2025
Treat-to-target of endoscopic remission in patients with inflammatory bowel disease in symptomatic remission on advanced therapies (QUOTIENT): rationale, design and protocol for an open-label, multicentre, pragmatic, randomised controlled trial
Singh S, Nguyen J, Fudman D, Gerich M, Shah S, Hudesman D, McConnell R, Lukin D, Flynn A, Hwang C, Sprung B, Gaidos J, Mattar M, Rubin D, Hashash J, Metwally M, Ali T, Ma C, Hoentjen F, Narula N, Bessissow T, Rosenfeld G, McCurdy J, Ananthakrishnan A, Cross R, Gaytan J, Gurrola E, Patel S, Siegel C, Melmed G, Weaver S, Power S, Zou G, Jairath V, Hou J. Treat-to-target of endoscopic remission in patients with inflammatory bowel disease in symptomatic remission on advanced therapies (QUOTIENT): rationale, design and protocol for an open-label, multicentre, pragmatic, randomised controlled trial. BMJ Open Gastroenterology 2025, 12: e001615. PMID: 40164445, PMCID: PMC11962770, DOI: 10.1136/bmjgast-2024-001615.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseAdvanced therapiesTreat-to-targetSymptomatic remissionBowel inflammationOpen-labelAsymptomatic patientsPatient-Centered Outcomes Research InstituteBowel diseaseControlled TrialsSafety of switchingClinical practiceActive bowel inflammationReduced bowel inflammationDeep remissionEndoscopic remissionTreatment failurePrimary endpointRandomised controlled trialsTargeted immunomodulationRemissionTherapyPatientsGood clinical practiceInformed consentIntegration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology
Erbay M, Manubolu V, Stein-Merlob A, Ferencik M, Mamas M, Lopez-Mattei J, Baldassarre L, Budoff M, Yang E. Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology. Current Cardiology Reports 2025, 27: 51. PMID: 39932640, PMCID: PMC11814013, DOI: 10.1007/s11886-025-02206-x.Peer-Reviewed Original ResearchConceptsRadiation-induced cardiovascular diseaseCoronary artery diseaseCardiovascular diseaseCardiac massComputed tomographyArtery diseaseChest CT scans of patientsCT scans of patientsIncreased risk of CVDInvasive coronary angiographyRisk of cardiovascular diseaseRisk of complicationsScans of patientsCardiovascular Computed TomographySeverity of cardiovascular diseaseNon-invasive imaging toolMonitoring of disease progressionManifestations of diseaseAsymptomatic patientsCardiac deteriorationIschemia evaluationCoronary angiographyPericardial diseaseCardiac changesRisk stratificationP-1574. Asymptomatic Bacteriuria Not a Predictor of Clinical Failure in Uncomplicated Urinary Tract Infections (uUTI): A Prospective Analysis of Women Treated for uUTI from the REASSURE Trial
Aronin S, Dunne M, Puttagunta S. P-1574. Asymptomatic Bacteriuria Not a Predictor of Clinical Failure in Uncomplicated Urinary Tract Infections (uUTI): A Prospective Analysis of Women Treated for uUTI from the REASSURE Trial. Open Forum Infectious Diseases 2025, 12: ofae631.1741. PMCID: PMC11776810, DOI: 10.1093/ofid/ofae631.1741.Peer-Reviewed Original ResearchPresence of asymptomatic bacteriuriaAsymptomatic bacteriuriaUncomplicated UTIClinical failureMMITT populationTOC visitClinical responseEfficacy endpointTreatment armsTreatment of uncomplicated UTIUncomplicated urinary tract infectionsPredictor of clinical failureTreatment of UTIUrinary tract infectionAdult womenAnalysis of womenCausative uropathogensDouble-dummyActive controlled trialUTI symptomsDouble-blindAsymptomatic patientsPrimary endpointTract infectionsEfficacy outcomes
2024
Carotid artery stenting versus carotid endarterectomy for symptomatic or asymptomatic extracranial carotid stenosis: A national cohort study
Krittanawong C, Ang S, Tangsrivimol J, Qadeer Y, Wang Z, Virk H, Khalid U, Sharma S, Dardik A. Carotid artery stenting versus carotid endarterectomy for symptomatic or asymptomatic extracranial carotid stenosis: A national cohort study. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 108094. PMID: 39424210, DOI: 10.1016/j.jstrokecerebrovasdis.2024.108094.Peer-Reviewed Original ResearchAsymptomatic carotid stenosisCarotid artery stenosisCarotid stenosisArtery stenosisAdverse eventsCohort studyAsymptomatic extracranial carotid stenosisNational population-based cohort studyPopulation-based cohort studyAssociated with lower adverse eventsAssociated with high mortalityAlternative to CEAExtracranial carotid stenosisSymptomatic carotid stenosisMortality of patientsCarotid artery stentingLower adverse eventsNational cohort studyAsymptomatic patientsClinical characteristicsArtery stentingPatient populationCarotid endarterectomyStenosisPatientsWhen Perfect Is the Enemy of Good: Results of a RAND Appropriateness Panel on Treat to Target in Asymptomatic Inflammatory Bowel Disease
Systrom H, Rai V, Singh S, Baidoo L, Cheifetz A, Devlin S, Gecse K, Irving P, Kaplan G, Kozuch P, Ullman T, Sparrow M, Melmed G, Siegel C. When Perfect Is the Enemy of Good: Results of a RAND Appropriateness Panel on Treat to Target in Asymptomatic Inflammatory Bowel Disease. The American Journal Of Gastroenterology 2024, 120: 420-430. PMID: 39008539, DOI: 10.14309/ajg.0000000000002964.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseAsymptomatic patientsChanging therapyStable diseaseEndoscopic remissionEndoscopic activityBowel diseaseAsymptomatic inflammatory bowel diseaseRAND/University of California Los Angeles Appropriateness MethodTreat-to-target strategyActive endoscopic diseaseUlcerative colitis patientsCrohn's disease patientsLos Angeles Appropriateness MethodExtensive diseaseDisease extentPatient ageAphthous ulcersRandomized studyEndoscopic diseaseClinical decision-makingColitis patientsAdvanced therapiesTreatment adjustmentAnonymous surveyComparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT
Katoch D, Nallagatla V, Liang J, Deng Y, Krishnamurti L. Comparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT. Transplantation And Cellular Therapy 2024, 30: s65. DOI: 10.1016/j.jtct.2023.12.103.Peer-Reviewed Original ResearchHematopoietic cell transplantationOutcomes of hematopoietic cell transplantationSickle cell diseaseSymptomatic SCD patientsAsymptomatic patientsDonor typeSymptomatic patientsPost-HCTSCD patientsHematopoietic cell transplantation comorbidity indexPost-transplant lymphoproliferative disorderMedian follow-up periodComplication of sickle cell diseaseIncidence of aGVHDReduced intensity conditioningSickle cell disease patientsFollow-up periodPropensity-matched modelStandardized mean differenceSecondary malignanciesLymphoproliferative disordersCell transplantationGraft survivalPatient ageAssociated with group classificationCHANGING THERAPY TO ACHIEVE ENDOSCOPIC HEALING IN ASYMPTOMATIC PATIENTS WITH IBD: WHEN IS PERFECT THE ENEMY OF GOOD?
Systrom H, Rai V, Singh S, Baidoo L, Cheifetz A, Devlin S, Gecse K, Irving P, Kaplan G, Kozuch P, Ullman T, Sparrow M, Melmed G, Siegel C. CHANGING THERAPY TO ACHIEVE ENDOSCOPIC HEALING IN ASYMPTOMATIC PATIENTS WITH IBD: WHEN IS PERFECT THE ENEMY OF GOOD? Inflammatory Bowel Diseases 2024, 30: s83-s83. DOI: 10.1093/ibd/izae020.180.Peer-Reviewed Original ResearchInflammatory bowel diseaseEndoscopic healingAsymptomatic patientsChanging therapyScenarios of patientsCrohn's diseaseUlcerative colitisInflammatory bowel disease specialistsTreat-to-target strategyAsymptomatic IBD patientsPatients aged >Treatment decision-makingStable diseaseEndoscopic improvementClinical remissionExtensive diseaseAnti-TNFEndoscopic progressionDisease extentAphthous ulcersEndoscopic inflammationRandomized studyCurrent therapiesEndoscopic diseaseClinical decision-makingP978 Changing therapy to achieve endoscopic healing in asymptomatic patients with IBD: When is perfect the enemy of good?
Systrom H, Rai V, Singh S, Baidoo L, Cheifetz A, Devlin S, Gecse K, Irving P, Kaplan G, Kozuch P, Ullman T, Sparrow M, Melmed G, Siegel C. P978 Changing therapy to achieve endoscopic healing in asymptomatic patients with IBD: When is perfect the enemy of good? Journal Of Crohn's And Colitis 2024, 18: i1764-i1764. DOI: 10.1093/ecco-jcc/jjad212.1108.Peer-Reviewed Original ResearchInflammatory bowel diseaseInflammatory bowel disease specialistsEndoscopic healingAsymptomatic patientsChanging therapyCrohn's diseaseUlcerative colitisTreat-to-target strategyAsymptomatic IBD patientsInfluence treatment decision-makingPatients aged >RAND/UCLA Appropriateness MethodIn-person meetingsScenarios of patientsTreatment decision-makingStable diseaseEndoscopic improvementClinical remissionExtensive diseaseAnti-TNFEndoscopic progressionDisease extentClinical decision-makingAphthous ulcersEndoscopic inflammation
2023
473. Trends among hospitalized pregnant patients with laboratory-confirmed SARS-CoV-2 — COVID-NET, 14 U.S. States, January 2021–January 2023
Havers F, Whitaker M, Milucky J, Patton M, Chatwani B, Chai S, Armistead I, Meek J, Openo K, Weigel A, Ryan P, Nunez V, Bye E, Rudin D, Engesser K, Bushey S, Moran N, Sutton M, Talbot H, Olsen K, Taylor C. 473. Trends among hospitalized pregnant patients with laboratory-confirmed SARS-CoV-2 — COVID-NET, 14 U.S. States, January 2021–January 2023. Open Forum Infectious Diseases 2023, 10: ofad500.543. PMCID: PMC10679218, DOI: 10.1093/ofid/ofad500.543.Peer-Reviewed Original ResearchSARS-CoV-2 testPositive SARS-CoV-2 testCOVID-19-Associated Hospitalization Surveillance NetworkHospitalized pregnant patientsPregnant patientsRespiratory symptomsClinical outcomesBooster dosesCOVID-19 respiratory symptomsIntensive care unit admissionPositive SARS-CoV-2SARS-CoV-2 infectionPrimary vaccination seriesSymptomatic pregnant patientsCare unit admissionAdverse clinical outcomesSevere clinical outcomesCOVID-19 vaccinationCOVID-19 infectionSARS-CoV-2Unit admissionVaccination seriesAsymptomatic patientsChart abstractionMechanical ventilationComparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT
Katoch D, Nallagatla V, Krishnamurti L. Comparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT. Blood 2023, 142: 3873. DOI: 10.1182/blood-2023-190977.Peer-Reviewed Original ResearchHematopoietic cell transplantationSickle cell diseaseComplications of SCDGraft failureOverall survivalAsymptomatic patientsAvascular necrosisSCD patientsDonor typeChronic GVHDCell transplantationCell diseaseOutcomes of HCTPost-transplant lymphoproliferative disorderSubstantial short-term morbidityCommon graft sourceExperienced graft failureHCT comorbidity indexAcute chest syndromeHLA-identical donorShort-term morbidityLong-term sequelaePotential curative optionSubset of patientsOrgan-specific complicationsPhysician responses to apple watch-detected irregular rhythm alerts
Demkowicz P, Dhruva S, Spatz E, Beatty A, Ross J, Khera R. Physician responses to apple watch-detected irregular rhythm alerts. American Heart Journal 2023, 262: 29-37. PMID: 37084933, PMCID: PMC10988207, DOI: 10.1016/j.ahj.2023.04.008.Peer-Reviewed Original ResearchConceptsAtrial fibrillationPrimary careEmergency medicinePhysician responsesDiagnostic testingUse of antiarrhythmicsClinical practice guidelinesMeasurement of BNPFurther diagnostic testingCase-based surveyLarge academic centerAF alertsAsymptomatic patientsPatient demographicsClinical symptomsTreatment optionsMedical historyPatient referralPhysician specialtyPractice guidelinesPhysician differencesRhythm monitoringAcademic centersUS FoodClinical complexityOcular complications of plasma cell dyscrasias
Singh R, Singhal S, Sinha S, Cho J, Nguyen A, Dhingra L, Kaur S, Sharma V, Agarwal A. Ocular complications of plasma cell dyscrasias. European Journal Of Ophthalmology 2023, 33: 1786-1800. PMID: 36760117, PMCID: PMC10472748, DOI: 10.1177/11206721231155974.Peer-Reviewed Original ResearchConceptsPlasma cell dyscrasiaMonoclonal gammopathyMultiple myelomaMalignant plasma cellsEfficacious treatment strategiesSearch of PubMedOcular presentationOcular complicationsTreating ophthalmologistClinical suspicionAsymptomatic patientsOphthalmological signsWaldenstrom's macroglobulinemiaSystemic findingsOphthalmologic disordersPre-malignantUnderlying diseasePosterior segmentPlasma cellsSkin changesTreatment strategiesOver-secretionEarly diagnosisCochrane DatabaseSystemic amyloidosisChapter 1 Computed tomography manifestations and prognosis of mild COVID-19 cases
Wang M, Fakhri G. Chapter 1 Computed tomography manifestations and prognosis of mild COVID-19 cases. 2023, 1-10. DOI: 10.1016/b978-0-443-18493-2.00001-2.Peer-Reviewed Original ResearchMild COVID-19 casesAsymptomatic patientsImaging findingsComputed tomographyAsymptomatic infectionNegative imaging findingsRespiratory tract specimensPositive nucleic acidCT manifestationsInfected casesComputed tomography manifestationsClinical symptomsMild casesAsymptomatic infected casesPatientsMild typeSARS-CoV-2InfectionSARS-CoV-2 virusClinical signsCommonest typeManifestationsCOVID-19 casesSymptomsPrognosisWolff-Parkinson-White (WPW) Syndrome
Vinocur J. Wolff-Parkinson-White (WPW) Syndrome. In Clinical Practice 2023, 103-127. DOI: 10.1007/978-3-031-41479-4_6.Peer-Reviewed Original ResearchAsymptomatic patientsRisk stratificationSudden deathCalcium channel blockersEarliest atrial activationAntidromic AVRTAsymptomatic WPWOrthodromic AVRTPharmacologic therapyUncommon manifestationCatheter ablationVariety of manifestationsAtrial fibrillationPathway conductionWolff-ParkinsonAccessory pathwaySerious manifestationsVentricular pacingBidirectional accessory pathwaysCatheter stabilityWhite syndromeAtrial activationFirst lesionPatientsWPW
2022
Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation
Akintoye E, Wang T, Nakhla M, Ali A, Fava A, Akyuz K, Popovic Z, Pettersson G, Gillinov A, Xu B, Griffin B, Desai M. Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation. JACC Cardiovascular Imaging 2022, 16: 13-24. PMID: 36274042, DOI: 10.1016/j.jcmg.2022.08.004.Peer-Reviewed Original ResearchConceptsTricuspid regurgitationMedian survival timeRisk factorsAsymptomatic patientsEchocardiographic parametersSurvival timeEarly interventionOptimal timingRight heart parametersSymptomatic tricuspid regurgitationSignificant tricuspid regurgitationFree wall strainHigh operative mortalitySex-matched cohortQuantitative echocardiographic assessmentKey prognostic markersCause mortalityOperative mortalityTR patientsEchocardiographic assessmentLate presentationPoor outcomePrognostic utilityPrognostic valuePrognostic markerDiseases of the pulmonary arteries: imaging appearances and pearls
Cortopassi IO, Gosangi B, Asch D, Bader AS, Gange CP, Rubinowitz AN. Diseases of the pulmonary arteries: imaging appearances and pearls. Clinical Imaging 2022, 91: 111-125. PMID: 36067656, DOI: 10.1016/j.clinimag.2022.08.018.Peer-Reviewed Educational MaterialsConceptsContrast-enhanced chest CTChest X-rayPulmonary arteryEnlarged pulmonary arteryPulmonary vascular pathologyPulmonary artery anatomyEveryday clinical practiceAsymptomatic patientsImaging findingsPulmonary vasculatureArtery anatomyChest CTUrgent treatmentMediastinal structuresVascular pathologyArteryClinical practicePhysiologic dataEntire thoraxVessel wallPatientsDetailed evaluationPathologyWide spectrumQuantification of flowPrognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy
Hutt E, Mentias A, Alashi A, Wadhwa R, Fava A, Lever HM, Thamilarasan M, Popovic ZB, Smedira NG, Desai MY. Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy. Progress In Cardiovascular Diseases 2022, 74: 11-18. PMID: 35952727, DOI: 10.1016/j.pcad.2022.08.002.Peer-Reviewed Original ResearchConceptsSeptal reduction therapyBNP ratioNT-proBNP ratioPrimary outcomeAsymptomatic patientsPrognostic valueObstructive hypertrophic cardiomyopathy patientsIncremental prognostic valueNormal NT-proBNPNT-pro BNPObstructive hypertrophic cardiomyopathyLong-term outcomesHypertrophic cardiomyopathy patientsCardiac transplantationNT-proBNPPrimary endpointCardiomyopathy patientsHypertrophic cardiomyopathyReduction therapyHigh riskPatientsDefibrillator dischargeSpline analysisOutcomesBNPEarly Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials
Ahmad Y, Howard J, Seligman H, Arnold A, Madhavan M, Forrest J, Geirsson A, Mack M, Lansky A, Leon M. Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100383. PMID: 39131941, PMCID: PMC11307849, DOI: 10.1016/j.jscai.2022.100383.Peer-Reviewed Original ResearchSurgical aortic valve replacementAsymptomatic severe aortic stenosisSevere aortic stenosisAortic stenosisHF hospitalizationCause mortalityEjection fractionPrespecified primary end pointSevere asymptomatic aortic stenosisSymptomatic severe aortic stenosisEnd pointAortic valve interventionAsymptomatic aortic stenosisHeart failure hospitalizationPrimary end pointAortic valve replacementClass I recommendationCornerstone of managementInitial conservative managementNormal ejection fractionRandomized Controlled TrialsCurrent treatment standardsIndividual end pointsAsymptomatic patientsEarly surgeryAn outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era
Roberts SC, Palacios C, Grubaugh ND, Alpert T, Ott IM, Breban MI, Initiative Y, Martinello RA, Smith C, Davis MW, Mcmanus D, Tirmizi S, Topal JE, Azar MM, Malinis M. An outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era. Transplant Infectious Disease 2022, 24: e13782. PMID: 34969164, DOI: 10.1111/tid.13782.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Infection prevention practicesSARS-CoV-2 outbreakTransplant unitCOVID-19-associated morbiditySolid organ transplant recipientsSARS-CoV-2 vaccinationPrevention practicesHospital day 18Potential index casesOrgan transplant recipientsInfection prevention behaviorsMonoclonal antibody therapyCOVID-19SARS-CoV-2 clustersHospital staff membersWhole-genome sequencingAsymptomatic patientsTransplant recipientsPositive patientsAtypical presentationImmunocompromised patientsAntibody therapyVaccination eraDisease progressionOptimizing Small, Low-Risk, Unruptured Intracranial Aneurysm Treatment Using Game Theory
Boltyenkov A, Wang J, Malhotra A, Katz J, Dehdashti A, White T, Martinez G, Pandya A, Sanelli P. Optimizing Small, Low-Risk, Unruptured Intracranial Aneurysm Treatment Using Game Theory. American Journal Of Neuroradiology 2022, 43: 176-180. PMID: 35027349, PMCID: PMC8985687, DOI: 10.3174/ajnr.a7392.Peer-Reviewed Original Research
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