2024
BK polyomavirus DNAemia, allograft rejection, and de novo donor‐specific antibodies after lowering target tacrolimus levels in pediatric kidney transplant recipients
Huang H, Xiang Y, George R, Winterberg P, Serluco A, Liverman R, Yildirim I, Garro R. BK polyomavirus DNAemia, allograft rejection, and de novo donor‐specific antibodies after lowering target tacrolimus levels in pediatric kidney transplant recipients. Pediatric Transplantation 2024, 28: e14791. PMID: 38808701, DOI: 10.1111/petr.14791.Peer-Reviewed Original ResearchConceptsDe novo donor-specific antibodiesTarget tacrolimus levelsDevelopment of de novo donor-specific antibodiesBiopsy-proven rejectionDonor-specific antibodiesMonths post-KTTacrolimus levelsTime of transplantationPediatric KT recipientsBK polyomavirusBKV-DNAemiaPost-KTPost-intervention cohortAllograft rejectionRecipient ageKT recipientsKidney transplantationPediatric kidney transplant recipientsLow tacrolimus levelsReduction of immunosuppressionKaplan-Meier survival analysisYounger recipient ageIndividualized immunosuppressive regimensKidney transplant recipientsRetrospective chart reviewClinical and Genomic-Based Decision Support System to Define the Optimal Timing of Allogeneic Hematopoietic Stem-Cell Transplantation in Patients With Myelodysplastic Syndromes
Tentori C, Gregorio C, Robin M, Gagelmann N, Gurnari C, Ball S, Caballero Berrocal J, Lanino L, D'Amico S, Spreafico M, Maggioni G, Travaglino E, Sauta E, Meggendorfer M, Zhao L, Campagna A, Savevski V, Santoro A, Al Ali N, Sallman D, Sole F, Garcia-Manero G, Germing U, Kroger N, Kordasti S, Santini V, Sanz G, Kern W, Platzbecker U, Diez-Campelo M, Maciejewski J, Ades L, Fenaux P, Haferlach T, Zeidan A, Castellani G, Komrokji R, Ieva F, Della Porta M, Bernardi M, Di Grazia C, Vago L, Rivoli G, Borin L, Chiusolo P, Giaccone L, Voso M, Bewersdorf J, Nibourel O, Beyá M, Jerez A, Hernández F, Kennedy K, Xicoy B, Ubezio M, Russo A, Todisco G, Mannina D, Bramanti S, Zampini M, Riva E, Bicchieri M, Asti G, Viviani F, Buizza A, Tinterri B, Kubasch A, Bacigalupo A, Raiola A, Rambaldi A, Passamonti F, Ciceri F. Clinical and Genomic-Based Decision Support System to Define the Optimal Timing of Allogeneic Hematopoietic Stem-Cell Transplantation in Patients With Myelodysplastic Syndromes. Journal Of Clinical Oncology 2024, 42: 2873-2886. PMID: 38723212, PMCID: PMC11328926, DOI: 10.1200/jco.23.02175.Peer-Reviewed Original ResearchHematopoietic stem-cell transplantationAllogeneic hematopoietic stem-cell transplantationStem-cell transplantationMyelodysplastic syndromeIPSS-MMolecular International Prognostic Scoring SystemInternational Prognostic Scoring SystemPrognostic scoring systemTime of transplantationProportion of patientsHigh-risk categoryOptimal timingProlonged life expectancyRevised IPSSIPSS-RRetrospective populationValidation cohortCurative treatmentClinical relevanceTransplantationPatientsModerately high-Scoring systemAverage survivalLife expectancyAllogeneic transplantation and cellular therapies in cutaneous T-cell lymphoma
Goyal A, Foss F. Allogeneic transplantation and cellular therapies in cutaneous T-cell lymphoma. Expert Review Of Anticancer Therapy 2024, 24: 41-58. PMID: 38224371, DOI: 10.1080/14737140.2024.2305356.Peer-Reviewed Original ResearchConceptsDonor lymphocyte infusionTotal body irradiationT-cell lymphomaCAR-T cell therapyCutaneous T-cell lymphomaT-cell therapySezary syndromeAllo-HSCTT cellsLymphocyte infusionCAR-TMycosis fungoidesAllogeneic hematopoietic stem cell transplantationCAR-T cell persistenceReduced-intensity conditioning regimensHematopoietic stem cell transplantationAdvanced stage MFTemporary disease controlTreatment of MF/SSCAR-T therapyInduce complete remissionCurative treatment optionStem cell transplantationNonmalignant T cellsTime of transplantation
2022
Addressing Diaphragm Dysfunction in Lung Transplant Recipients: The Expanding Role of Diaphragm Pacing
Onders R, Elgudin Y, Abu-Omar Y, Pelletier M, Chavin K, Schilz R. Addressing Diaphragm Dysfunction in Lung Transplant Recipients: The Expanding Role of Diaphragm Pacing. The Journal Of Heart And Lung Transplantation 2022, 41: s431-s432. DOI: 10.1016/j.healun.2022.01.1089.Peer-Reviewed Original ResearchVentilator induced diaphragm dysfunctionPhrenic nerve injuryLung transplant recipientsMonths post-transplantDiaphragm dysfunctionDiaphragm pacingLung transplantationMechanical ventilationNerve injuryDiaphragm electromyographyTransplant recipientsPost-transplantPost-operativelyNerve recoveryPhrenic nerve recoveryYear post-transplantationTime of transplantationSustained hip fracturesCOVID-19 sepsisDiaphragm recoveryDiaphragmatic dysfunctionRemoval of electrodesRespiratory failurePost-transplantationUneventful recoveryThe impact of induction therapy on mortality and treated rejection in cardiac transplantation: A retrospective study
Bellumkonda L, Oikonomou EK, Hsueh C, Maulion C, Testani J, Patel J. The impact of induction therapy on mortality and treated rejection in cardiac transplantation: A retrospective study. The Journal Of Heart And Lung Transplantation 2022, 41: 482-491. PMID: 35094919, DOI: 10.1016/j.healun.2022.01.008.Peer-Reviewed Original ResearchConceptsInduction therapyCause mortalityOutcome measuresLeft ventricular assist device therapyT-cell depleting agentsVentricular assist device therapyDual organ transplantsRoutine induction therapySecondary outcome measuresTime of transplantationPrimary outcome measureCox regression modelPropensity score adjustmentRisk of rejectionPrior transplantCardiac transplantationHeart transplantationUNOS databaseAdult patientsOverall survivalDevice therapyMedian ageRetrospective studyReceptor antagonistReduced odds
2021
Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
Fuery MA, Chouairi F, Natov P, Bhinder J, Rose Chiravuri M, Wilson L, Clark KA, Reinhardt SW, Mullan C, Miller PE, Davis RP, Rogers JG, Patel CB, Sen S, Geirsson A, Anwer M, Desai N, Ahmad T. Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates. Journal Of The American Heart Association 2021, 10: e023662. PMID: 34743559, PMCID: PMC9075266, DOI: 10.1161/jaha.121.023662.Peer-Reviewed Original ResearchConceptsLow-urgency patientsHigh-urgency patientsUrgency patientsCardiac transplantationAllocation system changeLonger waitlist timesOrgan Sharing databaseTime of transplantationCardiac transplantation candidatesNew allocation systemBaseline recipientPosttransplantation outcomesPosttransplantation survivalAdditional comorbiditiesClinical characteristicsConclusions PatientsHepatitis CIschemic timeTransplantation candidatesSharing databaseWaitlist timeWaitlist survivalUnited NetworkRetrospective analysisPatientsMechanical ventilation at the time of heart transplantation and associations with clinical outcomes
Miller PE, Mullan CW, Chouairi F, Sen S, Clark KA, Reinhardt S, Fuery M, Anwer M, Geirsson A, Formica R, Rogers JG, Desai NR, Ahmad T. Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes. European Heart Journal Acute Cardiovascular Care 2021, 10: 843-851. PMID: 34389855, PMCID: PMC8557439, DOI: 10.1093/ehjacc/zuab063.Peer-Reviewed Original ResearchConceptsHeart transplantationMechanical ventilationSingle-organ heart transplantationMedian waitlist timeOrgan Sharing databaseTime of transplantationMultivariable logistic regressionMultivariable adjustmentWaitlist timeClinical outcomesSharing databasePoor outcomeVentilated patientsUnited NetworkTemporary mechanical supportClinical acuityTransplantationPatientsPrevious dialysisLogistic regressionMortalityStrong associationReasonable outcomesOutcomesAssociationImpact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies
Chouairi F, Mullan CW, Sen S, Mori M, Fuery M, Elder RW, Lesse J, Norton K, Clark KA, Miller PE, Mulligan D, Formica R, Rogers JG, Jacoby D, Maulion C, Anwer M, Geirsson A, Desai NR, Ahmad T. Impact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies. PLOS ONE 2021, 16: e0247789. PMID: 33651802, PMCID: PMC7924739, DOI: 10.1371/journal.pone.0247789.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseAllocation system changeHeart allocation systemNew heart allocation policyNew heart allocation systemTransplantation of patientsOrgan Sharing databasePost-transplantation outcomesPost-transplant survivalTime of transplantationMechanical circulatory supportRate of transplantationNumber of patientsHeart allocation policyNew allocation systemStatus 1ACardiac transplantAdult patientsSharing databaseWaitlist survivalCirculatory supportClinical benefitCongenital cardiomyopathyUnited NetworkCHD patients
2020
Temporal trends and outcomes of patients waiting on left ventricular assist devices and inotropes for heart transplantation
Briasoulis A, Adegbala O, Akintoye E, Alvarez P. Temporal trends and outcomes of patients waiting on left ventricular assist devices and inotropes for heart transplantation. Clinical Transplantation 2020, 34: e13857. PMID: 32167606, DOI: 10.1111/ctr.13857.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceRight ventricular assist deviceVentricular assist deviceOutcomes of patientsTime of listingTime of transplantationHeart transplantationAssist deviceOrgan Sharing registryTerms of survivalStatus 1AInotropic therapyLVAD recipientsUnited NetworkWorse outcomesInotropesHigh riskWaiting listPatientsTransplantationLower ratesOutcomesTemporal trendsConfoundersRegistry
2019
Management of Renal Failure in the Liver Transplant Patient
Zimmerman M, Schiller J, Selim M, Kim J, Hong J. Management of Renal Failure in the Liver Transplant Patient. Current Transplantation Reports 2019, 6: 338-343. DOI: 10.1007/s40472-019-00259-w.Peer-Reviewed Original ResearchOrthotopic liver transplantationSimultaneous liver-kidney transplantationRenal failureIntraoperative renal replacement therapyCause of acute kidney injuryOrthotopic liver transplant recipientsManagement of renal failureInfluence outcomesLong-term graftConcomitant renal failureLiver transplant patientsSingle organ transplantationTime of transplantationLiver-kidney transplantationRenal replacement therapyAcute kidney injuryManagement of patientsSignificant renal injuryTransplant patientsCirrhotic patientsPatient survivalReplacement therapyLiver transplantationKidney injuryRenal injury
2018
The optimal timing of hepatitis C therapy in liver transplant‐eligible patients: Cost‐effectiveness analysis of new opportunities
Cortesi P, Belli L, Facchetti R, Mazzarelli C, Perricone G, De Nicola S, Cesana G, Duvoux C, Mantovani L, Strazzabosco M, Association T. The optimal timing of hepatitis C therapy in liver transplant‐eligible patients: Cost‐effectiveness analysis of new opportunities. Journal Of Viral Hepatitis 2018, 25: 791-801. PMID: 29406608, DOI: 10.1111/jvh.12877.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaDCC patientsTreatment strategiesIntestine Transplant AssociationProgression of HCVTransplant-eligible patientsHepatitis C therapyTransplant-related factorsCohort of patientsTime of transplantationDecision analytical modelCost-effectiveness analysisDAA effectivenessDAA treatmentEuropean LiverHCC presencePre-LTMELD scoreC therapyCirrhotic patientsDisease recurrenceTransplant centersSpecific regimenTransplant AssociationPatient level
2015
Changes in the methodology of pre‐heart transplant human leukocyte antibody assessment: an analysis of the United Network for Organ Sharing database
O'Connor MJ, Keeshan BC, Lin KY, Monos D, Lind C, Paridon SM, Mascio CE, Shaddy RE, Rossano JW. Changes in the methodology of pre‐heart transplant human leukocyte antibody assessment: an analysis of the United Network for Organ Sharing database. Clinical Transplantation 2015, 29: 842-850. PMID: 26172275, DOI: 10.1111/ctr.12590.Peer-Reviewed Original ResearchConceptsPanel reactive antibodyHuman leukocyte antibodiesOrgan Sharing databaseHeart transplantationReactive antibodiesGraft lossLeukocyte antibodiesSharing databaseUnited NetworkAntibody assessmentFlow cytometryClass IPre-transplant patientsUnderwent heart transplantationTime of transplantationPrimary outcome measureFlow cytometric assessmentGraft survivalMultivariable analysisOutcome measuresTransplantationCytometric assessmentPatientsStudy periodAntibodies
2012
P-109 Intestinal Transplantation for End Stage Crohn's Disease: Therapeutic Efficacy and Disease Recurrence
Koritsky D, Costa G, Bond G, Schuster B, Roberts M, Hoffman B, Stein W, Soltys K, Sogawa H, Rubin E, Regueiro M, Abu-Elmagd K. P-109 Intestinal Transplantation for End Stage Crohn's Disease: Therapeutic Efficacy and Disease Recurrence. Inflammatory Bowel Diseases 2012, 18: s58-s58. DOI: 10.1097/00054725-201212001-00142.Peer-Reviewed Original ResearchIrreversible intestinal failureDisease recurrenceCrohn's diseaseRecipient pretreatmentSurvival rateChronic rejectionGraft lossIntestinal failureMultivisceral transplantationTPN therapyGraft functionSurvival outcomesIntestinal transplantationTherapeutic efficacyActuarial patient survival ratesRisk of graft lossLongterm survival outcomesPositive lymphocytotoxic crossmatchDisease patientsConsecutive adult patientsYear survival rateTime of transplantationNon-Crohn's disease patientsPatient survival ratesLong-term outcomesO-4 Intestinal Transplantation for End Stage Crohn's Disease: Therapeutic Efficacy and Disease Recurrence
Koritsky D, Costa G, Bond G, Schuster B, Roberts M, Hoffman B, Stein W, Soltys K, Sogawa H, Rubin E, Regueiro M, Abu-Elmagd K. O-4 Intestinal Transplantation for End Stage Crohn's Disease: Therapeutic Efficacy and Disease Recurrence. Inflammatory Bowel Diseases 2012, 18: s3-s3. DOI: 10.1097/00054725-201212001-00005.Peer-Reviewed Original ResearchIrreversible intestinal failureDisease recurrenceCrohn's diseaseRecipient pretreatmentSurvival rateChronic rejectionGraft lossIntestinal failureMultivisceral transplantationTPN therapySurvival outcomesGraft functionIntestinal transplantationTherapeutic efficacyActuarial patient survival ratesLong-term survival outcomesRisk of graft lossPositive lymphocytotoxic crossmatchDisease patientsConsecutive adult patientsYear survival rateTime of transplantationNon-Crohn's disease patientsPatient survival ratesLong-term outcomesSplenic Irradiation as a Component of a Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Myelofibrosis with Massive Splenomegaly
Ito T, Akagi K, Kondo T, Kawabata H, Ichinohe T, Takaori-Kondo A. Splenic Irradiation as a Component of a Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Myelofibrosis with Massive Splenomegaly. The Tohoku Journal Of Experimental Medicine 2012, 228: 295. PMID: 23117264, DOI: 10.1620/tjem.228.295.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationAllogeneic hematopoietic stem cell transplantationStem cell transplantationSplenic irradiationMassive splenomegalyCell transplantationSurgical morbidityPrimary myelofibrosisPeripheral blood stem cell transplantationBlood stem cell transplantationReduced-intensity conditioning regimenReduced-intensity conditioning regimensUnrelated bone marrow transplantationPost-essential thrombocythemia myelofibrosisOnly curative strategyHLA-identical siblingsProportion of patientsTime of transplantationBone marrow transplantationBone marrow fibrosisDonor cell engraftmentSimilar clinical conditionsConditioning regimenConditioning regimensElderly patients
2009
Sclerosing peritonitis and mortality after liver transplantation
Mekeel K, Moss A, Reddy KS, Douglas D, Mulligan D. Sclerosing peritonitis and mortality after liver transplantation. Liver Transplantation 2009, 15: 435-439. PMID: 19326414, DOI: 10.1002/lt.21702.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAdultAscitesBacterial InfectionsCholestasisEndoscopy, Digestive SystemFatal OutcomeHumansIntestinal ObstructionLiver DiseasesLiver TransplantationMaleMalnutritionMiddle AgedParacentesisPeritonitisReoperationRisk FactorsSclerosisTomography, X-Ray ComputedTreatment OutcomeVascular DiseasesConceptsLiver transplantationBowel obstructionRefractory ascitesBacterial peritonitisEnd-stage liver diseasePartial small bowel obstructionMassive refractory ascitesSmall bowel obstructionEpisodes of peritonitisSpontaneous bacterial peritonitisTime of transplantationAbdominal painBiliary obstructionLiver diseasePeritoneal dialysisInferior venaPeritoneal surfaceFibrous peelPeritonitisPatientsTransplantationAscitesObstructionComplicationsEpisodes
2007
Neutralization of Macrophage Migration Inhibitory Factor (MIF) Reduces GVHD but Preserves GVL.
Miklos S, Mueller G, Lindner P, Chang Y, Holler E, Bucala R, Hildebrandt G. Neutralization of Macrophage Migration Inhibitory Factor (MIF) Reduces GVHD but Preserves GVL. Blood 2007, 110: 3234. DOI: 10.1182/blood.v110.11.3234.3234.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorAllo-SCTT cell activationClinical GVHDCell activationInhibitory factorWeight lossSeverity of GVHDTime of transplantationClinical scoring systemInflammatory cytokine secretionHalf of animalsT cell proliferationMouse macrophage migration inhibitory factorP815 tumor cellsTumor cell eliminationAcute graftHost diseaseSystemic inflammationMajor complicationsTNFα levelsSerum IFNγCell transplantationInflammatory cytokinesLaparoscopic incisional hernia repair after liver transplantation
Mekeel K, Mulligan D, Reddy KS, Moss A, Harold K. Laparoscopic incisional hernia repair after liver transplantation. Liver Transplantation 2007, 13: 1576-1581. PMID: 17969189, DOI: 10.1002/lt.21290.Peer-Reviewed Original ResearchConceptsLaparoscopic incisional hernia repairIncisional hernia repairLAP groupLiver transplantationHernia repairOP groupMore patientsLaparoscopic ventral hernia repairTime of transplantationLength of stayVentral hernia repairNontransplant patientsPrimary immunosuppressionWound complicationsRecurrent ascitesLaparoscopic approachMesh removalOpen repairRetrospective reviewDecreased incidenceMesh infectionIncisional herniaLower riskPatientsTransplantation
2005
A Comparison of Transfusion Requirements Between Living Donation and Cadaveric Donation Liver Transplantation: Relationship to Model of End-Stage Liver Disease Score and Baseline Coagulation Status
Frasco PE, Poterack KA, Hentz JG, Mulligan DC. A Comparison of Transfusion Requirements Between Living Donation and Cadaveric Donation Liver Transplantation: Relationship to Model of End-Stage Liver Disease Score and Baseline Coagulation Status. Anesthesia & Analgesia 2005, 101: 30-37. PMID: 15976201, DOI: 10.1213/01.ane.0000155288.57914.0d.Peer-Reviewed Original ResearchConceptsEnd-stage liver disease (MELD) scoreLiver Disease scoreComponent therapyTransplant patientsMELD scoreRed blood cellsDonation transplantationDonation transplantsIntraoperative transfusionCoagulation functionBlood cellsDisease scoreBaseline coagulation statusPreoperative fibrinogen concentrationLow MELD scoresTime of transplantationPreoperative coagulation testsSeverity of diseaseDegree of impairmentTransfusion exposureTransfusion requirementsLiver transplantLiver transplantationCoagulation statusTransplantation recipients
2002
Thrombendvenectomy for Organized Portal Vein Thrombosis at the Time of Liver Transplantation
Molmenti EP, Roodhouse TW, Molmenti H, Jaiswal K, Jung G, Marubashi S, Sanchez EQ, Gogel B, Levy MF, Goldstein RM, Fasola CG, Elliott EE, Bursac N, Mulligan D, Gonwa TA, Klintmalm GB. Thrombendvenectomy for Organized Portal Vein Thrombosis at the Time of Liver Transplantation. Annals Of Surgery 2002, 235: 292-296. PMID: 11807371, PMCID: PMC1422428, DOI: 10.1097/00000658-200202000-00019.Peer-Reviewed Original ResearchConceptsPortal vein thrombosisGraft survival ratesTime of transplantationLiver transplantationVein thrombosisMale patientsFemale patientsLiver diseasePortal veinControl groupSurvival rateEnd-stage liver diseaseOrthotopic liver transplantOrthotopic liver transplantationFirst postoperative dayIntensive care unitLength of stayCryptogenic cirrhosisDaily aspirinPVT groupPVT patientsTacrolimus immunosuppressionLiver transplantTransplant recipientsPostoperative day
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