2025
The effect of Cytomegalovirus seropositivity and recipient age on overall and allograft survival in liver transplant recipients
Lee I, Wilson A, Hanna K, Misawa R, Sogawa H, Veillette G, Nishida S, Dhand A, Okumura K. The effect of Cytomegalovirus seropositivity and recipient age on overall and allograft survival in liver transplant recipients. American Journal Of Transplantation 2025, 25: s118-s119. DOI: 10.1016/j.ajt.2024.12.233.Peer-Reviewed Original Research
2024
C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via selective activation of monocyte subsets
Kiefer J, Zeller J, Schneider L, Thomé J, McFadyen J, Hoerbrand I, Lang F, Deiss E, Bogner B, Schaefer A, Chevalier N, Horner V, Kreuzaler S, Kneser U, Kauke-Navarro M, Braig D, Woollard K, Pomahac B, Peter K, Eisenhardt S. C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via selective activation of monocyte subsets. Journal Of Advanced Research 2024, 72: 401-420. PMID: 38992424, PMCID: PMC12147648, DOI: 10.1016/j.jare.2024.07.007.Peer-Reviewed Original ResearchAcute allograft rejectionC-reactive proteinVascularized Composite AllotransplantationAllograft rejectionAcute rejectionAllograft survivalGraft rejectionAttenuate acute allograft rejectionPreventing acute allograft rejectionImmune responseLong-term allograft survivalFacial Vascularized Composite AllotransplantationClinical allograft rejectionReduced allograft survivalChronic allograft rejectionIntravital imagingNon-classical monocytesMarkers of inflammationAcute-phase reactantsImmune-inflammatory reactionPro-inflammatory propertiesMononuclear phagocyte systemAcute-phase responseGraft infiltrationInnate immune response
2022
Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice
Nakao T, Inomata T, Blanco T, Musayeva A, Tahvildari M, Amouzegar A, Yin J, Chauhan S, Chen Y, Dana R. Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice. Transplantation 2022, 107: 1302-1310. PMID: 36584368, PMCID: PMC10205651, DOI: 10.1097/tp.0000000000004424.Peer-Reviewed Original ResearchConceptsNK cell depletionAllograft survivalNatural killerNK cellsGraft survivalYounger recipientsRejection of corneal allograftsSuppressing NK cell responsesSuppressive function of TregsCell depletionActivity of NK cellsIn vitro suppression assaySecretion of interferon-gammaRegulatory T cell functionFlow cytometryNatural killer cell activityAllogeneic corneal transplantationCorneal allograft survivalCorneal transplant outcomesYoung graft recipientsFrequency of TregsNK cell responsesRegulatory T cellsFunction of TregsActivated natural killerA Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients’ Five-Tier Rating System
Wang K, Deng Y, Stewart D, Formica R. A Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients’ Five-Tier Rating System. Journal Of The American Society Of Nephrology 2022, 33: 1613-1624. PMID: 35537779, PMCID: PMC9342646, DOI: 10.1681/asn.2022010078.Peer-Reviewed Original ResearchConceptsComposite end pointTraditional end pointsTransplant programsEnd pointAllograft functionGraft survivalScientific RegistryFive-tier systemLong-term graft outcomeDonor graft survivalKidney transplant programAllograft failureAllograft survivalGraft outcomeTransplant recipientsGraft statusGraft failureEGFR differenceSRTR dataSurvival rateEGFRSurvivalRegistryMeaningful differencesConcept study
2021
Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes
Zhang Z, Sun Z, Fu J, Lin Q, Banu K, Chauhan K, Planoutene M, Wei C, Salem F, Yi Z, Liu R, Cravedi P, Cheng H, Hao K, O’Connell P, Ishibe S, Zhang W, Coca SG, Gibson IW, Colvin RB, He J, Heeger PS, Murphy B, Menon MC. Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes. Journal Of Clinical Investigation 2021, 131 PMID: 34499625, PMCID: PMC8592534, DOI: 10.1172/jci146643.Peer-Reviewed Original ResearchConceptsDeath-censored allograft lossAPOL1 risk allelesRisk allelesTransplant outcomesDeath-censored renal allograft survivalRenal allograft survivalChronic allograft rejectionKidney transplant waitlistKidney transplant cohortRisk allele carriersAllograft lossAllograft survivalGraft lossRejection episodesTransplant cohortAllograft rejectionDonor kidneysNative kidneysNK cellsImmunomodulatory roleTransplant waitlistAPOL1 genotypeClinical trialsHealthy controlsHispanic recipients
2020
Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review
Safi AF, Kauke M, Nelms L, Palmer WJ, Tchiloemba B, Kollar B, Haug V, Pomahač B. Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 327-335. PMID: 33229219, DOI: 10.1016/j.bjps.2020.10.003.Peer-Reviewed Original ResearchConceptsLocal immunosuppressionSystematic reviewAllograft survivalComposite allotransplantationAllograft survival dataCell-based therapy strategiesImproved allograft survivalMain immunosuppressive agentMeta-Analyses (PRISMA) guidelinesPreclinical animal studiesPreferred Reporting ItemsMalignant side effectsImmunosuppressive agentsPreclinical dataSignificant prolongationRat modelHuman trialsExclusion criteriaImmunosuppressionSide effectsAnimal studiesReporting ItemsPubMed databaseSystemic toxicityTherapy strategiesUrine Injury Biomarkers Are Not Associated With Kidney Transplant Failure.
Koyawala N, Reese PP, Hall IE, Jia Y, Thiessen-Philbrook HR, Mansour SG, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, Weng FL, Parikh CR. Urine Injury Biomarkers Are Not Associated With Kidney Transplant Failure. Transplantation 2020, 104: 1272-1279. PMID: 31568213, PMCID: PMC7384615, DOI: 10.1097/tp.0000000000002948.Peer-Reviewed Original ResearchConceptsAcute kidney injuryDonor Acute Kidney InjuryGraft failureInjury biomarkersSerum creatinineGraft outcomeKidney injuryComposite outcomeDeath-censored graft failureRisk of GFKidney injury molecule-1Cox proportional hazards modelLiver-type fatty acidSimilar allograft survivalStructural kidney damageKidney transplant recipientsInjury molecule-1Kidney transplant failureGlomerular filtration rateProportional hazards modelAKI kidneysAllograft survivalTransplant recipientsChart reviewNeutrophil gelatinaseGenome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis
Zhang Z, Menon MC, Zhang W, Stahl E, Loza BL, Rosales IA, Yi Z, Banu K, Garzon F, Sun Z, Wei C, Huang W, Lin Q, Israni A, Keating BJ, Colvin RB, Hao K, Murphy B. Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis. Kidney International 2020, 98: 758-768. PMID: 32454123, PMCID: PMC7483801, DOI: 10.1016/j.kint.2020.04.039.Peer-Reviewed Original ResearchConceptsAllograft survivalIntimal fibrosisDeath-censored allograft survivalLong-term allograft failureAcute rejection episodesDonor-recipient differencesRenal allograft survivalHuman leukocyte antigen (HLA) lociNon-HLA SNPsLong-term survivalAllograft failureHLA mismatchesKidney recipientsRejection episodesSubclinical rejectionAllograft fibrosisMultivariable analysisHistologic damageR differencesOrgan SharingCox modelFibrosisHLA regionSurvivalGenome-wide single-nucleotide polymorphism array data
2019
Immunologic benefit of maternal donors in pediatric living donor liver transplantation
Kim M, Akbari O, Genyk Y, Kohli R, Emamaullee J. Immunologic benefit of maternal donors in pediatric living donor liver transplantation. Pediatric Transplantation 2019, 23: e13560. PMID: 31402535, DOI: 10.1111/petr.13560.Peer-Reviewed Original ResearchConceptsLDLT recipientsPediatric LDLT recipientsPediatric LDLTImmune tolerancePost-transplantPrimary diagnosis of biliary atresiaImpact of graft typeMechanisms of immune toleranceDiagnosis of biliary atresiaOperational toleranceImprove outcomesLong-term follow-upPediatric LDLT patientsWithdrawal of immunosuppressionRegulatory T cellsImproving allograft survivalTime post-transplantDonor liver transplantationDeceased donor recipientsMaternal-fetal microchimerismRate of rejectionLDLT patientsAllograft survivalBiliary atresiaPatient survivalHeart-Kidney and Heart-Liver Transplantation Provide Immunoprotection to the Cardiac Allograft
Chou AS, Habertheuer A, Chin AL, Sultan I, Vallabhajosyula P. Heart-Kidney and Heart-Liver Transplantation Provide Immunoprotection to the Cardiac Allograft. The Annals Of Thoracic Surgery 2019, 108: 458-466. PMID: 30885846, DOI: 10.1016/j.athoracsur.2019.02.012.Peer-Reviewed Original ResearchConceptsHeart-kidney transplantationHeart-liver transplantationHT patientsPrior single-center studiesTen-year patient survivalAcute rejection episodesCardiac allograft survivalEquivalent postoperative outcomesFirst posttransplant yearOrgan Sharing databaseSingle-center studyKaplan-Meier curvesChi-square testAllograft survivalHLT patientsRejection episodesSimultaneous kidneyCardiac allograftsHeart transplantationImmunologic outcomesLiver allograftsLiver transplantationPosttransplant yearPostoperative outcomesSimultaneous transplantationLocal Delivery of Regulatory T Cells Promotes Corneal Allograft Survival
Shao C, Chen Y, Nakao T, Amouzegar A, Yin J, Tahvildari M, Lužnik Z, Chauhan S, Dana R. Local Delivery of Regulatory T Cells Promotes Corneal Allograft Survival. Transplantation 2019, 103: 182-190. PMID: 30247445, PMCID: PMC6309927, DOI: 10.1097/tp.0000000000002442.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAllograftsAnimalsAntigen-Presenting CellsChemotaxis, LeukocyteCorneaCorneal TransplantationCytokinesGraft SurvivalGreen Fluorescent ProteinsKineticsLymph NodesLymphocyte ActivationMaleMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicT-Lymphocytes, RegulatoryTh1 CellsConceptsDraining Lymph NodesTreg cellsAntigen-presenting cellsAllograft survivalIL-10Mature antigen-presenting cellsLong-term allograft survivalCorneal allograft recipientsCorneal allograft survivalTGF-bExpression of IFN-gCell-based immunotherapyLevels of IL-10Conventional T cellsPromote transplant survivalGFP transgenic miceCell-based modalitiesExpression of IFNGHost immune responseSuppress host immune responsesEnzyme-linked immunosorbent assayIpsilateral corneaTh1 frequencyReverse transcription polymerase chain reactionCorneal transplantation
2018
Deceased-donor acute kidney injury is not associated with kidney allograft failure
Hall IE, Akalin E, Bromberg JS, Doshi MD, Greene T, Harhay MN, Jia Y, Mansour SG, Mohan S, Muthukumar T, Reese PP, Schröppel B, Singh P, Thiessen-Philbrook HR, Weng FL, Parikh CR. Deceased-donor acute kidney injury is not associated with kidney allograft failure. Kidney International 2018, 95: 199-209. PMID: 30470437, PMCID: PMC6331055, DOI: 10.1016/j.kint.2018.08.047.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryCause graft failureGraft survivalGraft failureGraft functionKidney injuryComposite outcomeDeceased donorsDonor-recipient gender combinationsLong-term allograft survivalKidney Donor Profile IndexDonor AKI stageExpanded-criteria donationKidney allograft failureUtilization of kidneysGlomerular filtration rateCold ischemia timePre-specified variablesKidney machine perfusionAKI stageAllograft failureAllograft survivalCardiac deathIschemia timeRegulatory T Cell Modulation of Cytokine and Cellular Networks in Corneal Graft Rejection
Tahvildari M, Inomata T, Amouzegar A, Dana R. Regulatory T Cell Modulation of Cytokine and Cellular Networks in Corneal Graft Rejection. Current Ophthalmology Reports 2018, 6: 266-274. PMID: 31807370, PMCID: PMC6894425, DOI: 10.1007/s40135-018-0191-2.Peer-Reviewed Original ResearchCorneal transplantationAllograft survivalGraft rejectionT cellsActivation of effector T cellsIncreased risk of graft rejectionPromote corneal allograft survivalRegulatory T-cell modulationInduction of immune toleranceRisk of graft rejectionTherapeutic approachesCorneal allograft survivalExpansion of TregsCorneal graft rejectionEffector T cellsRegulatory T cellsPromote transplant survivalAdaptive immune responsesHigh-risk allograftsModulation of cytokinesHost bedTargeting TregsImmune toleranceGraft survivalTregs
2016
In Vivo Expansion of Regulatory T Cells by Low-Dose Interleukin-2 Treatment Increases Allograft Survival in Corneal Transplantation
Tahvildari M, Omoto M, Chen Y, Emami-Naeini P, Inomata T, Dohlman T, Kaye A, Chauhan S, Dana R. In Vivo Expansion of Regulatory T Cells by Low-Dose Interleukin-2 Treatment Increases Allograft Survival in Corneal Transplantation. Transplantation 2016, 100: 525-532. PMID: 26881788, PMCID: PMC4764457, DOI: 10.1097/tp.0000000000001044.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAllograftsAnimalsCell ProliferationCells, CulturedChemotaxis, LeukocyteCorneaCorneal TransplantationDrug Administration ScheduleForkhead Transcription FactorsGraft SurvivalInterferon-gammaInterleukin-2Interleukin-2 Receptor alpha SubunitLymphocyte ActivationMaleMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLT-Lymphocytes, RegulatoryTime FactorsConceptsCorneal allograft survivalLong-term allograft survivalRegulatory T cellsAllograft survivalIL-2T cellsCorneal transplantationImmunosuppressive functionImproving long-term allograft survivalLow-dose IL-2 administrationExpansion of regulatory T cellsLow doses of IL-2Graft-infiltrating immune cellsIL-2-treated groupLow-dose IL-2Survival of corneal allograftsDoses of IL-2In vitro proliferation assayAllogeneic corneal transplantationInfiltration of CD45Suppress alloimmune responsesFrequency of effector T cellsFrequency of TregsIL-2 administrationKaplan-Meier survival analysis
2015
The Impact of Donor and Recipient Renal Dysfunction on Cardiac Allograft Survival: Insights Into Reno-Cardiac Interactions
Laur O, Brisco MA, Kula AJ, Cheng SJ, Mangi AA, Bellumkonda L, Jacoby DL, Coca S, Tang WH, Parikh CR, Testani JM. The Impact of Donor and Recipient Renal Dysfunction on Cardiac Allograft Survival: Insights Into Reno-Cardiac Interactions. Journal Of Cardiac Failure 2015, 22: 368-375. PMID: 26616578, PMCID: PMC4904299, DOI: 10.1016/j.cardfail.2015.11.009.Peer-Reviewed Original ResearchConceptsRenal dysfunctionCardiac transplantationAdverse recipient outcomesCardiac allograft survivalOrgan Sharing registryGlomerular filtration ratePotent risk factorImpact of donorAllograft survivalCardiac allograftsRecipient deathRecipient outcomesUnited NetworkAdverse outcomesFiltration rateMyocardial necrosisRisk factorsCardiovascular diseaseHigh riskDonor characteristicsOlder ageRetransplantationDeathTransplantationDysfunction
2014
Facial and Hand Allotransplantation
Pomahac B, Gobble R, Schneeberger S. Facial and Hand Allotransplantation. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015651. PMID: 24478387, PMCID: PMC3935393, DOI: 10.1101/cshperspect.a015651.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationFacial transplantationLong-term immunosuppressionMinimization of immunosuppressionGood functional outcomeTreatment of patientsMultidisciplinary team approachNovel therapeutic optionsSevere facial disfigurementAllograft survivalHand allotransplantationSkin rejectionTherapeutic optionsFunctional outcomeLimb lossComposite allotransplantationSide effectsTeam approachTransplantationSurgical planningFacial disfigurementImmunosuppressionAllotransplantationComplex proceduresPatients
2011
Impact of Acute Rejection on Kidney Allograft Outcomes in Recipients on Rapid Steroid Withdrawal
Heilman RL, Nijim S, Chakkera HA, Devarapalli Y, Moss AA, Mulligan DC, Mazur MJ, Hamawi K, Williams JW, Reddy KS. Impact of Acute Rejection on Kidney Allograft Outcomes in Recipients on Rapid Steroid Withdrawal. Journal Of Transplantation 2011, 2011: 583981. PMID: 21647349, PMCID: PMC3103882, DOI: 10.1155/2011/583981.Peer-Reviewed Original ResearchClinical acute rejectionRapid steroid withdrawalDeath-censored graft survivalKidney transplant recipientsSubclinical rejectionGraft survivalControl groupAcute rejectionSteroid withdrawalTransplant recipientsRejection groupCR groupDeceased donor kidney transplantInferior graft survivalMean HLA mismatchesKidney allograft outcomesDonor kidney transplantsAllograft outcomesAllograft survivalProtocol biopsiesHLA mismatchesBorderline changesKidney transplantPrimary outcomePersistent inflammation
2010
Living Donor Kidney Transplantation With Multiple Renal Arteries in the Laparoscopic Era
Tyson MD, Castle EP, Ko EY, Andrews PE, Heilman RL, Mekeel KL, Moss AA, Mulligan DC, Reddy KS. Living Donor Kidney Transplantation With Multiple Renal Arteries in the Laparoscopic Era. Urology 2010, 77: 1116-1121. PMID: 21145095, DOI: 10.1016/j.urology.2010.07.503.Peer-Reviewed Original ResearchConceptsMultiple renal arteriesSingle renal arterySlow graft functionDonor kidney transplantationPatients' overall survivalGraft functionKidney transplantationRenal arteryOverall survivalSingle tertiary care academic centerTertiary care academic centerLong-term allograftClavien classification systemDelayed graft functionLong-term outcomesAcute rejectionAllograft survivalUrological complicationsPostoperative complicationsRetrospective reviewLaparoscopic eraAnatomic variationsHigh incidenceAcademic centersMRA groupEarly Graft Function After Laparoscopically Procured Living Donor Kidney Transplantation
Tyson M, Castle E, Andrews P, Heilman R, Mekeel K, Moss A, Mulligan D, Reddy K. Early Graft Function After Laparoscopically Procured Living Donor Kidney Transplantation. Journal Of Urology 2010, 184: 1434-1439. PMID: 20727548, DOI: 10.1016/j.juro.2010.06.013.Peer-Reviewed Original ResearchConceptsPoor early graft functionEarly graft functionLiving-donor kidney transplantationGraft functionDonor kidney transplantationAcute rejectionKidney transplantationMultivariate logistic regression modelGraft function groupDelayed graft functionDonor kidney transplantsInstitutional review boardLogistic regression modelsAllograft survivalGraft nephrectomyVascular complicationsKidney transplantPerioperative parametersIndependent predictorsTransplantation databaseClinical outcomesPatient survivalBlack ethnicityMale genderDonor age
2009
27: Targeting of the Histone Acetyltransferase, Myst1, Enhances Foxp3+ Regulatory T Cell Function and Prolongs Cardiac Allograft Survival
Gruber P, Wang L, de Zoeten E, Granger A, Zhou D, Hancock W. 27: Targeting of the Histone Acetyltransferase, Myst1, Enhances Foxp3+ Regulatory T Cell Function and Prolongs Cardiac Allograft Survival. The Journal Of Heart And Lung Transplantation 2009, 28: s74. DOI: 10.1016/j.healun.2008.11.033.Peer-Reviewed Original Research
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