospital Outcomes after the Use of Temporary Mechanical Circulatory Support as a Bridge to Heart Transplant
Siddiqui E, Okoh A, Tibuakuu M, Hirji S, Hameed I, Osho A, Singh S, Grewal J, Montgomery M, Camacho M, Bravo C. Racial Differences in In-Hospital Outcomes after the Use of Temporary Mechanical Circulatory Support as a Bridge to Heart Transplant. The Journal Of Heart And Lung Transplantation 2021, 40: s404-s405. DOI: 10.1016/j.healun.2021.01.1136.Peer-Reviewed Original ResearchTemporary mechanical circulatory supportMechanical circulatory supportHospital mortalityHeart transplantCirculatory supportRacial differencesAcute kidney injuryAllocation system changeIn-Hospital OutcomesNon-home dischargeIncidence of MACENational Inpatient SampleMultivariable logistic regressionHeart allocation systemTransplant allocation systemHospital complicationsPrior pacemakerPulmonary complicationsHospital deathHospital outcomesKidney injuryCardiac tamponadeDischarge dispositionIndependent predictorsInpatient SamplePlasma Donor-Derived Cell-Free DNA Levels are Not Affected by Prednisone Dose nor Time after Heart Transplant: Pilot Data from DOAR and SHORE
Ghafourian K, Bellumkonda L, Jenkins L, Teuteberg J. Plasma Donor-Derived Cell-Free DNA Levels are Not Affected by Prednisone Dose nor Time after Heart Transplant: Pilot Data from DOAR and SHORE. The Journal Of Heart And Lung Transplantation 2021, 40: s231. DOI: 10.1016/j.healun.2021.01.665.Peer-Reviewed Original ResearchConsensus conference on heart-kidney transplantation
Kobashigawa J, Dadhania DM, Farr M, Tang WHW, Bhimaraj A, Czer L, Hall S, Haririan A, Formica RN, Patel J, Skorka R, Fedson S, Srinivas T, Testani J, Yabu JM, Cheng X, Participants O. Consensus conference on heart-kidney transplantation. American Journal Of Transplantation 2021, 21: 2459-2467. PMID: 33527725, DOI: 10.1111/ajt.16512.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSimultaneous heart-kidney transplantHeart transplantKidney transplantationKidney diseaseConsensus conferenceEnd-stage heart diseaseConcomitant kidney diseaseDual-organ transplantationHeart-kidney transplantHeart-kidney transplantationMulti-organ transplantationReversible kidney injuryAdvanced kidney diseaseNon-inferior outcomesAvailable donor organsCardiorenal syndromeKidney injuryKidney functionStandardized careHeart diseaseSuccessful transplantationConsensus statementDonor organsOrgan transplantationTransplantation
2020
Survival on the Heart Transplant Waiting List
Bakhtiyar SS, Godfrey EL, Ahmed S, Lamba H, Morgan J, Loor G, Civitello A, Cheema FH, Etheridge WB, Goss J, Rana A. Survival on the Heart Transplant Waiting List. JAMA Cardiology 2020, 5: 1227-1235. PMID: 32785619, PMCID: PMC7675100, DOI: 10.1001/jamacardio.2020.2795.Peer-Reviewed Original ResearchConceptsVentricular assist deviceHeart transplant waiting listList survivalTransplant waiting listWaiting listMultivariable Cox proportional hazards regression analysisCox proportional hazards regression analysisProportional hazards regression analysisHeart transplantation waiting listAdjusted survival analysisHazards regression analysisTransplantation waiting listWait-listed candidatesCandidate risk factorsHeart transplantationList mortalityUNOS databaseClinical improvementHeart transplantPrimary outcomeAdjusted analysisSurvival outcomesKaplan-MeierPatient groupUnited NetworkEvaluation of Case Volumes of a Heart Transplant Program and Short-term Outcomes After Changes in the United Network for Organ Sharing Donor Heart Allocation System
Mori M, Wilson L, Ali A, Ahmad T, Anwer M, Jacoby D, Geirsson A, Krumholz HM. Evaluation of Case Volumes of a Heart Transplant Program and Short-term Outcomes After Changes in the United Network for Organ Sharing Donor Heart Allocation System. JAMA Network Open 2020, 3: e2017513. PMID: 32945877, PMCID: PMC7501535, DOI: 10.1001/jamanetworkopen.2020.17513.Peer-Reviewed Original ResearchConceptsYale-New Haven HospitalHeart transplant programShort-term outcomesHeart transplantHeart transplant volumeNew Haven HospitalDonor heartsPatient selectionRecipient selectionTransplant programsTransplant volumeWaiting listCase volumeDonor heart allocation systemPre-post cohort studyConservative patient selectionUnused donor heartsHeart allocation systemHigher median numberCirculatory assist devicesCohort studyPatient characteristicsMore patientsSingle centerCenter volumeSex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure
Gruen J, Caraballo C, Miller PE, McCullough M, Mezzacappa C, Ravindra N, Mullan CW, Reinhardt SW, Mori M, Velazquez E, Geirsson A, Ahmad T, Desai NR. Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure. JACC Heart Failure 2020, 8: 770-779. PMID: 32653446, DOI: 10.1016/j.jchf.2020.04.015.Peer-Reviewed Original ResearchConceptsAdverse eventsVentricular assist deviceClinical outcomesPotential underuseHigh riskAssist deviceEnd-stage heartWomen 65 yearsRisk of deathContinuous-flow LVADYears of ageAdvanced treatment optionsSex differencesHeart transplantationMultivariable adjustmentHeart failureHeart transplantSimilar incidenceTreatment optionsSimilar riskSurvival analysisLVADPatientsDevice malfunctionWomenSystematic Review: Treatment for Addictive Disorder in Transplant Patients
Luchsinger W, Zimbrean P. Systematic Review: Treatment for Addictive Disorder in Transplant Patients. American Journal On Addictions 2020, 29: 445-462. PMID: 32410396, DOI: 10.1111/ajad.13054.Peer-Reviewed Original ResearchConceptsTransplant patientsAlcohol use disorderUse disordersOrgan transplantationAddictive disordersSystematic reviewLiver transplant patientsOpioid use disorderNumber of patientsPromising treatment optionSubstance use disordersOpioid disordersFirst systematic reviewTransplant candidatesHeart transplantTreatment optionsCase reportOutcome measuresMedical statusHigh riskPatientsDatabases PubMedTreatment interventionsControl groupLiterature searchOutcomes of Heart Transplantation from Hepatitis C Seropositive Donors: An Updated Analysis of the United Network for Organ Sharing Registry
Li S, Moonsamy P, Osho A, Mohan N, Ong C, Lewis G, Coglianese E, Villavicencio M, D'Alessandro D, Sundt T, Funamoto M. Outcomes of Heart Transplantation from Hepatitis C Seropositive Donors: An Updated Analysis of the United Network for Organ Sharing Registry. The Journal Of Heart And Lung Transplantation 2020, 39: s119-s120. DOI: 10.1016/j.healun.2020.01.1001.Peer-Reviewed Original ResearchOrgan Sharing registryHCV statusHeart transplantationOverall survivalHeart transplantUnited NetworkDonor ageHepatitis C seropositive donorsComparable overall survivalLonger ischemic timesRecipients of HCVUse of ECMOMultivariate Cox regressionTime of transplantKaplan-Meier analysisLong-term outcomesAnalysis of outcomesVentricular assist deviceRecipient creatinineGraft outcomeHLA mismatchesSeropositive donorsHepatitis CMultiorgan transplantsAdult patientsChanges to the New United Network for Organ Sharing (UNOS) Heart Allocation System Did Not Affect Short Term Post-Transplant Mortality
Moonsamy P, Mohan N, Axtell A, Osho A, Ong C, Li S, D'Alessandro D, Sundt T, Funamoto M. Changes to the New United Network for Organ Sharing (UNOS) Heart Allocation System Did Not Affect Short Term Post-Transplant Mortality. The Journal Of Heart And Lung Transplantation 2020, 39: s73. DOI: 10.1016/j.healun.2020.01.1285.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationLeft ventricular assist devicePost-transplant mortalityNew allocation systemHeart transplantHeart allocation policyVentricular assist deviceUse of ECMOAssist deviceNew heart allocation policyWorse post-transplant outcomesIntra-aortic balloon pumpAdult heart transplantsOld allocation systemsPost-transplant deathPost-transplant outcomesShort-term outcomesShort-term mortalityHeart allocation systemNew United NetworkUNOS databaseIschemic timeOverall survivalPatient characteristicsBalloon pump
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